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Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | Award_Holder_Name | ORCiD | Involvement_Type | HRCS _Health_Category | HRCS_RAC_Category | UKCRC_Value_RAC | NIHR_Curated_Portfolio | Downstream_Partner_Country |
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Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | Award_Holder_Name | ORCiD | Involvement_Type | HRCS _Health_Category | HRCS_RAC_Category | UKCRC_Value_RAC | NIHR_Curated_Portfolio | Downstream_Partner_Country | |
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1 | 001/0013 | Preventing Falls amongst Older People: Socio-Economic and Ethnic Factors | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £179.782 | 1 september 2004 | 31 maart 2008 | BackgroundFalls and fractures amoungst older people are a major public health challenge. Suprisingly little is known about the association of falls and use of falls-related services with socio economic status and ethnicity. The present proposal is for a series of three studies to investigate the question: 'what are the socio-economic and ethnic differences in fall-related morality, morbidity, health care seeking behaviour and provision of services?' The first study will perform novel secondary analysis on three different existing data sources (ONS morality statistics, Hospital Episode Statistics (HES), and Health Survey for England (HSE). This will provide statistics variation in falls and health care seeking behaviour, but will not permit us to identify the reasons for observed variations, and may not provide sufficient data on ethnic minorities. To supplement the data on ethnic variations and to identify the reasons for variations we will undertake new primary research by carryi | Academic | The University of Manchester | M13 9PL | 53,467 | -2,234 | Professor Chris Todd | 0000-0001-6645-4505 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
2 | 001/0016 | Estimating Costs and Quality of Life Loss Due to Fractures | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £36.227 | 1 augustus 2004 | 31 maart 2008 | BackgroundEstimating the costs and quality of life loss due to fractures and falls.Fractures and falls are a serious cause of morbidity and cost society. The cost burden of fractures t society has been estimated in the region of 1.8 billion. Equally important is the health related quality lii loss (HRQoL) due to hip and other fall related fractures. In this proposal we seek to take advantage of number of data-sets we have to ascertain the cost and quality of life consequences of both fractures an falls in a primary care sample of women and a secondary care sample of men. These data will also allot a more detailed description of the costs and consequences of fractures. treatment received, length of stay at hospital, length of stay at residential care/ sheltered or nursing accommodation, and social services support. Resource use data will be combined with 2004 unit prices to obtain an updated estimate of the cost of treating hip, wrist, vertebral and other fractures. The data produced fr | Academic | University of York | YO10 5DD | 53,948 | -1,054 | Professor Cynthia Iglesias | 0000-0002-3426-0930 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
3 | 001/0017 | The Long Term Health and Health Care Outcomes of Accidental Injury | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £330.750 | 1 oktober 2004 | 31 januari 2008 | BackgroundBackground: Some previous research has examined long-term disability resulting from accidental injury using a wide variety of different measures, but little is known about quality of life and costs. The long-term health and health care burden in different types of accidents, patients, and injuries is also uncertain, and hence priorities for prevention and public health research are not evidencebased.Aims: This research project aims to quantify the long-term mortality, morbidity, and costs arising in different groups of accidentally injured patients. Morbidity will be assessed in terms of quality of life and post-traumatic stress as well as disability, and the overall burden of injury will be measured using Quality Adjusted Life Years lost.Design: Six existing injury datasets will be re-examined. Five of these datasets were collected by the Medical Care Research Unit in Sheffield between 1988 and 1997, and include a total of 8,588 injured patients admitted to over 50 different | Academic | University of Sheffield | S10 2TN | 53,381 | -1,489 | Professor Jon Nicholl | 0000-0001-5436-1264 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
4 | 001/0018 | Neighbourhood and Household Influences on Injuries to Preschool Children | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £159.022 | 1 oktober 2004 | 31 januari 2009 | BackgroundInjuries caused by accidents are a particular problem in young children and children's injury rates vary considerably from place replace Low-income neighbourhoods have higher child injury rates than high-income neighbourhoods, and recent research suggests that only part of the difference is due to variations in the social, economic and demographic composition of local populations. This research aims to find out the relative contributions of family characteristics and neighbourhood features to the risk of injury to children aged 0-4 years in Bristol and its surrounding region, to discover some of the mechanisms that create patterns of inequality. The objectives are:" to determine the risk factors acting at the level of the child, the household and the neighbourhood, and whether these risks act independently," to determine whether residents' perceptions ofneighbourhood and local social networks are related to geographical variations in the risk of injury," to determine the size | Academic | University of East Anglia | NR4 7TJ | 52,622 | 1,241 | Dr Robin Haynes | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
5 | 002/0010 | Cardiac Rhythm and Personal Exposure to Air Pollution in Patients with Heart Failure | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £249.178 | 1 oktober 2002 | 30 september 2007 | BackgroundThe majority of excess deaths associated with rises in air pollution appear to be from cardiac causes. Particles and nitrogen dioxide are the pollutants most closely associated with this effect but which of these, and the mechanisms, remain speculative. The hypothesis is that the effects are mediated by secondary changes in blood coagulability. Another is that pollution causes changes in the irritability of the heart, with changes in rate, rhythm and variability. These hypotheses are not in conflict and this project will investigate both.The study will look at the associations between exposure to particles and NO2, alterations in cardiac rhythm, and coagulation factors in 100 patients recrutied from 200 with stable heart failure. In each it will measure personal exposure to NO2 and estimate personal exposure to particle mass and number for 3 consecutive days on six separate occasions over a year. On the 3rd day it will record a 24-hour cardiograph and take blood for ind | Academic | University of Aberdeen | AB24 3FX | 57,165 | -2,100 | Professor Anthony Seaton | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
6 | 002/0015 | Health Effects of Long-Term Exposure to Air Pollutants in Scotland | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £188.761 | 1 april 2003 | 30 juni 2007 | BackgroundThe purpose of the proposed research is to simultaneously quantify the health effects of long-term exposure to air pollutants and shortening of life from short-term exposures. Primary outcome measures are cause-specific mortality and morbidity , with particular attention to cardiovascular outcomes. We will compare the results of cohort studies to corresponding estimates from time-series studies of the population from which the cohorts are drawn. Outcomes in 26,360 subjects in 3 cohorts will be investigated in the period between 1970 and 2002. Detailed baseline risk data and the unique advantages of the Scottish Health Record Linkage system (including algorithmic linking of individual hospital admission & mortality records) will enable novel ways of quantifying effect magnitudes in susceptible population sub-groups, and coherence in medical outcomes. We shall examine the potential for confounding and effect modification by both individual and aggregate level factors (including | Academic | University of Strathclyde | G1 1XQ | 55,861 | -4,245 | Dr Iain Beverland | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
7 | 002/0017 | Quantitative Systematic Review of Short Term Associations between Ambient Air Pollution (Particles, Ozone, Nitrogen Dioxide, Sulphur Dioxide and Carbon Monoxide), and Mortality and Morbidity | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £48.834 | 1 februari 2004 | 30 november 2007 | BackgroundThe published literature on the short term associations between air pollution and health is now very large. The traditional narrative review is no longer appropriate and there is now a trend towards adopting the methods of systematic review and meta-analysis (statistical combination of results from a number of studies) in the evaluation of observational epidemiological evidence. At the same time, there is a demand for more information about the size and consistency of estimates, and about factors affecting heterogeneity across different environments. Very few existing reviews have carried out quantification or have been reported to be systematic. We have identified all published literature and created a database of the relevant data. Up to August 2001, there were 242 time series studies of daily mortality or morbidity (eg hospital admissions) and 95 studies of daily lung function and symptoms in panels of subjects. These studies describe thousands of pollution-outcome e | Government/NHS | St George's University Hospitals NHS Foundation Trust | SW17 0QT | 51,427 | -0,176 | Professor Ross Anderson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
8 | 002/0039 | 2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £24.052 | 1 januari 2013 | 31 december 2013 | Organisation and conduct of a 2 day air pollution and health research review meeting on 23 & 24 April 2013. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2013 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site. | 2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research | Academic | Cranfield University | MK43 0AL | 52,070 | -0,631 | Dr Derrick Crump | Not Provided | Chief Investigator | Respiratory | 2. Aetiology | 2.2 Factors relating to physical environment | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
9 | 004/0080 | The Childhood Cancer Research Group | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2.201.890 | 1 januari 2008 | 30 april 2011 | BackgroundGeneral BackgroundThe Childhood Cancer Research Group (CCRG) is based in the University of Oxford. Currently housed at 57 Woodstock Road, Oxford OX2 6HJ, it is administratively part of the University Department of Paediatrics (itself located across several sites, several miles away). For the foreseeable future, the core funding of the CCRG is envisaged to come from the Department of Health for England (& Wales) through the Policy Research Programme, with a further contribution made on behalf of the Scottish Ministers. Additional funding from other sources is therefore to be sought in a complementary rather than substitutive fashion.The CCRG houses the National Registry of Childhood Tumours (NRCT) - a population based register of malignancies and benign brain tumours diagnosed in children (less than 15 years of age), and domiciled in England, Wales or Scotland at the time of diagnosis - which covers the 1950s incompletely and the period 1962 to the present day as completely | Academic | University of Oxford | OX1 2JD | 51,758 | -1,262 | Dr Michael Francis Grant Murphy | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
10 | 004/0086 | Modelling of Impact of Increasing GP Access to Diagnostic Tests for Cancer | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £39.890 | 1 november 2010 | 16 juni 2011 | Bowel cancer (or colorectal cancer) is the second most common cancer in England, with 30,727 new cases diagnosed in 2007 (ONS). However pathways for the diagnosis, treatment, and follow-up of bowel cancer vary considerably across England. In 2005 the Department of Health commissioned a study to assess the costs and benefits of the current bowel cancer service and the expected costeffectiveness of options for change to ensure that investment in bowel cancer services is directed to those areas that will give maximum benefit to patients. This study involved the development of a mathematical model of the pathways of care experienced by people who are suspected of having colorectal cancer and traces them through to either a negative „all clear? diagnosis or through subsequent treatment. This work informed the Cancer Reform Strategy of 2007. The work proposed here will develop the previous modelling of the colorectal cancer system specifically to examine ways of supporting primary care in | Background (400-800 characters): ScHARR has an internationally recognised work programme in colorectal cancer modelling. The models that ScHARR develops and maintains encapsulate the best current hypotheses regarding disease epidemiology and natural history, diagnostic test characteristics, treatment options and the organisation and delivery of cancer services within the UK. These models are used to provide support for policy decision making and the design of intervention evaluation studies, to develop and test hypotheses regarding disease natural history and to support the optimal design of interventions in the light of the full evidence base. This work programme has impacted directly on the Cancer Reform Strategy of 2007, the establishment of screening programmes in England and Ireland and on many NICE guidelines. Aims (400-800 characters): The research aims to understand the impact on lives saved and healthcare resources required of (i) introducing direct access to col | Academic | University of Sheffield | S10 2TN | 53,381 | -1,489 | Mr Jim Chilcott | Not Provided | Chief Investigator | Cancer and neoplasms | 8. Health and Social Care Services Research/8. Health and Social Care Services Research | 8.1 Organisation and delivery of services/8.2 Health and welfare economics | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
