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1
Healthcare Public Health and Preventing Premature Mortality
06/35/99
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Janet Clarkson
University of Dundee
1 September 2011
28 February 2019
INTERVAL Dental Recalls Trial [Investigation of NICE Technologies for Enabling Risk-Variable-Adjusted-Length Dental Recalls Trial] - Full Trial Follow-on
This parallel-group randomised controlled comparison of three forms of dental recall strategy (6 month recall, risk-based recall, and 24 month recall), will evaluate the effectiveness and cost effectiveness of these strategies by assessing their impact on maintaining oral health. Ethical concerns over the use of a 24 month recall interval expressed by some dental practitioners have been addressed by randomisation within two strata. The risk-based recall strategy is that advocated by the 2004 NICE guidance on Dental Recall - personalised variable intervals determined according to risk information derived from comprehensive oral health assessment and review. The two fixed-period recall strategies are the traditional six month interval between routine check-ups or 24 month recall interval between routine check-ups. The research will be carried out in general dental practices across the UK. Participating dentists will represent a cross-section of practitioners operating in a range of diffe
Complete
2,626,274.22
2
Healthcare Public Health and Preventing Premature Mortality
06/37/04
Health Technology Assessment
HTA Commissioned
Professor Paul Stallard
University of Bath
1 September 2008
30 June 2012
A single blind randomised controlled trial to determine the effectiveness of group cognitive behaviour therapy (CBT) in the prevention of depression in high risk adolescents
Classes of children aged 13-16 will be randomised to one of three, 10 week, Personal Social Health and Education (PSHE) conditions. The experimental condition will be based upon cognitive behaviour therapy and will specifically target depressive cognitions and mood. The second will be an attention control condition involving similar time and contact with external group leaders but will not include the active components of the CBT intervention. The third will be treatment as usual, i.e. PSHE delivered by the school. Symptoms of depression (Mood and Feelings Questionnaire), cognitions (Children's Automatic Thoughts Scale) and self-image (Self Image Profile) will be assessed at baseline, 6 and 12 months and an economic evaluation undertaken at 12 months. The primary analysis will explore the preventative effect of the intervention on children identified as "at risk" of depression i.e. those scoring high on the Mood and Feelings Questionnaire at initial screen and baseline assessment. Seco
Complete
1,016,857.19
3
Healthcare Public Health and Preventing Premature Mortality
06/43/05
Health Technology Assessment
HTA Commissioned
Professor Simon Gilbody
University of York
1 May 2009
31 October 2013
The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial
Depression is a major health problem. The majority of people with depression receive care from their GP. However, lots of people experiencing depression would also like to receive a "talking treatment" (counselling or psychotherapy). Cognitive Behaviour Therapy (CBT) seems to be the most effective type of talking treatment for depression but is not always immediately available in the NHS. Recently, therapists have developed a form of CBT that can be delivered by computer, which might make it easier to access this form of treatment. We call this "computerised CBT". There are different computerised packages, some of which are freely available and others which have to be paid for by the NHS. At the moment we do not know which of these works best for NHS patients with depression. The purpose of this study is to compare two (one free-to-use and one commercial) CBT packages to see if there are any additional benefits of offering this treatment to the care that people already receive from the
Complete
1,471,459
4
Health Improvement
06/85/11
Health Technology Assessment
HTA Commissioned
Professor Peymane Adab
University of Birmingham
1 November 2010
30 April 2016
A cluster randomised controlled trial of the effectiveness and cost-effectiveness of an obesity prevention intervention in primary school age children
Aim To assess the effectiveness and cost-effectiveness of a community-level, multi-component intervention programme in preventing obesity in 6-7 year old children, compared to usual practice. Design A cluster randomised controlled trial, using schools as units of randomisation and analysis. Setting Local Education Authority maintained primary schools within the West Midlands. Population Children age 6-7 attending primary schools in the West Midlands. Schools will be stratified according to urban vs. rural location, proportion of pupils from ethnic minority groups and proportion of children entitled to free school meals (as a proxy for deprivation). Schools in each stratum will be randomly allocated to intervention or control arms. Intervention A multi-component intervention programme will be delivered to schools in the intervention arm for one year. This programme consists of several elements; activities to increase the time spent doing physical activity within the school day, particip
Complete
2,651,248.34
5
Health Improvement
07/41/05
Health Technology Assessment
HTA Commissioned
Professor Simon Gilbody
University of York
1 December 2010
30 November 2013
Smoking cessation for people with severe mental illness: a pilot study and definitive randomised evaluation of a bespoke service
Smoking significantly impacts the physical health of people with severe mental illness (SMI) such as schizophrenia or bipolar disorder. Compared to the general population, a large proportion of SMI patients smoke and are likely to be heavy smokers with greater nicotine addiction. However these patients have greater difficulty in quitting and are less likely to receive help in quitting. Currently available smoking cessation services and drugs are aimed at the general public and their suitable for SMI patients is unknown. Mentally ill patients do express a desire to stop smoking, but they may require different strategies and greater support to help them quit smoking. To address this problem, we aim to evaluate a 'bespoke smoking cessation' (BSC) service, specifically tailored to individual SMI patients. A mental health nurse trained to deliver smoking cessation interventions will become the patient's mental health-smoking cessation practitioner (MH-SCP). They will work with the patient's
Complete
603,124.82
6
Health Protection
07/43/01
Health Technology Assessment
HTA Commissioned
Professor Jacqueline Cassell
University of Sussex
1 January 2010
28 February 2013
The relative clinical and cost-effectiveness of three contrasting approaches to partner notification for curable sexually transmitted infections (STIs): a cluster randomised trial in primary care
Increasing numbers of patients are diagnosed with sexually transmitted infections (STIs) in their GP surgery. This study is concerned with finding out the best way to enable treatment for the sexual partners of individuals diagnosed with sexually transmited infections (STIs) in their GP practice. This is called "partner notification". Treatment of partners is important for two reasons - to protect the original patient from reinfection, and to prevent the further spread of infection by infected partner(s). We will compare three different approaches to partner treatment: (i) PATIENT REFERRAL where patients are simply given information and asked to tell their partner about the problem and the need to be treated. (ii) CONTRACT REFERRAL, where, in addition to (i), patients will be asked to agree to a specialist health adviser (contact tracing expert) to inform partner(s) if this has not been done after a period of time (say, a week). (iii) PROVIDER REFERRAL, where, in addition to (i), patie
Complete
768,630.48
7
Health Improvement
08/14/41
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Sarah Lamb
University of Warwick
1 September 2010
28 February 2019
Prevention of Falls Injury Trial
Context: Common falls prevention strategies used in primary care settings include advice and information, structured exercise, and multi-factorial risk-reduction programmes. Little is known about the comparative effectiveness and cost-effectiveness of these strategies. Objective: To estimate the comparative effectiveness and cost-effectiveness of advice, structured exercise and a multi-factorial fall prevention programme, for the prevention of fall injuries among older people living in the community. Design: A 3-arm, cluster-randomised controlled trial with economic evaluation. The unit of randomisation will be the General Practice, and minimisation will be used to ensure balance in the allocation of practices by list size and area socio-economic status. Population: 9,000 people (60 practices) aged over 70 years living in the community, including people in sheltered accommodation, but excluding people living in nursing or residential care homes. Interventions: Practices will be randoml
Complete
2,423,783.18
8
Health Protection
08/17/01
Health Technology Assessment
HTA Commissioned
Professor Laura Rodrigues
London School of Hygiene & Tropical Medicine
1 May 2011
31 October 2015
Observational study to estimate the changes in the efficacy of BCG with time since vaccination
Two analytic observational studies will be conducted comparing the frequency of the BCG vaccine in people in people with and without a history of illhealth. Both studies will evaluate how the effect of BCG vaccine changes with time since vaccination. The first study will examine children aged from 0-17 years, born when BCG can be given in infancy. The second study will examine an adult age range from 23 to 37 years and aged 13-years old when the pre-2005 school aged BCG programme existed
Complete
1,738,408.08
9
Healthcare Public Health and Preventing Premature Mortality
08/1803/224
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Justin Keen
University of Leeds
1 September 2008
31 May 2011
Electronic services: implementation and impact
This study will: 1. Develop of a detailed narrative account of the implementation of shared electronic services for older people; 2. Establish the cost-effectiveness of shared electronic services used in hospital discharge processes for older people; 3. Evaluate the implementation of shared electronic patient records in diabetes services across NHS organizations in Yorkshire and Humber SHA. There is good evidence that partnerships involving health, social care and other organizations are difficult to establish in practice. Worse, in responding to demography, technological advances and other forces, health care is becoming ever more complex and expensive, suggesting that effective partnerships may be even more difficult to achieve in future. Electronic networks are increasingly viewed, across Government, as a key tool for achieving integrated service delivery in the face of current challenges. In the NHS the National Programme for Information Technology (IT) is in effect a major infrast
Complete
251,802
10
Healthcare Public Health and Preventing Premature Mortality
08/1803/226
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Mike Dent
Staffordshire University
1 November 2008
31 July 2011
Getting the benefit from electronic patient information that crosses organisational boundaries
This is a study of the organisation and management of patient information sharing across and between organisations. The PCTs in this project are each involved in a variety of initiatives to share information with other organisations. These initiatives are broadly of two kinds. They are part of national initiatives, such as within NPfIT, where technological platforms are being created that enable electronic patient records to be shared by many organisations. They are also engaged in local initiatives (e.g. community nursing) and the tailoring of NPfIT subsystems in support of local needs. This is a theory driven, empirically based, action research. There are two aims: 1) An examination of the implications and possibilities of sharing of e-Health records across organisational boundaries for improved clinical care and the better management of healthcare; 2) To identify the factors in the design, implementation and subsequent evolution of these systems to facilitate inter-organisational up
Complete
329,066
11
Healthcare Public Health and Preventing Premature Mortality
08/1806/261
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Stephen Peckham
London School of Hygiene & Tropical Medicine
1 November 2009
31 July 2013
Commissioning for long term conditions: hearing the voice of and engaging users
