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Public_Health_Outcomes_Framework
Award_Reference
Programme
Funding_Stream
Chief_Investigator
Contractor
Start_Date
End_Date
Award_Title
Abstract
Status
Funding_and_Awards_Link
Award Budget
1
Healthcare Public Health and Preventing Premature Mortality
06/35/99
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Janet Clarkson
University of Dundee
1 de setembre de 2011
28 de febrer de 2019
INTERVAL Dental Recalls Trial [Investigation of NICE Technologies for Enabling Risk-Variable-Adjusted-Length Dental Recalls Trial] - Full Trial Follow-on
This parallel-group randomised controlled comparison of three forms of dental recall strategy (6 month recall, risk-based recall, and 24 month recall), will evaluate the effectiveness and cost effectiveness of these strategies by assessing their impact on maintaining oral health. Ethical concerns over the use of a 24 month recall interval expressed by some dental practitioners have been addressed by randomisation within two strata. The risk-based recall strategy is that advocated by the 2004 NICE guidance on Dental Recall - personalised variable intervals determined according to risk information derived from comprehensive oral health assessment and review. The two fixed-period recall strategies are the traditional six month interval between routine check-ups or 24 month recall interval between routine check-ups. The research will be carried out in general dental practices across the UK. Participating dentists will represent a cross-section of practitioners operating in a range of diffe
Complete
2.626.274,22
2
Healthcare Public Health and Preventing Premature Mortality
06/37/04
Health Technology Assessment
HTA Commissioned
Professor Paul Stallard
University of Bath
1 de setembre de 2008
30 de juny de 2012
A single blind randomised controlled trial to determine the effectiveness of group cognitive behaviour therapy (CBT) in the prevention of depression in high risk adolescents
Classes of children aged 13-16 will be randomised to one of three, 10 week, Personal Social Health and Education (PSHE) conditions. The experimental condition will be based upon cognitive behaviour therapy and will specifically target depressive cognitions and mood. The second will be an attention control condition involving similar time and contact with external group leaders but will not include the active components of the CBT intervention. The third will be treatment as usual, i.e. PSHE delivered by the school. Symptoms of depression (Mood and Feelings Questionnaire), cognitions (Children's Automatic Thoughts Scale) and self-image (Self Image Profile) will be assessed at baseline, 6 and 12 months and an economic evaluation undertaken at 12 months. The primary analysis will explore the preventative effect of the intervention on children identified as "at risk" of depression i.e. those scoring high on the Mood and Feelings Questionnaire at initial screen and baseline assessment. Seco
Complete
1.016.857,19
3
Healthcare Public Health and Preventing Premature Mortality
06/43/05
Health Technology Assessment
HTA Commissioned
Professor Simon Gilbody
University of York
1 de maig de 2009
31 d'octubre de 2013
The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial
Depression is a major health problem. The majority of people with depression receive care from their GP. However, lots of people experiencing depression would also like to receive a "talking treatment" (counselling or psychotherapy). Cognitive Behaviour Therapy (CBT) seems to be the most effective type of talking treatment for depression but is not always immediately available in the NHS. Recently, therapists have developed a form of CBT that can be delivered by computer, which might make it easier to access this form of treatment. We call this "computerised CBT". There are different computerised packages, some of which are freely available and others which have to be paid for by the NHS. At the moment we do not know which of these works best for NHS patients with depression. The purpose of this study is to compare two (one free-to-use and one commercial) CBT packages to see if there are any additional benefits of offering this treatment to the care that people already receive from the
Complete
1.471.459
4
Health Improvement
06/85/11
Health Technology Assessment
HTA Commissioned
Professor Peymane Adab
University of Birmingham
1 de novembre de 2010
30 d'abril de 2016
A cluster randomised controlled trial of the effectiveness and cost-effectiveness of an obesity prevention intervention in primary school age children
Aim To assess the effectiveness and cost-effectiveness of a community-level, multi-component intervention programme in preventing obesity in 6-7 year old children, compared to usual practice. Design A cluster randomised controlled trial, using schools as units of randomisation and analysis. Setting Local Education Authority maintained primary schools within the West Midlands. Population Children age 6-7 attending primary schools in the West Midlands. Schools will be stratified according to urban vs. rural location, proportion of pupils from ethnic minority groups and proportion of children entitled to free school meals (as a proxy for deprivation). Schools in each stratum will be randomly allocated to intervention or control arms. Intervention A multi-component intervention programme will be delivered to schools in the intervention arm for one year. This programme consists of several elements; activities to increase the time spent doing physical activity within the school day, particip
Complete
2.651.248,34
5
Health Improvement
07/41/05
Health Technology Assessment
HTA Commissioned
Professor Simon Gilbody
University of York
1 de desembre de 2010
30 de novembre de 2013
Smoking cessation for people with severe mental illness: a pilot study and definitive randomised evaluation of a bespoke service
Smoking significantly impacts the physical health of people with severe mental illness (SMI) such as schizophrenia or bipolar disorder. Compared to the general population, a large proportion of SMI patients smoke and are likely to be heavy smokers with greater nicotine addiction. However these patients have greater difficulty in quitting and are less likely to receive help in quitting. Currently available smoking cessation services and drugs are aimed at the general public and their suitable for SMI patients is unknown. Mentally ill patients do express a desire to stop smoking, but they may require different strategies and greater support to help them quit smoking. To address this problem, we aim to evaluate a 'bespoke smoking cessation' (BSC) service, specifically tailored to individual SMI patients. A mental health nurse trained to deliver smoking cessation interventions will become the patient's mental health-smoking cessation practitioner (MH-SCP). They will work with the patient's