11 | 006/0034 | National Perinatal Epidemiology Unit (Jan 2006 - Dec 2010) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £5.818.310 | 1 januari 2006 | 31 oktober 2011 | BackgroundAs the future Programme of Work covers the period 2006-2010, we are aware that much of the work the NPEU will undertake in this period cannot be precisely specified at this stage as policy imperatives may change and new opportunities and priorities are difficult to predict. Therefore, the specific projects referred to in this document are mostly those that will be started early in the next Programme of Work and for which there is already a clear idea that the project is necessary and feasible. The current document assumes that all of the resources requested from the Department of Health for the proposed future Programme of Work 2006-2010 are granted. In addition, further prioritisation will take place following on-going discussions between the NPEU and the Department of Health RDD and Policy teams.Cross-cutting Theme 1: Service organisation and delivery Service provision, organisation and staffing are key inter-linked aspects of maternity care . The NSF places emphasis on | Academic | University of Oxford | OX1 2JD | 51,758 | -1,262 | Professor Peter Brocklehurst | 0000-0002-9950-6751 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Social Care | Award does not have an ODA Downstream Partner | ||
12 | 006/0035 | 4CHILD - The Four Counties Database of Cerebral Palsy, Vision Loss and Hearing Loss in Children | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £368.804 | 1 april 2003 | 31 januari 2009 | BackgroundAims: . To continue to monitor the rates and characteristics of children with major motor and sensory impairment born since 1984. . To provide support for local, regional and national research initiatives involving the ORECI data. (see Appendix 2) . To participate in research within the network of UKCP registers (Appendix 3). . To collaborate with 14 centres in Europe (SCPE) to develop a central database of children with cerebral palsy and for research (Appendix 4). Subject group: ORECI is a population-based register of childhood impairment. It includes all children with cerebral palsy, severe vision loss and/or sensorineural deafness born since 1984 to mothers resident in the four counties of Berkshire, Buckinghamshire, Northamptonshire and Oxfordshire. The register covers a population of 2.6 million and a birth population of 35,000 babies per year, which represents 5% of all births in England. Approximately 1700 children with impairments have been included on the regist | Academic | University of Oxford | OX1 2JD | 51,758 | -1,262 | Professor Jennifer Kurinczuk | 0000-0001-9554-6337 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
13 | 006/0036 | The Northern Congenital Abnormality Survey: A Collaborative Survey of Congenital Anomalies in the Northern Region | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £427.079 | 1 april 2003 | 31 januari 2009 | BackgroundCongenital anomalies are a significant cause of stillbirth and infant mortality accounting for around 1,000 stillbirths and 1,250 infant deaths in England and Wales annually. They also contribute to morbidity in the first years of life and beyond. The Northern Congenital Abnormality Survey (NorCAS), established in 1984, is an ongoing population based register of all congenital abnormalities arising within the population of the former Northern Region whether occurring in miscarriages, terminations of pregnancy or registered births, and whether diagnosed antenatally or later. Notification of cases is made from multiple sources, and all obstetric units in the Region contribute to the survey enabling high case ascertainment. It is managed by the Northern & Yorkshire Public Health Observatory in partnership with academic departments at Newcastle University. NorCAS is more complete than the National Congenital Anomaly System due to the strong local clinical network and the inclusio | Academic | University of Newcastle upon Tyne | NE1 7RU | 54,980 | -1,616 | Professor Judith Rankin | 0000-0001-5355-454X | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
14 | 006/0060 | Evaluating the Family Nurse Partnership Programme in England: a Randomised Controlled Trial | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £5.167.489 | 1 oktober 2008 | 31 maart 2016 | The Family Nurse Partnership (FNP) is a programme of home visits by specially trained nurses to support young first time mothers during their pregnancy and up to two years after birth. It has been developed in the US, and is currently undergoing an initial evaluation in England. Our proposed study will evaluate the impact of the FNP upon the health and well-being of both mother and child during pregnancy and childbirth and, in the first two years after birth, the child’s development and the mothers’ well-being. Measurements will include the baby’s weight, accidents and injuries to the young child and whether the mother has further pregnancies within the next two years. In the 20 geographical sites taking part in the study, 2400 women under 20 years old will be allocated at random to either enter the FNP programme or to continue receiving only existing local services for pregnant women. A research nurse will interview all participating women face-to-face at the start and end of the stud | BackgroundThe Family Nurse Partnership (FNP) is a structured programme of home visits delivered by specially trained nurses for at-risk first time mothers. Part of the Child Health Promotion Programme, this intensive intervention has been introduced to address the elevated risk of social exclusion and health disadvantage that such women and their off-spring face. The programme aims to modify behavioural risk factors and enhance protective factors through regular home visits that start in early pregnancy and continue until the child’s second birthday. Based on the original US programme which has been widely evaluated, the FNP is currently undergoing formative evaluation at 10 English sites. Ten more sites will join to form a sample for a trial of the effectiveness and cost-effectiveness of the FNP.AimsOur study aims firstly to evaluate the effectiveness of the FNP within three outcome domains: pregnancy and birth, child health and development, and parental life course and self-sufficien | Academic | Cardiff University | CF24 0DE | 51,484 | -3,166 | Professor Michael Robling | 0000-0002-1004-036X | Chief Investigator | Blood/Neurological | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.1 Primary prevention interventions to modify behaviours or promote well-being | Social Care | Award does not have an ODA Downstream Partner | |
15 | 006/0068 | Pre-Pregnancy Health and Care in England: Exploring Implementation and Public Health Impact | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £414.832 | 1 januari 2011 | 30 april 2014 | Research shows that the health and care of women and their partners before pregnancy and in the first weeks when a women may not realise she is pregnant is very important. Good health and pre pregnancy care at this time can improve the wellbeing of the baby and lead to the prevention of future disease in adulthood. Pre pregnancy care involves women and men taking care of themselves before pregnancy by eating healthily, not smoking and following guidelines for lifestyle and dietary advice. Women should take folic acid tablets to prevent spina bifida twelve weeks before pregnancy and for the first twelve weeks. Medication should be reviewed and environmental hazards avoided to prevent damage to the baby. Research has shown that many women and men are not aware and do not comply with guidelines for pre pregnancy care with only half to two-thirds of women planning their pregnancies. A study is proposed to examine pre-pregnancy health and care in England to find out which issues are imp | BackgroundGood maternal & paternal health before and at conception can shape a child's future life course. This raises the importance of pre pregnancy care for screening, prevention & management of risk factors that affect pregnancy outcomes & the future health of families. There is little information about the provision of pre pregnancy care in England. Better understanding of the bio-psychosocial, cultural and economic factors affecting access to pre pregnancy care is needed if services are to be improved and more pregnancies planned. Only about 50% of pregnancies are planned. Holistic study of the complexity of health care before and between pregnancies is needed to identify interventions that are effective & acceptable to women & men, and the key contextual factors that enable health gain.AimsThe overall aim of the study is to provide high quality evidence regarding the implementation & public health impact of pre pregnancy health & care for women & men in England in order to infor | Academic | University College London | WC1E 6BT | 51,524 | -0,132 | Professor Judith Stephenson | 0000-0002-8852-0881 | Chief Investigator | Reproductive Health and Childbirth | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
16 | 007/0015 | Adsorption of Prion Isoforms to Stainless Steel Surfaces: Implications for Surgical Decontamination Procedures | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £176.042 | 1 december 2006 | 31 januari 2009 | BackgroundVariations of grant management and staff. (i) the PI of this proposal has been moved from IAH to NIMR in 2005; (ii) it is now proposed to continue this project at the NIMR and to employ a new Research Assistant to carry out planned experiments on various cellular models including human and mouse neurospheres derived from EC and ES cells.Variations of animal and cellular studies. Some of the original experiments that were planned to be performed with animals will be carried out with human and mouse cellular models. We suggest restricting all experiments to human and mouse neurospheres derived from human embryonic carcinomas and mouse embryonal stem cells, focusing on the toxicity and physiological activity of endogenous PrP material obtained from cellular homogenates with elevated level of PrP expression, and also from blood serum. In addition various oligomeric and fibrillar forms of recombinant PrP protein will be tested using the same cellular models. Cell lines expressing | Undefined | MRC National Institute for Medical Research | NW7 1AA | 51,618 | -0,220 | Professor Guy Dodson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
17 | 007/0073 | Development of Rapid Visual and Epimicroscopy Techniques | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £755.147 | 1 januari 2002 | 31 maart 2009 | BackgroundAdvanced light microscopy techniques will be used to assess contamination of various grades of surgical steel coupons and medical instruments, initially using mucins, heparin sulphate and chondroitin sulphate, as models of saliva or brain glycosaminoglycan contamination, and blood. A mouse animal model will be used to supply infected brain homogenate for these contamination studies. Contaminated steel surfaces will be treated with proteinase K to remove normal prion and other brain material, leaving PrPsc which will be scraped/washed off, concentrated by ultrafiltration (assayed by two site ELISA) and serial dilutions injected into the brains of mice to show that the material is still infective. Sensitive pathological and behavioural measures will be used to assay for evidence of low levels of infectivity that might not lead to overt clinical disease.The industrial collaborators (Microgen Bioproducts) have developed a diagnostic kit capable of detecting specific protein ac | Academic | University of Southampton | SO17 1BJ | 50,934 | -1,396 | Professor Bill Keevil | 0000-0003-1917-7706 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
18 | 007/0074 | Heart Rate Variability as an Aid to Diagnosis of vCJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £102.349 | 1 januari 2002 | 30 juni 2004 | BackgroundThis is a pilot study to evaluate whether there is any clinical utility in the use of heart rate variability (HRV) measurement as a non-invasive, ante-mortem differential diagnosis for vCJD in human subjects. It has been suggested that the vagus nerve is the primary route of neuroinvasion of TSE agent after oral challenge. In that event, the vagal nuclei of the medulla oblongata are the first sites where abnormal prions will have the opportunity to damage the central nervous system. HRV is a widely used tool for assessing medullary brainstem function, and the objective of this study is to determine whether vCJD does affect HRV in an objectively quantifiable manner. HRV has already been described as a putative test for BSE in cattle in two patents filed by independent University research groups. AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJEC | Academic | The University of Manchester | M13 9PL | 53,467 | -2,234 | Dr Chris Pomfrett | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
19 | 007/0077 | Removal of Infective Protein Residues from Medical Instruments | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1.295.022 | 1 juni 2002 | 31 juli 2011 | BackgroundThis project has the objective of developing new methods to remove and verify the removal of prions from surgical instruments. The project consists of three interactive themes: 1) the development of plasma cleaning methods for the removal of biologically derived materials; 2) the development of 'on-line' fluorescence techniques for detection of protein residues; 3) biological verification of these methodologies. The outcome of the project will be an integrated and verified strategy for the decontamination and screening of surgical instruments.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field | Academic | University of Edinburgh | EH8 9YL | 55,948 | -3,187 | Professor Robert Baxter | Not Provided | Chief Investigator | Neurological | 5. Development of Treatments and Therapeutic Interventions | 5.3 Medical devices | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