The aim of this research will be to examine how commissioners enable voice and engagement of people with Long Term Conditions and identify what impact this has on the commissioning process and pattern of services. It will explore the processes and mechanisms by which local patient and representative groups for people with long term conditions engage with the commissioning processes in health and social care agencies. The research will examine in depth three case studies in three long term condition groups - diabetes, rheumatoid arthritis and neurological conditions. Our approach involves reviewing practice across the UK and then focussing on three geographical areas to examine practices of commissioning and purchasing health care for people with long term conditions, approaches to patient and public involvement, patterns of services for people with long term conditions and the activities of local patient and voluntary organisations for people with long term conditions. Methods of data
Complete
671,469.04
12
Healthcare Public Health and Preventing Premature Mortality
08/1806/264
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Judith Smith
Nuffield Trust
1 March 2010
29 February 2012
Commissioning high quality care for people with long term conditions - an action research study
The overall aim of this research is to explore how NHS commissioning can improve care for people living with long-term conditions. In doing this we will examine the organisation and processes of commissioning (such as needs assessment, service planning and specification, design of incentives and performance management) and other influences that are known to shape success (such as local clinical leadership) alongside outcomes. An action research approach will be adopted, with researchers working alongside three ‘commissioning communities' (primary care trusts and other local partner organisations) with a known track record of undertaking competent and innovative commissioning work. Within the three sites, we will focus on long-term condition (LTC) sub-groups, in order to investigate how commissioning does (or does not) work in practice. We draw on three theoretical frameworks to underpin and shape this research: first, the nature and levels of commissioning organisation in the NHS, and
Complete
442,313
13
Healthcare Public Health and Preventing Premature Mortality
08/1809/230
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Jenny Shaw
The University of Manchester
1 February 2009
31 July 2012
Health and social care services for older adults in prison
Prisoners aged 60 and over are the fastest-growing age group in the England and Wales prison system. It has been established that they have much more complex health and social needs than younger prisoners, and that these are often unmet. The cost of housing older prisoners has been estimated at six times that of younger prisoners. Despite this, there is no national strategy for the care and management of older prisoners, and few prisons provide any specialist services for their different needs. Transition in and out of prison is particularly difficult for older people, in particular the provision of relevant services for their increased health and social needs. This project aims to determine what health and social services are currently available for older prisoners; to explore the main issues of entering and leaving prison; and to design a new system of assessment and care planning for older people newly received into custody. Policy states that prison health services should be equiva
Complete
323,471.4
14
Healthcare Public Health and Preventing Premature Mortality
08/1809/232
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Barbara Hanratty
University of Liverpool
1 December 2008
31 August 2012
Transitions between services at the end of life for older people - patient and provider perspectives
More than two thirds of the UK population can expect to die when they are aged over 75 years, and the last year of life is a time of high service utilisation for older adults. The NHS End of Life Care programme acknowledges that people will be transferred many times between different settings in their final years, months, days and hours. Hence commissioners need to understand how and why older people make transitions between services, and the relationship between transitions and older people’s health and well-being. This study will consider three conditions, lung cancer, heart failure and stroke, that are the focus of current NHS policy, but differ in their disease trajectories and the provision of specialist end-of-life services. Aim: The aim of this project is to understand the patterns and causes of health service transitions and their association with older people’s experiences at the end of life. Type and location: This is a three-phase study, combining a quantitative analysis of
Complete
448,439.5
15
Healthcare Public Health and Preventing Premature Mortality
08/1809/250
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Ruth McDonald
University of Warwick
1 March 2009
28 February 2014
Evaluation of the advancing quality pay for performance programme in the NHS North West
Background: Using incentives to influence behaviour can produce benefits for patients, but it can have complex and unintended outcomes. From October 2008 hospitals in the North West of England will participate in a scheme which provides financial incentives for quality. This scheme, the ‘Advancing Quality’ Programme (AQP) is based on a US initiative which has been shown to improve the quality of care delivered. This study is an evaluation of the AQP initiative. Aims: (1) Provide a wide ranging and in-depth evaluation of AQP in the North West; (2) Identify key lessons for the adoption of PfP systems in the UK NHS; (3) Add to the evidence base concerning PfP systems. In order to achieve these aims, the four main objectives are to: (1) Identify the impact of AQP on key stakeholders (provider organisations, commissioners and patients) and clinical practice; (2) Assess the cost-effectiveness of AQP; (3) Identify the most important barriers to and facilitators of successful AQP implementatio
Complete
683,068.2
16
Health Improvement
08/58/02
Health Technology Assessment
HTA Commissioned
Dr Hazel Gilbert
University College London
1 June 2010
30 November 2015
A randomised trial to increase the uptake of smoking cessation services using Personal Targeted risk information and Taster Sessions
Recent figures show a reduction in smoking prevalence, but there is no room for complacency, smoking remains a major cause of ill health and mortality. Most smokers say they want to quit but only a tiny proportion make use of the free Smoking Cessation Services provided by the NHS. This research will evaluate, in a randomized trial, a two-pronged intervention to increase the number of people attending the services. We will recruit 60 general practices through the PCRN in areas that are representative of the English smoking cessation service. All smokers aged 16 and over identified from their medical records in participating practices will be sent a brief questionnaire to update their smoking status and to assess their dependence, motivation to quit, previous attendance at NHS services and to seek consent to participate in the trial. Current smokers who consent and are eligible will be randomized to: a) the Control Group to receive a generic letter advertising the NHS service and inviti
Complete
2,194,986.76
17
Healthcare Public Health and Preventing Premature Mortality
09/01/45
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Janet Clarkson
University of Dundee
1 April 2011
31 December 2016
Improving the Quality of Dentistry (IQuaD): A randomised controlled trial comparing oral hygiene advice and periodontal instrumentation for the prevention and management of periodontal disease in dentate adults attending dental primary care
Periodontal disease is the most common oral disease affecting adults. Effective self-care (tooth brushing and interdental aids) for plaque control and removal of risk factors such as calculus, by periodontal instrumentation (PI), commonly known as a “scale and polish”, are considered necessary to prevent and treat periodontal disease. A Cochrane review found evidence that psychological interventions resulted in improvements in oral hygiene behaviours but there is a lack of reliable evidence to inform clinicians of the relative effectiveness of different types of Oral Hygiene Advice (OHA) on the prevention of periodontal disease in adults. Similarly there is mixed evidence on the effectiveness and optimal frequency of PI. The majority of trials that have been carried out to date have been of poor to moderate quality with few conducted in primary care and a lack of patient centred outcomes and economic analyses reported. The IQuaD trial will investigate the effectiveness and cost effecti
Complete
2,344,184.23
18
Health Improvement
09/02/02
Health Technology Assessment
HTA Commissioned
Professor Julie Mytton
NHS Bristol, North Somerset and South Gloucestershire Integrated Care Board
1 January 2011
31 March 2013
The FAST (First-aid Advice & Safety Training) Parents programme for the prevention of recurrent unintentional home injuries in preschool children
Design: (1) theoretical phase and development of the parenting programme (2) a multi-centre feasibility study of the programme using a cluster randomised controlled trial. The theoretical phase will include two systematic reviews: (i) a Cochrane review of parenting programmes to prevent injury undertaken by two co-applicants will be updated (ii) a new qualitative review of the barriers and facilitators to parent engagement in parenting programmes. Setting: Children’s Centres in Bristol and Nottingham Target population for feasibility study: (1) Children’s Centres: those ranked highest for the number of children aged 0-4 years in their catchment area who have attended the local Children’s A&E department during the previous year will be invited to participate (2) Parents/carers: of children aged under 5 years who have sustained an unintentional physical injury or ingestion in the home that resulted in seeking medical attention during the recruitment period Health technology: In depth dis
Complete
395,636.54
19
Healthcare Public Health and Preventing Premature Mortality
09/1002/14
Health and Social Care Delivery Research
SDO Priority Areas Panel
Professor Sarah Salway
Sheffield Hallam University
1 October 2010
30 November 2012
Towards equitable commissioning for our multiethnic society: understanding and enhancing the critical utilisation of evidence by strategic commissioners and public health managers
We adopt an explicit Integrated Knowledge Translation model for the conduct of the study, bringing university researchers and PCT managers together in a collaborative team across the entire research process. We conceptualise knowledge mobilisation and utilisation within the commissioning cycle as resulting from dynamic interactions between individual agency, organisational rules, structures and processes, and the wider healthcare setting with its current restructuring agenda, all situated within the broader socio-political context of multicultural Britain. The study combines detailed case study investigation with wider consultation methods that allow us to engage with a broader sample of respondents in order to generalise theoretical understanding and develop research products that have wider relevance. Data generation involves three phases: (1) Expert interviews (N=30-40), (2) Detailed case studies of 3 PCTs involving multiple methods and examining both strategic and operational commi
Complete
348,174
20
Health Improvement
09/127/01
Health Technology Assessment
HTA Themed Call
Professor Alison Avenell
University of Aberdeen
1 October 2011
31 March 2013
Systematic reviews and integrated report on the quantitative and qualitative evidence base for the management of obesity in men
DESIGN: (1) Systematic review (SR) of randomised controlled trials (RCTs) of lifestyle and/or UK licensed medication with men only BMI of 30 kg/m2 (28 kg/m2 with cardiac risk factors) or over with follow-up of at least one year. (2) SR of RCTs of above interventions, separately by gender in same trial. (3) SR of UK interventions any study design, any duration. (4) SR of interventions to increase men's engagement with services for obesity. (5) SR of qualitative research with people with obesity, health professionals, lay and commercial organisations managing obesity, examining men, men in contrast to women. SEARCH STRATEGY: Medicine, Embase, Cinahl, Cochrane Controlled Trials Register, DARE, HTA databases, NHS Health Library, Psycinfo, NHS EED, ASSIA, British Nursing Index, Anthropology Plus and Social Science Citation Index, Picker and Joanna Briggs Institutes. We will contact lay and professional organisations. No language restrictions. REVIEW STRATEGY: Quantitative SR outcomes: chang
