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| Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | X | Y | Devolved_Administrations | English_Regions | Parliamentary_Constituencies | Local_Authorities | Integrated_Care_Boards |
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| Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | X | Y | Devolved_Administrations | English_Regions | Parliamentary_Constituencies | Local_Authorities | Integrated_Care_Boards | |
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1 | 001/0016 | Estimating Costs and Quality of Life Loss Due to Fractures | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £36,227 | 1 August 2004 | 31 March 2008 | Not Available | BackgroundEstimating the costs and quality of life loss due to fractures and falls.Fractures and falls are a serious cause of morbidity and cost society. The cost burden of fractures t society has been estimated in the region of 1.8 billion. Equally important is the health related quality lii loss (HRQoL) due to hip and other fall related fractures. In this proposal we seek to take advantage of number of data-sets we have to ascertain the cost and quality of life consequences of both fractures an falls in a primary care sample of women and a secondary care sample of men. These data will also allot a more detailed description of the costs and consequences of fractures. treatment received, length of stay at hospital, length of stay at residential care/ sheltered or nursing accommodation, and social services support. Resource use data will be combined with 2004 unit prices to obtain an updated estimate of the cost of treating hip, wrist, vertebral and other fractures. The data produced fr | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York Outer | NHS Humber and North Yorkshire Integrated Care Board | |
2 | 001/0018 | Neighbourhood and Household Influences on Injuries to Preschool Children | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £159,022 | 1 October 2004 | 31 January 2009 | Not Available | BackgroundInjuries caused by accidents are a particular problem in young children and children's injury rates vary considerably from place replace Low-income neighbourhoods have higher child injury rates than high-income neighbourhoods, and recent research suggests that only part of the difference is due to variations in the social, economic and demographic composition of local populations. This research aims to find out the relative contributions of family characteristics and neighbourhood features to the risk of injury to children aged 0-4 years in Bristol and its surrounding region, to discover some of the mechanisms that create patterns of inequality. The objectives are:" to determine the risk factors acting at the level of the child, the household and the neighbourhood, and whether these risks act independently," to determine whether residents' perceptions ofneighbourhood and local social networks are related to geographical variations in the risk of injury," to determine the size | Academic | University of East Anglia | NR4 7TJ | 52.622 | 1.241 | 619497 | 307667 | England | East of England | Norwich South | Norwich South | NHS Norfolk and Waveney Integrated Care Board | |
3 | 002/0015 | Health Effects of Long-Term Exposure to Air Pollutants in Scotland | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £188,761 | 1 April 2003 | 30 June 2007 | Not Available | BackgroundThe purpose of the proposed research is to simultaneously quantify the health effects of long-term exposure to air pollutants and shortening of life from short-term exposures. Primary outcome measures are cause-specific mortality and morbidity , with particular attention to cardiovascular outcomes. We will compare the results of cohort studies to corresponding estimates from time-series studies of the population from which the cohorts are drawn. Outcomes in 26,360 subjects in 3 cohorts will be investigated in the period between 1970 and 2002. Detailed baseline risk data and the unique advantages of the Scottish Health Record Linkage system (including algorithmic linking of individual hospital admission & mortality records) will enable novel ways of quantifying effect magnitudes in susceptible population sub-groups, and coherence in medical outcomes. We shall examine the potential for confounding and effect modification by both individual and aggregate level factors (including | Academic | University of Strathclyde | G1 1XQ | 55.861 | -4.245 | 259609 | 665397 | Scotland | Not Applicable | Glasgow Central | Glasgow City | Not Applicable | |
4 | 002/0026 | Quantification of Health Impact of Airborne Particulates: Comparing Estimates Based on Personal Exposure and Outdoor Concentrations | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £63,295 | 1 July 2008 | 31 March 2010 | Not Available | BackgroundNational estimates of the impacts of air pollutants, and specifically particulate matter (PM), on human health are required by the Department of Health in order to assess the significance of current concentrations, and the benefits of policies to reduce emissions. The current estimates used in polcy evaluation rely on relationships between pollutant concentration and health which are applied to modelled air pollution concentrations at urban background locations. However, the health outcome for any individual actually relates to the real personal exposure of that individual, indoors and outdoors, and at background and roadside sites. There is thus a need to assess whether health effects estimates based on personal exposure differ significantly from those based on ambient concentrations. AimsThe aim of this project is to provide a structured comparison of existing national methods of assessing the health impacts of PM10 used by the Interdepartmental Group on Costs and Benefits | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York Outer | NHS Humber and North Yorkshire Integrated Care Board | |
5 | 002/0027 | Health Implications of Polycyclic Aromatic Hydrocarbons in Indoor Environments | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £74,730 | 1 January 2009 | 31 March 2010 | Polycyclic aromatic hydrocarbons are a group of chemical substances emitted into the air from combustion processes. They get into indoor air from indoor sources such as smoking as well as infiltrating from outdoors. The concern over polycyclic aromatic hydrocarbons is that some of them are known to be carcinogenic (cancer causing) agents and breathing air polluted with them increases the risk of contracting lung cancer, even in non-smokers. Whilst the government funds widespread measurements of polycyclic aromatic hydrocarbons in outdoor air, there are very few measurements, particularly from the UK, of polycyclic aromatic hydrocarbons in indoor air. This project is concerned with using data and samples collected in an earlier study to compare the concentrations of polycyclic aromatic hydrocarbons in indoor air with those out-of-doors and to see whether the profile of individual compounds making up the mixture is similar indoors and outdoors. Using potency factors for the cancer-c | BackgroundPolycyclic aromatic hydrocarbons are known pollutants of indoor air. They arise from indoor sources such as tobacco smoke and cooking as well as from infiltration of outdoor air. PAH comprise a range of compounds and there is currently little information on whether the profile of compounds in indoor air matches that outdoors. Most probably it does not, since the sources will be significantly different. This has implications for the toxicity of the mixture and the suitability of the outdoor air quality standard as a guideline for indoor concentrations.AimsThese are as follows:• to investigate the concentrations and profile of PAH compounds in air sampled in UK indoor environments and to compare it with outdoor samples collected in the same localities;• by use of relative potency factors to estimate the carcinogenic risk associated with indoor air;• to evaluate whether the use of benzo(a)pyrene as a marker for the mixture is applicable to PAH in indoor air in the same wa | Academic | University of Birmingham | B15 2TT | 52.453 | -1.928 | 404997 | 283926 | England | West Midlands | Birmingham, Edgbaston | Birmingham, Edgbaston | NHS Birmingham and Solihull Integrated Care Board | |
6 | 002/0029 | Life Course Effects of Air Pollution (LEAP) on Cardiorespiratory Morbidity in the MRC National Survey of Health and Development (NSHD) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £170,556 | 1 March 2009 | 31 July 2012 | High levels of air pollution are associated with increased risk of death from heart and lung diseases. It is likely that they are also associated with development of these diseases. However, there are relatively few studies in this area, particularly in the UK. It is also not clear whether recent exposures have larger effects on health than past exposures, or whether the adverse effects of air pollution accumulate over time. Given recent developments in computing power and statistical techniques, it is now possible to produce estimates of air pollution exposures going back in time to the 1960s. These can be validated, because the UK has a long-running programme of air pollution monitoring with >3000 monitoring stations in existence at various points over the last 60 years. The UK also has a number of long-running health studies. One of these is the MRC National Survey of Health and Development (NSHD). This has used questionnaires and health measurements to follow approximately | BackgroundThere is persuasive evidence linking chronic air pollution exposures in adult life to increases in cardiovascular and respiratory mortality in non-UK cohorts. Corresponding impacts on morbidity are likely, but relatively little studied to date. The relative impact of cumulative vs. recent air pollution exposures is unclear. The UK is well placed to investigate both impacts of lifecourse exposures with individual level adjustment for confounders such as smoking and the relative importance of recent and cumulative exposures – it has long-running birth cohort studies to which exposure estimates can be applied, together with long-running pollution monitoring networks and area-based exposure models being developed and validated as part of existing Wellcome Trust- and EU-funded research.AimsThis proposal aims to investigate relationships between exposure to black smoke and SO2, over the full lifecourse and individual lung function, lung function decline and self-reported ischaemi | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51.499 | -0.179 | 526645 | 179284 | England | London | Cities of London and Westminster | Cities of London and Westminster | NHS North West London Integrated Care Board | |
7 | 002/0032 | An Investigation of the Effects of Long Term Exposure to Air Pollution on Cardiorespiratory Morbidity in a Large Population Cohort | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £196,938 | 1 April 2009 | 30 September 2012 | Exposure to air pollution has been associated with death and hopitalisations from both cardiovascular and respiratory diseases. Long term exposure to air pollution has been linked to a shortening of life but few studies have examined less severe endpoints such as first diagnosis of disease or hospital admission. This study aims to evaluate the effects of long term exposure to air pollutants on cardiovascular and respiratory morbidity and to identify the population groups most susceptible to this exposure. This will be achieved by using the General Practice Research Database, which contains linked electronic records of patient’s consultations with their general practitioners and admissions to hospital. The database comprises patients’ demographic information (gender, age, sex, ethnicity practice location and a community level marker of deprivation), clinical information (diagnoses, symptoms, and treatment) and other relevant information such as BMI, weight, smoking and alcohol consum | BackgroundFew studies have examined associations between long term exposure to air pollution and morbidity. Such studies require large validated longitudinal computerised medical records together with appropriate exposure data. The General Practice Research Database (GPRD) in the UK is a computerised database of anonymised longitudinal medical records from 432 primary care practices, covering over 13 million patients (4.6% of the population), containing clinical, demographic and lifestyle information. Hospital episodes and death certificate data from national systems are linked with the GPRD records. Modelled annual average concentrations of particles and pollutant gases are available for the UK on a fine spatial scale. These can be linked to the patient record anonymously using the postcode.AimsThe aims of this project are 1) to investigate the effects of long term exposure to air pollutants on cardiovascular and respiratory morbidity measured by first GP diagnosis of disease and by f | Academic | ST. GEORGE'S HOSPITAL MEDICAL SCHOOL | SW17 0RE | 51.428 | -0.175 | 526958 | 171445 | England | London | Tooting | Tooting | NHS South West London Integrated Care Board | |
8 | 002/0034 | Provision of Scientific Advice on Air Pollution and Nanotoxicology Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £18,559 | 1 October 2008 | 31 March 2012 | Not Available | BackgroundFor Dr Harrison to provide external scientific advice to the Department of Health, Policy Research Programme (PRP) and coordination of the air pollution and nanotoxicology related research projects in the PRP, reporting to Dr Ursula Wells at the Department of Health (DH). Dr Harrison will advise the DH on the scientific content and communication of research undertaken within its programmes and dedicated Units, ensuring the DH gets maximum benefit from this research activity and outputs.AimsNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Potential ImpactNEW PROJECT - this project was not commissioned throug | For-Profit Company | PTCH Consultancy Ltd | LE16 7HB | 52.492 | -0.906 | 474376 | 288836 | England | East Midlands | Harborough | Harborough | NHS Leicester, Leicestershire and Rutland Integrated Care Board | |
9 | 002/0036 | Measuring the Health Impacts of Nitrogen Dioxide in Air | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £7,226 | 1 January 2011 | 30 June 2011 | Not Available | BackgroundTBCAimsTBCPlan of InvestigationTBCPotential ImpactTBC | Academic | Health Protection Agency | NW9 5EQ | 51.595 | -0.255 | 520992 | 189896 | England | London | Hendon | Hendon | NHS North Central London Integrated Care Board | |
10 | 004/0064 | Cancer Screening Evaluation Unit | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2,908,312 | 1 January 2006 | 30 September 2011 | Not Available | BackgroundObjective: To study the prevalence of opportunistic smear taking in the NHS cervical screening programme between 1999 and 2003 and the relationship of this to screening interval policy.Design: A cohort study of nearly 2 million women, with data on screening at ages 20-64 from 1988-2003 has been constructed. Data from 1999-2003 have been used in this analysis. Screening episodes have been divided into those where the primary smear was initiated by the national call/recall system (invitational), normally at 3 or 5 yearly intervals, and those initiated by the GP or woman (opportunistic). Opportunistic smears were further classified as routine (occurring within 6 months of 3 or 5 years) or sporadic (occurring at other times).Setting: NHS cervical screening programme.Population: Four Health Authorities in England (now PCTs) with supplementary studies on national data. Results: In total, 72% of incident screen primary smears were invitational and 28% opportunistic. The propo | Academic | Institute of Cancer Research: Royal Cancer Hospital (The) | SW3 6JB | 51.490 | -0.174 | 526873 | 178394 | England | London | Chelsea and Fulham | Chelsea and Fulham | NHS North West London Integrated Care Board | |