Complete
603.124,82
6
Health Protection
07/43/01
Health Technology Assessment
HTA Commissioned
Professor Jacqueline Cassell
University of Sussex
1 de gener de 2010
28 de febrer de 2013
The relative clinical and cost-effectiveness of three contrasting approaches to partner notification for curable sexually transmitted infections (STIs): a cluster randomised trial in primary care
Increasing numbers of patients are diagnosed with sexually transmitted infections (STIs) in their GP surgery. This study is concerned with finding out the best way to enable treatment for the sexual partners of individuals diagnosed with sexually transmited infections (STIs) in their GP practice. This is called "partner notification". Treatment of partners is important for two reasons - to protect the original patient from reinfection, and to prevent the further spread of infection by infected partner(s). We will compare three different approaches to partner treatment: (i) PATIENT REFERRAL where patients are simply given information and asked to tell their partner about the problem and the need to be treated. (ii) CONTRACT REFERRAL, where, in addition to (i), patients will be asked to agree to a specialist health adviser (contact tracing expert) to inform partner(s) if this has not been done after a period of time (say, a week). (iii) PROVIDER REFERRAL, where, in addition to (i), patie
Complete
768.630,48
7
Health Improvement
08/14/41
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Sarah Lamb
University of Warwick
1 de setembre de 2010
28 de febrer de 2019
Prevention of Falls Injury Trial
Context: Common falls prevention strategies used in primary care settings include advice and information, structured exercise, and multi-factorial risk-reduction programmes. Little is known about the comparative effectiveness and cost-effectiveness of these strategies. Objective: To estimate the comparative effectiveness and cost-effectiveness of advice, structured exercise and a multi-factorial fall prevention programme, for the prevention of fall injuries among older people living in the community. Design: A 3-arm, cluster-randomised controlled trial with economic evaluation. The unit of randomisation will be the General Practice, and minimisation will be used to ensure balance in the allocation of practices by list size and area socio-economic status. Population: 9,000 people (60 practices) aged over 70 years living in the community, including people in sheltered accommodation, but excluding people living in nursing or residential care homes. Interventions: Practices will be randoml
Complete
2.423.783,18
8
Health Protection
08/17/01
Health Technology Assessment
HTA Commissioned
Professor Laura Rodrigues
London School of Hygiene & Tropical Medicine
1 de maig de 2011
31 d'octubre de 2015
Observational study to estimate the changes in the efficacy of BCG with time since vaccination
Two analytic observational studies will be conducted comparing the frequency of the BCG vaccine in people in people with and without a history of illhealth. Both studies will evaluate how the effect of BCG vaccine changes with time since vaccination. The first study will examine children aged from 0-17 years, born when BCG can be given in infancy. The second study will examine an adult age range from 23 to 37 years and aged 13-years old when the pre-2005 school aged BCG programme existed
Complete
1.738.408,08
9
Healthcare Public Health and Preventing Premature Mortality
08/1803/224
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Justin Keen
University of Leeds
1 de setembre de 2008
31 de maig de 2011
Electronic services: implementation and impact
This study will: 1. Develop of a detailed narrative account of the implementation of shared electronic services for older people; 2. Establish the cost-effectiveness of shared electronic services used in hospital discharge processes for older people; 3. Evaluate the implementation of shared electronic patient records in diabetes services across NHS organizations in Yorkshire and Humber SHA. There is good evidence that partnerships involving health, social care and other organizations are difficult to establish in practice. Worse, in responding to demography, technological advances and other forces, health care is becoming ever more complex and expensive, suggesting that effective partnerships may be even more difficult to achieve in future. Electronic networks are increasingly viewed, across Government, as a key tool for achieving integrated service delivery in the face of current challenges. In the NHS the National Programme for Information Technology (IT) is in effect a major infrast
Complete
251.802
10
Healthcare Public Health and Preventing Premature Mortality
08/1803/226
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Mike Dent
Staffordshire University
1 de novembre de 2008
31 de juliol de 2011
Getting the benefit from electronic patient information that crosses organisational boundaries
This is a study of the organisation and management of patient information sharing across and between organisations. The PCTs in this project are each involved in a variety of initiatives to share information with other organisations. These initiatives are broadly of two kinds. They are part of national initiatives, such as within NPfIT, where technological platforms are being created that enable electronic patient records to be shared by many organisations. They are also engaged in local initiatives (e.g. community nursing) and the tailoring of NPfIT subsystems in support of local needs. This is a theory driven, empirically based, action research. There are two aims: 1) An examination of the implications and possibilities of sharing of e-Health records across organisational boundaries for improved clinical care and the better management of healthcare; 2) To identify the factors in the design, implementation and subsequent evolution of these systems to facilitate inter-organisational up
Complete
329.066
11
Healthcare Public Health and Preventing Premature Mortality
08/1806/261
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Stephen Peckham
London School of Hygiene & Tropical Medicine
1 de novembre de 2009
31 de juliol de 2013
Commissioning for long term conditions: hearing the voice of and engaging users