Complete
238,552.41
21
Health Improvement
09/127/07
Health Technology Assessment
HTA Themed Call
Professor Maria Bryant
University of Leeds
1 September 2011
31 December 2012
Systematic review to identify and appraise outcome measures used to evaluate childhood obesity treatment interventions: evidence of purpose, application, validity, reliability and sensitivity
Background: There is a lack of consensus in determining appropriate outcome measures for the reliable and valid assessment of childhood obesity intervention. Comparisons between interventions are difficult, partly because of a shortage of validated outcome measures available, but also because the selected outcome measures differ between studies. Aim: The primary aim is to perform a systematic review to identify and appraise existing outcome measures for use in the evaluation of childhood obesity treatment interventions Methods: Two searches will be conducted: (1) Randomised controlled trials (RCTs), pilot and feasibility studies of childhood obesity treatment evaluation studies; and (2) outcome measures developed for use in childhood obesity interventions. Major electronic databases (e.g MEDLINE, EMBASE, PsycINFO, Science Citation Index, Global Health, etc.) from the date of inception will be used. Both searches will include search concepts for childhood and obesity and will consist of
Complete
170,130
22
Health Improvement
09/161/01
Health Technology Assessment
HTA Commissioned
Professor Linda Bauld
University of Stirling
1 October 2011
31 October 2014
Evaluating Long-term Outcomes of NHS Stop Smoking Services (ELONS)
Design: Observational study including: 1. Secondary analysis of routine data collected by SSSs using the North51 database 2. Prospective study of service clients from 9 PCTs Follow up at 4 weeks & 12 months. Gold standard NHS SSS client satisfaction questionnaire. Setting: NHS SSSs in England Target population: Smokers who make contact with NHS SSSs Health technologies: Treatment provided by SSSs – a combination of behavioural support and medication. We will focus on evaluating outcomes for smokers who receive one of the 5 main forms of behavioural support (intervention types) provided. These are: closed groups, rolling groups, one to one drop in, one to one appointments with a specialist adviser, one to one appointments with a sessional adviser (usually a pharmacist or practice nurse). Measurement of costs and outcomes: Primary outcome is prolonged abstinence at 12 months. We will also assess abstinence at 4 weeks. Measurement will follow the Russell Standard (intention to treat and b
Complete
819,952.38
23
Health Improvement
09/162/02
Health Technology Assessment
HTA Commissioned
Professor Kamlesh Khunti
University of Leicester
1 November 2012
31 October 2019
The PRmotion Of Physical activity through structured Education with differing Levels of ongoing Support for those with prediabetes (PROPELS): randomised controlled trial in a diverse multi-ethnic community
BACKGROUND Type 2 diabetes exerts a huge health and economic burden within the United Kingdom. Increasing levels of physical inactivity are one of the main causes of the growing prevalence of type 2 diabetes. However, evidenced-based approaches to promoting increased physical activity in the prevention diabetes are lacking. This study aims to bridge this gap in the evidence. DESIGN Randomized controlled trial; follow-up at 12 & 48 months. METHODS 1308 individuals aged 40-75 years and identified with impaired glucose regulation will be recruited from the community and primary care settings in the East-Midlands and East Anglia. Around 25% of recruited participants will be from a south Asian ethnic origin. Individuals will be randomized (1:1:1) to: 1) Detailed advice leaflet (control). 2) A 3.5-hour group-based structured education programme followed by annual group-based or telephone support up to 36 months. The initial structured education session is delivered by two trained educators a
Complete
1,747,568.36
24
Healthcare Public Health and Preventing Premature Mortality
09/1801/1054
Health and Social Care Delivery Research
Service Delivery and Organisation
Professor Helen Snooks
Swansea University
1 September 2010
31 August 2015
Predictive risk stratification: impact on care for people with or at risk of chronic conditions
New approaches to the management of chronic conditions are needed in order to shift the balance of care from the acute to primary and community sectors and improve services locally. The Welsh Assembly Government (WAG) has commissioned the development of a predictive risk stratification model (PRISM) for Wales to stratify people into one of four risk strata based on having an emergency admission in the following year. PRISM has the capacity to tailor care at individual patient level to patient need. Questions remain however about how the model will be adopted by potential users at each risk strata. The aim of the proposed study is to describe the processes of introducing PRISM in Wales and to estimate the effects on the delivery of care both to patients living with or at risk of developing a chronic condition, and to those with no perceived risk. A mixed-method ‘before, during and after’ quasi-experimental cohort study will be conducted with Intervention sites and Control sites. Changes
Complete
689,605.78
25
Health Protection
09/2000/37
Health and Social Care Delivery Research
HSDR Researcher Led
Dr Colin Simpson
The University of Edinburgh
1 January 2011
30 April 2013
Seasonal Influenza Vaccine Effectiveness (SIVE): exploitation of a unique community-based national linked dataset
Each year, influenza is a major contributor of death and illness. However, rates of vaccination particularly in at risk groups under 65 remain low. This is perhaps due to a relative paucity of information available on the effectiveness of the influenza vaccine. Policymakers will be reassured if evidence that the influenza vaccine is effective in preventing adverse health outcomes, emergency admissions to hospital and death. Using an existing unique patient level information resource from 41 general practices who receive an annual financial incentive to record all of their practice data electronically and covering a five percent age/sex representative sample of the Scottish population (generated from the National Institute for Health Research funded VIPER project Ref:09/84/90 with 1,020,000 person years of data available), which was linked to hospital, death certification and virological swab data and building on previously piloted work [Mooney et al, 2008], we will establish the influe
Complete
102,656.26
26
Healthcare Public Health and Preventing Premature Mortality
09/2000/65
Health and Social Care Delivery Research
HSDR Researcher Led
Professor David Harrison
Intensive Care National Audit & Research Centre
1 July 2011
31 December 2014
Ensuring comparisons of health-care providers are fair: risk modelling for quality improvement in the critically ill.
Objective 1. To improve current risk prediction models for critically ill patients Detailed statistical analysis plans will be developed, with input from the Expert Group (see: Team Expertise), to address each of the specific points detailed above (or other aspects of modelling identified as important by the Expert Group). Model improvements will be assessed both visually (e.g. by calibration plots) and using a panel of measures of model performance to encompass discrimination (c index or area under the ROC curve), calibration (Hosmer-Lemeshow test), and overall fit (Brier's score, Shapiro's Q, R-squared) using bootstrap methods to adjust these measures for overfitting to the data. Objective 2. To develop new risk prediction models for critically ill patients Learning from Objective 1 of the project will feed into the methods used for development of new models. Clinicians in the relevant fields will be consulted for their input into the design of the risk prediction models. Models will
Complete
166,562
27
Healthcare Public Health and Preventing Premature Mortality
09/2001/25
Health and Social Care Delivery Research
HSDR Researcher Led
Professor Glenn Robert
King's College London
1 August 2010
31 July 2012
Facilitating knowledge exchange between health care sectors, organisations and professions: studying ‘boundary spanning’ processes and their impact on health care quality
We will use an in-depth longitudinal, case study approach. Our case study is a project designed to improve services through collaboration between general practitioners, community services, voluntary groups and acute specialists over an 18 month period in the Southall area of London. The project includes the development of a network of leaders across organisational and community boundaries to facilitate knowledge creation and exchange, and is directly linked with a programme of ‘whole system’ stakeholder conferences to create organisational learning and change, together with community development. Fieldwork will be undertaken in the three specific topic areas in which boundary spanning activities will be undertaken as part of the case study: (a) Dementia, (b) Child & Family Health, and (c) Depression & anxiety in people from black and ethnic minority backgrounds. In seeking to test our research hypothesis we will: provide a rich ethnographic account of the boundary spanning processes (h
Complete
240,388.14
28
Healthcare Public Health and Preventing Premature Mortality
09/22/21
Health Technology Assessment
HTA Themed Call
Professor Steve Goodacre
The University of Sheffield
1 October 2010
31 December 2011
Cost-effectiveness of diagnostic strategies for suspected acute coronary syndrome (ACS)
We will undertake systematic reviews, meta-analysis and decision analysis modelling of the cost-effectiveness of (1) Biomarkers used to diagnose myocardial infarction (MI) and predict adverse events in suspected ACS, and (2) CT coronary angiography and exercise ECG as first-line tests for diagnosing coronary artery disease (CAD) in patients with troponin-negative suspected ACS. Systematic searches will identify cohort studies evaluating the technologies in suspected ACS, and estimates of key parameters for the model. Relevant studies will be identified through electronic searches of key databases, hand searches of key journals and contact with experts and authors. Standardised data will be extracted from each included article. Where appropriate, we will combine data to provide pooled estimates of the accuracy of investigations for MI, CAD and adverse events. The network of evidence will be summarised using Bayesian generalised evidence synthesis. We will develop a decision-analysis mod
Complete
173,447.22
29
Health Improvement
09/3000/03
Public Health Research Programme
PHR Researcher Led
Professor Paul Stallard
Oxfordshire & Buckinghamshire Mental Health NHS Foundation Trust
1 January 2011
31 December 2014
A randomised controlled cluster trial comparing the effectiveness and cost-effectiveness of a school-based cognitive–behaviour therapy programme (FRIENDS) in the reduction of anxiety and improvement in mood in children aged 9/10
DESIGN: Randomised controlled cluster trial comparing FRIENDS (delivered by health professional or school) vs. treatment as usual for the reduction and prevention of anxiety symptoms and low mood (i.e. reduced symptoms of depression) in children aged 9/10. SETTING: 45-54 junior schools in Bath and North East Somerset and Wiltshire. INTERVENTION BEING EVALUATED: FRIENDS is a manualised cognitive behaviour therapy (CBT) programme designed to improve children's mental health. Each child has a workbook and group leaders a comprehensive manual detailing the content and structure of each session. FRIENDS involves 10, 60-minute weekly sessions delivered to whole classes as part of the school PSHE programme. FRIENDS teaches children practical skills to identify their feelings; to learn to relax; to identify unhelpful thoughts and to replace them with more helpful thoughts; and how to face and overcome their problems and challenges. Initial training and regular supervision of leaders will be pr
Complete
1,279,979.48
30
Improving the Wider Determinants of Health
09/3001/06
Public Health Research Programme
PHR Researcher Led
Dr David Ogilvie
University of Cambridge
1 January 2010
28 February 2015
Health impacts of the Cambridgeshire Guided Busway
