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Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | X | Y | Devolved Administrations | English Regions | Parliamentary Constituencies | Local Authorities | Integrated Care Boards |
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Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | X | Y | Devolved Administrations | English Regions | Parliamentary Constituencies | Local Authorities | Integrated Care Boards | |
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1 | 001/0010 | Injury Trends and Social Gradients | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £88,155 | 1 August 2004 | 30 September 2007 | Not Available | BackgroundAims To contribute to evidence based accident prevention policy through:1. describing cause specific injury mortality gradients for children and young adults 2. determining whether gradients have widened or narrowed over last 10 years 3. determining how far gradients are explained by exposure to risk 4. identify geographic areas where injury rates are highest5. utilise the findings from aims 1-4 with those from other projects funded under this programme to develop bids for interventions designed to address inequalities in injury rates for children and young peopleResearch design and methods This project will be a secondary analysis of existing data sets including ONS mortality data, Hospital Episode Statistics and the Health Survey for England morbidity data and DoT travel survey data. These will be analysed using census denominators to identify social class, regional, and (where possible) ethnic group injury rate trends.Involvement of stakeholders A steering group will inclu | Academic | London School of Hygiene and Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | 529790 | 181879 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
2 | 001/0013 | Preventing Falls amongst Older People: Socio-Economic and Ethnic Factors | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £179,782 | 1 September 2004 | 31 March 2008 | Not Available | BackgroundFalls and fractures amoungst older people are a major public health challenge. Suprisingly little is known about the association of falls and use of falls-related services with socio economic status and ethnicity. The present proposal is for a series of three studies to investigate the question: 'what are the socio-economic and ethnic differences in fall-related morality, morbidity, health care seeking behaviour and provision of services?' The first study will perform novel secondary analysis on three different existing data sources (ONS morality statistics, Hospital Episode Statistics (HES), and Health Survey for England (HSE). This will provide statistics variation in falls and health care seeking behaviour, but will not permit us to identify the reasons for observed variations, and may not provide sufficient data on ethnic minorities. To supplement the data on ethnic variations and to identify the reasons for variations we will undertake new primary research by carryi | Academic | The University of Manchester | M13 9PL | 53.467 | -2.234 | 384691 | 397756 | England | North West | Manchester Central | Manchester | NHS Greater Manchester Integrated Care Board | |
3 | 001/0014 | Facilitators and Barriers to Older People Accepting and Complying With Interventions to Reduce Falling and Fractures | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £130,035 | 1 September 2004 | 31 October 2008 | Not Available | BackgroundThe overall aims of the project are to:identify the barriers and facilitators to the implementation of falls injury prevention strategies and programmes for older people and to investigate why older people may either refuse to participate in an intervention or, not adhere to specific social or clinical recommendationsMethodsThis will involve a two-phase process using both qualitative and quantitative methods. The first phase consists of a systematic literature review. Through inclusion of all available studies, including grey literature, the views, preferences and experiences of older people in relation to falls prevention strategies will be assessed alongside the effectiveness of interventions to promote falls injury prevention. The second phase, informed by the review, will involve focus groups and interviews to provide an in-depth investigation of older people's perceptions of fall injury prevention strategies. This will cover a broad range of interventions and will includ | Academic | University of Hertfordshire | AL10 9AB | 51.753 | -0.242 | 521517 | 207512 | England | East of England | Welwyn Hatfield | Welwyn Hatfield | NHS Hertfordshire and West Essex Integrated Care Board | |
4 | 002/0010 | Cardiac Rhythm and Personal Exposure to Air Pollution in Patients with Heart Failure | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £249,178 | 1 October 2002 | 30 September 2007 | Not Available | BackgroundThe majority of excess deaths associated with rises in air pollution appear to be from cardiac causes. Particles and nitrogen dioxide are the pollutants most closely associated with this effect but which of these, and the mechanisms, remain speculative. The hypothesis is that the effects are mediated by secondary changes in blood coagulability. Another is that pollution causes changes in the irritability of the heart, with changes in rate, rhythm and variability. These hypotheses are not in conflict and this project will investigate both.The study will look at the associations between exposure to particles and NO2, alterations in cardiac rhythm, and coagulation factors in 100 patients recrutied from 200 with stable heart failure. In each it will measure personal exposure to NO2 and estimate personal exposure to particle mass and number for 3 consecutive days on six separate occasions over a year. On the 3rd day it will record a 24-hour cardiograph and take blood for ind | Academic | University of Aberdeen | AB24 3FX | 57.165 | -2.100 | 394104 | 808245 | Scotland | Not Applicable | Aberdeen North | Aberdeen City | Not Applicable | |
5 | 002/0015 | Health Effects of Long-Term Exposure to Air Pollutants in Scotland | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £188,761 | 1 April 2003 | 30 June 2007 | Not Available | BackgroundThe purpose of the proposed research is to simultaneously quantify the health effects of long-term exposure to air pollutants and shortening of life from short-term exposures. Primary outcome measures are cause-specific mortality and morbidity , with particular attention to cardiovascular outcomes. We will compare the results of cohort studies to corresponding estimates from time-series studies of the population from which the cohorts are drawn. Outcomes in 26,360 subjects in 3 cohorts will be investigated in the period between 1970 and 2002. Detailed baseline risk data and the unique advantages of the Scottish Health Record Linkage system (including algorithmic linking of individual hospital admission & mortality records) will enable novel ways of quantifying effect magnitudes in susceptible population sub-groups, and coherence in medical outcomes. We shall examine the potential for confounding and effect modification by both individual and aggregate level factors (including | Academic | University of Strathclyde | G1 1XQ | 55.861 | -4.245 | 259609 | 665397 | Scotland | Not Applicable | Glasgow Central | Glasgow City | Not Applicable | |