20 | 007/0085 | Gene Targeted Transgenic Mice Expressing Human PRP as Models for Studying CJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £763.947 | 1 april 2003 | 31 mei 2007 | BackgroundWe have produced transgenic mice in which the endogenous murine PrP gene has been altered by gene targeting to replace the murine PrP coding region with that of human PrP. One line encodes 129MM and the other 129VV. This proposal aims to assess potential of these mice as models to study CJD, strains of TSE in humans and the influence of the 129 polymorphism in disease susceptibility. Mice will be innoculated with brain material which has been prepared in a WHO collaborative study as an International Reference Material for Diagnosis and Study of TSEs. Five different brains have been prepared and aliquoted at NIBSC, two sporadic CJD, one variant CJD and one non-CJD control all from 129MM individuals and one sCJD from a 129M129V individual. Material from a sCJD individual carrying a PrP gene encoding V129V129 (available from the CJD Surveillance Unit) will also be used in the study. For each successful transmission, strain typing, PrP deposition and PrPSc analysis will be carrie | Undefined | Institute for Animal Health | Professor Jean Manson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |||||
21 | 007/0094 | CJD Surgical Instrument Storage Facility | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £423.971 | 1 maart 2003 | 31 december 2013 | BackgroundA facility is required by the Department of Health for the long-term secure storage of surgical instruments used in connection with the treatment of patients subsequently found to be incubating variant Creutzfeld-Jakob disease (vCJD). The instruments used on each patient need to be fully identified and securely packaged on site prior to collection from surgical units in a safe and uniform manner. Following receipt, the instrument containers require rack-mounted storage in an environmentally controlled room for extended periods. The containers must be held in such a form that they can subsequently be sent out identified but unopened to researchers with appropriate facilities for further investigations.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] fi | Government/NHS | Public Health England | SE1 8UG | 51,502 | -0,109 | Dr J. Mark Sutton | 0000-0002-2288-0446 | Chief Investigator | Neurological | 2. Aetiology | 2.6 Resources and infrastructure (aetiology) | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
22 | 007/0101 | Surveillance for Asymptomatic Prion Infection in Primary Immunodeficiency Patients Exposed to UK Sourced Immunoglobulin | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £339.983 | 1 september 2006 | 31 maart 2015 | Variant Creutzfeldt-Jakob disease (vCJD) is a type of dementia, caused by an abnormal prion which originally came from cattle with ‘mad cow disease’ or bovine spongiform encephalopathy (BSE). In addition, we know that human to human transmission can occur. Blood donors who at the time were unaware that they were infected with vCJD, donated blood which infected recipients with vCJD. There are 3 known cases in the UK. This has only happened in the UK. Immunoglobulin is a product derived from blood used primarily to treat patients with antibody deficiencies. Each injection is made from several thousand blood donations. This means that any immunoglobulin infected with vCJD could possibly spread abnormal prions from person to person. Our research is to find out if this has happened to patients exposed to British-sourced immunoglobulin and we have recruited volunteers to participate in the study. VCJD and other prion diseases can only be diagnosed from tissue samples. We are collecting tissu | BackgroundThe possibility that the abnormal prions responsible for variant Creutzfeldt-Jakob disease (vCJD) may be transmitted through plasma products has considerable ramifications for patients with Primary Immunodeficiency (PID) receiving immunoglobulin.Although abnormal prions are transmissible by whole blood between animals, there are no data showing this can happen between humans. Abnormal prions can now be detected in lymphoid tissue from asymptomatically infected individuals with reasonable specificity and sensitivity. The technology to detect abnormal prions in blood samples is also improving.The proposed project will be carried out on approximately 130 PID patients exposed to UK sourced immunoglobulin between 1996 and 1998, attending PID centres across the UK. The proposal is to produce:- a confidential data base containing exposure details and prospective clinical evaluations- a retrospective and prospective collections of lymphoid and spleen material for histological prio | Government/NHS | Manchester University NHS Foundation Trust | M13 9WL | 53,462 | -2,228 | Dr Matthew Helbert | Not Provided | Chief Investigator | Neurological | 2. Aetiology | 2.4 Surveillance and distribution | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
23 | 007/0108 | Prion 1 Clinical Trial | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2.749.330 | 1 juni 2004 | 31 augustus 2008 | BackgroundBackground: The propagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, involves post-translational conversion of normal cellular prion protein (PrPC) to disease-associated forms (PrPSc). Quinacrine, an anti-malarial agent that potently blocks PrPSc production in vitro, was administered to patients with a variety of prion diseases to assess its safety and efficacy in altering the course of these invariably fatal and untreatable diseases.Methods: Patients with prion disease were recruited from neurologists in the UK and were offered a choice between: (1) randomisation to immediate, versus deferred (by six months), quinacrine; (2) immediate quinacrine; (3) no quinacrine. The primary endpoints were death and serious adverse events possibly/probably related to quinacrine.Findings: 107 patients were enrolled (45 sporadic, 2 iatrogenic, 18 variant and 42 inherited), 23 in a pilot and 84 in the main study. Only 2 patients chose random | Non-Profit/Charity | Medical Research Council | SN2 1FL | 51,567 | -1,785 | Professor John Collinge | 0000-0003-2220-7566 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
24 | 007/0110 | Evaluation of Ozone Sterilisation as Methods for Inactivation of TSE Agents | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £383.659 | 1 april 2005 | 31 januari 2009 | BackgroundThis project aims to evaluate a novel sterilisation protocol based on ozone as a method for the inactivation of TSE agents, specifically BSE/vCJD on surgical instruments. The proposal will be carried out as part of a larger package of work in collaboration with the manufacturer of the ozone steriliser (TSO3 inc, Quebec, Canada), University of Montreal and Health Canada. Current studies by TS03 have demonstrated the potential of ozone to destroy prions as assessed by Western blot and are currently looking at bioassays of scrapie strain 263K in hamsters.This section of work will evaluate the ability of an ozone steriliser to inactivate the BSE agent in direct comparison with a standard steam sterilisation protocol. The work will use BSE 301V dried onto surgical steel wires and implanted directly into the brain of VM mice, to generate a worse case for the possible entry of CJD into the human brain following neurosurgery. The inactivation process will be assessed principally agai | Academic | Health Protection Agency | NW9 5EQ | 51,595 | -0,255 | Dr J. Mark Sutton | 0000-0002-2288-0446 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
25 | 007/0120 | The Effect of Leucodepletion on Transmission of BSE by Transfusion of Sheep Blood Components | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £795.296 | 1 november 2005 | 31 maart 2007 | BackgroundThis project will use sheep experimentally infected with BSE as a model to study the risks of transmission of variant CJD by blood components in humans. The aim of the project is to determine the distribution of BSE infectivity in sheep blood components, and the effectiveness of human leucodepletion filters in removing infectivity. The methods used for collection of blood and separation and filtration of components will follow as closely as possible those routinely employed for human blood by transfusion services, and will initially be developed and validated for normal sheep blood in the laboratories of SNBTS. A secondary aim of the project is to develop a bioassay for measurement of titres of infectivity in blood components, using transgenic mouse lines that over-express ovine PrP. The sheep experiments will be carried out using BSE-infected donors and will assess the effect of leucodepleting blood components (plasma, platelets and erythrocytes) on transmission at a single | Undefined | Institute for Animal Health | Dr Fiona Houston | 0000-0002-4082-2274 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |||||
26 | 007/0160 | Gene Targeted Transgenic Mice Expressing Human PRP as Models for Studying CJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £203.761 | 1 april 2007 | 31 augustus 2008 | BackgroundWe have produced transgenic mice in which the endogenous murine PrP gene has been altered by gene targeting to replace the murine PrP coding region with that of human PrP. One line encodes 129MM and the other 129VV. This proposal aims to assess potential of these mice as models to study CJD, strains of TSE in humans and the influence of the 129 polymorphism in disease susceptibility. mice will be innoculated with brain material which has been prepared in a WHO collaborative study as an International Reference Material for Diagnosis and Study of TSEs. Five different brains have been prepared and aliquoted at NIBSC, two sporadic CJD, one variant CJD and one non-CJD control all from 129MM individuals and one sCJD from a 129M129V individual. Material from a sCJD individual carrying a PrP gene encoding V129V129 (available from the CJD Surveillance Unit) will also be used in the study. For each successful transmission, strain typing, PrP deposition and PrPSc analysis will be carrie | Undefined | The Roslin Institute | EH25 9RG | 55,866 | -3,201 | Professor Jean Manson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
27 | 007/0161 | Conditional Expression of PRP in the Gut of Transgenic Mice to Investigate the Uptake of Infectivity in the Gut in the TSEs | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £831.419 | 1 april 2007 | 31 januari 2011 | BackgroundWe aim to establish whether PrP expression in the gut is required for the uptake of TSE infectivity and whether in the absence of intestinal PrP expression, uptake and transport of infectivity to peripheral sites of agent replication is blocked. We will address this using two lines of gene-targeted transgenic mice which allow us to control the expression of the PrP gene in a temporal and/or spatial fashion. These mice allow us to switch PrP expression on (NS line) or off (ORFR line) when crossed with Cre recombinase transgenic mice. We will cross the ORFR and NS lines with an inducible P450-Cre line which expresses Cre recombinase in the stem cells of the intestine following administration of the p450-inducer, beta-napthoflavone. Used in conjunction with an inducible neurone-specific Cre line we will be able to control PrP expression in the intestine and neurones prior to orally infecting with a murine TSE agent. These studies will determine the potential for early inter | Undefined | The Roslin Institute | EH25 9RG | 55,866 | -3,201 | Professor Jean Manson | Not Provided | Chief Investigator | Neurological | 2. Aetiology | 2.1 Biological and endogenous factors | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
28 | 007/0169 | Investigating Dental Treatment as a Possible Risk Factor for Variant CJD | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £256.621 | 1 april 2008 | 30 september 2009 | BackgroundLittle work has been performed examining accurate past dental history of CJD cases and controls by direct review of dental records. The NCJDSU has MREC approval to collate information from the medical records of CJD cases and matched controls. Following on from a DH funded pilot study, this study will attempt to access the dental case records of UK variant CJD cases (n=166 as of 9/8/07) and 166 general population controls. In addition, payment schedule records will be accessed where possible in collaboration with NHSBSA Dental Practice Division (England and Wales) and NHSNSS Information and Statistics Division (Scotland). The case record and payment schedule data will be reviewed by a dental healthcare professional and will, where possible, include the presence or absence of oral disease, dates and types of treatment performed and additional risk factor information, e.g., human dura mater grafting. Data will be coded and entered into a database for subsequent analysis. Geogra | Academic | University of Edinburgh | EH8 9YL | 55,948 | -3,187 | Dr Hester Ward | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
29 | 009/0036 | A Randomised Controlled Trial of a Nurse-Led Self-Management Intervention for Patients Admitted to Hospital with Heart Failure | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £223.102 | 1 januari 2004 | 29 februari 2008 | BackgroundHeart Failure is associated with high costs and poor outcome. Patients with this diagnosis are expected to adhere to a complex behavioural regimen including taking medication, monitoring for signs of fluid re-accumulation and a range of life-style changes. Without intervention adherence is about 50%. Standard education alone does not modify this figure. We aim to explore the hypothesis that a brief nurse-Ied self-management intervention will empower patients to positively modify their behaviour and so outcome. The efficacy of this intervention, based on a problem solving approach using cognitive behavioural principles, will be assessed by a randomised controlled trial of 250 patients admitted to hospital with a definite diagnosis of heart failure, randomised to either the nurse-Ied intervention or standard hospital care. The primary outcome measure will be the number and duration of re-admissions at three months. Secondary analyses include costs, mortality at 12 months and pr | Government/NHS | Whittington Health NHS Trust | N19 5NF | 51,566 | -0,139 | Dr Suzanna Hardman | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