11 | 005/0146 | Safeguarding Children | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1,000,003 | 1 April 2006 | 31 March 2011 | Not Available | BackgroundHealth circumstances and needs of children and young people, incorporating work on families and parenting (e.g. continuation of work on parenting; stress in children: incidence and patterning of somatic symptoms and anxiety in children 7-11 years) Children and young people’s mental health and well-being (e.g. Child and adolescent mental health services - 24 hour cover study; social functioning, emotional wellbeing and mental health of unaccompanied asylum seeking children and young people)Innovative approaches to health service delivery (e.g. studies on healthy early years settings, healthy colleges, the role/contribution of nurses in promoting young people’s health through schools)Responsive stream (e.g. scoping studies on: health needs of children in secure settings; evidence base for audit tool to assess the quality of services for disabled children)Optional : any additional (brief) comments:• The expertise within TCRU has been used to meet the needs of both the “Child Pu | Undefined | DoES | SW1P 3BT | 51.498 | -0.130 | 529900 | 179334 | England | London | Cities of London and Westminster | Cities of London and Westminster | NHS North West London Integrated Care Board | |
12 | 006/0037 | The Mersey Cerebral Palsy Register | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £235,598 | 1 April 2003 | 31 January 2010 | Not Available | BackgroundAims of the project:To maintain and develop the Mersey Cerebral Palsy Register (MCPR). The register's aims are, within Merseyside and Cheshire, to monitor population trends in prevalence of cerebral palsy (CP); assess cohort effect on life expectancy of affected individuals; and determine trends in severity of functional disability.Research subject group:Cerebral Palsy, a group of disorders of movement and posture due to a defect/lesion of the immature brain, and the commonest cause of severe physical disability affecting children in England.Sample Size:Anticipated annual recruitment of 40-60 cases, (area has 25,000 births annually, and birth prevalence of CP of 2 to 2.5 per 1,000 live births)Type of Location:Population-based disease register, located within the University of Liverpool, established 1980, covers Merseyside and Cheshire. Case definition: a clinical diagnosis of CP, and mother resident in the area at time of birth.Methods of working:Identification by active su | Academic | University of Liverpool | L69 7ZX | 53.406 | -2.967 | 335836 | 390320 | England | North West | Liverpool, Riverside | Liverpool, Riverside | NHS Cheshire and Merseyside Integrated Care Board | |
13 | 006/0038 | Development and Maintenance of the Oxford Congenital Anomaly Register (OXCAR) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £203,676 | 1 July 2003 | 31 January 2009 | Not Available | BackgroundAims: To maintain and further develop this well established research register to enable the rapidly changing field of prenatal diagnosis to be monitored in an effective way so that research into areas of concern already identified may continue, collaboration with other registers be maintained and new areas for research developed. OXCAR has a proven track record of published research. Without funding it cannot continue. Subjects: OXCAR has data (collected from multiple sources) on all foetuses in whom there has been a suspicion of congenital malformation suspected prenatally and on all babies delivered with a congenital anomaly diagnosed postnatally since 1991 in a defined population within Oxfordshire (denominator population 6,000 births per annum). Methods: The development of the established local register would be to include the "Four Counties" (Oxon, Berks. Bucks, Northants). Collaborations with other registers has already allowed research into rare anomalies by the poolin | Academic | University of Oxford | OX1 2JD | 51.758 | -1.262 | 451034 | 206852 | England | South East | Oxford East | Oxford East | NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board | |
14 | 007/0015 | Adsorption of Prion Isoforms to Stainless Steel Surfaces: Implications for Surgical Decontamination Procedures | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £176,042 | 1 December 2006 | 31 January 2009 | Not Available | BackgroundVariations of grant management and staff. (i) the PI of this proposal has been moved from IAH to NIMR in 2005; (ii) it is now proposed to continue this project at the NIMR and to employ a new Research Assistant to carry out planned experiments on various cellular models including human and mouse neurospheres derived from EC and ES cells.Variations of animal and cellular studies. Some of the original experiments that were planned to be performed with animals will be carried out with human and mouse cellular models. We suggest restricting all experiments to human and mouse neurospheres derived from human embryonic carcinomas and mouse embryonal stem cells, focusing on the toxicity and physiological activity of endogenous PrP material obtained from cellular homogenates with elevated level of PrP expression, and also from blood serum. In addition various oligomeric and fibrillar forms of recombinant PrP protein will be tested using the same cellular models. Cell lines expressing | Undefined | MRC National Institute for Medical Research | NW7 1AA | 51.618 | -0.220 | 523343 | 192500 | England | London | Hendon | Hendon | NHS North Central London Integrated Care Board | |
15 | 007/0063 | The National CJD Surveillance Unit (CJDSU) Tissue Resource: Support for Continued Banking Activities | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £247,623 | 1 March 2003 | 30 April 2008 | Not Available | BackgroundThe National CJD Surveillance Unit (NCJDSU) was established in 1990 and in 1991 additional funding was obtained from the Department of Health (DH) to establish a neuropathology laboratory for pathological diagnosis, surveillance and research. Since then, NCJDSU has systematically collected a range of tissue samples from the central nervous system (CNS) and other tissues from a wide range of cases of human prion diseases and from other cases of progressive neurodegenerative diseases that were initially suspected as being human prion diseases, but in whom an alternative neuropathological diagnosis was made. All material in the NCJDSU bank has consent for research and local ethical committee approval has been obtained for the collection, storage and use of the material.In subsequent years it became clear that the tissue collected in NCJDSU formed an invaluable unique resource for research and increasing requests for access for the material (particularly variant CJD) were obtai | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
16 | 007/0074 | Heart Rate Variability as an Aid to Diagnosis of vCJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £102,349 | 1 January 2002 | 30 June 2004 | Not Available | BackgroundThis is a pilot study to evaluate whether there is any clinical utility in the use of heart rate variability (HRV) measurement as a non-invasive, ante-mortem differential diagnosis for vCJD in human subjects. It has been suggested that the vagus nerve is the primary route of neuroinvasion of TSE agent after oral challenge. In that event, the vagal nuclei of the medulla oblongata are the first sites where abnormal prions will have the opportunity to damage the central nervous system. HRV is a widely used tool for assessing medullary brainstem function, and the objective of this study is to determine whether vCJD does affect HRV in an objectively quantifiable manner. HRV has already been described as a putative test for BSE in cattle in two patents filed by independent University research groups. AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJEC | Academic | The University of Manchester | M13 9PL | 53.467 | -2.234 | 384591 | 396711 | England | North West | Manchester Central | Manchester Central | NHS Greater Manchester Integrated Care Board | |
17 | 007/0077 | Removal of Infective Protein Residues from Medical Instruments | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1,295,022 | 1 June 2002 | 31 July 2011 | Not Available | BackgroundThis project has the objective of developing new methods to remove and verify the removal of prions from surgical instruments. The project consists of three interactive themes: 1) the development of plasma cleaning methods for the removal of biologically derived materials; 2) the development of 'on-line' fluorescence techniques for detection of protein residues; 3) biological verification of these methodologies. The outcome of the project will be an integrated and verified strategy for the decontamination and screening of surgical instruments.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
18 | 007/0094 | CJD Surgical Instrument Storage Facility | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £423,971 | 1 March 2003 | 31 December 2013 | Not Available | BackgroundA facility is required by the Department of Health for the long-term secure storage of surgical instruments used in connection with the treatment of patients subsequently found to be incubating variant Creutzfeld-Jakob disease (vCJD). The instruments used on each patient need to be fully identified and securely packaged on site prior to collection from surgical units in a safe and uniform manner. Following receipt, the instrument containers require rack-mounted storage in an environmentally controlled room for extended periods. The containers must be held in such a form that they can subsequently be sent out identified but unopened to researchers with appropriate facilities for further investigations.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] fi | Government/NHS | Public Health England | SE1 8UG | 51.502 | -0.109 | 531361 | 179787 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
19 | 007/0107 | The Development of a Novel Human Cell Culture Model of Prion Disease | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £215,853 | 1 April 2004 | 31 March 2007 | Not Available | BackgroundThere are no human cell culture models of prion disease available, these are urgently needed for several reasons. This project aims to develop and characterise an in vitro cell culture system of human prion disease. Human and transgenic murine neural and non-neural cell lines are in development. These lines will be infected with various human, and BSE, prion strains; and cell populations screened for infected cells. All the techniques, infrastructure and collaborations necessary for the success of this project are already in place. This human cell line will be used as a diagnostic tool to develop a bioassay system to replace traditional mouse innoculation assays which are expensive and time-consuming, often taking up to one year for a result; a cell culture based bioassay would only take 3-4 weeks to achieve similair results. The human line will also be used for the development and screening of therapeutics aimed at the removal and clearance of human PrPSc. A clinical scienti | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
20 | 007/0115 | Retrospective Review of CJD and Related Disorders at Hammersmith NHS Trust | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £133,601 | 1 October 2004 | 31 August 2008 | Not Available | BackgroundThe purpose of this study is to review the cilnical and neuropathological features of cases of dementia diagnosed at Hammersmith Hospital NHS Trust since January 1970 including cases Creutzfeldt-Jakob disease (CJD), other human TSE and atypical dementias. This to establish whether cases of human TSE have been underdiagnosed and identify possible phenotypic variation. The study will provide data to the National Surveillance UnitAll cases of neurodegenerative disease diagnosed at post-mortem during the period 1970-2003.We estimate a sample of 1,000 cases. Tissue blocks and clinical records are on file at Hammersmith Hospitals NHS Trust.A premliminary survey will determine the adequateness of archival material. Cases retrieved wil be reviewed by two neuropathologists and sections from selected cases will be immunostained with the anti-PrP antibody in order to identify new cases and once indentified to characterise the pathological spectrum of human TSE. The cases previously | Undefined | West London Research Network | Not Available | ||||||||||
21 | 007/0119 | The Development of an Effective Treatment for Prion Infection of Humans | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £7,238,766 | 1 February 2006 | 30 June 2013 | Prion diseases are fatal untreatable brain disorders caused by prions, germs that grow in the brain. The best known is Creutzfeldt-Jakob disease (CJD). Unlike other germs, like bacteria and viruses, prions do not carry genes and are made just of protein. This protein (called PrP) is one of the body’s own proteins. Prions consist of clumps of misshapen PrP (rogue form) and grow and multiply as more and more normal PrP ends up in this form. Prions affect many types of animal, causing scrapie in sheep and BSE in cattle. Sometimes prions can jump from one species to another, and we know that BSE prions can infect humans and cause variant CJD. There is always a long delay (years or decades) between someone being infected with prions and developing the disease. Healthy carriers of infection can pose a risk to others if they donate blood or organs, and surgical instruments can also become contaminated by prions and pose a risk to other patients. Although only around 200 people have developed | BackgroundThe majority of the UK population have potentially been exposed to BSE prions, the causative agent of variant CJD. The number infected, eventual epidemic size and secondary transmission dynamics are unknown. The central molecular event in prion replication is the conversion of a neuronal glycoprotein (PrPc) into a conformational isomer that accumulates as aggregated material (PrPs) in a self-propagating process. The availability of PrPc substrate is an absolute requirement for prion propagation and pathogenesis. We propose to identify and characterise novel small molecules that stabilise the native conformation of PrPc and inhibit its ability to be recruited into PrP$0. Inhibition of prion replicationkinetics to below those of natural clearance mechanisms should cure prion infection. The MRC Unit has developed an effective collaboration with GlaxoSmithKline R&D Ltd, performed successful pilot stage studies and produced further experimental underpinning of our therapeutic stra | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