6 | 002/0025 | Pilot Study of Risks and Long Term Effects of Carbon Monoxide Poisoning | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £65,415 | 1 July 2008 | 30 September 2010 | Carbon monoxide poisonings arise mostly from faulty domestic appliances - gas heaters, boilers, stoves, cookers. Among those who survive poisoning incidents, the oxygen starvation may cause long-term damage, and there is a need to understand the risks and causes of various symptoms and conditions. A full study might recruit up to 800 cases from Scottish hospital A&E admissions in the last two decades, using postal questionnaires and details from hospital patient notes. The questionnaires will include questions on general health before and after the accident, lifestyle (smoking, alcohol), and questions relating to mental state, because we suspect some long-term symptom patterns may be due to psychological stress rather than physical damage. In some patients we may see symptoms of poisoning some time before the actual poisoning incident and this will indicate whether carbon monoxide poisoning goe unrecognised in the community both by doctors and the victims. In this pilot study we | Background In non-fatal CO poisoning, there may be acute hypoxic damage to the brain, and/or long-term sequelae in the central nervous system, including chronic cognitive impairment. The reporting of chronic symptoms following lower levels of exposure may be coloured by multiple factors, and in some cases the putative effects of CO poisoning may be better understood as a somatoform disorder. Using NHS Scotland electronic databases, it should be possible to identify up to 800 past CO poisoning victims and to obtain data about their symptoms and health status since the incident. This could both address long-term sequelae and investigate possibilities of somatoform disorders. We propose a pilot study to investigate the feasibility of the approach and to develop and validate appropriate methods. Aims Given the hypotheses to be tested by a full study (Section 9), we propose a pilot study with the aims: • to obtain permission to contact study patients and controls through S | Non-Profit/Charity | Institute of Occupational Medicine | EH14 4AP | 55.916 | -3.316 | 317743 | 669728 | Scotland | Not Applicable | Edinburgh South West | City of Edinburgh | Not Applicable | |
7 | 002/0027 | Health Implications of Polycyclic Aromatic Hydrocarbons in Indoor Environments | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £74,730 | 1 January 2009 | 31 March 2010 | Polycyclic aromatic hydrocarbons are a group of chemical substances emitted into the air from combustion processes. They get into indoor air from indoor sources such as smoking as well as infiltrating from outdoors. The concern over polycyclic aromatic hydrocarbons is that some of them are known to be carcinogenic (cancer causing) agents and breathing air polluted with them increases the risk of contracting lung cancer, even in non-smokers. Whilst the government funds widespread measurements of polycyclic aromatic hydrocarbons in outdoor air, there are very few measurements, particularly from the UK, of polycyclic aromatic hydrocarbons in indoor air. This project is concerned with using data and samples collected in an earlier study to compare the concentrations of polycyclic aromatic hydrocarbons in indoor air with those out-of-doors and to see whether the profile of individual compounds making up the mixture is similar indoors and outdoors. Using potency factors for the cancer-c | BackgroundPolycyclic aromatic hydrocarbons are known pollutants of indoor air. They arise from indoor sources such as tobacco smoke and cooking as well as from infiltration of outdoor air. PAH comprise a range of compounds and there is currently little information on whether the profile of compounds in indoor air matches that outdoors. Most probably it does not, since the sources will be significantly different. This has implications for the toxicity of the mixture and the suitability of the outdoor air quality standard as a guideline for indoor concentrations.AimsThese are as follows:• to investigate the concentrations and profile of PAH compounds in air sampled in UK indoor environments and to compare it with outdoor samples collected in the same localities;• by use of relative potency factors to estimate the carcinogenic risk associated with indoor air;• to evaluate whether the use of benzo(a)pyrene as a marker for the mixture is applicable to PAH in indoor air in the same wa | Academic | University of Birmingham | B15 2TT | 52.453 | -1.928 | 404851 | 283719 | England | West Midlands | Birmingham, Edgbaston | Birmingham | NHS Birmingham and Solihull Integrated Care Board | |
8 | 002/0038 | 2012 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £23,777 | 26 March 2012 | 31 December 2012 | Organisation and conduct of a 2 day air pollution and health research review meeting on 3 & 4 May 2012. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2012 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site. | 2012 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | Academic | Cranfield University | MK43 0AL | 52.070 | -0.631 | 494079 | 242615 | England | East of England | Mid Bedfordshire | Central Bedfordshire | NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board | |
9 | 002/0039 | 2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £24,052 | 1 January 2013 | 31 December 2013 | Organisation and conduct of a 2 day air pollution and health research review meeting on 23 & 24 April 2013. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2013 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site. | 2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | Academic | Cranfield University | MK43 0AL | 52.070 | -0.631 | 494079 | 242615 | England | East of England | Mid Bedfordshire | Central Bedfordshire | NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board | |
10 | 005/0163 | Developing Options for Evidence Based Formula for the Need for Children's Social Services | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £114,961 | 1 April 2005 | 31 July 2007 | Not Available | Background1. A small area analysis based on the national data set of activities and costs compiled for CIN 2003, attributing socio-economic characteristics from postcode districts and on subsets that are more homogenous with respect to ethnicity;2. Collection of ward identifiers on children in CIN 2003 from a representative sample of Local Authorities to replicate the small area analysis carried out in 19963. Analysing the individual data in CIN 2003 for all children and for subsets defined as in 1, to identify the factors that affect the level of expenditure on current clients.4. Combined analysis of one or more years of the national GHS in conjunction with CIN 2003 to assess the factors that influence the likelihood of a child being a current client.5. Special investigation of the factors affecting the costs of fostering with a view to developing a more robust adjustmentThroughout, the study will be designed and conducted in close collaboration with DfES and representatives of the Lo | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York | NHS Humber and North Yorkshire Integrated Care Board | |