The project will address the following primary research question: Is investment in new high-quality transport infrastructure associated with an increase in the use of active modes of travel (walking and cycling)? and the following secondary research questions: — What are the wider health impacts of changes in travel behaviour in terms of overall physical activity, wellbeing, sickness absence and carbon emissions? — What are the determinants of the use and uptake of active modes of travel? — How are any changes in travel behaviour distributed in the population? — How are any changes in travel behaviour brought about and experienced? — Are changes in travel behaviour sustained over time? The core of the project will be a controlled quasi-experimental cohort study with the following elements: Population: Adult commuters Intervention: New high-quality transport infrastructure provided in the intervention area Comparator: No comparable improvement to transport infrastructure in the control
Complete
1,184,572.78
31
Improving the Wider Determinants of Health
09/3001/13
Public Health Research Programme
PHR Researcher Led
Professor Judith Green
London School of Hygiene & Tropical Medicine
1 February 2010
31 July 2012
On the buses': evaluating the impact of introducing free bus travel for young people on the public health
There has been increasing interest in the ways in which transport policies affect the public health but to date, few robust evaluations of specific policies. This study aims to evaluate the impact of the introduction of free bus and tram travel to under 16 year olds in 2005 and under 18 year olds in 2006 in London. The aims of this policy included reducing transport exclusion among young people. This potentially had a positive effect on the determinants of health and health equity. However, there has also been concern that extending access to bus travel may have reduced the amount of healthier ‘active transport’ done by young people. There are also concerns about consequent impacts on other population groups, such as elderly people. Using a mixed method, quasi-experimental design, this study aims to provide empirical evidence for the impact of free bus travel on public health, and evaluate the economic costs and benefits. The objectives are to: 1. Determine the causal pathways that pla
Complete
534,376.86
32
Improving the Wider Determinants of Health
09/3002/08
Public Health Research Programme
PHR Researcher Led
Professor Christopher Bonell
London School of Hygiene & Tropical Medicine
1 June 2010
29 February 2012
The effects of schools and school-environment interventions on health: evidence mapping and syntheses
Methods The review will involve 3 stages: 1) a descriptive map of available evidence, plus a preliminary synthesis of intervention logic models and theories of school-level effects on health; 2) in-depth reviews and syntheses of evidence addressing our research questions; and 3) drafting of final report and other dissemination. Target population and setting Students, staff, parents and/or the local community of schools catering for those aged 4-18. Intervention being evaluated School environment (SE) interventions aiming to change the physical, social or cultural environment within schools to promote health. Search strategy In stage 1, we will include studies pertinent to our research questions: (RQ1) literature describing/explaining the theories and conceptual frameworks that are used to inform SE interventions or explain school-level influences on health; (RQ2) evaluation studies reporting on SE intervention effects on health, as well as cost, economic and econometric studies examini
Complete
182,641
33
Health Improvement
09/3004/01
Public Health Research Programme
PHR Commissioned
Professor Gail Mountain
The University of Sheffield
1 October 2011
30 June 2013
Putting Life in Years (PLINY): Telephone friendship groups research study. Evaluation of the effectiveness and cost effectiveness of an intervention to promote mental wellbeing in community living older people
DESIGN: Pragmatic two arm parallel group randomised controlled trial with feasibility phase. SETTING: Telephone befriending intervention: the homes of participants. TARGET POPULATION: People aged 75 years and over with reasonable cognitive function (Score of 18 and over on the MMSE) living independently or in sheltered/ extra care housing and able to converse and respond to English. RECRUITMENT: PCT mail outs, Local Authority involvement, Identification by voluntary sector organisations and through pro-active community engagement. INTERVENTION TO BE EVALUATED: Telephone befriending provided by local charities supported by AgeUK and the Community Network compared with treatment as usual (control). FEASIBILITY: An assessment of study feasibility will be made at 18 months, based on a pilot cohort of 90 people recruited at 9 months. The feasibility phase will evaluate willingness to be randomised into the study (recruitment rate) as well as the capacity of those delivering the services and
Complete
319,631.46
34
Health Improvement
09/3005/04
Public Health Research Programme
PHR Researcher Led
Professor Debbie Lawlor
University of Bristol
1 April 2011
31 May 2015
Active For Life Year 5: A cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet
Design: School-based cluster randomised controlled trial. Setting: State primary and junior schools with Year 5 children (aged 9-10) in the city of Bristol. Special schools will be excluded. Participants will be Year 5 children in these schools whose parents provide opt-out consent. Children will only have measurements if they provide assent. Target population: UK school children aged 9-10 Intervention: Schools randomised to the intervention (N=30; 750 children) will receive the intervention immediately and those randomised to control (N=30;750) after completion of the 2-year follow-up assessment. The intervention comprises: a) training for classroom teachers; b) provision of 16 lesson-plans and teaching materials, including pictures, CDs and journals; c) provision of 10 parental-child interaction homework activities (see detailed project description); d) information in the school newsletters about the importance of increasing physical activity, reducing sedentary behaviour and improvi
Complete
1,349,139.91
35
Health Improvement
09/3005/05
Public Health Research Programme
PHR Researcher Led
Professor Catherine Law
University College London
1 December 2010
30 November 2012
A population-level evaluation of a family-based community intervention for childhood overweight and obesity
Setting: Community-based health promotion intervention operating in over 300 schools and leisure centres throughout England from January 2006 - October 2010. Target population: Overweight (body mass index (BMI) greater than 91st centile) or obese (greater than 98th centile) children aged 7-13 years. Intervention: MEND, a multi-component, community-based intervention aiming to empower families of overweight/obese children to adopt and sustain healthy lifestyles. Measurement of outcomes and duration of follow-up in secondary analysis: Primary outcomes: change in BMI after participation in MEND, adjusted for age. Secondary outcomes: post-intervention changes in body esteem, self-esteem and 'Strengths and Difficulties' questionnaire (SDQ) - all validated. Duration of follow-up: 10 weeks using service data, benchmarked against 10 weeks, and 6 and 12 months in original and concurrent RCTs (funded separately). Secondary data analysis sample size: we will use all the data that are available, a
Complete
415,339.57
36
Improving the Wider Determinants of Health
09/3008/11
Public Health Research Programme
PHR Commissioned
Professor James Thomas
Institute of Education, University of London
1 April 2011
31 August 2012
Can specific approaches to community engagement help to reduce inequalities in health; for whom, under what circumstances, and with what resources? A mixed-methods evidence synthesis
DESIGN The project proposed is a synthesis of existing research. By analysing many evaluations of community engagement, we will identify approaches that are most often associated with reductions in inequalities in health, paying particular attention to the context of the research and the mechanisms by which communities are engaged and the ways this is thought to impact on intervention effectiveness. When we have identified a range of effective approaches, we will then consider their relative resource requirements in order to draw conclusions as to their potential cost implications for different stakeholders. REVIEW QUESTIONS Our overarching review question is: Can specific approaches to community engagement help to reduce inequalities in health; for whom, under what circumstances, and with what resources? Please see Section C4 for our detailed review questions. CONCEPTUAL FRAMEWORK Our conceptual framework (described in Section 3.4 of the full Project Description) understands 'communit
Complete
221,837
37
Health Protection
09/85/01
Health Technology Assessment
HTA Commissioned
Professor Jonathan Nguyen-Van-Tam
The University of Nottingham
24 August 2009
23 May 2011
Virus shedding and environmental deposition of novel A(H1N1) pandemic influenza virus
Very little is known about the new H1N1 pandemic virus. For example we do not know how long the virus is excreted by infected humans and how much virus is spread to surfaces and carried in the air. This is very important to know because it affects the advice that will be given to healthcare workers about controlling the spread of infection to themselves and other patients. It will also enable good quality advice to be given to families who will have to look after each other in their own homes. The best way to obtain this information is to ask patients who get pandemic flu to help us by agreeing to give a daily nose swab sample for just over one week so we can see how much virus is in the nose day by day and how quickly this disappears. At the same time we will take samples from the patients near environment (hard surfaces and air). We can then work out how much virus is being excreted, how long the ‘danger period’ is, whether surfaces are more or less important than air in terms of cat
Complete
249,121.9
38
Health Improvement
09/91/04
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Mike Crawford
Imperial College London
1 April 2011
31 March 2013
Alcohol misuse and sexual health: a randomised trial of brief intervention among people attending sexual health clinics.
Background Excessive alcohol consumption can harm health in a number of ways. Being drunk impairs judgement, increases the chances of accidents, and may lead to risk taking such as unprotected sexual contact. Between a third and a half of people who are seen in sexual health clinics drink at a level that may be harmful to their health. Brief interventions for excessive drinking have been shown to be effective in other healthcare settings but the impact of this intervention on sexual health has not been examined. Aims To examine the clinical and cost-effectiveness of brief intervention for alcohol misuse among people who attend sexual health clinics and consume excessive alcohol. To achieve this objective we will: 1. Test whether brief intervention reduces subsequent alcohol consumption measured six months later. 2. Examine whether brief intervention is associated with changes in sexual behaviour. 3. Estimate the cost and cost-effectiveness of this intervention. Methods A two-arm, paral
Complete
281,868.08
39
Health Protection
10/1007/01
Health and Social Care Delivery Research
SDO Priority Areas Panel
Professor Justin Waring
The University of Nottingham
1 June 2011
31 May 2013
Knowledge sharing across the boundaries between care processes, services and organisations: the contributions to ‘safe’ hospital discharge and reduced emergency readmission
The study is designed as four linked Work Packages (WPs) combining different forms of qualitative interviewing with observational research methods. Design: * WP1 (-2 to 2mnths): directed towards preparing and planning the study, including submitting ethical and research governance approvals; recruiting the researcher; synthesizing existing literatures and consulting with advisors to clarify research deliverables; * WP2 (3 to 10mnths): directed towards identifying, mapping and understanding the patterns of knowledge sharing involved in hospital discharge with a particular focus on the contributions to patient safety. This will involve the use of semi-structured interviews as well as questions take from existing social network surveys related to knowledge sharing; * WP3 (12 to 21mnths): directed towards producing a detailed and ‘real time’ understanding of hospital discharge through observations of interactions and knowledge sharing activities in and through ‘tracking’ patient discharge,
Complete
228,994.29
40
Healthcare Public Health and Preventing Premature Mortality
10/1008/09
Health and Social Care Delivery Research
SDO Studies Panel
Professor Diana Rose
South London and Maudsley NHS Foundation Trust
1 March 2011
30 April 2013
How do managers and leaders in the National Health Service and social care respond to service user involvement in mental health services in both its traditional and emergent forms?