30 | 009/0037 | A Randomised Controlled Trial of Exercise Rehabilitation in Addition to Specialist Heart Failure Nurse Intervention | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £312.248 | 1 februari 2004 | 30 september 2007 | BackgroundAims To investigate: (i) whether there are benefits from including exercise rehabilitation with specialist heart failure nurse management for patients with heart failure; (ii) the cost-effectiveness and patient acceptability of a predominantly home-based programme of rehabilitation; (iii) the patient experience of heart failure and exercise rehabilitation. Research Subject Group 11 (iv) Does multidisciplinary care improve outcomes? 11 (v): Patient and carer centred studies. Sample 270 patients admitted with decompensated heart failure or classified as NYHA III in previous 12 months, seen at a specialist heart failure clinic at a trust serving an inner city, multi-ethnic population. Methods RCT of exercise rehabilitation. The intervention group will be offered a predominantly home-based exercise programme to avoid the problems of low uptake and adherence to hospital rehabilitation programmes, in addition to specalist heart fail | Academic | University of Birmingham | B15 2TT | 52,453 | -1,928 | Professor Kate Jolly | 0000-0002-6224-2115 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
31 | 011/0035 | Barriers to the Effective Treatment of Injecting Drug Users | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £84.036 | 1 oktober 2005 | 30 juni 2007 | BackgroundThe proposed study will build on existing research to provide essential information on how IDU engagement with services can be improved and the cost/ benefit implications of successfully increasing take-up. Specifically, it will combine qualitative and economic data to investigate the nature and extent of barriers to the effective treatment of IDUs; the particular circumstances in which barriers do/ do not prevent ]DUs accessing treatment; how barriers may vary between key IDU sub-groups and between service types; ways of removing barriers to treating IDUs; the costs of IDUs not entering treatment; and the costs of removing barriers to IDU treatment. Following an initial review of the literature, in-depth interviews - incorporating structured economic components - will be conducted with 75 injectors recruited from needle exchanges in Leeds, and urban and rural West Yorkshire. Data will be collected on socio-demographic characteristics; life circumstances; drug use; treatment | Academic | Oxford Brookes University | OX3 0BP | 51,754 | -1,223 | Professor Joanne Neale | 0000-0003-1502-5983 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
32 | 011/0038 | User Involvement in Efforts to Improve the Quality of Drug Misuse Services: Factors That Promote and Hinder Successful Working | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £119.949 | 1 september 2005 | 30 september 2007 | BackgroundUser involvement has been recommended as a means of improving service quality. While research in other fields has identified factors which enhance effective involvement, very little independent research into user involvement in drug services has taken place.We therefore propose to combine a cross-sectional survey of service providers and user groups with a series of in-depth case studies with the aim of evaluating methods for user involvement. We will survey Trusts, voluntary sector service providers and user groups in 50 Drug Action Team areas and collect qualitative data from service providers and users in six areas through in-depth interviews, focus groups and non-participant observation. By combining the collection and analysis of qualitative and quantitative data we will estimate the level of user involvement in efforts to develop more accessible, acceptable and effective drug misuse services, examine different methods used for involving service users, and investigate fa | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51,498 | -0,177 | Professor Mike Crawford | 0000-0003-3137-5772 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
33 | 011/0041 | Exploring Young People's Views and Experiences of Drug Treatment Services - A Qualitative Study | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £101.054 | 1 september 2005 | 31 maart 2008 | BackgroundAbstract of Research: No more than 200 words covering the following topics: aims of project; research subject group; sample size, type and location; methods of working. Exploring young people's views and experiences of drug treatment services- a qualitative study. This study will inform policy and practice in the area of drug treatment services for young people. It will provide insights into:- Young people's decision to seek and processes leading to treatment- including barriers young- people faced in accessing treatment;Young people's views and experiences of treatment services;- The perceived impact of treatment on young people's lives- including any impact on their drug- use, associated risk behaviours, offending behaviour, mental and physical well-being and overall quality of life;The perceived impact of factors other than treatment on the level and nature of drug use in- which young people engage (identifying factors that may contribute to a young person's resilience to | Academic | National Centre for Social Research | EC1V 0AX | 51,527 | -0,103 | Ms Jane Lewis | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
34 | 011/0043 | Interventions for Children and Families Where There is Problematic Drug Use: The Development and Evaluation of an Inter-Agency Model of Good Practice in Devon | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £102.500 | 1 september 2005 | 30 juni 2008 | BackgroundThis study aims to promote the welfare and `visibility' of children with drug-misusing parents by improving multi-agency assessment and intervention. . This will be done through the development, piloting and evaluation of a model of inter-agency assessment and intervention which builds on both the Framework for the Assessment of Children in Need and their Families (Department of Health2000) and effective, evidence-based models drawn form both adult and child-focused practice. In partnership with Devon Social Services Department, Drug Action Teams, Devon Partnership Trust and a sample of families, we aim to develop shared protocols, procedures and effective models of work with children and parents, reducing unnecessary or prolonged periods in the `looked after'system which result in poor outcomes. The emphasis will be on child- centred practice within an holistic, family focused context which addresses the impact of particular environmental factors in both urban and rural area | Academic | University of Plymouth | PL4 8AA | 50,375 | -4,138 | Dr Brynna Kroll | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
35 | 011/0056 | Drug Recovery Wing (DRW) Pilots Evaluation | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £799.134 | 1 oktober 2012 | 28 februari 2016 | Following the UK drug strategy (2010) there has been a major commitment to ensuring that drug treatment services are maximising the opportunities for the recovery of dependent drug users and that drug users in prison and in the community have access to high quality recovery focussed treatment. Delivering abstinence focussed drug treatment services within prisons presents different challenges to those developed within the community not the least of which is the need to combine both treatment and custodial responsibilities. The research outlined in this application will answer questions in three main areas. First, based upon a detailed qualitative assessment of the drug recovery wings, it will provide a detailed description of the therapeutic programme within the wings and the experience of both staff and prisoners involved within them. This element of the research will provide rigorous information on how the wings are operating, what interventions are used with prisoners and how links | Background Following the UK Drug Strategy and the Patel report, there is a commitment to ensure that prisoners have access to high quality recovery-focussed drug and alcohol treatment services and that the link between prison and community is better managed. Research has shown that 50% of male prisoners and 65% of female prisoners have a drug problem (Singleton et al., 1997). According to Stewart (2009) who surveyed 1457 recently received prisoners across 49 prions in England 28% had used heroin in the last four weeks and 25% had used crack cocaine. It is known that in some cases prisoners are initiating injecting within prison (Boys, 2002) and that on release prisoners are at a heightened risk of death (Farrell and Marsden, 2007). Whilst prison offers an important opportunity for drug and alcohol treatment it is recognised that there are multiple challenges associated with the development of drug and alcohol services within prisons (McIntosh and Saville, 2006). Aims This research | Academic | University of York | YO10 5DD | 53,948 | -1,054 | Professor Charlie Lloyd | 0000-0003-3524-0947 | Chief Investigator | Mental Health | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
36 | 012/0016 | Social Medicine and Health Services Research Unit (2006 - 2010) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2.894.154 | 1 januari 2006 | 31 december 2011 | BackgroundThe work programmeThe Unit's focus will remain in two main areas. The first is in the nutritional epidemiology of asthma, the second on the role of airborne allergen in asthma exacerbations. A third area, which relates to each of these, is development of the molecular epidemiology of asthma, building on the experience of the STARS studies.Nutritional Epidemiology of AsthmaThe fellow replacing Dr Shaheen will take on a portfolio of work on asthma and nutrition. This includes ongoing work with the ECRHS data, new studies on asthma and dietary sodium, potentially work undertaken through the GA2LEN network of excellence, and a new application following up Dr Calvert's studies of nutrition and asthma in Africa.The trial of selenium supplementation in adults with asthma has now finished and is being analysed (Dr Shaheen). Dr Okoko though he will not any longer be formally on the DH unit strength will continue his studies of asthma and apple intake. A cross-sectional survey in schoo | Academic | Imperial College of Science, Technology and Medicine | SW7 2AZ | 51,498 | -0,177 | Professor Peter Burney | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
37 | 015/0307 | Revised Title: Evaluation of TB Control Interventions in the Community and Emergency Medicine Departments: The ACE Study (A & E Screening, Cohort review, Comprehensive local service review, Contact Tracing, Latent TB screening in Primary Care, Pre entry screening, Improving Service Coordination) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £414.455 | 1 september 2013 | 30 september 2016 | This proposal is focused upon early diagnosis, referral and treatment of latent and active tuberculosis, which has two key components: 1) ensuring optimal outcome for individuals; 2) contributing to disease control in public health terms by preventing further spread. A&E Departments are an important point of testing and referral for the client group that constitute those at greatest risk, as for many this will be their only interaction with the health service [Althaus et al 2011]. Currently, A&E Departments contribute about 20% of those diagnosed with TB (See table on p.7). The majority of these individuals are most likely to have presented with symptoms indicative of disease, compared to those attending for other reasons who would have been unlikely to have been tested or referred. This study will seek to evaluate specific measures currently being undertaken by the Health Protection Agency and the NHS to control TB as well as investigate whether case finding in for latent and a | Background: Control of infectious diseases requires prompt, effective identification and treatment to safeguard health and prevent transmission. Identifying those in high risk groups, evaluating signs and symptoms and referring individuals for testing and management are key to control efforts. Tuberculosis (TB) causes significant morbidity in the UK. Early treatment may have the greatest impact by interrupting transmission. Between 2000-9, TB cases in England rose from 12.4 to 16 per 100,000 with over 8000 cases diagnosed annually, mostly among individuals from identified risk groups. In London A&E accounts for 20% Mtb cases diagnosed and 49% from primary care overall. Aim: Research plan and methods Work Package 1: Determining the prevalence of latent TB infection and active TB disease and cost effectiveness of testing high risk groups attending A&E departments. An observational study, which prospectively recruits participants for latent TB testing, combined with health eco | Academic | University College London | WC1E 6BT | 51,524 | -0,132 | Professor Ibrahim Abubakar | 0000-0002-0370-1430 | Chief Investigator | Infection | 8. Health and Social Care Services Research/4. Detection, Screening and Diagnosis | 8.2 Health and welfare economics/4.4 Population screening | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