11 | 006/0037 | The Mersey Cerebral Palsy Register | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £235,598 | 1 April 2003 | 31 January 2010 | Not Available | BackgroundAims of the project:To maintain and develop the Mersey Cerebral Palsy Register (MCPR). The register's aims are, within Merseyside and Cheshire, to monitor population trends in prevalence of cerebral palsy (CP); assess cohort effect on life expectancy of affected individuals; and determine trends in severity of functional disability.Research subject group:Cerebral Palsy, a group of disorders of movement and posture due to a defect/lesion of the immature brain, and the commonest cause of severe physical disability affecting children in England.Sample Size:Anticipated annual recruitment of 40-60 cases, (area has 25,000 births annually, and birth prevalence of CP of 2 to 2.5 per 1,000 live births)Type of Location:Population-based disease register, located within the University of Liverpool, established 1980, covers Merseyside and Cheshire. Case definition: a clinical diagnosis of CP, and mother resident in the area at time of birth.Methods of working:Identification by active su | Academic | University of Liverpool | L69 7ZX | 53.406 | -2.967 | 335836 | 390320 | England | North West | Liverpool, Riverside | Liverpool | NHS Cheshire and Merseyside Integrated Care Board | |
12 | 006/0055 | NPEU Birth at Home in England | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £838,794 | 1 April 2007 | 31 January 2012 | Not Available | BackgroundThe Birth at Home study will collect outcomes of planned birth at home to allow comparison with outcomes measurede by the ongoing Evaluation of Maternity Units (www.npeu.ox.ac.uk/EMU) research programme amongst women at low risk of complications who have planned birth in midwifery units and obesteris units. Data items and methods for collection will be the same as in EMU. Cost-effectiveness of the different planned places will be compared. Phase 1 (April 2007 - march 2088, months 1-12), will act as a pilot study. During this phase the feasibility of collecting data from all women planning a home birth will be explored in three local authority areas. By the 9th month, feasibility of conducting the national study will be assessed and the decision made about whether or not to proceed to national-scale data collection. I ffeasibiliyt is not demonstrated the study will stop, be reported, and funding will be terminated on March 31st 2008.Transition period (January - March 200 | Academic | University of Oxford | OX1 2JD | 51.758 | -1.262 | 451034 | 206852 | England | South East | Oxford East | Oxford | NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board | |
13 | 006/0060 | Evaluating the Family Nurse Partnership Programme in England: a Randomised Controlled Trial | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £5,167,489 | 1 October 2008 | 31 March 2016 | The Family Nurse Partnership (FNP) is a programme of home visits by specially trained nurses to support young first time mothers during their pregnancy and up to two years after birth. It has been developed in the US, and is currently undergoing an initial evaluation in England. Our proposed study will evaluate the impact of the FNP upon the health and well-being of both mother and child during pregnancy and childbirth and, in the first two years after birth, the child’s development and the mothers’ well-being. Measurements will include the baby’s weight, accidents and injuries to the young child and whether the mother has further pregnancies within the next two years. In the 20 geographical sites taking part in the study, 2400 women under 20 years old will be allocated at random to either enter the FNP programme or to continue receiving only existing local services for pregnant women. A research nurse will interview all participating women face-to-face at the start and end of the stud | BackgroundThe Family Nurse Partnership (FNP) is a structured programme of home visits delivered by specially trained nurses for at-risk first time mothers. Part of the Child Health Promotion Programme, this intensive intervention has been introduced to address the elevated risk of social exclusion and health disadvantage that such women and their off-spring face. The programme aims to modify behavioural risk factors and enhance protective factors through regular home visits that start in early pregnancy and continue until the child’s second birthday. Based on the original US programme which has been widely evaluated, the FNP is currently undergoing formative evaluation at 10 English sites. Ten more sites will join to form a sample for a trial of the effectiveness and cost-effectiveness of the FNP.AimsOur study aims firstly to evaluate the effectiveness of the FNP within three outcome domains: pregnancy and birth, child health and development, and parental life course and self-sufficien | Academic | Cardiff University | CF24 0DE | 51.484 | -3.166 | 319119 | 176776 | Wales | Not Applicable | Cardiff Central | Cardiff | Not Applicable | |
14 | 007/0063 | The National CJD Surveillance Unit (CJDSU) Tissue Resource: Support for Continued Banking Activities | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £247,623 | 1 March 2003 | 30 April 2008 | Not Available | BackgroundThe National CJD Surveillance Unit (NCJDSU) was established in 1990 and in 1991 additional funding was obtained from the Department of Health (DH) to establish a neuropathology laboratory for pathological diagnosis, surveillance and research. Since then, NCJDSU has systematically collected a range of tissue samples from the central nervous system (CNS) and other tissues from a wide range of cases of human prion diseases and from other cases of progressive neurodegenerative diseases that were initially suspected as being human prion diseases, but in whom an alternative neuropathological diagnosis was made. All material in the NCJDSU bank has consent for research and local ethical committee approval has been obtained for the collection, storage and use of the material.In subsequent years it became clear that the tissue collected in NCJDSU formed an invaluable unique resource for research and increasing requests for access for the material (particularly variant CJD) were obtai | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
15 | 007/0073 | Development of Rapid Visual and Epimicroscopy Techniques | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £755,147 | 1 January 2002 | 31 March 2009 | Not Available | BackgroundAdvanced light microscopy techniques will be used to assess contamination of various grades of surgical steel coupons and medical instruments, initially using mucins, heparin sulphate and chondroitin sulphate, as models of saliva or brain glycosaminoglycan contamination, and blood. A mouse animal model will be used to supply infected brain homogenate for these contamination studies. Contaminated steel surfaces will be treated with proteinase K to remove normal prion and other brain material, leaving PrPsc which will be scraped/washed off, concentrated by ultrafiltration (assayed by two site ELISA) and serial dilutions injected into the brains of mice to show that the material is still infective. Sensitive pathological and behavioural measures will be used to assay for evidence of low levels of infectivity that might not lead to overt clinical disease.The industrial collaborators (Microgen Bioproducts) have developed a diagnostic kit capable of detecting specific protein ac | Academic | University of Southampton | SO17 1BJ | 50.934 | -1.396 | 442560 | 115135 | England | South East | Southampton, Test | Southampton | NHS Hampshire and Isle of Wight Integrated Care Board | |