Theoretical framework: The theoretical design to be used in this study is a combination of sociological analyses of the mental health user movement as a 'new social movement' and organisational studies. We shall consider changes in both these conceptual frameworks deriving from the changing nature of user involvement in England currently. Setting and samples:The study will take place in 3 NHS Foundation Trusts and concentrate primarily on 5 or 6 sites (user groups) in total as well as some individual users.. We will add one more site for the analysis of Personal Health Budgets (PHBs) as it is part of the national evaluation. Sampling frames vary with the different Phases of the research. The Trusts are the South London and Maudsley NHS Foundation Trust (SLAM), Central and North West London NHS Foundation Trust (CNWL) and Sussex Partnership Foundation Trust. The sampling of Trusts is theoretical. CNWL are paying close attention to lay representation at Board level and SLAM has several U
Complete
299,954
41
Health Protection
10/1008/12
Health and Social Care Delivery Research
SDO Studies Panel
Professor Matthew Cooke
University of Warwick
1 September 2011
31 August 2012
Patient Safety in UK Ambulance Services - a scoping review
Work Package (WP) 1 Systematic Literature Review (Months 1-8, JDF/AC/researcher). Search strategy: to be developed in consultation with Advisory Group. Data Sources: MEDLINE, EMBASE, Web of Science, HMIC, NHS Evidence-Health Information Resources Specialist Collections: emergency and urgent care, health management, CochraneDatabase of Systematic Reviews of systematic reviews in Database of Abstracts of Reviews of Effect via NHS Evidence, FADE, CASH, King’s Fund Library Catalogue, OpenDOAR, OpenSIGLE, DH publications library, NHS Confederation reports, plus major journals in the field, abstract books, conference proceedings and reference lists of retrieved publications. Data review and analysis: Include studies of any design exploring patient safety in AS. Data will be extracted by JDF, checked by AC, with disagreements resolved by discussion. Quality of evidence will be appraised based on the methodology adopted and using the SIGN critical appraisal tools. Reports and policy documents
Complete
140,615
42
Healthcare Public Health and Preventing Premature Mortality
10/1009/09
Health and Social Care Delivery Research
SDO NHS Evaluations Panel
Professor Naomi Fulop
University College London
1 September 2011
30 June 2017
Innovations in major system reconfiguration in England: a study of the effectiveness, acceptability and processes of implementation of different models of stroke care
THEORETICAL FRAMEWORK. We propose to study the reconfigurations in two ways. First, taking a more traditional health technology assessment approach to address 'what works and at what cost?'. However, this approach pays little attention to structural pressures, e.g. professional pressures or processes whereby organisations innovate as a result of economic or regulatory reasons (1). It also assumes innovation is progressive and poor adopters are conservative, whereas resistance may be a rational response (2). Therefore, drawing on innovations theory, we will study the reconfigurations in terms of Webster's (2) notion of a 'social matrix' i.e., not as a technical, rational set of issues but in terms of requiring 'co-creation' by a range of stakeholders that is only as strong as the network of relations that hold it together. Further, a major review of the evidence on diffusion of innovations identifies the characteristics of innovations that are more likely to be sustainable (3); we will
Complete
1,011,413.05
43
Healthcare Public Health and Preventing Premature Mortality
10/1011/22
Health and Social Care Delivery Research
HSDR Commissioned
Professor Rowena Jacobs
University of York
1 April 2012
30 September 2013
Do higher primary care practice performance scores predict lower rates of emergency admissions for persons with serious mental illness? An analysis of secondary panel data
Design and theoretical/conceptual framework: Effective primary care can have an important preventive role, and should therefore be associated with lower emergency admission rates. Quality indicators for mental health have been routinely measured in English primary care over a number of years as part of the Quality and Outcomes Framework (QOF). Our null hypothesis is that there is no association between QOF performance and emergency hospital admissions for people with mental illness either for mental or physical conditions. We will test for an association between changes in practices’ mental health QOF indicators and changes in their rates of emergency admission using data on all practices in England over the period 2004/05 to 2009/10. Our analysis will also estimate the impact of potential improvements in the QOF on subsequent mental health expenditure on secondary care. Sampling: We will construct a national dataset covering around 8000 English GP practices by drawing together routine
Complete
179,406.06
44
Healthcare Public Health and Preventing Premature Mortality
10/1011/48
Health and Social Care Delivery Research
HSDR Commissioned
Professor Martin Pitt
University of Exeter
1 January 2013
31 May 2014
The right cot, at the right time, at the right place - Using neonatal care data and computer simulation to improve the design and organisation of neonatal care networks
The model is based on discrete event simulation. In this type of simulation each infant exists as an independent object in the model and has associated details (such as gestational age at birth, entry level of care, home hospital, etc). The simulation runs through time and takes into account the variability experienced in the system (e.g. random occurrence of births with varying needs, fluctuating availability of staff). The simulation is animated; infants may be seen in different levels of care at each hospital and can be seen being transferred between hospitals when necessary. Each hospital of a network will be presented in the model. For each hospital the number of cots and the highest level of care each cot is capable of supporting will be specified. Care levels will be classified by Intensive Care, High Dependency Care and Special Care. These will be defined by the interventions being carried out and the level of nursing support required (according to BAPM guidelines). Though some
Complete
132,114
45
Healthcare Public Health and Preventing Premature Mortality
10/1011/67
Health and Social Care Delivery Research
HSDR Commissioned
Professor Susan Lea
King's College London
1 October 2011
30 September 2013
Enhancing the multi-agency management of individuals with enduring moderate to severe mental health needs(EMHN): client journeys and the NHS/CJS interface.
The project is informed by a conceptual and methodological framework developed by the multi-disciplinary team of academics and practitioners to evaluate a range of multi-agency services and initiatives through mixed methods (Creswell, 2009). This framework is responsive to identified need (Wadsworth, 2001), adopting Burke’s (1998) principles of participatory evaluation through the engagement of stakeholders at all stages of the research process to ensure the meaningful utilisation of findings (Papineau & Kiely, 1996) to enhance multi-agency working and service user outcomes. The framework is also informed by the tenets of community psychology which espouse collaborative working with traditionally marginalised groups and understanding people within their social contexts (Orford, 2008). A three stage methodology (two using secondary and one primary data) is planned. Stage 1 A short practice-focussed review will examine how national policy has been interpreted and translated at the region
Complete
326,279.87
46
Health Protection
10/2000/29
Health and Social Care Delivery Research
Health Services Research
Professor Bruce Guthrie
University of Dundee
1 October 2011
31 March 2014
Measuring prevalence, reliability and variation in high risk prescribing in general practice using multilevel modelling in a population database
The study is needed because primary care prescribing is a significant source of patient harm and improving patient safety is a priority for the NHS. Measurement is the first step on the road to improving safety, but it is important that measures are valid, reliable, and suitable for their intended purpose. The study aim is to define and implement a set of indicators of high-risk prescribing in existing electronic clinical data in order determine their validity for safety improvement, clinical governance and appraisal/revalidation purposes. The overall study design is a cross-sectional analysis of a large dataset extracted from existing general practice electronic clinical records. The first objective is to define and operationalise an appropriate set of indicators. We will achieve this by iteratively cycling between discussing candidate indicators and specifications with an expert advisory group and operationalising these indicators in real-life clinical data. The second objective is t
Complete
186,702.73
47
Healthcare Public Health and Preventing Premature Mortality
10/2002/13
Health and Social Care Delivery Research
HSDR Researcher Led
Professor Jane South
Leeds Metropolitan University
1 February 2012
31 March 2013
A systematic review of the effectiveness and cost-effectiveness of peer-based interventions to maintain and improve offender health in prison settings
Background: The prison population have high levels of poor health and more needs to be known about effective interventions in this vulnerable population. Research indicates that peer-based approaches can be a mechanism for supporting healthcare delivery and health improvement in prison settings, but the evidence has not been systematically reviewed. This study will address this research gap and provide information to support decision making in the NHS by undertaking a synthesis of evidence on peer-based interventions. Aim: The primary aim of the study is to review the effectiveness and cost effectiveness of peer-based interventions to improve and maintain health in prisons and young offender institutions. The study will identify the types of intervention, when provided (with reference to offender health care pathways) and outcomes. It will also examine positive and negative impacts for services. Conceptual framework: The study will use a categorisation of peer interventions with refere
Complete
179,791
48
Healthcare Public Health and Preventing Premature Mortality
10/2002/49
Health and Social Care Delivery Research
HSDR Researcher Led
Dr Sionnadh Mclean
Sheffield Hallam University
1 January 2012
28 February 2013
TURNUP: Targeting the Use of Reminders & Notifications for Uptake by Populations
This study will review different types of patient reminders with the aim of identifying those that are most effective in improving attendance at appointments and patient satisfaction. An additional aim is to investigate the variables which influence the effectiveness of those reminder systems. This mixed methods review will bring together primary comparative studies with qualitative studies and process evaluations on factors contributing to appropriate responses to such reminders. Exhaustive searches will be conducted across a range of appropriate databases. Search terms will relate to the encounter (eg appointment), the purpose of the appointment (eg immunisation, health check), the technologies involved (eg text) and the outcome (missed appointment, satisfaction). Included studies will have been undertaken in the UK or UK-comparable context. Intervention studies involving reminder systems will be the focus of the analysis but descriptive and empirical papers on appointment behaviours
Complete
87,589
49
Health Protection
10/2002/52
Health and Social Care Delivery Research
HSDR Researcher Led
Professor Susan White
University of Birmingham
1 April 2012
30 September 2013
Making the Case in Safeguarding: Enhancing Safe Practice at the Interface between Hospital Services and Children’s Social Care
Events leading to the deaths of children, such as Peter Connelly, are marked by repeated miscommunications and misdiagnoses during hospital attendances and admissions. In addition to those killed or seriously injured, children experiencing neglect or who are vulnerable or "at risk" in other ways (e.g. serious disabilities, mental health needs) are also more likely to present at Emergency Departments (ED) and/or to have hospital appointments or admissions. Despite this, the NHS Patient Safety First (PSF) initiative currently does not attend to safeguarding children at risk from abuse. Decision-making at this interface is perforce extremely challenging, e.g. children are usually accompanied by parents, often cannot speak, and much evidence is "soft" and difficult to codify. The goal of this research is to develop a tool-kit of transferable methods, based on clinician-led innovation in one hospital (Pennine Acute Trust), extending and adapting extant PSF tools . The aim of the tool-kit is
Complete
151,048.17
50
Health Improvement
10/3002/07
Public Health Research Programme
PHR Commissioned
Professor Dorothy Newbury-Birch
University of Newcastle upon Tyne
1 October 2011
31 July 2013
A feasibility trial of screening and brief alcohol intervention to prevent hazardous drinking in young people aged 14-15 in a high school setting (SIPS JR-HIGH)
Although the proportion of young people in England aged between 11-15 years who report that they have drunk alcohol decreased from 62% to 51% between 1988 and 2009, the mean amount consumed rose from 6.4 to 11.6 units of alcohol per week between 1994 and 2009 (NHS Information Centre 2010). Moreover, drinking increases steadily throughout adolescence (NHS Information Centre 2010). Early and excessive drinking in adolescence is associated with intellectual impairment, increased risk of accidents, injuries, self harm, unprotected sex, violence and accidental death (Kaner and Bewick 2010). The adverse effects of risky drinking are disproportionately experienced by younger adolescents and by individuals from disadvantaged backgrounds. Screening and brief intervention techniques are known to be effective at reducing hazardous drinking in adults and they have been developed and evaluated in adolescents with positive effects. However, most of this work has focused on older adolescents attendin
Complete
306,675.17
51
Health Improvement
10/3006/07
Public Health Research Programme
PHR Commissioned
Professor Tamsin Ford
University of Exeter
1 June 2012
28 February 2018