The aim of this research will be to examine how commissioners enable voice and engagement of people with Long Term Conditions and identify what impact this has on the commissioning process and pattern of services. It will explore the processes and mechanisms by which local patient and representative groups for people with long term conditions engage with the commissioning processes in health and social care agencies. The research will examine in depth three case studies in three long term condition groups - diabetes, rheumatoid arthritis and neurological conditions. Our approach involves reviewing practice across the UK and then focussing on three geographical areas to examine practices of commissioning and purchasing health care for people with long term conditions, approaches to patient and public involvement, patterns of services for people with long term conditions and the activities of local patient and voluntary organisations for people with long term conditions. Methods of data
Complete
671.469,04
12
Healthcare Public Health and Preventing Premature Mortality
08/1806/264
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Judith Smith
Nuffield Trust
1 de març de 2010
29 de febrer de 2012
Commissioning high quality care for people with long term conditions - an action research study
The overall aim of this research is to explore how NHS commissioning can improve care for people living with long-term conditions. In doing this we will examine the organisation and processes of commissioning (such as needs assessment, service planning and specification, design of incentives and performance management) and other influences that are known to shape success (such as local clinical leadership) alongside outcomes. An action research approach will be adopted, with researchers working alongside three ‘commissioning communities' (primary care trusts and other local partner organisations) with a known track record of undertaking competent and innovative commissioning work. Within the three sites, we will focus on long-term condition (LTC) sub-groups, in order to investigate how commissioning does (or does not) work in practice. We draw on three theoretical frameworks to underpin and shape this research: first, the nature and levels of commissioning organisation in the NHS, and
Complete
442.313
13
Healthcare Public Health and Preventing Premature Mortality
08/1809/230
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Jenny Shaw
The University of Manchester
1 de febrer de 2009
31 de juliol de 2012
Health and social care services for older adults in prison
Prisoners aged 60 and over are the fastest-growing age group in the England and Wales prison system. It has been established that they have much more complex health and social needs than younger prisoners, and that these are often unmet. The cost of housing older prisoners has been estimated at six times that of younger prisoners. Despite this, there is no national strategy for the care and management of older prisoners, and few prisons provide any specialist services for their different needs. Transition in and out of prison is particularly difficult for older people, in particular the provision of relevant services for their increased health and social needs. This project aims to determine what health and social services are currently available for older prisoners; to explore the main issues of entering and leaving prison; and to design a new system of assessment and care planning for older people newly received into custody. Policy states that prison health services should be equiva
Complete
323.471,4
14
Healthcare Public Health and Preventing Premature Mortality
08/1809/232
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Barbara Hanratty
University of Liverpool
1 de desembre de 2008
31 d'agost de 2012
Transitions between services at the end of life for older people - patient and provider perspectives
More than two thirds of the UK population can expect to die when they are aged over 75 years, and the last year of life is a time of high service utilisation for older adults. The NHS End of Life Care programme acknowledges that people will be transferred many times between different settings in their final years, months, days and hours. Hence commissioners need to understand how and why older people make transitions between services, and the relationship between transitions and older people’s health and well-being. This study will consider three conditions, lung cancer, heart failure and stroke, that are the focus of current NHS policy, but differ in their disease trajectories and the provision of specialist end-of-life services. Aim: The aim of this project is to understand the patterns and causes of health service transitions and their association with older people’s experiences at the end of life. Type and location: This is a three-phase study, combining a quantitative analysis of
Complete
448.439,5
15
Healthcare Public Health and Preventing Premature Mortality
08/1809/250
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Ruth McDonald
University of Warwick
1 de març de 2009
28 de febrer de 2014
Evaluation of the advancing quality pay for performance programme in the NHS North West
Background: Using incentives to influence behaviour can produce benefits for patients, but it can have complex and unintended outcomes. From October 2008 hospitals in the North West of England will participate in a scheme which provides financial incentives for quality. This scheme, the ‘Advancing Quality’ Programme (AQP) is based on a US initiative which has been shown to improve the quality of care delivered. This study is an evaluation of the AQP initiative. Aims: (1) Provide a wide ranging and in-depth evaluation of AQP in the North West; (2) Identify key lessons for the adoption of PfP systems in the UK NHS; (3) Add to the evidence base concerning PfP systems. In order to achieve these aims, the four main objectives are to: (1) Identify the impact of AQP on key stakeholders (provider organisations, commissioners and patients) and clinical practice; (2) Assess the cost-effectiveness of AQP; (3) Identify the most important barriers to and facilitators of successful AQP implementatio
Complete
683.068,2
16
Health Improvement
08/58/02
Health Technology Assessment
HTA Commissioned
Dr Hazel Gilbert
University College London
1 de juny de 2010
30 de novembre de 2015
A randomised trial to increase the uptake of smoking cessation services using Personal Targeted risk information and Taster Sessions