22 | 007/0120 | The Effect of Leucodepletion on Transmission of BSE by Transfusion of Sheep Blood Components | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £795,296 | 1 November 2005 | 31 March 2007 | Not Available | BackgroundThis project will use sheep experimentally infected with BSE as a model to study the risks of transmission of variant CJD by blood components in humans. The aim of the project is to determine the distribution of BSE infectivity in sheep blood components, and the effectiveness of human leucodepletion filters in removing infectivity. The methods used for collection of blood and separation and filtration of components will follow as closely as possible those routinely employed for human blood by transfusion services, and will initially be developed and validated for normal sheep blood in the laboratories of SNBTS. A secondary aim of the project is to develop a bioassay for measurement of titres of infectivity in blood components, using transgenic mouse lines that over-express ovine PrP. The sheep experiments will be carried out using BSE-infected donors and will assess the effect of leucodepleting blood components (plasma, platelets and erythrocytes) on transmission at a single | Undefined | Institute for Animal Health | Not Available | ||||||||||
23 | 007/0131 | vCJD Tissue Infectivity Studies | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £3,801,748 | 1 July 2005 | 30 June 2014 | Not Available | Backgroundlatrogenic transmission of CJD via neuronal tissue has been described both in experimental models and in a clinical setting. The risk of transmission via other tissues is less well described. Whilst variant CJD infectivity levels have been defined in tonsils and spleen (Bruce et al. 2001), those in other organs and tissues are not known. This project aims to assess the levels of infectivity in a further twenty tissues and organs identified as posing a risk for the iatrogenic transmission of variant CJD. The project will use tissue samples collected by the National CJD Surveillance Unit from patients with vCJD and evaluate their ability to generate infection in RIII mice over an extended period of incubation of 600 days (as per Bruce et al. 2001). Infection will be assessed in life by monitoring for recognised clinical signs and confirmed post mortem by histopathological examination of brain tissue sections. Animals will be housed in purpose-built accommodation on the Porton s | Government/NHS | Public Health England | SE1 8UG | 51.502 | -0.109 | 531361 | 179787 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
24 | 007/0136 | National Tonsil Archive phase III | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £7,024,560 | 1 April 2006 | 31 March 2013 | Not Available | BackgroundThe overall aim of the prion prevalence tissue archive is to estimate the prevalence of infection with the BSE agent in residents of England who are likely to have been exposed to the BSE agent through their diet. This will be achieved by measuring the prevalence of detectable abnormal prion protein (PrPsc) in the tonsil tissue of at least 50,000 residents of England born before 1st January 1996.The project will be implemented in three phases: Phase one: Establishing a project management team Phase two: Developing a preliminary collection network Phase three: National roll-out and main collection.This application is for funding to establish a project management team at PHLS to develop the scientific, logistic, ethical, financial and accountability framework for establishing national collection of tonsil tissue.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHIS | Academic | Health Protection Agency | NW9 5EQ | 51.595 | -0.255 | 520992 | 189896 | England | London | Hendon | Hendon | NHS North Central London Integrated Care Board | |
25 | 007/0141 | Screening Blood for High Risk Donations (National Blood Service) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £141,334 | 1 November 2002 | 30 September 2007 | Not Available | BackgroundTo determine the feasibility of using quantitation of an erythroid protein (EDRF aka AHSP) as a surrogate marker for vCJD in human blood. To this end we collected and stored blood samples from normal blood donors and from patients with various neurological and haematological diseases and developed quantitative assays for measurement of EDRF and mRNA and protein in whole blood and determined the normal range (in blood donors) and variations in expression occurring in patients samples without vCJD.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Policy RelevanceUnknown | Academic | University of Cambridge | CB2 1TN | 52.205 | 0.116 | 544705 | 258430 | England | East of England | Cambridge | Cambridge | NHS Cambridgeshire and Peterborough Integrated Care Board | |
26 | 007/0169 | Investigating Dental Treatment as a Possible Risk Factor for Variant CJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £256,621 | 1 April 2008 | 30 September 2009 | Not Available | BackgroundLittle work has been performed examining accurate past dental history of CJD cases and controls by direct review of dental records. The NCJDSU has MREC approval to collate information from the medical records of CJD cases and matched controls. Following on from a DH funded pilot study, this study will attempt to access the dental case records of UK variant CJD cases (n=166 as of 9/8/07) and 166 general population controls. In addition, payment schedule records will be accessed where possible in collaboration with NHSBSA Dental Practice Division (England and Wales) and NHSNSS Information and Statistics Division (Scotland). The case record and payment schedule data will be reviewed by a dental healthcare professional and will, where possible, include the presence or absence of oral disease, dates and types of treatment performed and additional risk factor information, e.g., human dura mater grafting. Data will be coded and entered into a database for subsequent analysis. Geogra | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
27 | 009/0031 | The South London Stroke Register (SLSR) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £343,465 | 1 August 2003 | 31 January 2010 | Not Available | BackgroundThe South London Stroke Register (SLSR) is a research register of international standing covering a multi ethnic inner city population of 235,000, which has been ongoing since 1995. The SLSR aims to develop chronic disease methodology (case ascertainment, multi level modelling for outcome assessment) and prospectively estimate the burden of disease (incidence and outcome), analyse the predictors of risk and outcome, monitor trends in incidence and survival and estimate and model the resource use and cost of care. Funding is sought to continue data collection that will be utilised by a multidisciplinary programme of health services research and training to inform policy and planning. The SLSR uses multiple sources of notification and capture-recapture techniques to identify all cases of stroke with assessments in the acute stage and at 3 months and annually. Outcomes are assessed in terms of impairment, disability and handicap. By the end of the project 12 years of data will h | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
28 | 009/0036 | A Randomised Controlled Trial of a Nurse-Led Self-Management Intervention for Patients Admitted to Hospital with Heart Failure | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £223,102 | 1 January 2004 | 29 February 2008 | Not Available | BackgroundHeart Failure is associated with high costs and poor outcome. Patients with this diagnosis are expected to adhere to a complex behavioural regimen including taking medication, monitoring for signs of fluid re-accumulation and a range of life-style changes. Without intervention adherence is about 50%. Standard education alone does not modify this figure. We aim to explore the hypothesis that a brief nurse-Ied self-management intervention will empower patients to positively modify their behaviour and so outcome. The efficacy of this intervention, based on a problem solving approach using cognitive behavioural principles, will be assessed by a randomised controlled trial of 250 patients admitted to hospital with a definite diagnosis of heart failure, randomised to either the nurse-Ied intervention or standard hospital care. The primary outcome measure will be the number and duration of re-admissions at three months. Secondary analyses include costs, mortality at 12 months and pr | Government/NHS | Whittington Health NHS Trust | N19 5NF | 51.566 | -0.139 | 529078 | 186930 | England | London | Islington North | Islington North | NHS North Central London Integrated Care Board | |
29 | 009/0045 | British Women's Heart & Health Study: The Causes and Consequences of Cardiovascular Disease in Older Women | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £311,909 | 1 January 2007 | 31 March 2009 | Not Available | BackgroundThe British Women's Heart and Health Study is concerned with the causes of heart disease and stroke in women, and how best to prevent and treat these diseases. This study began in 1999 when we examined and collected information from 4,286 women from 23 towns across Britain. Since then we have continued to monitor these women by reviewing their medical records (with their permission) and through a mailed questionnaire in 2003, to which 90% responded. We have already produced important research from this study but further research is needed in this area. Continuing to monitor these women will provide important information about which women developheart disease and stroke, how these diseases can be prevented, what are the best treatments and whether women from across the country receive best treatment, and if not, what factors influence differences in treatment. Although women are the main focus of this study, we work closely with a parallel study of men (British Regional Heart | Academic | London School of Hygiene and Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | 529790 | 181879 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
30 | 009/0046 | Research Analysis for National Stroke Strategy | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £10,000 | 1 August 2007 | 31 January 2008 | Not Available | BackgroundFor effective delivery of the DH’s Stroke Strategy consultation document, ‘A new ambition for stroke’, it is important to justify the proposed interventions and service configurations and their workforce implications in terms of the underpinning evidence base.AimsThis proposal will identify the detailed recommendations in the Stroke Strategy and assess the strength of the evidence for each of them. Plan of Investigation1. Key applicants will independently read the consultation document and detailed working papers from the 6 Project groups and identify any proposed interventions or ways of working (early August).2. Meet with RCP Clinical Effectiveness team/NICE acute guidelines leads who develop the guidelines to map items identified in 1 with guidelines and current evidence (mid August).3. Where there is no evidence or low level evidence in the guidelines for a proposal in the strategy, a search of the literature (where not already recently undertaken by the guideline develop | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
31 | 009/0049 | British Women's Heart and Health Study (BWHHS) 2009-2012 aka British Regional Heart Study (Women) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £538,932 | 1 October 2009 | 31 March 2013 | Heart attacks and strokes are the commonest cause of death in British women. While we know a lot about their life style causes – smoking, physical inactivity and unhealthy eating – we still do not have good explanations for why people living in deprived neighbourhoods, places with air pollution and where there is no sense of community seem to have higher chances of suffering from heart attacks and strokes. In this project we will use information already collected from over 8000 older women and men drawn from 24 small to middle sized towns in Britain. These people have been studied over several years providing information about heart attacks and strokes. We have repeated questionnaires about their health behaviours and any disabilities suffered, and the women have given us blood to examine how their bodies are functioning and have had a physical examination for blood pressure, weight and lung power. We have also collected information on heart attacks and strokes suffered through | BackgroundCardiovascular disease remains the commonest cause of death in Britain with 88,323 women and 82,015 men dying of circulatory diseases in England and Wales in 2007. The influence of environmental factors – air pollution, neighbourhood adversity and social capital – on health, in particular on cardiovascular disease, is of growing public and political interest. Research in these areas has thrown up inconsistent findings, often using relatively weak ecological designs. Furthermore, if associations are found causal interpretation is difficult as adjustment for confounding factors is often inadequate. Finally, mechanisms of action are seldom explored because of the ecological designs used.AimsTo examine the associations of a) area deprivation, social capital and air pollution with CVD incidence and b) the effect of these environmental characteristics on survival free of disability amongst women with and without prevalent CVD. We will compare the relative strength of the associat | Academic | London School of Hygiene and Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | 529790 | 181879 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
32 | 010/0003 | The Yorkshire Register of Diabetes in Children and Young People | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £302,999 | 1 April 2003 | 31 January 2009 | Not Available | BackgroundRising numbers of children and young people with diabetes are of great public health concern and present an increasing burden to the NHS. Population-based registers of diabetes in this vulnerable age group are essential for monitoring trends, evaluating standards of care and researching disease aetiology. The Yorkshire Register of Diabetes in Children and Young Adults is a well-established high quality population-based register of over 4,000 0-29 year olds diagnosed since 1978. Data are held at the Paediatric Epidemiology Group, Leeds University, alongside other chronic disease registers and where researchers have skills in analysing population-based data applying various methodologies. The aim of the register is to describe the epidemiology of diabetes, investigate the molecular and environmental aetiology and facilitate health services research. Individuals are ascertained from two sources (hospitals and GPs), with completeness estimated at 99%, and basic clinical and demog | Academic | University of Leeds | LS2 9JT | 53.808 | -1.553 | 429512 | 434722 | England | Yorkshire and The Humber | Leeds Central | Leeds Central | NHS West Yorkshire Integrated Care Board | |
33 | 011/0035 | Barriers to the Effective Treatment of Injecting Drug Users | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £84,036 | 1 October 2005 | 30 June 2007 | Not Available | BackgroundThe proposed study will build on existing research to provide essential information on how IDU engagement with services can be improved and the cost/ benefit implications of successfully increasing take-up. Specifically, it will combine qualitative and economic data to investigate the nature and extent of barriers to the effective treatment of IDUs; the particular circumstances in which barriers do/ do not prevent ]DUs accessing treatment; how barriers may vary between key IDU sub-groups and between service types; ways of removing barriers to treating IDUs; the costs of IDUs not entering treatment; and the costs of removing barriers to IDU treatment. Following an initial review of the literature, in-depth interviews - incorporating structured economic components - will be conducted with 75 injectors recruited from needle exchanges in Leeds, and urban and rural West Yorkshire. Data will be collected on socio-demographic characteristics; life circumstances; drug use; treatment | Academic | Oxford Brookes University | OX3 0BP | 51.754 | -1.223 | 453717 | 206473 | England | South East | Oxford East | Oxford East | NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board | |