16 | 007/0077 | Removal of Infective Protein Residues from Medical Instruments | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1,295,022 | 1 June 2002 | 31 July 2011 | Not Available | BackgroundThis project has the objective of developing new methods to remove and verify the removal of prions from surgical instruments. The project consists of three interactive themes: 1) the development of plasma cleaning methods for the removal of biologically derived materials; 2) the development of 'on-line' fluorescence techniques for detection of protein residues; 3) biological verification of these methodologies. The outcome of the project will be an integrated and verified strategy for the decontamination and screening of surgical instruments.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
17 | 007/0099 | Examination of the Potential for Transmission of vCJD through Dentistry | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1,510,737 | 1 May 2004 | 31 March 2010 | Not Available | BackgroundThe evidence base for a risk -assessment of the potential for transmission of human spongiform encephalopathy through dental procedures is extremely limited. This is particularly so in respect to variant Creutzfeldt-Jakob disease with its recent origin, wider tissue distribution and unknown level of incidence. To help address the paucity of data available, five key areas of uncertainty have been identified for detailed investigation: 1. Prion distribution and infectivity in oral tissues. 2. Determination of the residual soiling of instruments used in dentistry. 3. Dental instrument decontamination procedures and the inactivation of vCm infectivity. 4. Determination of human tissue contamination of Dental Unit Water Systems (DUWS). 5. Investigation of the extent of aerosolisation of human tissue during dental procedures. These investigations will be of two separate types and take place in two distinct locations. Laboratory-based studies specifically utilising vCm/BSE infectiou | Undefined | Centre for Emergency Preparedness & Response | SP4 0JG | 51.135 | -1.700 | 421069 | 137358 | England | South West | Salisbury | Wiltshire | NHS Bath and North East Somerset, Swindon and Wiltshire Integrated Care Board | |
18 | 007/0101 | Surveillance for Asymptomatic Prion Infection in Primary Immunodeficiency Patients Exposed to UK Sourced Immunoglobulin | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £339,983 | 1 September 2006 | 31 March 2015 | Variant Creutzfeldt-Jakob disease (vCJD) is a type of dementia, caused by an abnormal prion which originally came from cattle with ‘mad cow disease’ or bovine spongiform encephalopathy (BSE). In addition, we know that human to human transmission can occur. Blood donors who at the time were unaware that they were infected with vCJD, donated blood which infected recipients with vCJD. There are 3 known cases in the UK. This has only happened in the UK. Immunoglobulin is a product derived from blood used primarily to treat patients with antibody deficiencies. Each injection is made from several thousand blood donations. This means that any immunoglobulin infected with vCJD could possibly spread abnormal prions from person to person. Our research is to find out if this has happened to patients exposed to British-sourced immunoglobulin and we have recruited volunteers to participate in the study. VCJD and other prion diseases can only be diagnosed from tissue samples. We are collecting tissu | BackgroundThe possibility that the abnormal prions responsible for variant Creutzfeldt-Jakob disease (vCJD) may be transmitted through plasma products has considerable ramifications for patients with Primary Immunodeficiency (PID) receiving immunoglobulin.Although abnormal prions are transmissible by whole blood between animals, there are no data showing this can happen between humans. Abnormal prions can now be detected in lymphoid tissue from asymptomatically infected individuals with reasonable specificity and sensitivity. The technology to detect abnormal prions in blood samples is also improving.The proposed project will be carried out on approximately 130 PID patients exposed to UK sourced immunoglobulin between 1996 and 1998, attending PID centres across the UK. The proposal is to produce:- a confidential data base containing exposure details and prospective clinical evaluations- a retrospective and prospective collections of lymphoid and spleen material for histological prio | Government/NHS | Manchester University NHS Foundation Trust | M13 9WL | 53.462 | -2.228 | 384979 | 396212 | England | North West | Manchester Central | Manchester | NHS Greater Manchester Integrated Care Board | |
19 | 007/0104 | Conditional Expression of PRP in the Gut of Transgenic Mice to Investigate the Uptake of Infectivity in the Gut in the TSEs | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £341,422 | 1 August 2005 | 31 March 2007 | Not Available | BackgroundWe aim to establish whether PrP expression in the gut is required for the uptake of TSE infectivity and whether in the absence of intestinal PrP expression, uptake and transport of infectivity to peripheral sites of agent replication is blocked. We will address this using two lines of gene-targeted transgenic mice which allow us to control the expression of the PrP gene in a temporal and/or spatial fashion. These mice allow us to switch PrP expression on (NS line) or off (ORFR line) when crossed with Cre recombinase transgenic mice. We will cross the ORFR and NS lines with an inducible P450-Cre line which expresses Cre recombinase in the stem cells of the intestine following administration of the p450-inducer, beta-napthoflavone. Used in conjunction with an inducible neurone-specific Cre line we will be able to control PrP expression in the intestine and neurones prior to orally infecting with a murine TSE agent. These studies will determine the potential for early inter | Undefined | Institute for Animal Health | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | |||
20 | 007/0107 | The Development of a Novel Human Cell Culture Model of Prion Disease | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £215,853 | 1 April 2004 | 31 March 2007 | Not Available | BackgroundThere are no human cell culture models of prion disease available, these are urgently needed for several reasons. This project aims to develop and characterise an in vitro cell culture system of human prion disease. Human and transgenic murine neural and non-neural cell lines are in development. These lines will be infected with various human, and BSE, prion strains; and cell populations screened for infected cells. All the techniques, infrastructure and collaborations necessary for the success of this project are already in place. This human cell line will be used as a diagnostic tool to develop a bioassay system to replace traditional mouse innoculation assays which are expensive and time-consuming, often taking up to one year for a result; a cell culture based bioassay would only take 3-4 weeks to achieve similair results. The human line will also be used for the development and screening of therapeutics aimed at the removal and clearance of human PrPSc. A clinical scienti | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