The effectiveness and cost effectiveness of the Incredible Years Teacher Classroom Management programme in primary school children: a cluster randomised controlled trial, with parallel economic and process evaluations
Design: A cluster randomised controlled trial with recruitment staggered over three years. The unit of randomisation is the school, and randomisation will be stratified to ensure balance on the following school characteristics: level of deprivation; rural/urban location; involvement in other emotional enrichment programmes. One teacher per school will participate. Setting: 80 primary schools in Devon, Torbay and Plymouth. Target population: Primary school age children from Reception and Years 1-4 in the class of the one teacher per school recruited to the trial. Teachers with mixed year groups, fewer than 15 children in their class, or in the classroom fewer than four days per week will be excluded. Intervention being evaluated: The IY TCM course; a manualised six-day course delivered to groups of up to 10 teachers. Control teachers will receive the intervention in the following academic year, which is a prerequisite for schools agreeing to participate. Schools will be randomised to in
Complete
1,791,277.77
52
Improving the Wider Determinants of Health
10/3009/06
Public Health Research Programme
PHR Researcher Led
Professor David Elliott
University of Bradford
1 May 2012
30 April 2014
Manipulating the appearance of steps and stairs to make them safer for older people to negotiate
Research Design: A repeated measures laboratory based study, investigating adaptive gait in independently mobile older people. Setting. The gait and vision laboratory at the University of Bradford. Target population: Subjects will be recruited from a group of 50 retired volunteers who regularly sit as patients in undergraduate clinics at the University’s Eye Clinic and from a group of 200 older people on the mailing list of Bradford Older People’s Forum. Healthy subjects will be recruited using exclusion and inclusion criteria used previously. Intervention being evaluated: Adaptive gait when ascending and descending steps and stairs will be assessed with and without a variety of modifications to the appearance of both single and multiple steps. Measurement of outcomes: In all stepping experiments, three-dimensional lower limb segmental kinematic data of the stepping action will be collected (at 100Hz) using an eight-camera, motion capture system (Vicon MX; Oxford Metrics Ltd, Oxford, U
Complete
191,480.36
53
Health Improvement
10/32/02
Health Technology Assessment
HTA Commissioned
Professor Tess Harris
St George's, University of London
1 March 2012
31 May 2017
Randomised controlled trial of a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45-74 years
Background Physical activity (PA) is vital for health, yet most adults are inactive and do not achieve the recommended 30 minutes of moderate intensity activity on 5 or more days weekly. Adults' most common PA is walking, light intensity if strolling, moderate if brisker. Pedometers measure step-count and can increase walking, but most trials have had short-term outcomes, have not separated out pedometer effects from other support and have reported only step-counts, not time spent at different PA intensities. Design: Primary care based 3-arm randomized controlled trial with 12 month follow-up and health economic & qualitative evaluations. Participants: 993 inactive patients aged 45-74 years with no contraindications to increasing their moderate intensity PA will be recruited by postal invitation from 6 South West London general practices and randomly allocated into three groups. All participants will have their PA assessed objectively (step-count & time spent at different PA intensitie
Complete
1,266,989
54
Health Protection
10/4001/04
Evidence Synthesis Programme
Not Available
Professor Andrew Smith
University Hospitals of Morecambe Bay NHS Foundation Trust
1 December 2010
31 July 2014
Enhancing the safety, quality and productivity of perioperative care
An estimated one million people undergo surgery in the UK each year. Safety is vital; unintended adverse events are estimated to cost the NHS up to £400 000 per Trust per year through increased costs, length of stay and litigation (National Audit Office: A Safer Place for Patients, 2005). Organisational efficiency in the operating theatre is key to income generation from elective surgery and impacts on targets relating to cancer treatment, time spent in Accident and Emergency and non-clinical cancellation of surgery. The theme of the programme is the quality, safety and productivity of perioperative care. New reviews Safety: e.g. perioperative monitoring Quality: perioperative management of high-risk patients, focusing on obesity, the elderly and people with diabetes mellitus Productivity: e.g. theatre list scheduling and utilisation and enhanced postoperative recovery programmes As some of the topics are complicated and involve more complex interventions, we plan to do 16 new reviews.
Complete
417,211
55
Healthcare Public Health and Preventing Premature Mortality
10/4001/13
Evidence Synthesis Programme
Not Available
Dr Karen Rees
University of Warwick
1 June 2011
31 March 2015
Lifestyle and pharmacological interventions for the primary prevention of cardiovascular disease
Cardiovascular disease (CVD) is still the number one cause of death and disability in the UK. The burden of disease will increase with an aging population and increasing levels of obesity and sedentary lifestyles. Prevention of CVD by targeting modifiable factors (smoking, physical inactivity, obesity, high blood pressure, raised cholesterol levels) remains a key public health priority. Successive guidance (e.g. The National Service Framework for Coronary Heart Disease (NSF CHD, DH 2000)) has been important in reducing deaths from CVD, but has indicated that a shift in emphasis is required towards primary prevention. This shift has been further highlighted by the report Destination 2020 (Cardio Vascular Coalition), which builds on the 10 year targets of the NSF CHD and which particularly welcomes the national roll out of the Vascular Risk Assessment Programme to assess, manage and reduce risk in all those aged 40-74 (Putting Prevention First, DH 2008). NICE guidance on prevention of CV
Complete
418,500.3
56
Healthcare Public Health and Preventing Premature Mortality
10/4001/15
Evidence Synthesis Programme
Not Available
Professor Clive Adams
The University of Nottingham
1 March 2011
28 February 2014
Cost effective treatments and diagnostic approaches for people with schizophrenia within the NHS
Schizophrenia, an illness often starting in teenage years, affects the ability to think, perceive, feel and move. With a lifetime prevalence of 1%, one person in approximately every 25 households, will either have or will develop this disabling illness. In terms of NHS economics, schizophrenia costs are second only to stroke; outweighing those associated with heart disease or cancer (2007 - £2bn). Costs to social services, voluntary sectors and the criminal justice system are also considerable (2007 - £4bn for unemployment alone). This programme aims to review key treatments/approaches that are comparatively inexpensive and universally accessible. Inexpensive treatments/techniques for schizophrenia do exist. We are less clear if good diagnostic tests are available. This work will help review diagnostic data and have the potential to offset introduction of unproven techniques to the NHS. 1. Linking Cochrane and NHS' Map of Medicine, engaging end-users, Project Ref: 10/4000/17 , DoH Ref:
Complete
399,896
57
Health Improvement
10/57/21
Health Technology Assessment
HTA Clinical Trials & Evaluation
Professor Ann Ashburn
University of Southampton
1 May 2013
30 November 2017
A Randomised Controlled Trial of the Effectiveness of PDSAFE to prevent Falls among People with Parkinson's Disease
DESIGN: Multi-centred, individually randomised two-group controlled trial proceeded by 3-months monitoring of individual fall rate and a pilot study. A qualitative study of personal insights and an economic evaluation will run in parallel and be integrated with the main RCT. SETTING: Participants for the main trial will be identified from four areas in the south of England. We will work with the members of the DeNDRoN network as well as PD nurses and PD specialists to recruit participants. We will also approach Parkinson’s UK local support groups, primary care consortia and outpatient services. TARGET POPULATION: People with a confirmed diagnosis of PD, live at home, have experienced at least one fall in the previous 12 months and can understand and follow instructions will be eligible for recruitment to the trial. RANDOMISATION: We will recruit 600 to the pre-randomisation falls collection period, we estimate with drop outs approximately 540 will be randomly allocated to one of two gr
Complete
1,938,051.5
58
Healthcare Public Health and Preventing Premature Mortality
10/66/01
Health Technology Assessment
HTA Commissioned
Professor Peter Scanlon
Gloucestershire Hospitals NHS Foundation Trust
1 May 2012
31 October 2014
Development of a cost-effectiveness model for optimization of the screening interval in diabetic retinopathy screening.
Our aims and objectives are to: • Use demographic and routinely collected clinical information from 15000 patients in 85 Gloucestershire GP practices to develop a risk score for each patient and to identify patient groups whose risk of retinopathy progression is low and whose screening interval can be safely extended; • Model what the influence of the grading classification error is on over referrals and under referrals and how that influence changes over time, taking into account sequential grading results and hospital outcome results, comparing screening intervals that vary according to risk score against current standard practice (annual screening intervals for all patients) and other fixed-interval approaches. • Extend our results to multi-ethnic populations • Determine if assigning diabetic patients to differing diabetic retinopathy screening intervals using a risk estimation model is cost-effective when compared to current practice, which is annual screening of all eligible patie
Complete
435,430
59
Health Improvement
10/93/04
Health Technology Assessment
HTA Commissioned
Professor Caroline Free
London School of Hygiene & Tropical Medicine
1 March 2013
30 June 2015
Can text messages increase safer sexual health behaviours in young people? Intervention development and pilot trial.
Design: Part A: Intervention development. Part B: A pilot randomised controlled trial. Part C: Final modifications to the intervention. Setting: Recruitment: community sexual health clinics, general practices and pharmacies. Intervention delivery: via mobile phones in the community. Target population: Chlamydia screening programme participants diagnosed with chlamydia or gonorrhoea and/or who have had unsafe sex in the last year (more than one partner and at least one occasion of unprotected sex). Part A: Developing the intervention: Existing evidence: New results from our txt2stop trial show that text-messaging interventions can sustain health behaviour change in the long term. The text based intervention doubled biochemically verified smoking cessation at six months: 10.7% txt2stop versus 4.9% control, RR 2.20 (95% CI 1.80-2.68)(2). Mobile phones are able to provide confidential and non-judgemental support, which is essential for a sexual health intervention(3). Interactive support c
Complete
484,697.12
60
Healthcare Public Health and Preventing Premature Mortality
11/1015/12
Health and Social Care Delivery Research
SDO Studies Panel
Professor Gillian Parker
University of York
1 June 2012
30 June 2015
Transforming Community Health Services for Children and Young People who are Ill:A Quasi-Experimental Evaluation
DESIGN AND THEORETICAL FRAMEWORK Interrupted time series (ITS), supported by longitudinal qualitative research and a cost consequence study, to address the research aims outlined above. ITS design is appropriate when randomisation is not feasible, e.g. when evaluating organizational change and when time series data are available e.g. Health Episode Statistics (HES). The design will support quantitative analysis of change over time in outcomes and costs and qualitative analysis of change over time in processes. This mixed methods approach is appropriate when additional information is needed to interpret quantitative measurements, generating understanding of how service redesign has worked, for whom, in what context and at what cost (i.e. providing a ‘realistic evaluation’). There are two main outcomes for the ITS analysis – hospital admission for the most frequently occuring, common childhood conditions presenting for acute, non-elective care, and length of stay for all conditions in ch
Complete
387,053.04
61
Healthcare Public Health and Preventing Premature Mortality
11/1022/01
Health and Social Care Delivery Research
HSDR Commissioned
Dr Lindsay Blank
The University of Sheffield
1 November 2012
31 January 2014
How can international evidence on interventions to manage referral from primary to specialist non-emergency care be applied in a UK context? Development of an inclusive systematic review and logic model
We plan to use an innovative method, which combines systematic review and logic modelling techniques to develop an evidence-based framework to define links between interventions and health outcomes. The evidence synthesis and accompanying logic model will provide a strategic perspective on the understanding of how international referral management interventions may be applied in the UK context. It will uncover and evaluate assumptions underpinning how interventions may lead to enhanced outcomes and provide a framework for communication and discussion. The work will thus be directly relevant for informing NHS managers and other stakeholders and for developing practice. The synthesis will also provide an overview of the current state of knowledge in the field and indicate where further research is needed. By examining links between interventions and outcomes it will provide valuable insights into the outcome measures currently in use and have the potential to inform the future measuremen
Complete
173,526.33
62
Healthcare Public Health and Preventing Premature Mortality
11/21/02
Health Technology Assessment
HTA Commissioned
Professor Adnan Tufail
Moorfields Eye Hospital NHS Foundation Trust
1 December 2012
31 December 2014
Can automated Diabetic Retinopathy Image Assessment softwares replace one or more steps of manual imaging grading and is this cost-effective for the NHS Diabetic Eye Screening Programme?