34 | 011/0036 | Estimating and Explaining Early Exit from Drug Treatment | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £114,743 | 1 June 2005 | 31 March 2008 | Not Available | BackgroundThis project focuses on dependent drug users who do not engage, or drop out early from tier 3 and 4 services, despite having offered a place in treatment.This research wil provide policy-relevant information by achieving the following aims:- To provide an estimate of the rates of early exit from tier 3 and 4 services in two regions of England - one provincial and metroplitan- To identify the characteristics of those dependent drug users who are most likely not to engage or exit early- To provide information on why drug users do not engage in treatment or leave early-To make recommendations on how rates of early exit can be reduced.All these aims will be achieved with a specific emphasis on groups who are particularly vulnerable to early exit, includiong women, members of ethnic minority groups, young people (aged 18-25) and offenders.The research will involve quantitative (logistic regression) analysis of monitoring and primart data on treatment attendance of over 3,000 peopl | Academic | University of Kent | CT2 7NZ | 51.299 | 1.071 | 614184 | 159965 | England | South East | Canterbury | Canterbury | NHS Kent and Medway Integrated Care Board | |
35 | 011/0037 | National Survey of Care Co-Ordination in Drug Treatment Services: A Multi-Method Observational Study of Implementation, Model Development, Treatment Process and Service-Based Outcomes | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £124,598 | 1 September 2005 | 30 June 2008 | Not Available | BackgroundWe will use these data to describe the development of care co-ordination nationally and identify a typology of emerging models. These will be described in terms of organisational structure and process. We will then describe how these different models of care co-ordination appear to impact on client engagement, retention in treatment and inter-agency working. This will enable us to identify factors that promote or hinder good care co-ordination practice in relation to a number of client sub-groups. AimsThe study aims to examine the implementation of care co-ordination in drug treatment services, to describe emerging models of practice, and to assess the potential for impact on client engagement, retention and co-ordination of services. Plan of InvestigationThe research will be implemented in two phases: In phase I, we will conduct a survey of treatment agencies in all English DAT regions. In phase II, we will complete a multi-method investigation of care co-ordinati | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51.499 | -0.179 | 526645 | 179284 | England | London | Cities of London and Westminster | Cities of London and Westminster | NHS North West London Integrated Care Board | |
36 | 011/0042 | Interventions for Children and Young People with Drugs Misusing Carers | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £137,443 | 1 June 2005 | 30 April 2008 | Not Available | BackgroundThis study addresses the needs of families and associates of drug misusers. It will (a) determine what support services are available in England for children and young people aged between 5 and 16 who have drung misusing carers and (b) examine a number of services in greater depth to establish the extent to which they meet users' needs.The study will consist of three phases:1) Familiarisation with existing literature and evidence relating to the effects of drug misuse on families and to initiative which support children and young people living in difficult circumstances.2) A scoping study of services available in England to support the children of drug misusers, and the subsequent creation of a typology of such services.3) An in-depth study, combining qualitative and quantitative data, of 10 services selected from the typology. This will include personal interviews with service providers and project workers, a quantitative study of current and recent service users, and one- | Undefined | Policy Research Bureau | EC2A 4LU | 51.523 | -0.086 | 532854 | 182122 | England | London | Islington South and Finsbury | Islington South and Finsbury | NHS North Central London Integrated Care Board | |
37 | 011/0056 | Drug Recovery Wing (DRW) Pilots Evaluation | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £799,134 | 1 October 2012 | 28 February 2016 | Following the UK drug strategy (2010) there has been a major commitment to ensuring that drug treatment services are maximising the opportunities for the recovery of dependent drug users and that drug users in prison and in the community have access to high quality recovery focussed treatment. Delivering abstinence focussed drug treatment services within prisons presents different challenges to those developed within the community not the least of which is the need to combine both treatment and custodial responsibilities. The research outlined in this application will answer questions in three main areas. First, based upon a detailed qualitative assessment of the drug recovery wings, it will provide a detailed description of the therapeutic programme within the wings and the experience of both staff and prisoners involved within them. This element of the research will provide rigorous information on how the wings are operating, what interventions are used with prisoners and how links | Background Following the UK Drug Strategy and the Patel report, there is a commitment to ensure that prisoners have access to high quality recovery-focussed drug and alcohol treatment services and that the link between prison and community is better managed. Research has shown that 50% of male prisoners and 65% of female prisoners have a drug problem (Singleton et al., 1997). According to Stewart (2009) who surveyed 1457 recently received prisoners across 49 prions in England 28% had used heroin in the last four weeks and 25% had used crack cocaine. It is known that in some cases prisoners are initiating injecting within prison (Boys, 2002) and that on release prisoners are at a heightened risk of death (Farrell and Marsden, 2007). Whilst prison offers an important opportunity for drug and alcohol treatment it is recognised that there are multiple challenges associated with the development of drug and alcohol services within prisons (McIntosh and Saville, 2006). Aims This research | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York Outer | NHS Humber and North Yorkshire Integrated Care Board | |
38 | 012/0305 | LWEC EEHI: Traffic Pollution and Health in London | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £650,000 | 1 March 2011 | 31 December 2014 | Need to insert Abstract | Introduction Urbanisation and dependence on motorised transport has increased population exposure to traffic hazards. Traumatic injuries aside, these include toxic air pollutants and noise (which we refer to as traffic pollution) for which there is increasing evidence for adverse health effects. Near-road pollution is a complex mixture of particle and gas phase components that are influenced by both exhaust and non-exhaust vehicle emissions, resuspension of road dust, atmospheric processes and photochemical reactions. To achieve more effective traffic management policies and reduce the public health burden, it will be necessary to develop more realistic, flexible and sophisticated approaches to exposure assessment. Important gaps and uncertainties exist in our understanding of health effects of traffic pollution (Health Effects Institute [HEI], 2010). First, there is an inadequate understanding of patterns of human exposure to traffic and a lack of adequate models with which to evaluat | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
39 | 014/0005 | Data Archiving | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £6,913 | 1 March 2012 | 30 June 2012 | Not Available | Data Archiving | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York Outer | NHS Humber and North Yorkshire Integrated Care Board | |
40 | 015/0307/01 | Revised Title: Evaluation of TB Control Interventions in the Community and Emergency Medicine Departments: The ACE Study (A and E Screening, Cohort review, Comprehensive local service review, Contact Tracing, Latent TB screening in Primary Care, Pre entry screening, Improving Service Coordination) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £104,260 | 1 July 2016 | 31 December 2017 | Background: Control of infectious diseases requires prompt, effective identification and treatment to safeguard health and prevent transmission. Identifying those in high risk groups, evaluating signs and symptoms and referring individuals for testing and management are key to control efforts. Tuberculosis (TB) causes significant morbidity in the UK. Early treatment may have the greatest impact by interrupting transmission. Between 2000-9, TB cases in England rose from 12.4 to 16 per 100,000 with over 8000 cases diagnosed annually, mostly among individuals from identified risk groups. In London A&E accounts for 20% Mtb cases diagnosed and 49% from primary care overall. Aim: Research plan and methods Work Package 1: Determining the prevalence of latent TB infection and active TB disease and cost effectiveness of testing high risk groups attending A&E departments. An observational study, which prospectively recruits participants for latent TB testing, combined with health economics model | Background: Control of infectious diseases requires prompt, effective identification and treatment to safeguard health and prevent transmission. Identifying those in high risk groups, evaluating signs and symptoms and referring individuals for testing and management are key to control efforts. Tuberculosis (TB) causes significant morbidity in the UK. Early treatment may have the greatest impact by interrupting transmission. Between 2000-9, TB cases in England rose from 12.4 to 16 per 100,000 with over 8000 cases diagnosed annually, mostly among individuals from identified risk groups. In London A&E accounts for 20% Mtb cases diagnosed and 49% from primary care overall. Aim: Research plan and methods Work Package 1: Determining the prevalence of latent TB infection and active TB disease and cost effectiveness of testing high risk groups attending A&E departments. An observational study, which prospectively recruits participants for latent TB testing, combined with health economics model | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
41 | 015/0313 | Identifying interventional approaches to improve health care access for Hepatitis B in high prevalence groups.- A study of knowledge, beliefs, and attitudes about Hepatitis B among Chinese and Far East Asian residents of South Yorkshire and factors restricting appropriate risk evaluation, testing, preventative activities and referral for treatment to inform review of current policy. | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £266,671 | 1 October 2013 | 31 March 2017 | Hepatitis B – a serious infectious disease caused by a virus transmitted in blood and body fluids – is common among migrant Chinese communities , being found in around 1 in 10 people. However, research in the UK and elsewhere shows that access to healthcare is low among this population, and that late diagnosis and delayed treatment is widespread. US research has found poor understanding about hepatitis B in migrant Chinese communities, with lack of awareness about risks and mistaken beliefs regarding transmission. These studies also suggest healthcare professionals may not offer testing appropriately. To-date, UK research is limited and we know little about the barriers to testing and treatment in this context. The present study addresses this knowledge gap. In South Yorkshire, Chinese residents constitute 0.2 - 1.3% of the population and pilot work by members of the research team has confirmed high levels of infection and low levels of testing and treatment in this | Background: The high prevalence of hepatitis B inChinaand other Far East Asian countries has been well documented in international epidemiological studies. Transmission occurs most frequently vertically, but also sexually, among household contacts and through healthcare. Chronic carriage is frequent, with considerable disease burden including morbidity and mortality from cirrhosis and hepatocellular carcinoma. Early treatment can prevent complications; however, access to specialist healthcare is known to be impaired in this group. Aims: This study objective is to identify the factors associated with poor levels of diagnosis and treatment operating at three levels in theUK: the Chinese community, the health care providers and the health system. This in turn should provide a base to help formulate policy to improve prevention and care. Three aims are: 1 - To identify within the target communities health seeking behaviours as well as knowledge, attitudes and misconceptions in rela | Government/NHS | Sheffield Teaching Hospitals NHS Foundation Trust | S10 2SB | 53.378 | -1.496 | 433595 | 386960 | England | Yorkshire and The Humber | Sheffield Central | Sheffield Central | NHS South Yorkshire Integrated Care Board | |
42 | 016/0058 | Nursing Research Unit (2007-2012) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2,512,956 | 1 October 2007 | 31 December 2012 | Not Available | BackgroundHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.AimsHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Potential ImpactHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Policy RelevanceUnknown | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
43 | 016/0065 | Improving Health through Resource Management | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £252,495 | 1 November 2004 | 29 February 2008 | Not Available | BackgroundThis study explores how HRM interventions can contribute to positive employee attitudes and behaviours and to improved performance. The study brings together a team that have been at the forefront of both HRM and health policy research, and who have experience of working together on a variety of projects. Whilst we have considerable knowledge of HRM in the NHS, the research team also has an extensive understanding of leading-edge practices in other sectors, a factor that allows for additional insights into HRM in the NHS. The main purpose of the study is to examine the HR-performance link and to get inside the `black box' of behaviours that flow from effective HRM, thus extending previous work in this area. Three aims of the study are: to provide detailed synthesis of existing knowledge linking HR to organisational performance; to assess the impact of HR interventions on performance for different types of services within specific NHS organisations and; to develop guidance for | Academic | The University of Manchester | M13 9PL | 53.467 | -2.234 | 384591 | 396711 | England | North West | Manchester Central | Manchester Central | NHS Greater Manchester Integrated Care Board | |