21 | 007/0113 | Predicting Future Numbers of Cases of vCJD 2 | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £268,353 | 1 May 2005 | 30 November 2008 | Not Available | BackgroundThe aims of the project are:To develop vCJD prediction models which:i) take into account differences in the evolution of the vCJD epidemic in different birth cohorts, regional differences in the incidence of vCJD, the possibility of secondary transmission among humansii) incorporate data available on asymptomatic infections (appendix, tonsil, blood)iii) distinguish between different short-term trends in the pattern of disease occurrenceTo investigate the efficiency and cost-effectiveness of different strategies for testing for asymptomatic infection.Current data on vCJD cases in the UK are available through the NCJDSU. Population estimates will be obtained from the Census Dissemination Unit. Data on risk of secondary transmission of vCJD through transfusions of blood and blood products from the Transfusion Medicine Epidemiological Review will be available through the NCJDSU. Data from surveys deploying tests for asymptomatic infection will be obtained by negotiation with the | Academic | London School of Hygiene and Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | 529790 | 181879 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
22 | 007/0119 | The Development of an Effective Treatment for Prion Infection of Humans | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £7,238,766 | 1 February 2006 | 30 June 2013 | Prion diseases are fatal untreatable brain disorders caused by prions, germs that grow in the brain. The best known is Creutzfeldt-Jakob disease (CJD). Unlike other germs, like bacteria and viruses, prions do not carry genes and are made just of protein. This protein (called PrP) is one of the body’s own proteins. Prions consist of clumps of misshapen PrP (rogue form) and grow and multiply as more and more normal PrP ends up in this form. Prions affect many types of animal, causing scrapie in sheep and BSE in cattle. Sometimes prions can jump from one species to another, and we know that BSE prions can infect humans and cause variant CJD. There is always a long delay (years or decades) between someone being infected with prions and developing the disease. Healthy carriers of infection can pose a risk to others if they donate blood or organs, and surgical instruments can also become contaminated by prions and pose a risk to other patients. Although only around 200 people have developed | BackgroundThe majority of the UK population have potentially been exposed to BSE prions, the causative agent of variant CJD. The number infected, eventual epidemic size and secondary transmission dynamics are unknown. The central molecular event in prion replication is the conversion of a neuronal glycoprotein (PrPc) into a conformational isomer that accumulates as aggregated material (PrPs) in a self-propagating process. The availability of PrPc substrate is an absolute requirement for prion propagation and pathogenesis. We propose to identify and characterise novel small molecules that stabilise the native conformation of PrPc and inhibit its ability to be recruited into PrP$0. Inhibition of prion replicationkinetics to below those of natural clearance mechanisms should cure prion infection. The MRC Unit has developed an effective collaboration with GlaxoSmithKline R&D Ltd, performed successful pilot stage studies and produced further experimental underpinning of our therapeutic stra | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
23 | 007/0120 | The Effect of Leucodepletion on Transmission of BSE by Transfusion of Sheep Blood Components | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £795,296 | 1 November 2005 | 31 March 2007 | Not Available | BackgroundThis project will use sheep experimentally infected with BSE as a model to study the risks of transmission of variant CJD by blood components in humans. The aim of the project is to determine the distribution of BSE infectivity in sheep blood components, and the effectiveness of human leucodepletion filters in removing infectivity. The methods used for collection of blood and separation and filtration of components will follow as closely as possible those routinely employed for human blood by transfusion services, and will initially be developed and validated for normal sheep blood in the laboratories of SNBTS. A secondary aim of the project is to develop a bioassay for measurement of titres of infectivity in blood components, using transgenic mouse lines that over-express ovine PrP. The sheep experiments will be carried out using BSE-infected donors and will assess the effect of leucodepleting blood components (plasma, platelets and erythrocytes) on transmission at a single | Undefined | Institute for Animal Health | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | Not Available | |||
24 | 007/0136 | National Tonsil Archive phase III | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £7,024,560 | 1 April 2006 | 31 March 2013 | Not Available | BackgroundThe overall aim of the prion prevalence tissue archive is to estimate the prevalence of infection with the BSE agent in residents of England who are likely to have been exposed to the BSE agent through their diet. This will be achieved by measuring the prevalence of detectable abnormal prion protein (PrPsc) in the tonsil tissue of at least 50,000 residents of England born before 1st January 1996.The project will be implemented in three phases: Phase one: Establishing a project management team Phase two: Developing a preliminary collection network Phase three: National roll-out and main collection.This application is for funding to establish a project management team at PHLS to develop the scientific, logistic, ethical, financial and accountability framework for establishing national collection of tonsil tissue.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHIS | Academic | Health Protection Agency | NW9 5EQ | 51.595 | -0.255 | 520992 | 189896 | England | London | Hendon | Barnet | NHS North Central London Integrated Care Board | |
25 | 007/0163 | Investigation into Transmissibility of TSEs via Blood | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £9,377 | 1 April 2007 | 31 August 2008 | Not Available | BackgroundThe research protocol will include collection of blood and preparation of buff y coat from animals involved in one MAFF-funded pathogenesis studies. Blood samples will be taken on the basis of 10ml per Kg body weight at various time points and used either as whole blood or blood processed to give buffy coat. Buffy coat samples will only be taken from animals which are being killed either at terminal stages of disease or as part of one of the pre-clinical kill points of the pathogenesis experiments. The blood and buffy coat will be transfused or introduced intravenously into recipient animals which will subsequently be maintained for their natural lifespan. Each animal will be examined regularly for clinical signs of TSE. Those animals which develop clinical signs of infection will be killed and subjected to a full post-mortem examination. Selected tissues will be taken for histopathological studies and immunochemical testing for the disease-related form of the PrP protein. Ot | Undefined | The Roslin Institute | EH25 9RG | 55.866 | -3.201 | 325005 | 664178 | Scotland | Not Applicable | Midlothian | Midlothian | Not Applicable | |