DESIGN: An observational study to quantify screening performance, diagnostic accuracy and cost-effectiveness of automated primary grading, in routine English practice. Three automated software programmes will be assessed. Study phase 1 is retrospective: the automated software packages will grade 18,000 screening episodes, which have been manually graded, from patients attending diabetic retinopathy (DR) screening programme. Phase 2 is a prospective implementation study of an additional 6,000 screening episodes from the same clinic. Manual grading will be 2-field-2 step, by human graders who meet English National Screening Programme (ENSPDR) quality assurance standards and is the reference standard for this study. SETTING: Diabetic eye screening service in England compliant with ENSPDRstandards. TARGET POPULATION: Diabetic patients over 12 years of age eligible for DR screening, attending a London PCT screening programme with a wide spectrum of ages and ethnicity(24%South Asian, 17% bla
Complete
303,869.35
63
Health Improvement
11/3002/02
Public Health Research Programme
PHR Commissioned
Professor Jacqueline Barnes
Birkbeck, University of London
1 February 2013
31 July 2016
Randomised trial of the effectiveness of Group Family Nurse Partnership (gFNP) programme in improving outcomes for high-risk mothers and preventing abuse
Study design: The study will comprise a randomised controlled trial in which eligible families will be randomly allocated to one of two arms i) gFNP delivered over 76 weeks; ii) standard care. Setting: Family Nurses employed by the local NHS trust in conjunction with local councils as part of the Family Nurse Partnership team will provide the intervention in local Sure Start Children's Centres. Inclusion criteria: Expectant mothers prior to 16 weeks gestation and with expected delivery dates within 4 to 6 weeks of each other (per site). Eligibility criteria are either: aged under 20, expecting second or subsequent child, no qualifications or maximum 4 GCSEs at Grade C; or aged 20 to 23, expecting first or subsequent child, no educational qualifications or maximum 4 GCSEs at C, and one of: current or history of mental health problems, ever in care of social services, lives in workless household, or never employed. Intervention: Group Family Nurse Partnership (gFNP) - groups of on averag
Complete
1,315,970.24
64
Health Protection
11/3004/02
Public Health Research Programme
PHR Commissioned
Associate Professor Philip Edwards
London School of Hygiene & Tropical Medicine
1 January 2013
31 December 2014
What is the effect of reduced street lighting on crime and road traffic accidents at night? A mixed methods study
Objectives: (1) To conduct a nationwide analysis of street-level data for all local authorities (LAs) where street lighting reduction schemes have been introduced by 2012; to quantify (with adequate power and precision) the impact of these schemes on night-time traffic injuries and on all crimes. (2) To use qualitative research methods to identify articulated public views about street lighting reduction schemes and their consequences, and the role these views have played in local decision making. (3) To develop an inventory of all quantified costs and benefits of street lighting reduction schemes and to examine variation in the costs and benefits of schemes. Objective 1 Design: Controlled interrupted time series analysis. Setting: All local authorities of England & Wales. Target population: People who were victims of road traffic collisions or street crime. Intervention being evaluated: Any street lighting reduction schemes implemented by 2012 (to include switching selected street ligh
Complete
414,315.32
65
Improving the Wider Determinants of Health
11/3005/07
Public Health Research Programme
PHR Researcher Led
Dr David Ogilvie
University of Cambridge
1 January 2013
30 June 2016
The M74 study: longitudinal follow-up of the health effects of a new urban motorway
DESIGN. Mixed-method study, using a combination of quantitative and qualitative research methods to evaluate both individual- and population-level changes in health and health-related behaviour coupled with achieving an in-depth understanding of how these changes are experienced and brought about. The study will comprise three main components: (1) CORE SURVEYS OF LOCAL STUDY AREAS to compare changes in neighbourhood perceptions, travel behaviour, physical activity and wellbeing in the intervention and control areas by means of combined cohort (baseline achieved total n=1322) and repeat cross-sectional (target total n=3000. minimum required total n=1200) follow-up surveys of local residents, coupled with an environmental audit (documentary analysis, interviews and site visits) to ascertain whether the intervention was implemented as originally planned, to elucidate its broader environmental impact and to identify any potential area-level confounders. (2) TWO-TIER IN-DEPTH STUDY of a sub
Complete
692,282.71
66
Improving the Wider Determinants of Health
11/3005/31
Public Health Research Programme
PHR Researcher Led
Professor Paul Wilkinson
London School of Hygiene & Tropical Medicine
1 April 2013
30 September 2016
The impact of home energy efficiency interventions and winter fuel payments on winter- and cold-related mortality and morbidity in England: evaluation of a natural experiment
It has been long recognized that the UK has a large and unacceptable burden of excess winter mortality and morbidity (generally upward of 25,000 excess winter deaths each year), which is greater than that of many comparable northern European countries with colder climates. Although part of the winter excess is attributable to influenza and other seasonal infections, time-series studies suggest the major part of the seasonal burden is related to exposure to cold.[1,2] Theoretical considerations and some direct evidence from the UK, New Zealand and elsewhere suggest that housing may play an important role in determining that vulnerability,[3,4] though it is also recognized that exposures to cold through outdoor excursions may also be important. There has therefore been much interest in, and debate about, the contribution that interventions on housing quality may have on winter- and cold-related mortality and morbidity, especially in the context of rapidly worsening UK figures on fuel pov
Complete
531,727.52
67
Health Improvement
11/3009/04
Public Health Research Programme
PHR Commissioned
Dr Julia Bailey
University College London
1 March 2013
31 August 2014
Sexual health promotion delivered by digital media: scoping review
Aim: This work will scope, appraise and synthesise available evidence on digital interventions for sexual health for young people, integrating the findings with key informant views (both professional and lay) to produce summaries of evidence on investment in future research, development and implementation of digital interventions for sexual health. Objectives: * To appraise and synthesise evidence on effectiveness, cost-effectiveness and mechanism of action of digital interventions for sexual health * To determine optimal research methods for intervention evaluation * To determine optimal practice for intervention development and identify 'front running' interventions * To appraise and synthesise evidence on contexts for successful implementation of digital interventions for sexual health * To delineate gaps in available evidence * To provide evidence-based pointers for local and national policy in relation to the adoption and implementation of digital interventions for sexual health *
Complete
259,320.46
68
Health Improvement
11/3010/02
Public Health Research Programme
PHR Commissioned
Dr Lisa Szatkowski
The University of Nottingham
1 January 2013
30 September 2015
Development and evaluation of a novel intervention providing insight into the tobacco industry to prevent the uptake of smoking in school-aged children
Design: Iterative design, piloting, assessment and refinement of a multi-component intervention, whose effectiveness will then be evaluated in a cluster-randomised controlled trial. Setting: Secondary schools in the East Midlands. Target population: Students aged 11-13, the age group where large numbers of young people begin to experiment with smoking. Intervention: This project will develop and test a new intervention comprising materials for schools and families to prevent the uptake of smoking in young people. We plan to pilot, evaluate and refine a promising novel resource (Operation Smoke Storm) developed by the Hammersmith and Fulham Stop Smoking Service, for teachers delivering Personal, Social, Health and Economic (PSHE) education, in which young people assume the role of secret agents working undercover in the tobacco industry. Operation Smoke Storm is strongly evidence-based and draws heavily on the ideas of the US Truth Campaign. The package combines paper-based, audiovisual
Complete
386,454.12
69
Health Improvement
11/3050/30
Public Health Research Programme
PHR Researcher Led
Professor Iain Crombie
University of Dundee
1 July 2013
30 September 2016
Reducing binge drinking among disadvantaged men through a brief intervention delivered by mobile phone: a multi-centre randomised controlled trial
Design: The study is a four centre parallel group randomised controlled trial. The components of the study were developed and tested in a feasibility study. Target population: Men aged 25-44 years living in areas of high deprivation who have had two or more episodes of binge drinking (>8 units in a single session) in the preceding month. To ensure good coverage of disadvantaged men two recruitment strategies will be used: through primary care and by community outreach. Intervention: The intervention is a series of Short Message Service (SMS) delivered by mobile phone. The intervention is based on effective empirical studies on alcohol and text message interventions. It employs theoretical models of behaviour change particularly the Health Action Process Approach and incorporates techniques from Motivational Interviewing and Communication Theory. The messages were constructed to take advantage of the conventional pattern of heavy weekend drinking: before weekend drinking, after a heavy
Complete
873,649.72
70
Health Protection
11/4002/05
Evidence Synthesis Programme
Not Available
Dr Thomas Jefferson
Cochrane Acute Respiratory Infections Group
1 November 2011
31 July 2012
A096 Vaccines for preventing influenza in healthy children
Scientific/policy justification for review/review update Efforts to minimise the impact of influenza have mainly centred on the use of vaccines. Influenza vaccines are a global intervention with policies recommending extension of coverage to children of all ages in the USA, Canada and a growing number of countries. Vaccines were the mainstay of protection from the recent influenza pandemic. Despite such widespread policy promotion, recent reviews have suggested poor quality of evidence from field studies supporting vaccination and a considerable degree of uncertainty on the effects of influenza vaccines. Our review was the first to show lack of evidence of the effects of inactivated influenza vaccines in very young children and the limited nature of the evidence in older children. Since 2007 15-20 studies assessing the effects of the increasing coverage in children have been published. Recently, concerns about harms (ranging from febrile convulsions to narcolepsy) have undermined child
Complete
5,000
71
Healthcare Public Health and Preventing Premature Mortality
11/4002/53
Evidence Synthesis Programme
Not Available
Professor Peter Langhorne
Cochrane Stroke Group
1 November 2011
31 July 2012
Services for reducing duration of hospital care for acute stroke patients
Scientific/policy justification for review/review update Stroke is the commonest cause of severe acquired adult disability in the UK. Most stroke patients are admitted to hospital where they usually receive their rehabilitation. Services have been developed that offer patients an early discharge from hospital with more rehabilitation at home (early supported discharge, ESD). The original Cochrane Review of 11 trials (1597 patients) suggested that appropriately resourced ESD services provided for a selected group of stroke patients may reduce long term dependency and admission to institutional care as well as reducing the length of hospital stay. These initial observations influenced clinical guidelines and encouraged some development of such services in the UK. However more robust information from a wider range of settings would greatly assist service planning. We are currently aware of at least a further six trials (700 patients) that cover two new countries and five novel service set