44 | 016/0077 | An Evaluation of Supplementary Prescribing in Nursing and Pharmacy | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £249,436 | 1 August 2005 | 31 July 2008 | Not Available | BackgroundThis proposal has three aims: to assess the barriers to and the factors facilitating SPNP, to identify the impact of SPNP on professional practice, patient experiences and cost, and to inform planning for current and future prescribers. Data collection consists of three stages. Firstly, 40 targeted telephone interviews with key informants will be conducted alongside analysis of key literatures. Secondly, a questionnaire survey will be conducted with all nurses and pharmacists currently registered as qualified prescribers in England. Finally, in-depth case studies will be undertaken in varying clinical areas across primary, secondary and tertiary care settings. These will use a mixed methods approach incorporating non-participant observation of clinical practice, various assessment instruments and interviews with patients, nurses, pharmacists GPs and hospital physicians. Findings will allow an assessment of medication errors and safety, patient and health professional experie | Academic | University of Sheffield | S10 2TN | 53.381 | -1.489 | 434120 | 387290 | England | Yorkshire and The Humber | Sheffield Central | Sheffield Central | NHS South Yorkshire Integrated Care Board | |
45 | 016/0100 | Developing Team Based Working in NHS Organisations | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £91,907 | 1 March 2006 | 31 January 2009 | Not Available | BackgroundThis research will evaluate interventions in NHS organisations to promote team based working (TBW) and to determine what hepls and hinders TBW. We will examine the extent to which TBW predicts organisational performance, employee well being and patient satisfaction. The result will be practical quidelines for NHS organisations on how to implement TBW. The research has three elements: 1. Qualitative data from interventions in ten case study trusts: We will evaluate interventions designed to increase levels of TBW focusing on which aspects of the interventions are most powerful (e.g. HR systems, top management support, organisational culture and structure, team leader and facilitator training); the barriers and facilitators in TBW; and the impact of these interventions on patient care. 2. Qualitative data from twenty NHS trusts: Using the Healthcare Commission National Staff Survey (HCNSS) data, we will identify those trusts with the best record for TBW and determine how th | Academic | Aston University | B4 7ET | 52.487 | -1.891 | 407502 | 287641 | England | West Midlands | Birmingham, Ladywood | Birmingham, Ladywood | NHS Birmingham and Solihull Integrated Care Board | |
46 | 016/0116 | Cohort Studies of Doctors Careers 2011-2013 | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £936,660 | 1 April 2011 | 31 March 2013 | For any health care system, its qualified professionals are its most important asset. This means having the right number of doctors, with the right training, in the right specialties in the right places. The project comprises questionnaire-based surveys in which all doctors who qualified from all medical schools in the UK, in one year in every three, are surveyed. The doctors are sent questionnaires in their first year after qualification, at three, five and seven years, and at longer time intervals after that. The doctors are asked about their future career intentions and they are then followed up to study their career progression, any changes of intentions, and their eventual destinations. The questionnaires include closed questions on a range of specific themes. They also include free text comments from the respondents, who are invited to write to us, if they wish, about any aspect of their training, career choice, career plans and progression, and working in medicine. The free te | Background: The planning and provision of health services is fundamentally underpinned by the distribution of doctors: this includes the distribution of doctors by specialty, geographical location and grade. Policy interests include the maintenance of a sufficient supply, without over-production, of doctors to enable the NHS to meet its service commitments; assessment of doctors’ views on their education and training; junior doctors’ hours and patterns of working; changes to GP and consultant contracts; equality of opportunity by gender and ethnicity; societal change in the domestic roles of men and women; and changing expectations in society generally in respect of the balance between work and family/leisure time. For these reasons, among others, research into doctors' careers is important. Aims: To determine the career choices of UK doctors, at regular intervals after qualification, and to study the factors which influence them; to study career progression, | Academic | University of Oxford | OX1 2JD | 51.758 | -1.262 | 451034 | 206852 | England | South East | Oxford East | Oxford East | NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board | |
47 | 016/0118 | Cohort Studies of Doctors’ Careers 2013 – 2015 | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2,407,348 | 1 April 2013 | 31 March 2018 | Our work is based in the Medical Careers Research Group, University of Oxford. We survey all doctors who qualified from all medical schools in the UK, in selected years. The doctors are sent (by email and by post) questionnaires in the first year after qualification and at regular time intervals after that. The doctors are asked about their future career intentions and followed up to study their career progression. The questionnaires also invite doctors to comment to us about any aspect of their training, career choice, career plans and progression, and working in medicine. These comments reflect the current plans and preoccupations of each generation of doctors. The study includes over 62,000 doctors from 13 year-of-qualification cohorts. We have a unique body of information, and research that needs continuously updating to ensure that it remains relevant to the present and future. Qualified professionals are a vital asset to any health care system. The medical workforce needs to comp | BACKGROUND: Planning and provision of health services is fundamentally underpinned by the distribution of doctors: this includes the distribution of doctors by specialty, geographical location and grade. Policy interests include maintenance of sufficient supply, without over-production, of doctors to enable the NHS to meet service commitments; assessment of doctors’ views on education and training; junior doctors’ hours and patterns of working; changes to GP and consultant contracts; equality of opportunity by gender and ethnicity; and changing expectations in society, generally, of the balance between work and family/leisure time. During the two years covered by this application, 2013-15, new features of the medical education environment will be bedding in, including greater use of ‘run-through’ training, new monitoring arrangements via Health Education England, and the new NHS Commissioning Boards. The effect of changes like these on doctors’ career dynamics and views will be of fun | Academic | University of Oxford | OX1 2JD | 51.758 | -1.262 | 451034 | 206852 | England | South East | Oxford East | Oxford East | NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board | |
48 | 017/0033 | An Observational Study of the Effect of Different Methods of Targeting Helicopter Ambulances | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £271,156 | 1 September 2004 | 30 September 2007 | Not Available | BackgroundAn experimental, controlled, before-and-after study of the effect of direct call-out on the appropriateness of helicopter emergency ambulance call-out will be carried out.The study aims to determine whether direct call-out of the helicopter by emergency personnel at the scene rather than indirect call-out via the ambulance service can improve the targeting for the helicopter to patients who need its services.Between September 2004 and March 2005 criteria for call-out and a direct call-out telephone number will be issued to all emergency personnel in the catchment area of the Teeside helicopter. Training and support will be provided.Appropriates of call-out measured by injury severity, need for immediate resuscitation, conformity to pre-specified call-out criteria, and a blinded expert panel assessment will be assessed. Changes in appropriates during 6 months - one year before direct call-out was introduced and 6 months to one year after will be compared with changes in the c | Academic | University of Sheffield | S10 2TN | 53.381 | -1.489 | 434120 | 387290 | England | Yorkshire and The Humber | Sheffield Central | Sheffield Central | NHS South Yorkshire Integrated Care Board | |
49 | 018/0042 | Public Health Research Consortium | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £4,081,815 | 1 October 2005 | 30 September 2011 | Not Available | BackgroundThe Public Health Research Consortium (PHRC) brings together senior researchers from 10 UK institutions in a new integrated programme of research. Its aim is to strengthen the evidence base for interventions to improve health, with a strong emphasis on tackling socioeconomic inequalities in health. The consortium is funded by England's Department of Health Policy Research Programme for a 5-year period from October 2005. The PHRC is built around a series of research studies, together with associated projects and dissemination activities to facilitate the translation of evidence into policy and practice. A major focus in on understanding and addressing inequalities in risk factors and wider determinants, including obesity and cigarette smoking. The PHRC is directed by Professor Hilary Graham (Department of Health Sciences, University of York) with a team of collaborators with expertise in public health, social epidemiology, sociology, health sciences, social marketing and h | Academic | University of York | YO10 5DD | 53.948 | -1.054 | 462215 | 450672 | England | Yorkshire and The Humber | York Outer | York Outer | NHS Humber and North Yorkshire Integrated Care Board | |
50 | 018/0063 | New Deal for Communities & Health Inequalities: Phase II | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £530,903 | 1 January 2010 | 30 September 2013 | Not Available | BackgroundThe government is committed to reducing health inequalities between socio-economic groups. New Deal for Communities (NDC), an area-based regeneration initiative begun in 1999 in 39 disadvantaged neighbourhoods in England could contribute to these targets because it focuses on key determinants of health inequalities: unemployment, crime, education and the physical environment. In 2005 we completed a scoping study, commissioned by DH, to assess the feasibility of evaluating the impact on health inequalities of the New Deal for Communities (Popay, et. al. 2005). We assessed the availability and coverage of relevant data sources and conducted a preliminary data analysis (Stafford et. al. 2008). We concluded that a full evaluation of the impact of the NDC initiative on health inequalities was both feasible and desirable and this research proposal puts forward such an evaluation.AimsThe aims are to investigate the medium term impacts of the NDC initiative on health inequalities | Academic | University of Lancaster | LA1 4YW | 54.010 | -2.786 | 348558 | 457442 | England | North West | Lancaster and Fleetwood | Lancaster and Fleetwood | NHS Lancashire and South Cumbria Integrated Care Board | |
51 | 018/0067 | Inequalities in Health Scientific Adviser: Evaluations of (a) Vascular Checks, and (b) Healthy Towns Initiatives | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £44,250 | 1 October 2008 | 28 February 2011 | Not Available | BackgroundHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.AimsHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.Plan of InvestigationHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.Potential ImpactHISTORIC PROJECT - all available project details have been transferred to respective fields in this database. | Academic | University of Bath (The) | BA2 7AY | 51.379 | -2.327 | 377327 | 164526 | England | South West | Bath | Bath | NHS Bath and North East Somerset, Swindon and Wiltshire Integrated Care Board | |
52 | 018/0073 | Understanding Society | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £200,000 | 21 January 2011 | 31 March 2012 | Not Available | Understanding Society | Undefined | Economic and Social Research Council (ESRC) | SN2 1UJ | 51.567 | -1.785 | 415016 | 185339 | England | South West | North Swindon | North Swindon | NHS Bath and North East Somerset, Swindon and Wiltshire Integrated Care Board | |
53 | 019/0014 | A Study of the Efficacy and Cost-Effectiveness of MRSA Screening and Monitoring On Surgical Wards Using a New, Rapid Molecular Test (EMMS) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1,071,177 | 1 July 2005 | 30 September 2011 | Not Available | BackgroundRecently a sensitive and specific PCR based test has become available (IDI Infectio MRSA) which can be used to screen patients for the carriage of MRSA. This test has been licensed by the FDA and Health Canada but has not yet been evaluated for cost-effectiveness in a U.K. NHS setting. We propose to carry out a prospective comparative study in which the rapid provision of screening results within the working day will be compared with the provision of results using conventional culture based techniques and standard NHS reporting systems. In order to assess outcomes in a rigorous fashion, once patients have been identified as being colonised or infected with MRSA, standard hand contact and isolation or if this proves impossible, cohorting precautions will be instituted in both arms of the study. The target population will be all surgical admissions to 7 surgical wards within the Birmingham Heartlands Hospital. Wards will be divided into molecular who will receive results rapi | Academic | University of Birmingham | B15 2TT | 52.453 | -1.928 | 404997 | 283926 | England | West Midlands | Birmingham, Edgbaston | Birmingham, Edgbaston | NHS Birmingham and Solihull Integrated Care Board | |
54 | 019/0044 | Assessment of Baseline Age-Specific Antibody Prevalence and Incidence of Infection to Novel Influenza A (H1N1)v | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £177,907 | 1 August 2009 | 30 September 2010 | Not Available | BackgroundStudy managed by NETSCC. Please refer to managing agent.AimsStudy managed by NETSCC. Please refer to managing agent.Plan of InvestigationStudy managed by NETSCC. Please refer to managing agent.Potential ImpactStudy managed by NETSCC. Please refer to managing agent. | Academic | Health Protection Agency | NW9 5EQ | 51.595 | -0.255 | 520992 | 189896 | England | London | Hendon | Hendon | NHS North Central London Integrated Care Board | |