26 | 007/0169 | Investigating Dental Treatment as a Possible Risk Factor for Variant CJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £256,621 | 1 April 2008 | 30 September 2009 | Not Available | BackgroundLittle work has been performed examining accurate past dental history of CJD cases and controls by direct review of dental records. The NCJDSU has MREC approval to collate information from the medical records of CJD cases and matched controls. Following on from a DH funded pilot study, this study will attempt to access the dental case records of UK variant CJD cases (n=166 as of 9/8/07) and 166 general population controls. In addition, payment schedule records will be accessed where possible in collaboration with NHSBSA Dental Practice Division (England and Wales) and NHSNSS Information and Statistics Division (Scotland). The case record and payment schedule data will be reviewed by a dental healthcare professional and will, where possible, include the presence or absence of oral disease, dates and types of treatment performed and additional risk factor information, e.g., human dura mater grafting. Data will be coded and entered into a database for subsequent analysis. Geogra | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
27 | 007/1031 | National Prion Monitoring Cohort | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £3,036,383 | 1 April 2008 | 31 March 2012 | Not Available | BackgroundThe National Prion Monitoring Cohort comprises three strata: 1) symptomatic patients with confirmed prion disease (Appendix 1), 2) asymptomatic individuals with confirmed pre-clinical prion infection or disease (confirmed genetic mutation or positive PrP immunocytochemistry or Western blot on tissue biopsy but no symptoms at present) and 3) asymptomatic individuals without a confirmed diagnosis but at high risk due to known exposure (either through iatrogenic exposures , or close kinship with a person with confirmed inherited prion disease (IPD)). The first stratum includes those patients already enrolled in any of the threeparts of the PRION-1 trial (randomised controlled trial of immediate versus deferredquinacrine, open-label study of quinacrine, or study of no quinacrine treatment), patients receiving pentosan polysulphate, terminally ill patients not eligible for PRION-1 and patients not wishing to join PRION-1. The second stratum would include those individuals without | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
28 | 009/0036 | A Randomised Controlled Trial of a Nurse-Led Self-Management Intervention for Patients Admitted to Hospital with Heart Failure | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £223,102 | 1 January 2004 | 29 February 2008 | Not Available | BackgroundHeart Failure is associated with high costs and poor outcome. Patients with this diagnosis are expected to adhere to a complex behavioural regimen including taking medication, monitoring for signs of fluid re-accumulation and a range of life-style changes. Without intervention adherence is about 50%. Standard education alone does not modify this figure. We aim to explore the hypothesis that a brief nurse-Ied self-management intervention will empower patients to positively modify their behaviour and so outcome. The efficacy of this intervention, based on a problem solving approach using cognitive behavioural principles, will be assessed by a randomised controlled trial of 250 patients admitted to hospital with a definite diagnosis of heart failure, randomised to either the nurse-Ied intervention or standard hospital care. The primary outcome measure will be the number and duration of re-admissions at three months. Secondary analyses include costs, mortality at 12 months and pr | Government/NHS | Whittington Health NHS Trust | N19 5NF | 51.566 | -0.139 | 529110 | 186912 | England | London | Islington North | Islington | NHS North Central London Integrated Care Board | |
29 | 009/0052 | Evaluation of the NHS Health Checks programme | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £550,080 | 1 January 2012 | 30 September 2020 | This study will be one of the first major evaluations of the NHS Health Checks programme designed to reduce heart attacks and stroke. In a local study in three east London Boroughs (pop 800,000) and in a national study based on 4 million people in the national QResearch database we will access GP records to determine the following. Uptake of the NHS health Checks programme and variation by age, gender, ethnic group and deprivation to see if the Checks are accessible and equitably provided. Views of providers on implementing the Checks (east London study). The extent to which the Checks identify people who are at low, medium and high risk of heart attack or stroke using a high quality ‘risk score’ to predict these risks. The extent to which people at high risk (a greater than 1 in 5 chance of a heart attack or stroke in 10 years) are treated with statins or for high blood pressure. New diagnoses of diabetes, hypertension and chronic kidney disease as a result of the Checks – and the ext | Evaluation of the NHS Health Checks programme | Academic | Queen Mary University of London | E1 4NS | 51.525 | -0.041 | 536021 | 182455 | England | London | Bethnal Green and Bow | Tower Hamlets | NHS North East London Integrated Care Board | |
30 | 010/0003 | The Yorkshire Register of Diabetes in Children and Young People | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £302,999 | 1 April 2003 | 31 January 2009 | Not Available | BackgroundRising numbers of children and young people with diabetes are of great public health concern and present an increasing burden to the NHS. Population-based registers of diabetes in this vulnerable age group are essential for monitoring trends, evaluating standards of care and researching disease aetiology. The Yorkshire Register of Diabetes in Children and Young Adults is a well-established high quality population-based register of over 4,000 0-29 year olds diagnosed since 1978. Data are held at the Paediatric Epidemiology Group, Leeds University, alongside other chronic disease registers and where researchers have skills in analysing population-based data applying various methodologies. The aim of the register is to describe the epidemiology of diabetes, investigate the molecular and environmental aetiology and facilitate health services research. Individuals are ascertained from two sources (hospitals and GPs), with completeness estimated at 99%, and basic clinical and demog | Academic | University of Leeds | LS2 9JT | 53.808 | -1.553 | 429512 | 434722 | England | Yorkshire and The Humber | Leeds Central | Leeds | NHS West Yorkshire Integrated Care Board | |
31 | 011/0036 | Estimating and Explaining Early Exit from Drug Treatment | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £114,743 | 1 June 2005 | 31 March 2008 | Not Available | BackgroundThis project focuses on dependent drug users who do not engage, or drop out early from tier 3 and 4 services, despite having offered a place in treatment.This research wil provide policy-relevant information by achieving the following aims:- To provide an estimate of the rates of early exit from tier 3 and 4 services in two regions of England - one provincial and metroplitan- To identify the characteristics of those dependent drug users who are most likely not to engage or exit early- To provide information on why drug users do not engage in treatment or leave early-To make recommendations on how rates of early exit can be reduced.All these aims will be achieved with a specific emphasis on groups who are particularly vulnerable to early exit, includiong women, members of ethnic minority groups, young people (aged 18-25) and offenders.The research will involve quantitative (logistic regression) analysis of monitoring and primart data on treatment attendance of over 3,000 peopl | Academic | University of Kent | CT2 7NZ | 51.299 | 1.071 | 614184 | 159965 | England | South East | Canterbury | Canterbury | NHS Kent and Medway Integrated Care Board | |