Recent figures show a reduction in smoking prevalence, but there is no room for complacency, smoking remains a major cause of ill health and mortality. Most smokers say they want to quit but only a tiny proportion make use of the free Smoking Cessation Services provided by the NHS. This research will evaluate, in a randomized trial, a two-pronged intervention to increase the number of people attending the services. We will recruit 60 general practices through the PCRN in areas that are representative of the English smoking cessation service. All smokers aged 16 and over identified from their medical records in participating practices will be sent a brief questionnaire to update their smoking status and to assess their dependence, motivation to quit, previous attendance at NHS services and to seek consent to participate in the trial. Current smokers who consent and are eligible will be randomized to: a) the Control Group to receive a generic letter advertising the NHS service and inviti
Complete
2.194.986,76
17
Healthcare Public Health and Preventing Premature Mortality
09/01/45
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Janet Clarkson
University of Dundee
1 d'abril de 2011
31 de desembre de 2016
Improving the Quality of Dentistry (IQuaD): A randomised controlled trial comparing oral hygiene advice and periodontal instrumentation for the prevention and management of periodontal disease in dentate adults attending dental primary care
Periodontal disease is the most common oral disease affecting adults. Effective self-care (tooth brushing and interdental aids) for plaque control and removal of risk factors such as calculus, by periodontal instrumentation (PI), commonly known as a “scale and polish”, are considered necessary to prevent and treat periodontal disease. A Cochrane review found evidence that psychological interventions resulted in improvements in oral hygiene behaviours but there is a lack of reliable evidence to inform clinicians of the relative effectiveness of different types of Oral Hygiene Advice (OHA) on the prevention of periodontal disease in adults. Similarly there is mixed evidence on the effectiveness and optimal frequency of PI. The majority of trials that have been carried out to date have been of poor to moderate quality with few conducted in primary care and a lack of patient centred outcomes and economic analyses reported. The IQuaD trial will investigate the effectiveness and cost effecti
Complete
2.344.184,23
18
Health Improvement
09/02/02
Health Technology Assessment
HTA Commissioned
Professor Julie Mytton
NHS Bristol, North Somerset and South Gloucestershire Integrated Care Board
1 de gener de 2011
31 de març de 2013
The FAST (First-aid Advice & Safety Training) Parents programme for the prevention of recurrent unintentional home injuries in preschool children
Design: (1) theoretical phase and development of the parenting programme (2) a multi-centre feasibility study of the programme using a cluster randomised controlled trial. The theoretical phase will include two systematic reviews: (i) a Cochrane review of parenting programmes to prevent injury undertaken by two co-applicants will be updated (ii) a new qualitative review of the barriers and facilitators to parent engagement in parenting programmes. Setting: Children’s Centres in Bristol and Nottingham Target population for feasibility study: (1) Children’s Centres: those ranked highest for the number of children aged 0-4 years in their catchment area who have attended the local Children’s A&E department during the previous year will be invited to participate (2) Parents/carers: of children aged under 5 years who have sustained an unintentional physical injury or ingestion in the home that resulted in seeking medical attention during the recruitment period Health technology: In depth dis
Complete
395.636,54
19
Healthcare Public Health and Preventing Premature Mortality
09/1002/14
Health and Social Care Delivery Research
SDO Priority Areas Panel
Professor Sarah Salway
Sheffield Hallam University
1 d'octubre de 2010
30 de novembre de 2012
Towards equitable commissioning for our multiethnic society: understanding and enhancing the critical utilisation of evidence by strategic commissioners and public health managers
We adopt an explicit Integrated Knowledge Translation model for the conduct of the study, bringing university researchers and PCT managers together in a collaborative team across the entire research process. We conceptualise knowledge mobilisation and utilisation within the commissioning cycle as resulting from dynamic interactions between individual agency, organisational rules, structures and processes, and the wider healthcare setting with its current restructuring agenda, all situated within the broader socio-political context of multicultural Britain. The study combines detailed case study investigation with wider consultation methods that allow us to engage with a broader sample of respondents in order to generalise theoretical understanding and develop research products that have wider relevance. Data generation involves three phases: (1) Expert interviews (N=30-40), (2) Detailed case studies of 3 PCTs involving multiple methods and examining both strategic and operational commi
Complete
348.174
20
Health Improvement
09/127/01
Health Technology Assessment
HTA Themed Call
Professor Alison Avenell
University of Aberdeen
1 d'octubre de 2011
31 de març de 2013
Systematic reviews and integrated report on the quantitative and qualitative evidence base for the management of obesity in men
DESIGN: (1) Systematic review (SR) of randomised controlled trials (RCTs) of lifestyle and/or UK licensed medication with men only BMI of 30 kg/m2 (28 kg/m2 with cardiac risk factors) or over with follow-up of at least one year. (2) SR of RCTs of above interventions, separately by gender in same trial. (3) SR of UK interventions any study design, any duration. (4) SR of interventions to increase men's engagement with services for obesity. (5) SR of qualitative research with people with obesity, health professionals, lay and commercial organisations managing obesity, examining men, men in contrast to women. SEARCH STRATEGY: Medicine, Embase, Cinahl, Cochrane Controlled Trials Register, DARE, HTA databases, NHS Health Library, Psycinfo, NHS EED, ASSIA, British Nursing Index, Anthropology Plus and Social Science Citation Index, Picker and Joanna Briggs Institutes. We will contact lay and professional organisations. No language restrictions. REVIEW STRATEGY: Quantitative SR outcomes: chang
Complete
238.552,41
21
Health Improvement
09/127/07
Health Technology Assessment
HTA Themed Call
Professor Maria Bryant
University of Leeds
1 de setembre de 2011
31 de desembre de 2012
Systematic review to identify and appraise outcome measures used to evaluate childhood obesity treatment interventions: evidence of purpose, application, validity, reliability and sensitivity