55 | 019/0047 | Active Prospective Surveillance for Guillain-Barre Syndrome (GBS) and Fisher Syndrome (FS) in Children | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £64,209 | 21 September 2009 | 30 September 2012 | The study will be carried out using methodology that has been developed by the British Paediatric Surveillance Unit (BPSU). Each month a surveillance card listing the conditions currently under surveillance is sent by the BPSU office in the Royal College of Paediatrics and Child Health to all consultant paediatricians in the UK. Paediatricians are asked to return the card, reporting cases seen in the previous month (or indicating “no cases”). Our proposal is that we send a questionnaire to each paediatrician who reports a case via the BPSU office. The completed questionnaires would be returned to the paediatric GBS surveillance team in Cambridge. Our questionnaire would ask about the clinical history, relevant physical findings and results of investigations in children with GBS/FS. It would also ask for the name and address of the child’s general practitioner (GP) and for identifying information – the child’s name, date of birth, home postcode, hospital number and NHS number. | BackgroundOur proposal is that we perform active prospective surveillance for Guillain-Barré Syndrome (GBS) and Fisher Syndrome (FS) in UK children using the system developed by British Paediatric Surveillance Unit (BPSU). GBS is an important cause of acute flaccid paralysis worldwide and it is believed that immune stimulation plays a central role in its pathogenesis. GBS was an identified risk with swine flu vaccines used in the United States in 1976 – it is thought that 1 extra case of GBS occurred with every 100,000 doses of vaccine. The exact reason why the 1976 vaccine increased the risk of GBS remains unknown. We would work in collaboration with Professor Elizabeth Miller, the Head of Vaccination, Health Protection Agency (HPA) who is also conducting active prospective surveillance for GBS in the adult population in collaboration with the British Neurological Surveillance Unit.AimsResearch questions/surveillance objectives;To determine how many new cases of Guillain-Barré syndro | Government/NHS | Cambridge University Hospitals NHS Foundation Trust | CB2 0QQ | 52.174 | 0.139 | 546375 | 254988 | England | East of England | South Cambridgeshire | South Cambridgeshire | NHS Cambridgeshire and Peterborough Integrated Care Board | |
56 | 019/0048 | Market Research Evaluation of the Secretary of State HCAI Public Campaign to Improve Public Confidence in Clean, Safe Care in the NHS | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £44,542 | 16 February 2010 | 15 October 2010 | Not Available | BackgroundIn September 2008, Secretary of State for Health announced a public/patient campaignto inform the public and patients of action being taken to reduce healthcare associatedinfections (HCAI). The aim of this campaign is to combat public perceptions that theNHS is not ‘getting infections under control’. These perceptions exist despite the factthat data indicates that the number of healthcare associated infections are, in fact,down compared to the same period in previous years. Thus the aim of the publiccampaign is to reduce unnecessary anxiety, challenge misconceptions, outlineresponsibilities and generally build public and patient confidence in the ability of theNHS to control and prevent healthcare associated infections.The NHS Institute for Improvement and Innovation (NHSI) has been commissioned todeliver this HCAI campaign as a social movement (that is getting people to changeperceptions) to increase the proportion of the public and patients who believe thatHCAI are in contr | For-Profit Company | Ipsos MORI UK Limited | E1W 1YW | 51.507 | -0.067 | 534232 | 180499 | England | London | Poplar and Limehouse | Poplar and Limehouse | NHS North East London Integrated Care Board | |
57 | 019/0050 | The NOW study - the National One Week prevalence audit of MRSA (Methicillin resistant Staphylococcus aureus) screening | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £268,206 | 1 December 2010 | 30 June 2012 | It has long been a national priority to reduce MRSA because of its infections, mortality & cost. Most patients with MRSA are not infected but colonised ie carry the germ on their skin so could pass it on others. The basis of MRSA reduction is isolation of all colonised/infected patients in side rooms or isolation units and screening for asymptomatic carriers who are then isolated & get eradication therapy. Studies suggest that hospital levels of MRSA depend on the isolation capacity & the intensity of screening. Increasing one or the other reduces the level of MRSA, and could generate substantial savings by avoiding the costs of isolating & treating MRSA patients. Although national guidelines recommend only screening those patients considered to be at high risk for carrying MRSA, national policy is to screen all elective admissions from April 2009 and from December 2010 to screen all acute admissions. Previous modelling done on the limited clinical & cost data available indicates | BackgroundReduction of MRSA is a top national priority in the 2010-1 NHS Operating framework. The basis of MRSA reduction is isolation of all colonised & infected MRSA patients and screening for asymptomatic carriers who are then isolated. National guidelines recommend screening those at highest risk of MRSA carriage (risk based screening) but national policy is to screen all elective and, from Dec 2010, all emergency (acute)admissions. The limited available evidence in clinical & modelling studies suggests that screening all admissions costs more than risk based screening without achieving significantly greater reductions in MRSA. The Parliamentary Accounts Committee called for the DoH to commission research into the effectiveness, cost-effectiveness & implementation of the screening programme.AimsA national audit of MRSA screening carried out over one week in each acute NHS trust will (a) provide data on the extra yield from routine admission v risked based screening(b) provide | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
58 | 02/02/01 | Computed tomographic colonography versus colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (the SIGGAR trials) | NIHR (non-ODA) | Research | Complete | Health Technology Assessment | Commissioned | HTA Commissioned | £1,739,905 | 1 February 2004 | 30 June 2011 | CT colonography (CTC) is a new health technology for examination of the large bowel that is disseminating at a rapid rate, based on results from small trials that suggest that it is as sensitive as colonoscopy for detecting bowel cancer and large polyps but safer and more acceptable to patients. Many advocate using CTC to screening for bowel cancer (notably in the USA where the technique has received considerable media attention) but in the UK it is more likely that it will find a role for detecting bowel cancer in patients who have symptoms.
The symptoms of bowel cancer are very non-specific (e.g. abdominal pain, rectal bleeding, change in bowel habit, etc) and most people who have these symptoms won't have bowel cancer. However, they may still need to see a doctor and undergo a bowel examination in order to exclude the disease. The standard tests for looking at the large bowel are colonoscopy and barium enema. Colonoscopy involves the passage of a thin endoscope around the large b | CT colonography (CTC) is a new health technology for whole-colon examination that is disseminating at a rapid rate, based on results suggesting that it is as sensitive as colonoscopy for colonic cancer and large polyps but safer and more acceptable to patients. In the UK the use of CTC as a screening tool is controversial but a systematic review of the literature suggests that it is very sensitive for cancer and may thus have an important role in the NHS for rapid, accurate, acceptable, safe, and cost-effective investigation of symptomatic patients, most of whom are older and less tolerant of colonoscopy. CTC will be compared to the accepted standards of total colonoscopy and barium enema in two parallel, prospective multicentre randomised trials (randomised 2 to 1 in favour of the standard test), with choice of the standard test depending on local factors such as availability and expertise. The detection or exclusion of significant colorectal neoplasia (cancer and/or polyps >1cm) will | Academic | Imperial College London | SW7 2AZ | 51.499 | -0.179 | 526645 | 179284 | England | London | Cities of London and Westminster | Cities of London and Westminster | NHS North West London Integrated Care Board | |
59 | 02/06/02 | Long-term randomised controlled trial in primary care of the effectiveness and cost-effectiveness of levonorgestrel containing coil (Mirena) against standard treatment
for menorrhagia: LAST trial | NIHR (non-ODA) | Research | Complete | Health Technology Assessment | Commissioned | HTA Commissioned | £1,434,393 | 1 November 2004 | 31 December 2014 | Heavy periods (menorrhagia) is a very common problem affecting women's lives. The impact of this condition has considerable demand on time and resources in primary and secondary care. However, it is unclear which treatment options are the most effective and the most acceptable to women, particularly in the long term, and experience of care varies widely. Currently 1 in 5 women in the UK have a hysterectomy, half of whom present with heavy periods. This trial will assess the effectiveness, cost-effectiveness and acceptability of using the levonorgestrel IUS (Mirena coil) compared to standard medical treatment for women with menorrhagia presenting in primary care.
We want to involve around 120 general practices each recruiting 4 to 5 women with menorrhagia per year to the trial. We wish to recruit around 1200 patients over a two to three year period, commencing November 2004. We will then follow up women, by questionnaire over several years, to look at outcomes such as menorrha | 1. Previous trials show that Mirena is more effective than standard medical treatment in reducing the amount of menstrual blood loss in the short term but have not addressed quality of life or longer-term outcomes. We, therefore, propose a RCT, by intention to treat, to evaluate the effects of Mirena versus standard medical treatment (based on RCOG guidelines) over the longer term and in the primary care setting.
2. The project will measure patient centred and surgical outcomes over the "patient journey" along with resource use, in primary and secondary care, over time.
3. The project will model the utilisation and costs of the different intended treatments on the basis of these data. We will thereby be able to confirm, or refute, the hypothesis that treatment of menorrhagia with Mirena in primary care results in gain for patient and health services in the short and long-term compared to standard medical treatment.
4. Extensive sensitivity analysis will be conducted to explore th | Academic | University of Birmingham | B15 2TT | 52.453 | -1.928 | 404997 | 283926 | England | West Midlands | Birmingham, Edgbaston | Birmingham, Edgbaston | NHS Birmingham and Solihull Integrated Care Board | |
60 | 020/0053 | The Role of Networked Technology in Dementia Care | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £88,286 | 1 December 2006 | 30 June 2008 | Not Available | BackgroundBackground: Carers of people with dementia bear a huge social and psychological burden. They often spend a majority of time caring, and are frequently socially isolated. Networked technologies that can offer (e.g.) the remote delivery of social support, of accessible information, and the remote monitoring of behaviour, have potential benefits for these carers. To guide their successful implementation, it is important to have an understanding of the views of users and non-users and to identify the barriers and facilitators to the uptake of new technologies.Aims: To investigate the attitudes and behaviour of carers of people with dementia to networked information and communication technologies.Subjects and setting: Primary caregivers of people with dementia in Warwickshire and Coventry.Methods: 1. Scoping exercise of literature review and key informant interviews. 2. In-depth interview study with carers purposively recruited from health and social care settings and voluntary or | Academic | University of Warwick | CV4 8UW | 52.386 | -1.565 | 429718 | 276483 | England | West Midlands | Coventry South | Coventry South | NHS Coventry and Warwickshire Integrated Care Board | |
61 | 020/0056 | Modelling the Impact of Service Innovation in Chronic Disease Management | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £128,943 | 1 December 2006 | 30 June 2008 | Not Available | BackgroundIndividual trials and small scale pilot projects have demonstrated the effectiveness of telecare in improving individual care outcomes and supporting independent living. However, little is known about the likely impact of telecare for chronic disease sufferers at the care system level. This project aims to use simulation modelling (system dynamics) and economic analysis to explore the possible impact of telecare on a local health and social care system. In doing so it will address questions about the effectiveness and efficiency of chronic care delivery, and how telecare might enhance current delivery models. It uses the example of stroke care services but the approach is designed to be generic. The research will involve a series of work packages to identify stakeholders (GPs, acute hospital, social services, voluntary sector, patients) and their key concerns, conceptualise current stroke care delivery, develop simulation and economic models to analyse current and alternative | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51.499 | -0.179 | 526645 | 179284 | England | London | Cities of London and Westminster | Cities of London and Westminster | NHS North West London Integrated Care Board | |
62 | 021/0019 | Health Facilitation and Learning Disability. Evaluating the Role of Health Facilitators. | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £230,631 | 1 October 2003 | 28 February 2007 | Not Available | BackgroundThis project, submitted under research initiative LDR1, uses mixed methods to evaluate the impact of health facilitation on the experience of people with learning disabilities (LD}. The study is particularly concerned to ensure user views inform the development of health facilitation and in particular the role of the Health Facilitators (HF}: a new service development. The research, based in Leeds, has two elements. Element one is quantitative and determines the level of access in primary care for people with LD before and after the implementation of HF and explores the factors associated with variations in access. The sample will include data from GP records and is based on a random sample of 400 people with LD drawn from five PCTs. Element two is qualitative and will focus on the process of service support and health outcomes from the perspectives of the key stakeholders. Interviews will be undertaken with 25 relevant professionals, 30 people with LD and 30 family carers | Academic | University of Leeds | LS2 9JT | 53.808 | -1.553 | 429512 | 434722 | England | Yorkshire and The Humber | Leeds Central | Leeds Central | NHS West Yorkshire Integrated Care Board | |
63 | 023/0087 | Mental Health Legislation: Current Research Evidence and Key Themes | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £236,121 | 1 September 2004 | 30 June 2007 | Not Available | BackgroundTo assemble and analyse information to support the introduction, implementation and future evaluation of the new Mental Health Act. The project will result in:(1) a comprehensive summary of all available ongoing research and information-tracking projects on both current and proposed mental health legislation;(2) synthesis of the data on all formal admissions routinely forwarded to the DH between 1998 and 2004; (3) a comprehensive synthesis of all existing data-based research into the use of current mental health legislation (Mental Health Act 1983) to update the previous systematic review undertaken by Churchill et al (1999);(4) more detailed analysis of three key themes relating to the implementation of the new Mental Health Act as follows:(a) Ethnicity and compulsory detention;(b) Capacity for consent to treatment;(c) International experiences of implementing and applying Community Treatment Orders.AimsHISTORIC PROJECT - Entire abstract transferred from the previous databas | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