32 | 011/0041 | Exploring Young People's Views and Experiences of Drug Treatment Services - A Qualitative Study | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £101,054 | 1 September 2005 | 31 March 2008 | Not Available | BackgroundAbstract of Research: No more than 200 words covering the following topics: aims of project; research subject group; sample size, type and location; methods of working. Exploring young people's views and experiences of drug treatment services- a qualitative study. This study will inform policy and practice in the area of drug treatment services for young people. It will provide insights into:- Young people's decision to seek and processes leading to treatment- including barriers young- people faced in accessing treatment;Young people's views and experiences of treatment services;- The perceived impact of treatment on young people's lives- including any impact on their drug- use, associated risk behaviours, offending behaviour, mental and physical well-being and overall quality of life;The perceived impact of factors other than treatment on the level and nature of drug use in- which young people engage (identifying factors that may contribute to a young person's resilience to | Academic | National Centre for Social Research | EC1V 0AX | 51.527 | -0.103 | 531689 | 182599 | England | London | Islington South and Finsbury | Islington | NHS North Central London Integrated Care Board | |
33 | 011/0056 | Drug Recovery Wing (DRW) Pilots Evaluation | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £799,134 | 1 October 2012 | 28 February 2016 | Following the UK drug strategy (2010) there has been a major commitment to ensuring that drug treatment services are maximising the opportunities for the recovery of dependent drug users and that drug users in prison and in the community have access to high quality recovery focussed treatment. Delivering abstinence focussed drug treatment services within prisons presents different challenges to those developed within the community not the least of which is the need to combine both treatment and custodial responsibilities. The research outlined in this application will answer questions in three main areas. First, based upon a detailed qualitative assessment of the drug recovery wings, it will provide a detailed description of the therapeutic programme within the wings and the experience of both staff and prisoners involved within them. This element of the research will provide rigorous information on how the wings are operating, what interventions are used with prisoners and how links | Background Following the UK Drug Strategy and the Patel report, there is a commitment to ensure that prisoners have access to high quality recovery-focussed drug and alcohol treatment services and that the link between prison and community is better managed. Research has shown that 50% of male prisoners and 65% of female prisoners have a drug problem (Singleton et al., 1997). According to Stewart (2009) who surveyed 1457 recently received prisoners across 49 prions in England 28% had used heroin in the last four weeks and 25% had used crack cocaine. It is known that in some cases prisoners are initiating injecting within prison (Boys, 2002) and that on release prisoners are at a heightened risk of death (Farrell and Marsden, 2007). Whilst prison offers an important opportunity for drug and alcohol treatment it is recognised that there are multiple challenges associated with the development of drug and alcohol services within prisons (McIntosh and Saville, 2006). Aims This research | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York | NHS Humber and North Yorkshire Integrated Care Board | |
34 | 012/0016 | Social Medicine and Health Services Research Unit (2006 - 2010) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2,894,154 | 1 January 2006 | 31 December 2011 | Not Available | BackgroundThe work programmeThe Unit's focus will remain in two main areas. The first is in the nutritional epidemiology of asthma, the second on the role of airborne allergen in asthma exacerbations. A third area, which relates to each of these, is development of the molecular epidemiology of asthma, building on the experience of the STARS studies.Nutritional Epidemiology of AsthmaThe fellow replacing Dr Shaheen will take on a portfolio of work on asthma and nutrition. This includes ongoing work with the ECRHS data, new studies on asthma and dietary sodium, potentially work undertaken through the GA2LEN network of excellence, and a new application following up Dr Calvert's studies of nutrition and asthma in Africa.The trial of selenium supplementation in adults with asthma has now finished and is being analysed (Dr Shaheen). Dr Okoko though he will not any longer be formally on the DH unit strength will continue his studies of asthma and apple intake. A cross-sectional survey in schoo | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51.498 | -0.177 | 526645 | 179284 | England | London | Cities of London and Westminster | Westminster | NHS North West London Integrated Care Board | |
35 | 012/0305 | LWEC EEHI: Traffic Pollution and Health in London | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £650,000 | 1 March 2011 | 31 December 2014 | Need to insert Abstract | Introduction Urbanisation and dependence on motorised transport has increased population exposure to traffic hazards. Traumatic injuries aside, these include toxic air pollutants and noise (which we refer to as traffic pollution) for which there is increasing evidence for adverse health effects. Near-road pollution is a complex mixture of particle and gas phase components that are influenced by both exhaust and non-exhaust vehicle emissions, resuspension of road dust, atmospheric processes and photochemical reactions. To achieve more effective traffic management policies and reduce the public health burden, it will be necessary to develop more realistic, flexible and sophisticated approaches to exposure assessment. Important gaps and uncertainties exist in our understanding of health effects of traffic pollution (Health Effects Institute [HEI], 2010). First, there is an inadequate understanding of patterns of human exposure to traffic and a lack of adequate models with which to evaluat | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Lambeth | NHS South East London Integrated Care Board | |