Background: There is a lack of consensus in determining appropriate outcome measures for the reliable and valid assessment of childhood obesity intervention. Comparisons between interventions are difficult, partly because of a shortage of validated outcome measures available, but also because the selected outcome measures differ between studies. Aim: The primary aim is to perform a systematic review to identify and appraise existing outcome measures for use in the evaluation of childhood obesity treatment interventions Methods: Two searches will be conducted: (1) Randomised controlled trials (RCTs), pilot and feasibility studies of childhood obesity treatment evaluation studies; and (2) outcome measures developed for use in childhood obesity interventions. Major electronic databases (e.g MEDLINE, EMBASE, PsycINFO, Science Citation Index, Global Health, etc.) from the date of inception will be used. Both searches will include search concepts for childhood and obesity and will consist of
Complete
170.130
22
Health Improvement
09/161/01
Health Technology Assessment
HTA Commissioned
Professor Linda Bauld
University of Stirling
1 d'octubre de 2011
31 d'octubre de 2014
Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS)
Design: Observational study including: 1. Secondary analysis of routine data collected by SSSs using the North51 database 2. Prospective study of service clients from 9 PCTs Follow up at 4 weeks & 12 months. Gold standard NHS SSS client satisfaction questionnaire. Setting: NHS SSSs in England Target population: Smokers who make contact with NHS SSSs Health technologies: Treatment provided by SSSs – a combination of behavioural support and medication. We will focus on evaluating outcomes for smokers who receive one of the 5 main forms of behavioural support (intervention types) provided. These are: closed groups, rolling groups, one to one drop in, one to one appointments with a specialist adviser, one to one appointments with a sessional adviser (usually a pharmacist or practice nurse). Measurement of costs and outcomes: Primary outcome is prolonged abstinence at 12 months. We will also assess abstinence at 4 weeks. Measurement will follow the Russell Standard (intention to treat and b
Complete
819.952,38
23
Health Improvement
09/162/02
Health Technology Assessment
HTA Commissioned
Professor Kamlesh Khunti
University of Leicester
1 de novembre de 2012
31 d'octubre de 2019
The PRmotion Of Physical activity through structured Education with differing Levels of ongoing Support for those with prediabetes (PROPELS): randomised controlled trial in a diverse multi-ethnic community
BACKGROUND Type 2 diabetes exerts a huge health and economic burden within the United Kingdom. Increasing levels of physical inactivity are one of the main causes of the growing prevalence of type 2 diabetes. However, evidenced-based approaches to promoting increased physical activity in the prevention diabetes are lacking. This study aims to bridge this gap in the evidence. DESIGN Randomized controlled trial; follow-up at 12 & 48 months. METHODS 1308 individuals aged 40-75 years and identified with impaired glucose regulation will be recruited from the community and primary care settings in the East-Midlands and East Anglia. Around 25% of recruited participants will be from a south Asian ethnic origin. Individuals will be randomized (1:1:1) to: 1) Detailed advice leaflet (control). 2) A 3.5-hour group-based structured education programme followed by annual group-based or telephone support up to 36 months. The initial structured education session is delivered by two trained educators a
Complete
1.747.568,36
24
Healthcare Public Health and Preventing Premature Mortality
09/1801/1054
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Helen Snooks
Swansea University
1 de setembre de 2010
31 d'agost de 2015
Predictive risk stratification: impact on care for people with or at risk of chronic conditions
New approaches to the management of chronic conditions are needed in order to shift the balance of care from the acute to primary and community sectors and improve services locally. The Welsh Assembly Government (WAG) has commissioned the development of a predictive risk stratification model (PRISM) for Wales to stratify people into one of four risk strata based on having an emergency admission in the following year. PRISM has the capacity to tailor care at individual patient level to patient need. Questions remain however about how the model will be adopted by potential users at each risk strata. The aim of the proposed study is to describe the processes of introducing PRISM in Wales and to estimate the effects on the delivery of care both to patients living with or at risk of developing a chronic condition, and to those with no perceived risk. A mixed-method ‘before, during and after’ quasi-experimental cohort study will be conducted with Intervention sites and Control sites. Changes
Complete
689.605,78
25
Health Protection
09/2000/37
Health and Social Care Delivery Research
HSDR Researcher Led
Dr Colin Simpson
The University of Edinburgh
1 de gener de 2011
30 d'abril de 2013
Seasonal Influenza Vaccine Effectiveness (SIVE): exploitation of a unique community-based national linked dataset
Each year, influenza is a major contributor of death and illness. However, rates of vaccination particularly in at risk groups under 65 remain low. This is perhaps due to a relative paucity of information available on the effectiveness of the influenza vaccine. Policymakers will be reassured if evidence that the influenza vaccine is effective in preventing adverse health outcomes, emergency admissions to hospital and death. Using an existing unique patient level information resource from 41 general practices who receive an annual financial incentive to record all of their practice data electronically and covering a five percent age/sex representative sample of the Scottish population (generated from the National Institute for Health Research funded VIPER project Ref:09/84/90 with 1,020,000 person years of data available), which was linked to hospital, death certification and virological swab data and building on previously piloted work [Mooney et al, 2008], we will establish the influe
Complete
102.656,26
26
Healthcare Public Health and Preventing Premature Mortality
09/2000/65
Health and Social Care Delivery Research
HSDR Researcher Led
Professor David Harrison
Intensive Care National Audit & Research Centre
1 de juliol de 2011
31 de desembre de 2014
Ensuring comparisons of health-care providers are fair: risk modelling for quality improvement in the critically ill.