64 | 023/0143 | Clinical Evaluation of the Diagnosis of Autistic Disorder in the Adult Psychiatric Morbidity Survey 2006 - 2008 (APMS) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £45,863 | 1 April 2008 | 31 January 2009 | Not Available | BackgroundNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.AimsNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.Plan of InvestigationNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.Potential ImpactNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database. | Academic | University of Leicester | LE1 7RH | 52.621 | -1.126 | 459297 | 302901 | England | East Midlands | Leicester South | Leicester South | NHS Leicester, Leicestershire and Rutland Integrated Care Board | |
65 | 023/0144 | A systematic review of the causes of Attention Deficit Hyperactivity Disorder (ADHD) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £60,975 | 1 April 2009 | 31 August 2010 | Few childhood difficulties provoke as much concern and controversy within our society as the disorders of attention, impulse control and activity, clinically known as Attention Deficit Hyperactivity Disorder (ADHD). Often the discussions about ADHD, its causes and its treatment take place in a highly emotionally charged atmosphere which can lead to decisions being made that are not based on the best available evidence. In this research project we will comprehensively review the evidence about the causes of ADHD in a systematic way looking not only at research that has already been published in scientific journals but also at studies that have only recently been completed or have not yet been published.We will be asking questions like: Do the difficulties we know as ADHD arise from differences in a person’s biological make up or are they a consequence of modern lifestyle choices such as watching TV instead of playing outside? If ADHD does exist how much of the risk of developing it depe | BackgroundADHD is a complex and heterogeneous disorder that has very serious negative consequences for sufferers and their families. Whilst there is considerable evidence to support a biological basis for ADHD we are a long way from a full causal explanation. The relative contributions made by genes and environmental factors, including various lifestyle factors such as excessive use of electronic media, and their interactions with each other are not well understood and continue to be debated. Importantly these discussions between scientists, clinicians, policy makers and the general public can easily become unnecessarily polarised resulting in confusion and misunderstanding about the nature of ADHD and thwarting progress towards the development of new methods of treatment and prevention.AimsThe aim of this research is to conduct a comprehensive open minded systematic review of the literature relevant to the causes of ADHD by including both peer reviewed and grey literature. The main re | Academic | University of Dundee | DD1 4HN | 56.457 | -2.978 | 339808 | 729895 | Scotland | Not Applicable | Dundee West | Dundee City | Not Applicable | |
66 | 023/0145 | Systematic review of the incidence and prevalence of schizophrenia and other psychoses in England | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £69,611 | 1 June 2009 | 31 March 2011 | Psychotic symptoms (e.g. hallucinations, delusions, strange behaviour) characterise the most serious mental disorders, in particular schizophrenia and, less commonly, mania and severe depression. These conditions are often associated with considerable social disability, stigma, and family burden. In the UK, recent estimates put the total societal costs of schizophrenia at £6.7 billion. Much of these costs arose from lost productivity and informal care and private expenditures borne by families. If we can better understand the distribution of these disorders in England, and what factors may cause them, we can provide valuable information for healthcare planners to provide better services to the people who need them most and reduce the burden placed on sufferers and the people who have to care for them.We will conduct a comprehensive review of all available published and unpublished literature on the incidence (new cases) and prevalence (new cases and existing cases combined ) of schi | BackgroundSchizophrenia & other psychotic disorders are associated with considerable social disability, stigma and family burden. In the UK, recent estimates put the total societal costs of schizophrenia at £6.7 billion. Our understanding of the epidemiology of these disorders has changed radically in recent years as studies have shown that incidence varies by gender & place. In particular, there is emerging evidence that the environment (both social and physical) increases risk over the life course. Prevalence has been studied less, but for public policy and service planning purposes it is clearly important. Thus, a systematic review of the incidence, prevalence and environmental correlates of schizophrenia & other psychoses will inform public policy and may reveal clues about aetiology.AimsTo determine:1. Whether the incidence & prevalence of schizophrenia & other psychoses are increasing (or decreasing) over time in England? 2. Whether geographical, ethnic & gender differences in in | Academic | University of Cambridge | CB2 1TN | 52.205 | 0.116 | 544705 | 258430 | England | East of England | Cambridge | Cambridge | NHS Cambridgeshire and Peterborough Integrated Care Board | |
67 | 023/0148 | BIDS (Best Interests Decisions Study) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £213,532 | 15 February 2010 | 15 October 2011 | According to the Mental Capacity Act, a person can be assessed as not capable of making a particular decision, in which case that decision should be made for him/her, according to his or her best interests. Although the Act gives guidance about how this should be done, we do not know how best interests decisions are currently being made. This situation has a direct impact on the rights of those people who may lack capacity to make a particular decision, especially those whose capacity is often in question - those with dementia, mental health issues, brain injury or learning disabilities. This research will give clear and wide information on how the current guidance is being interpreted for different groups of people, and different types of decision (e.g. health, legal or social care). 1. In order to have an overview of current practice, we will use a large-scale online survey to get information from 400 people who have made best-interests decisions for someone who lacks capacity.2. W | BackgroundThe 2005 Mental Capacity Act (MCA) is innovative in formulating a principled, legislative framework to protect the rights of individuals in decision making, in the assessment of capacity and the making of best interests decisions. Research about best interests decisions since the Act however has highlighted confusions in practice (Myron et al, 2008), concerns about tokenism (Donnelly, 2009) and challenges relating to the resolution of conflicts (Joyce, 2007). There are still several unanswered questions about how the best interests principle impacts on the experience of those lacking capacity (Stanley and Manthorpe, 2008) and how it is interpreted in major life-threatening situations (Hegde et al., 2006). AimsOur own research in this area has highlighted the need to deliver both robust and quantifiable knowledge of current practice, while also seeking better understandings of how best interests decisions are made. Thus the central aim is to deliver evidence about the exten | Academic | University of Bristol | BS8 1QU | 51.457 | -2.607 | 357902 | 173302 | England | South West | Bristol West | Bristol West | NHS Bristol, North Somerset and South Gloucestershire Integrated Care Board | |
68 | 023/0149 | Research to review the quality of Independent Mental Health Advocate (IMHA) Services | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £245,906 | 15 March 2010 | 31 January 2012 | People with mental health problems, who are detained under the Mental Health Act now have a right to support from an independent mental health advocate (IMHA). The role of this advocate is to ensure that the person’s rights are protected and to support them to be involved in decisions about their care and treatment. This research aims to find out how well these advocacy services are working and to look at the quality of the services they offer. The research will be carried out by a research team led by the University of Central Lancashire that includes mental health service users. We will identify who makes use of advocacy services, what occurs when they do, and what they get out of it. There will be two stages to the research. First we will look for available research and expert opinion to help us make sense of what people think makes a good IMHA service. This will involve reviewing literature on advocacy and talking to people, including advocates and service users, in focus groups. | BackgroundThe Mental Health Act 2007 introduced the provision of independent mental health advocacy (IMHA) to ensure that detained patients understand their rights under the Act and are supported to participate in decisions about their care and treatment. Whilst the concept of independent mental health advocacy is not new, the IMHA role is distinctive and previous evaluative research in the field sparse. Studies have been undertaken largely in hospital settings and a small number of studies in relation to black and minority ethnic communities have raised questions about equity of access and style of provision. Variations in terms of quality and capacity have also been noted alongside an absence of accepted quality standards to guide the effective commissioning of IMHA services.AimsThe overarching aim of the research is to review the extent to which IMHA services in England are providing effective and appropriate help to patients under the Mental Health Act 1983(as amended by the MHA 2 | Academic | University of Central Lancashire | PR1 2HE | 53.761 | -2.707 | 353463 | 429675 | England | North West | Preston | Preston | NHS Lancashire and South Cumbria Integrated Care Board | |
69 | 023/0167 | Risk and resilience: Self-harm and suicide ideation, attempts and completion among high risk groups and the population as a whole. | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £155,829 | 1 October 2013 | 31 May 2017 | This research directly addresses the first three research specification questions. Existing general population survey data allow for examination of prevalence, trends, patterning, and risk and protective factors for: self-harm, and suicide ideation, attempts and completion, for the population as a whole and for a wide range of different groups. We will apply consistent and innovative population segmentation analysis techniques to a variety of survey datasets. Central to the study is the review of statistical findings with people with lived experience of self-harm and suicidal crisis through facilitated participatory consultation. General population samples include people without contact with health and social services, and enable people with and without experience of suicidal crisis to be compared. Questions administered sensitively by self-completion mean some people report experiences they have never told anyone - service provider or friend - before, people invisible to other forms | Background With the launch of the new national suicide prevention strategy, high quality research is needed to support its implementation and evaluation of progress. Government and Research Councils have highlighted that ultilising existing data sources can be an efficient and effective use of resources. Epidemiological survey datasets are inclusive of people not in contact with services, enable subgroups to be identified and include controls for comparison. Excellent data resources exist, which have only been partially examined. Aims 1. To prioritise factors to address to reduce suicide behavior among people with a history of self-harm. Including identifying the different factors that predict people who self-harm and have a history of suicide attempts and those who self-harm and have not attempted suicide. 2. To identify the patterns, associations and characteristics of self-harm and suicide behaviour, including risk and protective factors relevant at a time of economic recession, | Academic | National Centre for Social Research | EC1V 0AX | 51.527 | -0.103 | 531689 | 182599 | England | London | Islington South and Finsbury | Islington South and Finsbury | NHS North Central London Integrated Care Board | |
70 | 024/0043 | Biomarker Discovery for the Assessment of Zinc Status | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £474,178 | 1 April 2011 | 31 March 2014 | Not Available | Biomarker Discovery for the Assessment of Zinc Status | Academic | University of Aberdeen | AB24 3FX | 57.165 | -2.100 | 394037 | 808227 | Scotland | Not Applicable | Aberdeen North | Aberdeen City | Not Applicable | |
71 | 024/0044 | Development of a Dose-Responsive Biological Marker for Sucrose Intake Based on Metabolomics and Machine Learning | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £96,721 | 1 April 2011 | 31 July 2011 | Not Available | Development of a Dose-Responsive Biological Marker for Sucrose Intake Based on Metabolomics and Machine Learning | Academic | Cranfield University | MK43 0AL | 52.070 | -0.631 | 493946 | 242155 | England | East of England | Mid Bedfordshire | Mid Bedfordshire | NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board | |
72 | 024/0047 | Exploratory and Developmental Trial of a Family Centred Nutrition Intervention Delivered in Children’s Centres and the Home Environment | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £314,184 | 1 April 2011 | 31 October 2012 | Not Available | Exploratory and Developmental Trial of a Family Centred Nutrition Intervention Delivered in Children’s Centres and the Home Environment | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | 529662 | 182170 | England | London | Holborn and St Pancras | Holborn and St Pancras | NHS North Central London Integrated Care Board | |