36 | 013/0007 | Health Promotion and Public Health Reviews Facility | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £4,057,348 | 1 August 2004 | 31 May 2014 | Not Available | BackgroundThis programme of work builds on 9 years of DH funding to the EPPI-Centre to develop a research capacity in policy-relevant systematic research synthesis for health promotion and public health (HP & PH). The new programme has distinctive features, specifically an enhanced focus on the provision of policy-relevant research reviews, the provision of training in systematic review methods, more intensive networking with other key players in the field, and the further development of accessible user-friendly databases of HP & PH research filling an important gap in the evidence base for HP & PH. The aims of the new programme are: 1/ to undertake a series of innovative, policy-relevant and broadly based systematic reviews of the evidence in key topic areas underpinning HP & PH decision-making; 2/ to provide a reviews facility encompassing training, materials and tools for those wishing to undertake systematic reviews; 3/ to co-ordinate review and bibliographic work in HP & PH, thr | Academic | Institute of Education, University of London | WC1H 0AL | 51.523 | -0.128 | 529973 | 182112 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
37 | 014/0005 | Data Archiving | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £6,913 | 1 March 2012 | 30 June 2012 | Not Available | Data Archiving | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York | NHS Humber and North Yorkshire Integrated Care Board | |
38 | 015/0306 | Effectiveness of testing for treatment of hard-to-reach groups for latent tuberculosis, hepatitis B virus and hepatitis C virus in England: The HALT Study | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £875,672 | 1 January 2013 | 30 June 2017 | The aim of this programme of work is to inform the control of hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection and latent tuberculosis infection (LTBI) by assessing the cost effectiveness of active case finding, case holding and treatment. In particular, as outlined in the invitation to tender, our specific objectives include: 1. To determine whether case finding of LTBI, HBV and HCV in hard-to-reach groups is costeffective (Work package 1 and 3), 2. To determine whether case holding during treatment for HBV and HCV in hard-to-reach groups is cost-effective (Work package 1 and 3), 3. To determine the factors that could influence uptake of vaccination for HBV in hard-toreach groups via a community outreach programme (Work package 1), 4. To assess the likelihood of adverse effects when individuals over the age of 35 years are treated for LTBI (Work package 2). | Hard-to-reach groups, such as homeless persons, substance misusers and exprisoners, have difficulty accessing, and remaining engaged with, healthcare services as a result of a variety of lifestyle factors. The same factors render them susceptible to a range of infectious diseases, such as TB and hepatitis. To examine the effectiveness and cost-effectiveness of two key methods to prevent the transmission of infection in the hard-to-reach: a) testing for LTBI, chronic HBV and HCV, b) supported HBV/HCV treatment among those with diagnosed infection. This will be in addition to assessing barriers to the success of HBV community vaccination programmes. Finally, determine whether side effects really should prohibit treatment of LTBI in individuals over 35 years of age. Research plan and methods of investigation: Hard-to-reach individuals will be screened in the community for LTBI, HBV and HCV infection. Individuals identified with chronic HCV and HBV will be randomly assigned to eit | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Camden | NHS North Central London Integrated Care Board | |
39 | 015/0313 | Identifying interventional approaches to improve health care access for Hepatitis B in high prevalence groups.- A study of knowledge, beliefs, and attitudes about Hepatitis B among Chinese and Far East Asian residents of South Yorkshire and factors restricting appropriate risk evaluation, testing, preventative activities and referral for treatment to inform review of current policy. | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £266,671 | 1 October 2013 | 31 March 2017 | Hepatitis B – a serious infectious disease caused by a virus transmitted in blood and body fluids – is common among migrant Chinese communities , being found in around 1 in 10 people. However, research in the UK and elsewhere shows that access to healthcare is low among this population, and that late diagnosis and delayed treatment is widespread. US research has found poor understanding about hepatitis B in migrant Chinese communities, with lack of awareness about risks and mistaken beliefs regarding transmission. These studies also suggest healthcare professionals may not offer testing appropriately. To-date, UK research is limited and we know little about the barriers to testing and treatment in this context. The present study addresses this knowledge gap. In South Yorkshire, Chinese residents constitute 0.2 - 1.3% of the population and pilot work by members of the research team has confirmed high levels of infection and low levels of testing and treatment in this | Background: The high prevalence of hepatitis B inChinaand other Far East Asian countries has been well documented in international epidemiological studies. Transmission occurs most frequently vertically, but also sexually, among household contacts and through healthcare. Chronic carriage is frequent, with considerable disease burden including morbidity and mortality from cirrhosis and hepatocellular carcinoma. Early treatment can prevent complications; however, access to specialist healthcare is known to be impaired in this group. Aims: This study objective is to identify the factors associated with poor levels of diagnosis and treatment operating at three levels in theUK: the Chinese community, the health care providers and the health system. This in turn should provide a base to help formulate policy to improve prevention and care. Three aims are: 1 - To identify within the target communities health seeking behaviours as well as knowledge, attitudes and misconceptions in rela | Government/NHS | Sheffield Teaching Hospitals NHS Foundation Trust | S10 2SB | 53.378 | -1.496 | 433595 | 386960 | England | Yorkshire and The Humber | Sheffield Central | Sheffield | NHS South Yorkshire Integrated Care Board | |
40 | 016/0030 | Nursing Research Unit (See Notes before Sending and Correspondence) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2,107,097 | 1 October 2002 | 31 March 2008 | Not Available | BackgroundThe Nursing Research Unit (NRU) is a unique and established national centre for nursing research that contributes to professional, academic and policy development. It has expertise in research on the evaluation of change in complex health care organisations and on the health care workforce. Funded by the Department of Health Policy Research Programme, its main aims are:1 To carry out primary R&D2 To develop research methods and techniques designed to facilitate and enhance the quality of research into nursing and contribute to debate in the wider health care and research community3 To act as a centre for information and advice on nursing research4 To contribute to research capacity building in nursing 5 To disseminate research findings to the professional and academic communitiesCurrently our work focuses on research that answers questions like these:Do nurses make a difference?What helps and hinders successful change in health care practice?What career pathways do health se | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Lambeth | NHS South East London Integrated Care Board | |
No results