Complete
5,000
72
Health Protection
11/46/07
Health Technology Assessment
HTA Commissioned
Professor Steve Goodacre
The University of Sheffield
1 August 2012
31 October 2021
Pandemic Respiratory Infection Emergency System Triage (PRIEST)
Objectives: To optimise the triage of people using the emergency care system (111 and 999 calls, ambulance conveyance, or hospital emergency department) with suspected respiratory infections during a pandemic and identify the most accurate triage method for predicting severe illness among patients attending the emergency department with suspected respiratory infection. Design: Prospective observational cohort study. Setting: 40 acute hospital emergency departments and one ambulance service Population: Patients presenting to the emergency department, attended by a 999 ambulance or calling NHS 111 with suspected pandemic respiratory infection. Interventions: Triage methods to predict need for hospital care, including current triage practice, existing triage methods and potential new triage methods. Outcomes: Adverse outcome, defined as death or requiring cardiovascular, respiratory or renal support. Plan of analysis: We will estimate the accuracy of current triage practice and the discri
Complete
768,376.84
73
Health Protection
11/46/12
Health and Social Care Delivery Research
HSDR Commissioned
Professor Marian Knight
University of Oxford
1 June 2012
31 January 2022
Maternal and perinatal outcomes of pandemic influenza in pregnancy
Design: National cohort study using the UK Obstetric Surveillance System (UKOSS). Setting: All consultant-led hospital maternity units. Target population: Pregnant women. Health technologies being assessed: Pandemic influenza or other pandemic infection such as COVID-19. Measurement of costs and outcomes: The following outcomes will be compared between women with pandemic infection and comparison women, and explored in different subgroups according to management variations: maternal death, maternal level 3 critical care unit admission, other major maternal complication, preterm birth, congenital anomaly, perinatal death. Sample size: The primary objective of this study is to determine the incidence of pandemic infection in pregnancy. The study size will therefore be dependent on the infection rate among pregnant women, together with the UK maternity rate (currently approximately 750,000 maternities per year). If the patterns are similar to the 2009 influenza pandemic, we anticipate ide
Complete
135,417.07
74
Health Protection
11/46/14
Health Technology Assessment
HTA Commissioned
Professor Wei Shen Lim
Nottingham University Hospitals NHS Trust
1 December 2012
31 December 2019
Double-blinded randomised controlled trial of early low dose steroids in patients admitted to hospital with influenza infection during a pandemic
Design: Pragmatic mutli-centre double-blind randomized trial. Setting: Hospital in-patient services in England, Scotland and Wales Target Population: Adults (> 16 years old) hospitalized with an influenza-like illness during a pandemic. Health Technologies being assessed: Dexmethasone 6 mg once daily for 5 days from the day of hospital admission, given as adjuvant therapy, in addition to standard care. Based on current national guidelines, standard care will be expected to comprise of supportive measures (fluid and oxygen supplementation), antivirals and antibiotics as appropriate. Measurement of outcomes: The choice of primary outcome measure takes account of the need for simplicity in a trial conducted during a pandemic and of how pandemic severity influences clinical priorities. For a high severity pandemic, a high proportion will be admitted to intensive care, and/or die and so in this situation the primary outcome would be the composite measure of death or admission to intensive c
Complete
493,885.2
75
Health Protection
11/46/21
Health and Social Care Delivery Research
HSDR Commissioned
Dr Gideon Rubin
King's College London
1 August 2012
31 March 2022
Evaluating and improving communication with the public during a pandemic, using rapid turn around telephone surveys
DESIGN: The project has four stages. The first three occur prior to the pandemic, the fourth during the pandemic. Stage 1 consists of meetings with stakeholders and a re-review of existing literature. This will allow us to generate items for a new telephone survey that will assess uptake and predictors of protective behaviours among the general public during a pandemic. Stage 2 consists of three rounds of cognitive interviews which we will use to refine the wording of our new questions. Stage 3 consists of a cross-sectional telephone survey of a randomly selected, demographically representative sample of the British population during a normal flu season, with a one week follow-up of the same sample. Stage 4 consists of weekly telephone surveys conducted during the pandemic, with follow-up of specific samples as required. SETTING: Stages 1 and 2 will take place within King's College London. Telephone surveys in Stages 3 and 4 will recruit representative samples of the general public wit
Complete
565,638.01
76
Health Protection
11/46/22
Health Technology Assessment
HTA Commissioned
Professor Malcolm (Calum) Semple
University of Liverpool
1 January 2013
30 April 2022
Real time refinement and validation of criteria and tools used in primary care to aid hospital referral decisions for patients of all ages in the event of surge during an influenza pandemic.
Design: A prospective analysis, linking criteria in a GP's assessment of patients presenting with syndromic respiratory disease (influenza like illness), to immediate management decisions and patient outcomes. Objective: Assessment, refinement and validation of various triage tools to guide GP referral of patients with syndromic respiratory disease (influenza like illness) during a pandemic in readiness for use should widespread illness exceed health care capacity (surge). Method: GPs using EMISWeb / SystmOne will record their assessment and management of patients with syndromic respiratory disease (influenza like illness) which includes COVID-19, in the routine electronic health care systems. These systems automatically offer structured data capture for various clinical presentations. Such a structured page has been prepared for use in the event of an outbreak of any pathogen of public health interest, initially with intent to function for syndromic presentation of a respiratory illne
Complete
303,839.1
77
Healthcare Public Health and Preventing Premature Mortality
11/95/03
Health Technology Assessment
HTA Commissioned
Professor Jane Morrell
The University of Nottingham
1 November 2012
31 July 2014
An evidence synthesis to evaluate the clinical effectiveness and cost-effectiveness of interventions to prevent postnatal depression.
Design: Systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies. Search strategy: We will 1. use major health-related, and health economic electronic bibliographic databases; 2. consult via the internet key health service organisations and guideline producing bodies; 3. consult national/international experts in research/practice in preventing PND; 4. search the UK CRN Portfolio Database, archive of NRR, CCT and its links, Clinical Trials.gov, HSRProj and Index to Theses to identify ongoing/recently completed research; 5. use existing systematic reviews to identify relevant studies; 6. identify Grey literature; 7. examine reference lists of included studies for further relevant references and, if appropriate, use the citation facility in Web of Science to search for specific papers/authors; 8. restrict searches to English language trials or systematic reviews, with no date restriction. For the qualitative literature synthesis we will include quali
Complete
171,505
78
Healthcare Public Health and Preventing Premature Mortality
12/135/02
Health and Social Care Delivery Research
HSDR Commissioned
Emeritus Professor Martin Roland
University of Cambridge
1 April 2013
30 September 2014
Outpatient services and primary care: scoping review, case studies and international comparisons
This application has been prepared at the invitation of Health Services and Delivery Research (HS&DR) to update an SDO funded review of outpatient services published in 2007 (www.netscc.ac.uk/hsdr/projdetails.php?ref=08-1518-082). The aims of this updated review are similar to those of our previous study, namely to: 1. Identify and review what is currently known about strategies involving primary care that are designed to improve the effectiveness and efficiency of outpatient services. 2. Comment on the impact of such schemes on the organisation of primary care, on the primary care workforce, on access, clinical outcomes for patients and on patient experience. 3. Identify and comment on the potential for innovative models of care to be replicated more widely. 4. Identify the needs for future research in this area, both in terms of primary research and systematic reviews that might be needed. 5. Summarise the findings in a way that will be readily accessible to policy-makers and manager
Complete
250,804.78
79
Health Improvement
12/137/05
Health Technology Assessment
HTA Commissioned
Dr Miranda Pallan
University of Birmingham
1 September 2014
31 May 2017
Development of a culturally adapted weight management programme for children of Pakistani and Bangladeshi origin
We will undertake two work packages (WPs), informed by the MRC complex interventions framework. WP1 (Theoretical and modelling phase): Development of a children's weight management programme that is culturally adapted for Bangladeshi and Pakistani (BP) families, but is suitable to be delivered in a diverse community encompassing multiple ethnic groups. WP2 (exploratory phase): A feasibility study to evaluate the acceptability of the developed weight management programme and to assess the feasibility of a future definitive trial. The setting for the study is Birmingham; a diverse city with 44% of children from minority ethnic groups (MEGs), and 20% from BP communities. The NHS offers a group-based community weight management programme for parents of children aged 4-11 years (First Steps), targeting all ethnic groups. Parents are invited to attend 7 sessions, with the children attending the first and last sessions. Sessions are interactive and practical covering nutrition education, beha
Complete
522,548.31
80
Healthcare Public Health and Preventing Premature Mortality
12/138/02
Health Technology Assessment
HTA Commissioned
Professor Fiona Burns
University College London
1 June 2014
30 September 2016
Feasibility and acceptability of home sampling kits to increase the uptake of HIV testing among black Africans in the United Kingdom: The Haus study.
Design: We propose a two stage, mixed-method design. Health technology being assessed: An HIV home sampling kit (HSK) collection device for use with a lab-based screening test for HIV. Stage I Aim: To develop an HSK-based intervention to increase the provision and uptake of HIV testing among black Africans using existing community and healthcare provision. Specific objectives: 1. Clarify barriers and facilitators to provision, access and use of HIV HSK by black Africans, in primary care, pharmacies and community outreach 2. Determine appropriate HSK-based intervention models for different settings 3. Determine control population and robust HIV result management pathways 4. Develop intervention manuals to enable intervention delivery Settings: •London and Glasgow. •Primary care, pharmacies, and community outreach programs. Target populations: •Black African adults. •GPs, pharmacists, and community based organisations in contact with black African communities. •HIV prevention & HIV care
Complete
491,050.28
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