73 | 024/0051 | 25(OH)D half-life as a marker of vitamin D expenditure and function | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £274,651 | 2 July 2012 | 9 June 2014 | Vitamin D is essential for bone health and development. Recent evidence also suggests a broader role for vitamin D in other conditions. The prevalence of a low vitamin D status is higher amongst older than younger people and the functionality of vitamin D is reduced, which may be related to ageing processes. Vitamin D status is usually assessed by measuring the amount of 25-hydroxyvitamin D (25(OH)D) in the blood but this depends on both the amount of vitamin D coming into the body from the diet and skin and the amount being used up (vitamin D expenditure). We have developed a method to determine vitamin D expenditure –25(OH)D half-life. There is a lack of clarity what the vitamin D expenditure and thus requirements of different groups of the population is and how this is affected by their vitamin D status, age, body composition kidney function and other factors. This study will capitalise on a vitamin D supplementation trial in the elderly in Newcastle (VDOP) and a 25(OH)D | Background Vitamin D is important for calcium homeostasis and skeletal metabolism and in other areas of health and disease prevention. Recently the IOM updated their recommendations, but recognised that there are uncertainties about how and what amount of vitamin D is needed to achieve the plasma concentrations of 25-hydroxyvitamin D (25(OH)D) associated with optimal health outcomes in different population groups. The plasma concentration of 25(OH)D is used to assess vitamin D status. However, the relationships between intake, plasma 25(OH)D and vitamin D function are not well understood and are influenced by physiological factors including baseline 25(OHD, life-stage and body composition. New biomarkers to assess vitamin D expenditure and function are needed. Aims in relation to the issue to be addressed This study aims to assess the 25(OH)D half-life, reflecting the expenditure of 25(OH)D, and its relationship with determinants such as vitamin D supply, age, kidney function an | Undefined | MRC Human Nutrition Research Unit | CB1 9NL | 52.183 | 0.181 | 549193 | 256059 | England | East of England | Cambridge | Cambridge | NHS Cambridgeshire and Peterborough Integrated Care Board | |
74 | 025/0014 | Coordinating Initiative on Older People | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £208,456 | 1 April 2002 | 31 January 2009 | Not Available | BackgroundThis post is to support the academic quality of the Department of Health's Research Programme which accompanies implementation of the National Service Framework for Older People. The Academic Co-ordinator will offer external scientific and expert advice, support and assistance. This will include: (i) advising on the commissioning process; (ii) advising on and assisting with the management of the programme of studies, communicating with the project researchers, monitoring progress, fostering communication between the projects, disseminating information and establishing links with other programmes, networks, etc.; (iii) advising on completion of projects, enhancing dissemination of findings and identifying their implications for policy and practice. The role of the Academic Co-ordinatior (which will occupy on average one day per week of the Co-ordinator's time over the next three years) is advisory to the Director of Research and Development.AimsHISTORIC PROJECT - Entire abs | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
75 | 025/0050 | Abuse and Neglect of Older People: Secondary Analysis of Prevalence Survey Data | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £58,894 | 1 September 2008 | 28 February 2009 | Not Available | BackgroundThe UK Prevalence Survey of Abuse and Neglect of Older People (UKPS) published a report in 2007 which focused on a conservative definition of elder mistreatment and looked at a number of socio-demographic characteristics associated with mistreatment. The aims of this project are to extend the analysis in three ways:(1) to explore a much wider range of factors associated with mistreatment by linking the UKPS dataset with data from the Health Survey for England; (2) to provide a better understanding of the factors associated with mistreatment by undertaking logistic regression analysis so that the significance of different characteristics can be examined after taking other characteristics into account; (3) to provide estimates for mistreatment using wider definitions than those used in the 2007 report, including mistreatment: since age 65; involving neighbours and acquaintances; carried out by strangers; and, to examine how risk factors vary by these definitions. The research g | Academic | National Centre for Social Research | EC1V 0AX | 51.527 | -0.103 | 531689 | 182599 | England | London | Islington South and Finsbury | Islington South and Finsbury | NHS North Central London Integrated Care Board | |
76 | 025/0053 | Analysis of Secondary data sources study | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £80,077 | 1 June 2009 | 31 March 2011 | We do not know how many people living in care homes and older people staying in hospital are abused or neglected, or do not have their rights to dignity respected. This is not for lack of information gathering; professionals in care homes and hospitals complain about unending paperwork and numerous inspections and targets. Despite the many potential sources of information about abuse, neglect and undignified treatment to be found in complaints, personal accounts, inspection reports and inquiries, this information is rarely pulled together. This study seeks to draw together all the information sources about these important issues and to ask what works, what is useful and if any improvements in use of information could be made. We are a research team with a wide range of experience in working with information in this area and a commitment to making sure that the trouble of collecting it and analysing it is worth the effort. The study will collate the main sources of information and will | BackgroundThis proposal responds to the call for an initial scoping exercise of existing secondary data sources. We propose to investigate ways to improve the co-ordination of data collection from different sources and the analysis of quantitative and qualitative data sets. The background is complex and multifaceted ; we have a range of data that reports ‘abuse’ and ‘crime’, a wealth of regulatory data about good and poor practice and powerful testimonies of what happens when things ‘go wrong’. Multiple organisations collect and analyse data, but much data is not collated nor used to maximum effect. In the light of policy goals to remove unnecessary bureaucracy and to encourage risk taking and choice, the sustainability of existing data collection mechanisms may be even more fragile.AimsThe main aim of the study is to improve the collection and analysis of existing data to optimize their use for policy development, quality assurance and in contextualizing findings from other studies. I | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | 531085 | 180144 | England | London | Vauxhall | Vauxhall | NHS South East London Integrated Care Board | |
77 | 025/0054 | Organisational Dynamics of Respect and Dignity in Elder Care | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £377,094 | 1 April 2009 | 30 September 2012 | Whilst many workers are motivated to care for people in a sensitive way, the underlying causes of mistreatment of older people in residential settings have not been thoroughly investigated. This study of what happens between residents, workers, managers and visitors in care settings will examine circumstances which contribute to good care or to the mistreatment of older people. The study will improve understanding of the context, causes and impact of abuse, neglect and/or loss of dignity in institutional settings so that they may be prevented in the future.Older people will be involved as researchers and advisors throughout the study. Older people will be represented on a panel that will meet regularly throughout the research project to influence the priorities and focus of the research. They will actively participate in phase 2.The project has three phases. The first phase (6 months) will review existing knowledge about the mistreatment of older people in residential or institutional | BackgroundFor older people care in an institutional setting often involves experiences of loss of dignity (Tadd 2007) and/or abuse (e.g. Action on Elder Abuse 2006; Garner and Evans 2002, Juklestad 2001, 2007; Lothian and Philp 2001). To improve systems of protection it is necessary to understand how and why mistreatment occurs. Calman et al (2007) illustrated differences between health care workers’ aspirations and practice. Tadd et al (2006) showed that codes of practice had only a limited effect on nurses’ behaviour. There is, therefore, a need for a study which can closely examine systems and practices in organisations caring for older people to understand what constitutes loss of dignity and abuse for patients in such settings and to understand how well-meaning staff may come to commit abuses.Aims1. To identify institutional dynamics underlying abuse, neglect and loss of dignity in the care of older people in order to inform policy and practice developments.2. To understand the | Academic | University of East Anglia | NR4 7TJ | 52.622 | 1.241 | 619497 | 307667 | England | East of England | Norwich South | Norwich South | NHS Norfolk and Waveney Integrated Care Board | |
78 | 025/0056 | Promoting Excellence in All Care Homes (PEACH) Exploring Knowledge, Practices & Training Needs of the Care Home Workforce | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £449,266 | 1 April 2009 | 31 March 2012 | What we know:Many people believe that abuse, neglect & lack of dignity are widespread in institutional care for older people, but we have little evidence that this is so. There is limited evidence that some care home staff commit psychological abuse to older residents. We also know what care workers claim affects their ability to provide appropriate care including values & motivation of individuals, such as their attitude to older people and job satisfaction, organisational factors such as the numbers of staff and residents, inadequate resources such as poor environments with lack of facilities & lack of education.What we don't know:We need to know more about the actual experiences of care home staff, the care practices in care homes and what impact education has on attitudes, practices, and behaviour.What we will do:- observe care practices & interactions between residents & paid carers in 8 different care homes.- ask staff to complete questionnaires about their attitudes to older p | BackgroundDespite belief that abuse, neglect & lack of dignity is common in institutional care for older people, hard evidence is lacking. A systematic review identified only 5 care home studies with 16% of staff admitting significant psychological abuse. Identified obstacles to appropriate care include values & motivation of practitioners, organisational factors, inadequate resources & lack of education. For many paid carers these factors result in frustration & loss of personal dignity. There is little guidance or training in relation to dignified care & lack of knowledge about recognising & dealing with abuse & neglect. The proposed study will build on work being undertaken by Tadd with the NHS workforce & will inform the prevalence study of abuse & neglect of older people in care homes. Aims1.Explore views & experiences of care home sector & workforce in relation to provision of dignified care & avoidance of abuse & neglect2.Explore effect of an evidence based training interven | Academic | Cardiff University | CF24 0DE | 51.484 | -3.166 | 319119 | 176776 | Wales | Not Applicable | Cardiff Central | Cardiff | Not Applicable | |
79 | 025/0058 | Healthbridge: National Evaluation of Dementia Advisors and Peer Support Networks | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £649,564 | 1 April 2010 | 30 September 2012 | The National Dementia Strategy encourages the use of peer support networks and dementia advisors to support families. However, the evidence base for these activities is weak. We intend to evaluate the pilot networks and advisors that have been set up in England. We aim to: 1. Describe the range of peer support network and dementia advisor pilot services and to support their development.2. Assess these new service models in relation to:a. Influence on the wellbeing of people with dementia and carers.b. Contribution to achieving the objectives of the National Dementia Strategy.c. How they work with other health and social care services. 3. Identify ways in which the new service models help people with dementia and carers. Phase 1 is organised around a series of national collaborative workshops and will support the learning across these new services and support the development of the services. Phase 1 will also collect and analyse data about what difference the new services make to people | BackgroundThe National Dementia Strategy (DoH 2009) promotes the use of peer support networks and dementia advisors. This acknowledges the part that lay and peer support and advisors can play in supporting communities and families, promoting: access to individuals who are marginalised, access from marginalised communities into health and social care systems, and alternative delivery mechanisms to a professional provider. However, the evidence base for the effectiveness of peer and lay roles and support is weak and the evidence is not sufficient to support or refute the role in promoting health and improving quality of life. The project team bring together expertise from 4 Universities and a range of health, social science disciplines with a distinct public health and knowledge exchange focus.Aims1. To describe the range of peer support network and dementia advisor pilot services, their evolution, establishment and delivery and governance characteristics, and to support their effective | Academic | University of Edinburgh | EH8 9YL | 55.948 | -3.187 | 325946 | 673376 | Scotland | Not Applicable | Edinburgh East | City of Edinburgh | Not Applicable | |
80 | 025/0064 | PANICOA Care Home Final Study; In Depth Examination of Care | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £526,269 | 21 March 2011 | 10 January 2013 | News stories often report mistreatment in care homes but good practice gets little publicity. Mistreatment in many forms does occur, even though most staff and owners want to provide good care and despite systems of inspection of care homes. What is not known is how widespread it is or why it occurs in some homes but not others. Simple surveys, for example using questionnaires asking residents about mistreatment, do not provide a reliable picture. This study plans to use 12 very detailed case studies involving the researchers spending time over a number of weeks in each care home. We will; 1. Observe in detail the care of a number of residents who require a lot of personal care such as those with advanced dementia or communication problems 2. From this observation identify potential good and poor practice issues and carry out in-depth observations and interviews with other residents, care workers and managers to see how this practice relates to the organisational culture, and ho | Background (400-800 characters): Positive public messages about institutional care are rare with a perception that mistreatment is commonplace (Hussein 2007), but providing robust research evidence in this field raises challenges of definitions and obtaining robust data. From the small amount of research into mistreatment in institutional settings some indicators, markers and risk factors have been identified. Commonly occurring organizational features associated with reduction in care quality have been identified (Hyde et al 2009). Both concrete behaviours and subjective experiences of residents are important in understanding the prevalence of mistreatment and experiences need to be understood in the context of reasonable expectations of trustworthiness in relationships (Dixon et al forthcoming). Aims (400-800 characters): The study will analyse positive and negative care experiences in relation to the contexts, cultures and factors that positively or negatively pre-dispos | Academic | University of East Anglia | NR4 7TJ | 52.622 | 1.241 | 619497 | 307667 | England | East of England | Norwich South | Norwich South | NHS Norfolk and Waveney Integrated Care Board | |
No results