Objective 1. To improve current risk prediction models for critically ill patients Detailed statistical analysis plans will be developed, with input from the Expert Group (see: Team Expertise), to address each of the specific points detailed above (or other aspects of modelling identified as important by the Expert Group). Model improvements will be assessed both visually (e.g. by calibration plots) and using a panel of measures of model performance to encompass discrimination (c index or area under the ROC curve), calibration (Hosmer-Lemeshow test), and overall fit (Brier's score, Shapiro's Q, R-squared) using bootstrap methods to adjust these measures for overfitting to the data. Objective 2. To develop new risk prediction models for critically ill patients Learning from Objective 1 of the project will feed into the methods used for development of new models. Clinicians in the relevant fields will be consulted for their input into the design of the risk prediction models. Models will
Complete
166.562
27
Healthcare Public Health and Preventing Premature Mortality
09/2001/25
Health and Social Care Delivery Research
HSDR Researcher Led
Professor Glenn Robert
King's College London
1 d'agost de 2010
31 de juliol de 2012
Facilitating knowledge exchange between health care sectors, organisations and professions: studying ‘boundary spanning’ processes and their impact on health care quality
We will use an in-depth longitudinal, case study approach. Our case study is a project designed to improve services through collaboration between general practitioners, community services, voluntary groups and acute specialists over an 18 month period in the Southall area of London. The project includes the development of a network of leaders across organisational and community boundaries to facilitate knowledge creation and exchange, and is directly linked with a programme of ‘whole system’ stakeholder conferences to create organisational learning and change, together with community development. Fieldwork will be undertaken in the three specific topic areas in which boundary spanning activities will be undertaken as part of the case study: (a) Dementia, (b) Child & Family Health, and (c) Depression & anxiety in people from black and ethnic minority backgrounds. In seeking to test our research hypothesis we will: provide a rich ethnographic account of the boundary spanning processes (h
Complete
240.388,14
28
Healthcare Public Health and Preventing Premature Mortality
09/22/21
Health Technology Assessment
HTA Themed Call
Professor Steve Goodacre
The University of Sheffield
1 d'octubre de 2010
31 de desembre de 2011
Cost-effectiveness of diagnostic strategies for suspected acute coronary syndrome (ACS)
We will undertake systematic reviews, meta-analysis and decision analysis modelling of the cost-effectiveness of (1) Biomarkers used to diagnose myocardial infarction (MI) and predict adverse events in suspected ACS, and (2) CT coronary angiography and exercise ECG as first-line tests for diagnosing coronary artery disease (CAD) in patients with troponin-negative suspected ACS. Systematic searches will identify cohort studies evaluating the technologies in suspected ACS, and estimates of key parameters for the model. Relevant studies will be identified through electronic searches of key databases, hand searches of key journals and contact with experts and authors. Standardised data will be extracted from each included article. Where appropriate, we will combine data to provide pooled estimates of the accuracy of investigations for MI, CAD and adverse events. The network of evidence will be summarised using Bayesian generalised evidence synthesis. We will develop a decision-analysis mod
Complete
173.447,22
29
Health Improvement
09/3000/03
Public Health Research Programme
PHR Researcher Led
Professor Paul Stallard
Oxfordshire & Buckinghamshire Mental Health NHS Foundation Trust
1 de gener de 2011
31 de desembre de 2014
A randomised controlled cluster trial comparing the effectiveness and cost-effectiveness of a school-based cognitive–behaviour therapy programme (FRIENDS) in the reduction of anxiety and improvement in mood in children aged 9/10
DESIGN: Randomised controlled cluster trial comparing FRIENDS (delivered by health professional or school) vs. treatment as usual for the reduction and prevention of anxiety symptoms and low mood (i.e. reduced symptoms of depression) in children aged 9/10. SETTING: 45-54 junior schools in Bath and North East Somerset and Wiltshire. INTERVENTION BEING EVALUATED: FRIENDS is a manualised cognitive behaviour therapy (CBT) programme designed to improve children's mental health. Each child has a workbook and group leaders a comprehensive manual detailing the content and structure of each session. FRIENDS involves 10, 60-minute weekly sessions delivered to whole classes as part of the school PSHE programme. FRIENDS teaches children practical skills to identify their feelings; to learn to relax; to identify unhelpful thoughts and to replace them with more helpful thoughts; and how to face and overcome their problems and challenges. Initial training and regular supervision of leaders will be pr
Complete
1.279.979,48
30
Improving the Wider Determinants of Health
09/3001/06
Public Health Research Programme
PHR Researcher Led
Dr David Ogilvie
University of Cambridge
1 de gener de 2010
28 de febrer de 2015
Health impacts of the Cambridgeshire Guided Busway
The project will address the following primary research question: Is investment in new high-quality transport infrastructure associated with an increase in the use of active modes of travel (walking and cycling)? and the following secondary research questions: — What are the wider health impacts of changes in travel behaviour in terms of overall physical activity, wellbeing, sickness absence and carbon emissions? — What are the determinants of the use and uptake of active modes of travel? — How are any changes in travel behaviour distributed in the population? — How are any changes in travel behaviour brought about and experienced? — Are changes in travel behaviour sustained over time? The core of the project will be a controlled quasi-experimental cohort study with the following elements: Population: Adult commuters Intervention: New high-quality transport infrastructure provided in the intervention area Comparator: No comparable improvement to transport infrastructure in the control
Complete
1.184.572,78
31
Improving the Wider Determinants of Health
09/3001/13
Public Health Research Programme
PHR Researcher Led
Professor Judith Green
London School of Hygiene & Tropical Medicine
1 de febrer de 2010
31 de juliol de 2012