38 | 015/0313 | Identifying interventional approaches to improve health care access for Hepatitis B in high prevalence groups.- A study of knowledge, beliefs, and attitudes about Hepatitis B among Chinese and Far East Asian residents of South Yorkshire and factors restricting appropriate risk evaluation, testing, preventative activities and referral for treatment to inform review of current policy. | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £266.671 | 1 oktober 2013 | 31 maart 2017 | Hepatitis B – a serious infectious disease caused by a virus transmitted in blood and body fluids – is common among migrant Chinese communities , being found in around 1 in 10 people. However, research in the UK and elsewhere shows that access to healthcare is low among this population, and that late diagnosis and delayed treatment is widespread. US research has found poor understanding about hepatitis B in migrant Chinese communities, with lack of awareness about risks and mistaken beliefs regarding transmission. These studies also suggest healthcare professionals may not offer testing appropriately. To-date, UK research is limited and we know little about the barriers to testing and treatment in this context. The present study addresses this knowledge gap. In South Yorkshire, Chinese residents constitute 0.2 - 1.3% of the population and pilot work by members of the research team has confirmed high levels of infection and low levels of testing and treatment in this | Background: The high prevalence of hepatitis B inChinaand other Far East Asian countries has been well documented in international epidemiological studies. Transmission occurs most frequently vertically, but also sexually, among household contacts and through healthcare. Chronic carriage is frequent, with considerable disease burden including morbidity and mortality from cirrhosis and hepatocellular carcinoma. Early treatment can prevent complications; however, access to specialist healthcare is known to be impaired in this group. Aims: This study objective is to identify the factors associated with poor levels of diagnosis and treatment operating at three levels in theUK: the Chinese community, the health care providers and the health system. This in turn should provide a base to help formulate policy to improve prevention and care. Three aims are: 1 - To identify within the target communities health seeking behaviours as well as knowledge, attitudes and misconceptions in rela | Government/NHS | Sheffield Teaching Hospitals NHS Foundation Trust | S10 2SB | 53,378 | -1,496 | Professor Andrew Lee/Dr Alicia Beatriz Vedio | 0000-0002-9795-3793/Not Provided | Joint Lead Applicant/Chief Investigator | Infection | 7. Management of Diseases and Conditions/4. Detection, Screening and Diagnosis | 7.1 Individual care needs/4.3 Influences and impact | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
39 | 016/0049 | Developing Skills in the NHS | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £232.172 | 1 december 2003 | 30 juni 2008 | BackgroundThis proposal outlines plans for the identification, analysis and evaluation of the use; of the skills escalator concept and associated support for learning in the NHS. The skills escalator aims to attract a wider range of people to work in the NHS whilst also supporting career potential and development across its workforce. Through investing in a lifelong learning approach, the NHS seeks to encourage staff towards new ways of working which extend their current skills and contribute to wider service/process redesign and improvements in health services. The proposed evaluation is -intended to be both academically rigorous and practically relevant. It has three main aims: to identify and map the use of the skills escalator and associated support for learning; to analyse and evaluate the outcome of these practices; and to develop methodologies for the local evaluation of such practices. The approach we propose is intended to make maximum use of existing sources of data including | Academic | The University of Manchester | M13 9PL | 53,467 | -2,234 | Dr Anne McBride | 0000-0003-1047-1319 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
40 | 016/0058 | Nursing Research Unit (2007-2012) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £2.512.956 | 1 oktober 2007 | 31 december 2012 | BackgroundHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.AimsHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Potential ImpactHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Policy RelevanceUnknown | Academic | King's College London | SE1 8WA | 51,505 | -0,113 | Professor Jill Maben | 0000-0002-6168-0455 | Chief Investigator | Generic Health Relevance | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
41 | 016/0068 | A Longitudinal Study of Conflict and Containment in Acute Psychiatric Wards | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £151.738 | 1 december 2003 | 29 februari 2008 | BackgroundHigh rates of conflict between patients and professionals, plus use of containment measures on acute psychiatric wards, produce a negative patient experience, put nurses and patients at risk, and sap nursing morale. Previous research suggests that the factors that may be important in the production by nurses of low conflict, high therapy wards are: their positive appreciation of patients, their emotional self-regulation, and the psychosocial structure of the ward. This study will use a longitudinal follow up design, with 15 acute psychiatric wards, in order to examine the relationship between (i) nurses' positive appreciation of patients, nurses' emotional self regulation, the effective structuring of ward's rules and routine , and (ii) rates of conflict and containment. Multiple methods will be used, including use of officially collected data, additional measures collected by nurses on a shift by shift basis, repeat interviews of nurses and other disciplines, and repeat f | Academic | City, University of London | EC1V 0HB | 51,528 | -0,103 | Professor Len Bowers | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
42 | 016/0070 | General Primary Care Nursing in Prisons: The Essentials of Care | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £244.050 | 1 juli 2004 | 31 maart 2007 | BackgroundThis is a twenty month collaborative research project that will map how mainstream NHS standards in nursing translate to the prison setting, to ensure the equivalence of primary health care provision within prisons to that available outside. The setting up for a prisoner refernece group and a prison nurses' stakeholder conference at the start of the research will support user and stakeholder involvement at all stages. Qualitative interview data from prisoners and nurses working in prisons in a geographical cluster sample of 16 prisons in England (15% of all prisons in England) will be together with published evidence and all prisoner groups (including category A,young offenders, women, open, and private prisons) will be included.The research will also: provide an economic cost consequences type of analysis of specified nurse/GP activities in primary care that that will help inform decisions about the best use of resources in prison health care; build capacity and capability | Academic | University of the West of England, Bristol | BS16 1QY | 51,501 | -2,547 | Dr Jane Powell | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
43 | 016/0071 | What Makes a Good First Contact Nurse in Primary Care? | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £210.192 | 1 mei 2004 | 31 augustus 2007 | BackgroundAim: To provide new evidence on how patients and practitioners define and experience good first contact nursing in relation to minor illness, preventative care and chronic illness management in general practice settings. This includes identifying those characteristics, approaches and models of first contact general practice nursing that denote quality in terms of the match between service functions and nursing skills, consultation style, access and patient defined outcomes. Research Subject Group: Primary Care Trust leads for primary care development, users of first contact services in general practices/health centres and primary care practitioners and managers. Methods, sample and location: The research will be delivered in three phases. First a national survey of first contact nursing services in PCTs across England (n-303) will be conducted to provide for the fIrst time a taxonomy of the extent, nature and configuration of provision in general practice. Second an in-depth | Academic | University of Leeds | LS2 9JT | 53,808 | -1,553 | Professor Francine Cheater | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
44 | 016/0074 | How Do Nurses Use New Technologies to Inform Decision-Making? | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £254.378 | 1 november 2004 | 31 maart 2008 | Background1. Identify areas of practice in the NHS where new decision support technologies have beenintroduced or where their introduction is imminent.2. Explore how new technologies are used to inform nurse decision making in practice and thepotential effect these may have on the care delivery process and patient outcomes.3. Examine the role of education and training in the introduction and use of new technologies inpractice.The above aims will be addressed using a mixed methods approach:i)Telephone survey of more than 25% (140) of Health Care Trusts in England.ii)Systematic review of the effectiveness of computerised clinical decision support systems in nursing.iii)Secondary analysis of existing data sets of nurses engaging with decision technologies. Data includes 380 hours of observation, 296 interviews and 14,000 out of hours recorded consultation calls.iv)A series of four case studies with data analysed at the level of clinician, department and organisation. Sites will be purposi | Academic | University of York | YO10 5DD | 53,948 | -1,054 | Professor DAWN DOWDING | 0000-0001-5672-8605 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
45 | 016/0084 | International Recruitment for Health Professionals: A Development Evaluation | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £47.278 | 1 juli 2005 | 30 november 2007 | BackgroundIn accordance with the tender brief, the proposed evaluation sets out to:-Document/map the international recruitment initiatives/methods currently being, or that could potentially be, used by and on behalf of the NHS to attract doctors, nurses and AHPs;-Distinguish the features associated with good/best/effective (including ethical) practice in terms of direct outcomes;-Capture the broadest possible set of stakeholder perspectives on impacts, costs and benefits of different schemes;-Help inform UK policy and NHS organisations' activities by establishing an analytical framework against which the success of different international recruitment actions can be judged.To achieve these aims the evaluation methodology will consist of:-A rapid literature/secondary evidence review, and initial consultations with relevant UK and EU-level stakeholders;-A national scoping survey of recruiters/schemes and NHS employers operating at national, regional/sub regional and local level to ascerta | Academic | The University of Manchester | M13 9PL | 53,467 | -2,234 | Professor Paula Hyde | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
46 | 016/0085 | Front Line Managers and Delivery of Effective People Management | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £59.457 | 1 februari 2005 | 31 mei 2008 | BackgroundThe effective delivery of people management by front line managers, including clinical professionals with managerial responsibilities is central to agenda for Change especially KSF. recent research has indicated a relative neglect of this population in HR management yet they are of findamental importance in 'bringing policies to life' Qualitative and quantitive research in four acute trusts and two ambulance trusts chosen to allow comparisons in performance will explore FLM roles in implementing HR policies,, examine the barriers to undertaking the roles on employee attitudes and behaviour, and in knowledge sharing. Two final areas focus on how FLMs are themselves managed, and the links to patient care and operational performance. The research will be undertaken in two departments or direcorates in the four acute trusts )one better and one less good) and accross the two ambulance trusts. Interviews with the senior management team at at trust and directorate level will be | Academic | University of Bath (The) | BA2 7AY | 51,379 | -2,327 | Ms Susan Hutchinson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
47 | 016/0107 | Scientific Advisor: Nursing Research Unit and Nursing Related Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £87.251 | 14 december 2006 | 13 juni 2008 | BackgroundTo provide external scientific advice to the Department of Health Policy Research Programme (PRP) and the Director of the Department of health funded Nursing research Unit and coordination for the NQI and associated research projects in the PRP reporting to Dr Susan Lonsdale at the Department of Health (DH). The scientific advisor will be responsible for agreeing work plans, monitoring progress, securing and disseminating outputs and advising the DH. AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database. | Academic | University of Surrey | GU2 7XH | 51,243 | -0,588 | Professor Pamela Smith | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
48 | 016/0113 | Scientific Advisor: Nursing and Workforce Related Research | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £15.392 | 14 juni 2008 | 13 januari 2009 | BackgroundNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.AimsNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Potential ImpactNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database. | For-Profit Company | Abi Masterson Consulting Ltd | SE1 2DE | 51,501 | -0,073 | Ms Abigail Masterson | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
49 | 017/0033 | An Observational Study of the Effect of Different Methods of Targeting Helicopter Ambulances | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £271.156 | 1 september 2004 | 30 september 2007 | BackgroundAn experimental, controlled, before-and-after study of the effect of direct call-out on the appropriateness of helicopter emergency ambulance call-out will be carried out.The study aims to determine whether direct call-out of the helicopter by emergency personnel at the scene rather than indirect call-out via the ambulance service can improve the targeting for the helicopter to patients who need its services.Between September 2004 and March 2005 criteria for call-out and a direct call-out telephone number will be issued to all emergency personnel in the catchment area of the Teeside helicopter. Training and support will be provided.Appropriates of call-out measured by injury severity, need for immediate resuscitation, conformity to pre-specified call-out criteria, and a blinded expert panel assessment will be assessed. Changes in appropriates during 6 months - one year before direct call-out was introduced and 6 months to one year after will be compared with changes in the c | Academic | University of Sheffield | S10 2TN | 53,381 | -1,489 | Professor Jon Nicholl | 0000-0001-5436-1264 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
50 | 018/0063 | New Deal for Communities & Health Inequalities: Phase II | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £530.903 | 1 januari 2010 | 30 september 2013 | BackgroundThe government is committed to reducing health inequalities between socio-economic groups. New Deal for Communities (NDC), an area-based regeneration initiative begun in 1999 in 39 disadvantaged neighbourhoods in England could contribute to these targets because it focuses on key determinants of health inequalities: unemployment, crime, education and the physical environment. In 2005 we completed a scoping study, commissioned by DH, to assess the feasibility of evaluating the impact on health inequalities of the New Deal for Communities (Popay, et. al. 2005). We assessed the availability and coverage of relevant data sources and conducted a preliminary data analysis (Stafford et. al. 2008). We concluded that a full evaluation of the impact of the NDC initiative on health inequalities was both feasible and desirable and this research proposal puts forward such an evaluation.AimsThe aims are to investigate the medium term impacts of the NDC initiative on health inequalities | Academic | University of Lancaster | LA1 4YW | 54,010 | -2,786 | Professor Jennie Popay | 0000-0001-9234-908X | Chief Investigator | Inflammatory and Immune System | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
51 | 018/0067 | Inequalities in Health Scientific Adviser: Evaluations of (a) Vascular Checks, and (b) Healthy Towns Initiatives | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £44.250 | 1 oktober 2008 | 28 februari 2011 | BackgroundHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.AimsHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.Plan of InvestigationHISTORIC PROJECT - all available project details have been transferred to respective fields in this database.Potential ImpactHISTORIC PROJECT - all available project details have been transferred to respective fields in this database. | Academic | University of Bath (The) | BA2 7AY | 51,379 | -2,327 | Professor Ken Judge | Not Provided | Chief Investigator | Generic Health Relevance | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
52 | 018/0073 | Understanding Society | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £200.000 | 21 januari 2011 | 31 maart 2012 | Understanding Society | Undefined | Economic and Social Research Council (ESRC) | SN2 1UJ | 51,567 | -1,785 | Not Provided | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
53 | 019/0015 | Healthcare Associated Infection Research Network | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £1.727.430 | 1 december 2005 | 31 oktober 2014 | BackgroundThe HCAI-RN aims to:· Establish a focus for the strategic development of HCAI research· Coordinate with other research funders to explore how best to bring relevant research into the managed network· Provide a resource for the management of DH funded HCAI research· Provide advice and assisting with the development of specific DH research topics· Developing research at TVU which supports the DH HCAI action plan.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Policy RelevanceThe CMO report 'winning ways' set out priorities for healthcare | Academic | The University of West London | W5 5RF | 51,507 | -0,303 | Professor Heather Loveday | 0000-0003-2259-8149 | Chief Investigator | Infection | 8. Health and Social Care Services Research | 8.5 Resources and infrastructure (health services) | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
54 | 019/0016 | Rapid Testing For MRSA: St Thomas | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £280.000 | 1 november 2005 | 31 maart 2009 | BackgroundThere is an assumption, which has not been tested, that quicker detection of MRSA carriers will lead to lower transmission within hospitals. Technology to obtain results more rapidly is being developed. Currently a new, PCR-based method of MRSA detection (IDI-MRSA) (IDI) provides a screening tool that is much faster but also more expensive than standard methods. We propose to investigate whether significantly faster detection of MRSA cases does lead to reduction in transmission and other adverse outcomes by means of a randomised, crossover trial on both medical and surgical wards. Rapid screening by IDI will be compared with our current method of MRSA screening, with the aim of assessing the impact of shortening time to MRSA result. The primary outcome will be reduction in transmission of MRSA. Secondary outcomes include incidence of MRSA bacteraemia, length of hospital stay, use of isolation facilities, bed utilisation and nursing workload. Test-specific outcomes will be sen | Government/NHS | Guy's and St Thomas' NHS Foundation Trust | SE1 9RT | 51,503 | -0,087 | Dr Dakshika Jeyaratnam | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | AMR | Award does not have an ODA Downstream Partner | ||
55 | 019/0029 | Behavioural Response to Pandemic Influenza in the UK | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £187.000 | 1 november 2007 | 30 april 2008 | BackgroundConsideration of the social science of infectious disease, in this case pandemic influenza (PI) and its implications for understanding societal responses requires two clarifications:1. That the nature of the disease organism and its epidemiology be clearly specified. This is to take account of the complex resonances between the micro level of the pathogen, the intermediate level of its epidemiology, and the macro implications of these resonances for epidemic progression and effects on society and economy. This can be described as the pathogen signature. For this reason, the pathogen, its life cycle and its epidemiology as currently understood, are described in Section 2 of the Proposal.2. Specification of the types of phenomena contained within the human behavioural response as it applies in this context. This is discussed in Section 3 of the Proposal.This project will consider behavioural responses to PI in the UK, building on research by the Innogen Centre as part of t | Undefined | Economic and Social Research Council (ESRC) | SN2 1UJ | 51,567 | -1,785 | Professor Joyce Tait | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
56 | 019/0030 | Pre-Clinical Evaluation of Candidate Pre-Pandemic Influenza Vaccines: Proposal from the Pandemic Influenza Vaccine Evaluation Consortium (PIVEC - A) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £500.065 | 1 juni 2008 | 31 oktober 2010 | BackgroundA comprehensive programme of pre-clinical and clinical research is proposed using stock-piled pre-pandemic influenza vaccines with the aim of evaluating their relative protective efficacy and interchangeability in children, adults and the elderly. We propose “head to head “studies in the ferret animal model and clinical trials in humans using the same vaccines and vaccination schedules that will reflect realistic options for use of the stock-piled vaccines and thus provide a more secure evidence base to support their use. Parallels between indicative experimental animal models and immunogenicity data obtained from human trials will provide the most comprehensive evidence. Optimal interpretation of data requires common evaluation methods likely to reflect relevant correlates of protection in both human and animal systems. These include measurement of functional antibody and assessment of cell-mediated immunity in response to vaccination in the human and evaluation of protecti | Academic | Health Protection Agency | NW9 5EQ | 51,595 | -0,255 | Professor Maria Zambon | 0000-0002-8897-7881 | Chief Investigator | Infection | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.4 Vaccines | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
57 | 019/0043 | Head-to-Head Comparison of Two H1N1 Swine InfluenzaVaccines in Children Aged 6 Months to 12 Years | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £613.678 | 1 oktober 2009 | 31 januari 2011 | BackgroundStudy managed by NETSCC. Please refer to managing agent.AimsStudy managed by NETSCC. Please refer to managing agent.Plan of InvestigationStudy managed by NETSCC. Please refer to managing agent.Potential ImpactStudy managed by NETSCC. Please refer to managing agent. | Academic | Health Protection Agency | NW9 5EQ | 51,595 | -0,255 | Professor Elizabeth Miller | 0000-0002-1884-0097 | Chief Investigator | Infection | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.4 Vaccines | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
58 | 019/0048 | Market Research Evaluation of the Secretary of State HCAI Public Campaign to Improve Public Confidence in Clean, Safe Care in the NHS | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £44.542 | 16 februari 2010 | 15 oktober 2010 | BackgroundIn September 2008, Secretary of State for Health announced a public/patient campaignto inform the public and patients of action being taken to reduce healthcare associatedinfections (HCAI). The aim of this campaign is to combat public perceptions that theNHS is not ‘getting infections under control’. These perceptions exist despite the factthat data indicates that the number of healthcare associated infections are, in fact,down compared to the same period in previous years. Thus the aim of the publiccampaign is to reduce unnecessary anxiety, challenge misconceptions, outlineresponsibilities and generally build public and patient confidence in the ability of theNHS to control and prevent healthcare associated infections.The NHS Institute for Improvement and Innovation (NHSI) has been commissioned todeliver this HCAI campaign as a social movement (that is getting people to changeperceptions) to increase the proportion of the public and patients who believe thatHCAI are in contr | For-Profit Company | Ipsos MORI UK Limited | E1W 1YW | 51,507 | -0,067 | Ms Anna Quigley | Not Provided | Chief Investigator | Infection | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
59 | 019/0053 | The Patient Experience of the MRSA Screening Process and the Impact of an MRSA-Positive Result | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £64.516 | 5 januari 2012 | 31 december 2012 | MRSA is a bacteria carried by many people on the skin and in the nose. Among healthy people it does not usually cause problems. However, in hospitals where people are unwell, MRSA can cause life threatening infections that are difficult to treat. Screening patients, by wiping a cotton bud swab over parts of the body, can determine if they carry MRSA. In England most patients going into hospital are screened. If a patient is found to be carrying MRSA (known as being MRSA positive ) it can be removed. Removal of MRSA is called decolonisation , and involves using a special body wash, shampoo and nasal cream. Patient representatives have suggested that people going into hospital: can be anxious about developing a MRSA infection; may not receive full information about screening; and if they are carrying MRSA, may find using the decolonisation treatment difficult. This study will explore patient s experiences of MRSA screening and in particular, of being MRSA positive. It will also inv | Reducing healthcare associated infection (HCAI) is a priority for the NHS and screening all patients for MRSA on admission to hospital is mandatory, affecting over 14 million patients per year. Research suggests that patients have a poor understanding of MRSA and may be afraid of contracting it if admitted to hospital. However, we do not understand patients experiences of MRSA screening and decolonisation and there is little information to inform screening protocols from a patient perspective and no patient reported experience measures (PREMs). This study aims to explore the MRSA screening process from the perspective of the patient and provide an assessment of the role that screening plays in reassuring patients and maintaining confidence in efforts to minimise the risk of acquiring HCAI. The objectives of the study are to: RO1. Examine the patient s experience of MRSA screening and decolonisation with a particular focus on those who are colonised with MRSA prior to or on admissio | Academic | University of West London | W5 5RF | 51,507 | -0,303 | Professor Heather Loveday | 0000-0003-2259-8149 | Chief Investigator | Infection | 4. Detection, Screening and Diagnosis | 4.3 Influences and impact | AMR | Award does not have an ODA Downstream Partner | |
60 | 02/06/02 | Long-term randomised controlled trial in primary care of the effectiveness and cost-effectiveness of levonorgestrel containing coil (Mirena) against standard treatment
for menorrhagia: LAST trial | NIHR (non-ODA) | Research | Complete | Health Technology Assessment | Commissioned | HTA Commissioned | £1.434.393 | 1 november 2004 | 31 december 2014 | Heavy periods (menorrhagia) is a very common problem affecting women's lives. The impact of this condition has considerable demand on time and resources in primary and secondary care. However, it is unclear which treatment options are the most effective and the most acceptable to women, particularly in the long term, and experience of care varies widely. Currently 1 in 5 women in the UK have a hysterectomy, half of whom present with heavy periods. This trial will assess the effectiveness, cost-effectiveness and acceptability of using the levonorgestrel IUS (Mirena coil) compared to standard medical treatment for women with menorrhagia presenting in primary care.