On the buses': evaluating the impact of introducing free bus travel for young people on the public health
There has been increasing interest in the ways in which transport policies affect the public health but to date, few robust evaluations of specific policies. This study aims to evaluate the impact of the introduction of free bus and tram travel to under 16 year olds in 2005 and under 18 year olds in 2006 in London. The aims of this policy included reducing transport exclusion among young people. This potentially had a positive effect on the determinants of health and health equity. However, there has also been concern that extending access to bus travel may have reduced the amount of healthier ‘active transport’ done by young people. There are also concerns about consequent impacts on other population groups, such as elderly people. Using a mixed method, quasi-experimental design, this study aims to provide empirical evidence for the impact of free bus travel on public health, and evaluate the economic costs and benefits. The objectives are to: 1. Determine the causal pathways that pla
Complete
534.376,86
32
Improving the Wider Determinants of Health
09/3002/08
Public Health Research Programme
PHR Researcher Led
Professor Christopher Bonell
London School of Hygiene & Tropical Medicine
1 de juny de 2010
29 de febrer de 2012
The effects of schools and school-environment interventions on health: evidence mapping and syntheses
Methods The review will involve 3 stages: 1) a descriptive map of available evidence, plus a preliminary synthesis of intervention logic models and theories of school-level effects on health; 2) in-depth reviews and syntheses of evidence addressing our research questions; and 3) drafting of final report and other dissemination. Target population and setting Students, staff, parents and/or the local community of schools catering for those aged 4-18. Intervention being evaluated School environment (SE) interventions aiming to change the physical, social or cultural environment within schools to promote health. Search strategy In stage 1, we will include studies pertinent to our research questions: (RQ1) literature describing/explaining the theories and conceptual frameworks that are used to inform SE interventions or explain school-level influences on health; (RQ2) evaluation studies reporting on SE intervention effects on health, as well as cost, economic and econometric studies examini
Complete
182.641
33
Health Improvement
09/3004/01
Public Health Research Programme
PHR Commissioned
Professor Gail Mountain
The University of Sheffield
1 d'octubre de 2011
30 de juny de 2013
Putting Life in Years (PLINY): Telephone friendship groups research study. Evaluation of the effectiveness and cost effectiveness of an intervention to promote mental wellbeing in community living older people
DESIGN: Pragmatic two arm parallel group randomised controlled trial with feasibility phase. SETTING: Telephone befriending intervention: the homes of participants. TARGET POPULATION: People aged 75 years and over with reasonable cognitive function (Score of 18 and over on the MMSE) living independently or in sheltered/ extra care housing and able to converse and respond to English. RECRUITMENT: PCT mail outs, Local Authority involvement, Identification by voluntary sector organisations and through pro-active community engagement. INTERVENTION TO BE EVALUATED: Telephone befriending provided by local charities supported by AgeUK and the Community Network compared with treatment as usual (control). FEASIBILITY: An assessment of study feasibility will be made at 18 months, based on a pilot cohort of 90 people recruited at 9 months. The feasibility phase will evaluate willingness to be randomised into the study (recruitment rate) as well as the capacity of those delivering the services and
Complete
319.631,46
34
Health Improvement
09/3005/04
Public Health Research Programme
PHR Researcher Led
Professor Debbie Lawlor
University of Bristol
1 d'abril de 2011
31 de maig de 2015
Active For Life Year 5: A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet
Design: School-based cluster randomised controlled trial. Setting: State primary and junior schools with Year 5 children (aged 9-10) in the city of Bristol. Special schools will be excluded. Participants will be Year 5 children in these schools whose parents provide opt-out consent. Children will only have measurements if they provide assent. Target population: UK school children aged 9-10 Intervention: Schools randomised to the intervention (N=30; 750 children) will receive the intervention immediately and those randomised to control (N=30;750) after completion of the 2-year follow-up assessment. The intervention comprises: a) training for classroom teachers; b) provision of 16 lesson-plans and teaching materials, including pictures, CDs and journals; c) provision of 10 parental-child interaction homework activities (see detailed project description); d) information in the school newsletters about the importance of increasing physical activity, reducing sedentary behaviour and improvi
Complete
1.349.139,91
35
Health Improvement
09/3005/05
Public Health Research Programme
PHR Researcher Led
Professor Catherine Law
University College London
1 de desembre de 2010
30 de novembre de 2012
A population-level evaluation of a family-based community intervention for childhood overweight and obesity
Setting: Community-based health promotion intervention operating in over 300 schools and leisure centres throughout England from January 2006 - October 2010. Target population: Overweight (body mass index (BMI) greater than 91st centile) or obese (greater than 98th centile) children aged 7-13 years. Intervention: MEND, a multi-component, community-based intervention aiming to empower families of overweight/obese children to adopt and sustain healthy lifestyles. Measurement of outcomes and duration of follow-up in secondary analysis: Primary outcomes: change in BMI after participation in MEND, adjusted for age. Secondary outcomes: post-intervention changes in body esteem, self-esteem and 'Strengths and Difficulties' questionnaire (SDQ) - all validated. Duration of follow-up: 10 weeks using service data, benchmarked against 10 weeks, and 6 and 12 months in original and concurrent RCTs (funded separately). Secondary data analysis sample size: we will use all the data that are available, a
Complete
415.339,57
36
Improving the Wider Determinants of Health
09/3008/11
Public Health Research Programme
PHR Commissioned
Professor James Thomas
Institute of Education, University of London
1 d'abril de 2011
31 d'agost de 2012