We want to involve around 120 general practices each recruiting 4 to 5 women with menorrhagia per year to the trial. We wish to recruit around 1200 patients over a two to three year period, commencing November 2004. We will then follow up women, by questionnaire over several years, to look at outcomes such as menorrha | 1. Previous trials show that Mirena is more effective than standard medical treatment in reducing the amount of menstrual blood loss in the short term but have not addressed quality of life or longer-term outcomes. We, therefore, propose a RCT, by intention to treat, to evaluate the effects of Mirena versus standard medical treatment (based on RCOG guidelines) over the longer term and in the primary care setting.
2. The project will measure patient centred and surgical outcomes over the "patient journey" along with resource use, in primary and secondary care, over time.
3. The project will model the utilisation and costs of the different intended treatments on the basis of these data. We will thereby be able to confirm, or refute, the hypothesis that treatment of menorrhagia with Mirena in primary care results in gain for patient and health services in the short and long-term compared to standard medical treatment.
4. Extensive sensitivity analysis will be conducted to explore th | Academic | University of Birmingham | B15 2TT | 52,453 | -1,928 | Professor Janesh Gupta | 0000-0003-3052-8423 | Chief Investigator | Reproductive Health and Childbirth | 6. Evaluation of Treatments and Therapeutic Interventions | 6.3 Medical devices | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
61 | 020/0052 | Integrating Telecare Systems for Chronic Disease Management in the Community; What Needs to Be Done? | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £561.189 | 1 november 2006 | 30 juni 2010 | BackgroundThe purpose of the study is to: (i) To identify, describe and understand those factors that promote or inhibit the implementation and integration of telecare systems for chronic disease management in the community with reference to key stakeholders; (ii) To make practical recommendations for the effective resolution of implementation and integration problems in the UK. The objectives of the study are to underpin the development of workable telecare systems for people with chronic disease in the community, and develop principles for this grounded in the experiences of key stakeholders across a range of lay, professional, and private sector communities. We will undertake six interlinked work-packages which span the objectives set out in the commissioning brief, and which aim to step beyond current research, (which provides considerable data on problems of implementation, integration and normalisation within specific NHS contexts), to better understand developments across policy | Academic | University of Newcastle upon Tyne | NE1 7RU | 54,980 | -1,616 | Professor Carl May | 0000-0002-0451-2690 | Chief Investigator | Mental Health | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
62 | 020/0054 | Telemonitoring & Self Management in Hypertension (Tasminh2): A Randomised Controlled Trial & Qualitative Evaluation of the Efficacy & Acceptability of Telemonitoring & Self Management in the Control of Hypertension | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £329.828 | 1 februari 2007 | 31 januari 2010 | BackgroundControlling blood pressure is a key aspect of cardiovascular disease prevention, but until recently has been the sole preserve of health professionals. Self management of hypertension is an under researched area in which potential benefits for both patients and professionals are great. We propose a primary care based randomised controlled trial with embedded economic and qualitative analyses in order to evaluate the costs and effects of increasing patient involvement in blood pressure management, specifically with respect to home monitoring and self titration of anti hypertensive medication compared to usual care. Transmission of remote monitoring results to participating practices will ensure that practice staff are able to engage with self management and provide assistance where required. The sample size is 478 patients which is sufficient to detect clinically significant differences in systolic blood pressure between self management and usual care. Secondary outcomes will | Academic | University of Birmingham | B15 2TT | 52,453 | -1,928 | Professor Richard McManus | 0000-0003-3638-028X | Chief Investigator | Cardiovascular | 7. Management of Diseases and Conditions | 7.1 Individual care needs | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
63 | 023/0087 | Mental Health Legislation: Current Research Evidence and Key Themes | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £236.121 | 1 september 2004 | 30 juni 2007 | BackgroundTo assemble and analyse information to support the introduction, implementation and future evaluation of the new Mental Health Act. The project will result in:(1) a comprehensive summary of all available ongoing research and information-tracking projects on both current and proposed mental health legislation;(2) synthesis of the data on all formal admissions routinely forwarded to the DH between 1998 and 2004; (3) a comprehensive synthesis of all existing data-based research into the use of current mental health legislation (Mental Health Act 1983) to update the previous systematic review undertaken by Churchill et al (1999);(4) more detailed analysis of three key themes relating to the implementation of the new Mental Health Act as follows:(a) Ethnicity and compulsory detention;(b) Capacity for consent to treatment;(c) International experiences of implementing and applying Community Treatment Orders.AimsHISTORIC PROJECT - Entire abstract transferred from the previous databas | Academic | King's College London | SE1 8WA | 51,505 | -0,113 | Ms Alison Tingle | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
64 | 023/0088 | Arts and Mental Health Research Project | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £50.000 | 1 januari 2005 | 30 september 2007 | BackgroundFollowing the recommendations of the Social Exclusion Unit Report Mental Health and Social Exclusion (2004), DCMS and DH agreed to commit £50,000 each, including VAT, to jointly fund a research project which would report by end 2006.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database. Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database. Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database. | Undefined | Department for Culture, Media and Sport | Professor Jennifer Secker | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |||||
65 | 023/0141 | Assessing the Impact of the Mental Health Act 2007 (The AMEND study) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £372.551 | 1 oktober 2008 | 30 juni 2012 | The Mental Health Act 2007 amends the 1983 Act by changing the definition of a mental disorder and the criteria for detention. The 2007 Act abolishes categories of disorder, instead a single definition applies throughout the Act. It also introduces a new “appropriate medical treatment” test, abolishing the “treatability” criterion of the 1983 Act. There was concern that under the treatability criterion, certain groups, such as people with personality disorder (PD), learning disability or sexual deviance were prevented from receiving compulsory treatment, since clinicians consider these conditions to be untreatable. The “appropriate medical treatment” test instead allows individuals with such disorders to be treated against their will if medical treatment appropriate for the disorder is available. There has also been concern that under the 1983 Act, patients from Black and Minority Ethnic (BME) groups were more likely to be detained.The AMEND study aims to understand how the new Act is | BackgroundThe Mental Health Act 2007 changes the definition of a mental disorder and the criteria for detention, introducing an “appropriate medical treatment” test and abolishing the “treatability” criterion of the 1983 Act. There was concern that under the treatability test, certain groups, such as people with personality disorder (PD), learning disability or sexual deviance were prevented from receiving compulsory treatment, since clinicians consider these conditions to be untreatable. There has also been concern that under the 1983 Act, patients from Black and Minority Ethnic (BME) groups were more likely to be detained.AimsThe AMEND project aims to explore how the changes in the defintion of mental disorder and detention criteria of the 2007 Act impact upon clinical practice, user experience and service availability. The specific objectives are as follows:1. Has the new Act led to a change in the numbers, proportion, diagnostic status and ethnic background of individuals being de | Government/NHS | Birmingham and Solihull Mental Health NHS Foundation Trust | B1 3RB | 52,484 | -1,917 | Professor Swaran Singh | 0000-0003-3454-2089 | Chief Investigator | Generic Health Relevance | 8. Health and Social Care Services Research/8. Health and Social Care Services Research | 8.1 Organisation and delivery of services/8.3 Policy, ethics and research governance | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
66 | 023/0143 | Clinical Evaluation of the Diagnosis of Autistic Disorder in the Adult Psychiatric Morbidity Survey 2006 - 2008 (APMS) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £45.863 | 1 april 2008 | 31 januari 2009 | BackgroundNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.AimsNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.Plan of InvestigationNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database.Potential ImpactNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred to respective fields in this database. | Academic | University of Leicester | LE1 7RH | 52,621 | -1,126 | Professor Traolach Brugha | 0000-0002-9786-9591 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
67 | 023/0148 | BIDS (Best Interests Decisions Study) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £213.532 | 15 februari 2010 | 15 oktober 2011 | According to the Mental Capacity Act, a person can be assessed as not capable of making a particular decision, in which case that decision should be made for him/her, according to his or her best interests. Although the Act gives guidance about how this should be done, we do not know how best interests decisions are currently being made. This situation has a direct impact on the rights of those people who may lack capacity to make a particular decision, especially those whose capacity is often in question - those with dementia, mental health issues, brain injury or learning disabilities. This research will give clear and wide information on how the current guidance is being interpreted for different groups of people, and different types of decision (e.g. health, legal or social care). 1. In order to have an overview of current practice, we will use a large-scale online survey to get information from 400 people who have made best-interests decisions for someone who lacks capacity.2. W | BackgroundThe 2005 Mental Capacity Act (MCA) is innovative in formulating a principled, legislative framework to protect the rights of individuals in decision making, in the assessment of capacity and the making of best interests decisions. Research about best interests decisions since the Act however has highlighted confusions in practice (Myron et al, 2008), concerns about tokenism (Donnelly, 2009) and challenges relating to the resolution of conflicts (Joyce, 2007). There are still several unanswered questions about how the best interests principle impacts on the experience of those lacking capacity (Stanley and Manthorpe, 2008) and how it is interpreted in major life-threatening situations (Hegde et al., 2006). AimsOur own research in this area has highlighted the need to deliver both robust and quantifiable knowledge of current practice, while also seeking better understandings of how best interests decisions are made. Thus the central aim is to deliver evidence about the exten | Academic | University of Bristol | BS8 1QU | 51,457 | -2,607 | Professor Valerie Williams | Not Provided | Chief Investigator | Disputed aetiology and other | 8. Health and Social Care Services Research | 8.3 Policy, ethics and research governance | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
68 | 023/0165 | Understanding the role of social media in the aftermath of youth suicides | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £183.871 | 1 september 2013 | 30 juni 2015 | This study is relevant to preventing media encouragement of suicidal behaviour (research area 4). It concerns young people s use of Internet-based social media. The research is important as there has been considerable concern about how the use of social media may have contributed to the maintenance of suicide clusters, for example in the case of Bridgend in early 2008. The study will use the Cardiff Online Social Media Observatory (COSMOS) to collect and explore social media (especially via Twitter and Facebook). We will compare how social media communication is used following suicides and traffic accidents in young people aged 18 or under. In particular attention will be paid to: i) the frequency of such communication, ii) what sentiments are expressed and iii) any social networks revealed by social media contacts. Deaths of young people in England during the study period will be identified via Child Death Overview Panels and daily news med | BACKGROUND Up to 2% of suicides cluster in time and space and this phenomenon occurs most often in young people. There has been considerable concern expressed about the possible role of social media in maintaining suicide clusters. For example, in the Bridgend case in early 2008 there was concern about RIP sites glorifying the deaths. Very little is known, however, about the use of social media following a young person s death and it may be that young people s social media communication following a peer s suicide is not any different from that which follows other kinds of sudden death. AIMS The over-arching research question for the study is How is social media communication used by young people in the aftermath of a youth suicide and how does this compare with the aftermath of an young person s accidental death? Sub-questions are: What kind of language is used in relation to the deceased and what kind of sentiment and tension is expressed? What is the frequency of social m | Academic | Cardiff University | CF24 0DE | 51,484 | -3,166 | Professor Jonathan Scourfield | 0000-0001-6218-8158 | Chief Investigator | Mental Health | 2. Aetiology | 2.3 Psychological social and economic factors | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