Can specific approaches to community engagement help to reduce inequalities in health; for whom, under what circumstances, and with what resources? A mixed-methods evidence synthesis
DESIGN The project proposed is a synthesis of existing research. By analysing many evaluations of community engagement, we will identify approaches that are most often associated with reductions in inequalities in health, paying particular attention to the context of the research and the mechanisms by which communities are engaged and the ways this is thought to impact on intervention effectiveness. When we have identified a range of effective approaches, we will then consider their relative resource requirements in order to draw conclusions as to their potential cost implications for different stakeholders. REVIEW QUESTIONS Our overarching review question is: Can specific approaches to community engagement help to reduce inequalities in health; for whom, under what circumstances, and with what resources? Please see Section C4 for our detailed review questions. CONCEPTUAL FRAMEWORK Our conceptual framework (described in Section 3.4 of the full Project Description) understands 'communit
Complete
221.837
37
Health Protection
09/85/01
Health Technology Assessment
HTA Commissioned
Professor Jonathan Nguyen-Van-Tam
The University of Nottingham
24 d'agost de 2009
23 de maig de 2011
Virus shedding and environmental deposition of novel A(H1N1) pandemic influenza virus
Very little is known about the new H1N1 pandemic virus. For example we do not know how long the virus is excreted by infected humans and how much virus is spread to surfaces and carried in the air. This is very important to know because it affects the advice that will be given to healthcare workers about controlling the spread of infection to themselves and other patients. It will also enable good quality advice to be given to families who will have to look after each other in their own homes. The best way to obtain this information is to ask patients who get pandemic flu to help us by agreeing to give a daily nose swab sample for just over one week so we can see how much virus is in the nose day by day and how quickly this disappears. At the same time we will take samples from the patients near environment (hard surfaces and air). We can then work out how much virus is being excreted, how long the ‘danger period’ is, whether surfaces are more or less important than air in terms of cat
Complete
249.121,9
38
Health Improvement
09/91/04
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Mike Crawford
Imperial College London
1 d'abril de 2011
31 de març de 2013
Alcohol misuse and sexual health: a randomised trial of brief intervention among people attending sexual health clinics.
Background Excessive alcohol consumption can harm health in a number of ways. Being drunk impairs judgement, increases the chances of accidents, and may lead to risk taking such as unprotected sexual contact. Between a third and a half of people who are seen in sexual health clinics drink at a level that may be harmful to their health. Brief interventions for excessive drinking have been shown to be effective in other healthcare settings but the impact of this intervention on sexual health has not been examined. Aims To examine the clinical and cost-effectiveness of brief intervention for alcohol misuse among people who attend sexual health clinics and consume excessive alcohol. To achieve this objective we will: 1. Test whether brief intervention reduces subsequent alcohol consumption measured six months later. 2. Examine whether brief intervention is associated with changes in sexual behaviour. 3. Estimate the cost and cost-effectiveness of this intervention. Methods A two-arm, paral
Complete
281.868,08
39
Health Protection
10/1007/01
Health and Social Care Delivery Research
SDO Priority Areas Panel
Professor Justin Waring
The University of Nottingham
1 de juny de 2011
31 de maig de 2013
Knowledge sharing across the boundaries between care processes, services and organisations: the contributions to ‘safe’ hospital discharge and reduced emergency readmission
The study is designed as four linked Work Packages (WPs) combining different forms of qualitative interviewing with observational research methods. Design: * WP1 (-2 to 2mnths): directed towards preparing and planning the study, including submitting ethical and research governance approvals; recruiting the researcher; synthesizing existing literatures and consulting with advisors to clarify research deliverables; * WP2 (3 to 10mnths): directed towards identifying, mapping and understanding the patterns of knowledge sharing involved in hospital discharge with a particular focus on the contributions to patient safety. This will involve the use of semi-structured interviews as well as questions take from existing social network surveys related to knowledge sharing; * WP3 (12 to 21mnths): directed towards producing a detailed and ‘real time’ understanding of hospital discharge through observations of interactions and knowledge sharing activities in and through ‘tracking’ patient discharge,
Complete
228.994,29
40
Healthcare Public Health and Preventing Premature Mortality
10/1008/09
Health and Social Care Delivery Research
SDO Studies Panel
Professor Diana Rose
South London and Maudsley NHS Foundation Trust
1 de març de 2011
30 d'abril de 2013
How do managers and leaders in the National Health Service and social care respond to service user involvement in mental health services in both its traditional and emergent forms?
Theoretical framework: The theoretical design to be used in this study is a combination of sociological analyses of the mental health user movement as a 'new social movement' and organisational studies. We shall consider changes in both these conceptual frameworks deriving from the changing nature of user involvement in England currently. Setting and samples:The study will take place in 3 NHS Foundation Trusts and concentrate primarily on 5 or 6 sites (user groups) in total as well as some individual users.. We will add one more site for the analysis of Personal Health Budgets (PHBs) as it is part of the national evaluation. Sampling frames vary with the different Phases of the research. The Trusts are the South London and Maudsley NHS Foundation Trust (SLAM), Central and North West London NHS Foundation Trust (CNWL) and Sussex Partnership Foundation Trust. The sampling of Trusts is theoretical. CNWL are paying close attention to lay representation at Board level and SLAM has several U
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299.954
No hi ha cap resultat.
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