69 | 023/0168 | Understanding Lesbian, Gay, Bisexual and Trans (LGBT) Adolescents' Suicide, Self-Harm and Help-Seeking Behaviour | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £312.860 | 1 februari 2014 | 30 juni 2016 | International research indicates that LGBT adolescents rates of suicide attempts can be between four and seven times those of their heterosexual peers. In the UK, however, there is a lack of evidence about LGBT adolescents suicide, self-harm and help-seeking behaviour. The result of this research deficiency is that we do not currently have the evidence required to develop effective and appropriate suicide prevention policy and service provision. The aim of the proposed research is to reduce the risk of suicide in lesbian, gay, bisexual and trans (LGBT) adolescents (aged 16-25) by providing evidence, which is currently missing, to inform suicide prevention policy and mental health service delivery. LGBT young people are a hard-to-reach group which require sensitive but robust research methods to produce valid findings. Our mixed-methods research programme utilizes a two-phase procedure, over 23 months, to produce reliable evidence concerning this vulnerable group. Phase one will c | Background International research demonstrates that LGBT youth are at much higher risk of suicide compared to their heterosexual counterparts (3). Stonewall research found that half of lesbian and bisexual women participants under the age of twenty had deliberately harmed themselves and sixteen percent had attempted to take their life (4). King et al s (5) systematic review of sexual orientation and mental health research (mainly from the US) found that the higher risk of suicide and self-harm in LGB adults is likely to be related to social hostility and stigma (6). The UK evidence base is very limited. Consequently (and despite this higher population risk and manifest health inequality), there is an insufficient understanding of why LGBT adolescents may be at a high risk of suicidal feelings and self-harm. Furthermore, research on their help seeking behaviour which will be important in planning services to address this need, is non-existent (6). The purpose of the proposed study | Academic | University of Lancaster | LA1 4YW | 54,010 | -2,786 | Professor Elizabeth McDermott | Not Provided | Chief Investigator | Mental Health | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.1 Primary prevention interventions to modify behaviours or promote well-being | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
70 | 024/0031 | Healthy Start – understanding the use of vouchers | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £249.845 | 1 november 2010 | 30 november 2012 | Good nutrition during pregnancy and early childhood is important for life-long health of mothers and children, but families with low-incomes tend to eat too few fresh fruit and vegetables. Healthy Start aims to improve the nutrition of pregnant women and young families (with children up to 4 years old) living on low incomes by giving them vouchers to spend on milk, fresh fruit or vegetables, or infant formula, and access to free Healthy Start vitaminsThis study aims to understand the views and experiences of women and health professionals on Healthy Start vouchers. We will ask both groups about: the system for deciding who is eligible and getting vouchers to families; whether getting the vouchers helps people to change what they buy or what they eat in ways that might improve nutrition; and how well the programme is integrated with other health initiatives, like breastfeeding promotion or change4life. In 15 locations, we will interview 10 women living on a low income who are pregnan | BackgroundWhile good nutrition during pregnancy and the early years is important for life-long and intergenerational health [1, 2], there is evidence of low consumption of fresh fruit and vegetables in low income households [3, 4]. Healthy Start aims to improve the nutritional status of low-income pregnant and breastfeeding women and their young children via provision of vouchers for fresh fruit and vegetables, milk, and infant formula, together with access to Healthy Start-branded vitamins. Early evaluation and assessment of this and similar programmes show some positive outcomes but also procedural barriers to uptake, low vitamin use, and poor links with other relevant initiatives [5-8].AimsThis study aims to understand the views and experiences of women and health professionals on Healthy Start voucher use. Priorities for exploration include:• Measurable behaviour change likely to result in improved nutritional status including decisions about breastfeeding versus formula• Successes | Academic | University of Bristol | BS8 1QU | 51,457 | -2,607 | Dr Patricia Lucas | 0000-0002-0469-8085 | Chief Investigator | Generic Health Relevance/Reproductive Health and Childbirth | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.1 Primary prevention interventions to modify behaviours or promote well-being | Social Care | Award does not have an ODA Downstream Partner | |
71 | 024/0035 | The Dose Response of Fruit and Vegetables on Insulin Resistance in Healthy Participants who are Overweight and at High - Risk of Cardiovascular Disease (CVD): A Randomised Control Trial | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £213.829 | 1 april 2011 | 31 augustus 2011 | The Dose Response of Fruit and Vegetables on Insulin Resistance in Healthy Participants who are Overweight and at High - Risk of Cardiovascular Disease (CVD): A Randomised Control Trial | Academic | Queen's University of Belfast | BT7 1NN | 54,585 | -5,934 | Professor Michelle McKinley | 0000-0003-3386-1504 | Chief Investigator | Metabolic and Endocrine/Cardiovascular | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.3 Nutrition and chemoprevention | Diabetes/Obesity | Award does not have an ODA Downstream Partner | ||
72 | 024/0038 | Effects of Increased Consumption of Leaf and Stalk Vegetables and Beetroot on Cardiovascular Function (‘VegBP’ Study) | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £457.555 | 1 april 2011 | 31 juli 2013 | Effects of Increased Consumption of Leaf and Stalk Vegetables and Beetroot on Cardiovascular Function (‘VegBP’ Study) | Academic | University of Newcastle upon Tyne | NE1 7RU | 54,980 | -1,616 | Professor Chris Seal | Not Provided | Chief Investigator | Inflammatory and Immune System/Neurological | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.3 Nutrition and chemoprevention | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
73 | 024/0039 | Integrated Dietary Intervention to Reduce Risk of Cardiovascular Disease | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £600.862 | 1 april 2011 | 31 december 2012 | Integrated Dietary Intervention to Reduce Risk of Cardiovascular Disease | Academic | King's College London | SE1 8WA | 51,505 | -0,113 | Professor Tom Sanders | Not Provided | Chief Investigator | Generic Health Relevance/Cardiovascular | 3. Prevention of Disease and Conditions, and Promotion of Well-Being | 3.1 Primary prevention interventions to modify behaviours or promote well-being | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
74 | 024/0049 | Inter-relationship between vitamin D requirements for the UK population and calcium intake: does low dietary calcium increase vitamin D requirement? | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £246.315 | 1 juli 2012 | 30 mei 2014 | What is the public health issue/concern? Defining the dietary requirement for vitamin D for the UK population is central to SACN s current re-evaluation of vitamin D dietary reference values (DRV). There is some experimental evidence that calcium intake could modify/impact on these vitamin D requirements, but more clarity is needed in relation to whether this is the case in healthy individuals. The recent DoH s research specification prioritized the need to identify vitamin D requirements at various levels of calcium intake in the UK population. How will our proposed research address this? We propose to use a two-part approach: A) a post hoc analysis of existing vitamin D RCT data (from FSA and EU-funded projects) to explore the impact of calcium intake on the vitamin D requirements: B) to directly investigate the causal relationship between different levels of calcium intake, ranging from low-moderate to high, on serum 25(OH)D concentrations, and to determine the impact of | Background: Calcium and vitamin D are metabolically inter-related to serve endocrine functions. However, their interactions may have implications for the regulation of 25(OH)D production and catabolism, and consequently for dietary vitamin D requirement. At low calcium intakes, animal/observational data suggests that serum 25(OH)D is diminished due to an increased conversion to 1,25(OH)2D, as well as its enhanced catabolism. While such perturbations may confound the estimation of the true requirement for vitamin D, this has received relatively little research attention to date in healthy humans. This has particular relevance for defining the dietary requirement for vitamin D for the UK population, the brief of the SACN Vitamin D Working Group. Aims and objectives: Our main aim will be to test the following: Null hypothesis: that the level of calcium intake has no impact on dietary vitamin D requirements for the UK population Alternate hypothesis: that the leve | Undefined | University College Cork | 2118 | Professor Kevin Cashman | Not Provided | Chief Investigator | Metabolic and Endocrine/Musculoskeletal | 1. Underpinning Research/3. Prevention of Disease and Conditions, and Promotion of Well-Being | 1.1 Normal biological development and functioning/3.1 Primary prevention interventions to modify behaviours or promote well-being | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |||
75 | 024/0051 | 25(OH)D half-life as a marker of vitamin D expenditure and function | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £274.651 | 2 juli 2012 | 9 juni 2014 | Vitamin D is essential for bone health and development. Recent evidence also suggests a broader role for vitamin D in other conditions. The prevalence of a low vitamin D status is higher amongst older than younger people and the functionality of vitamin D is reduced, which may be related to ageing processes. Vitamin D status is usually assessed by measuring the amount of 25-hydroxyvitamin D (25(OH)D) in the blood but this depends on both the amount of vitamin D coming into the body from the diet and skin and the amount being used up (vitamin D expenditure). We have developed a method to determine vitamin D expenditure –25(OH)D half-life. There is a lack of clarity what the vitamin D expenditure and thus requirements of different groups of the population is and how this is affected by their vitamin D status, age, body composition kidney function and other factors. This study will capitalise on a vitamin D supplementation trial in the elderly in Newcastle (VDOP) and a 25(OH)D | Background Vitamin D is important for calcium homeostasis and skeletal metabolism and in other areas of health and disease prevention. Recently the IOM updated their recommendations, but recognised that there are uncertainties about how and what amount of vitamin D is needed to achieve the plasma concentrations of 25-hydroxyvitamin D (25(OH)D) associated with optimal health outcomes in different population groups. The plasma concentration of 25(OH)D is used to assess vitamin D status. However, the relationships between intake, plasma 25(OH)D and vitamin D function are not well understood and are influenced by physiological factors including baseline 25(OHD, life-stage and body composition. New biomarkers to assess vitamin D expenditure and function are needed. Aims in relation to the issue to be addressed This study aims to assess the 25(OH)D half-life, reflecting the expenditure of 25(OH)D, and its relationship with determinants such as vitamin D supply, age, kidney function an | Undefined | MRC Human Nutrition Research Unit | CB1 9NL | 52,183 | 0,181 | Dr Inez Schoenmakers | Not Provided | Chief Investigator | Metabolic and Endocrine | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/1. Underpinning Research | 3.1 Primary prevention interventions to modify behaviours or promote well-being/1.1 Normal biological development and functioning | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
76 | 025/0023 | Improving Access to Care for People with Dementia and Their Carers: A Cross- Cultural Qualitative Study | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £198.107 | 1 april 2003 | 30 september 2007 | BackgroundDementia is one of the most common and serious disorders of later life. There are profound impacts on the person with dementia, their family and carers, and also on health, social and voluntary services. Despite this only 10-15% of people with dementia are referred to specialist services, with particularly low rates of referral from minority ethnic groups. Large numbers of people with dementia and their carers may therefore not have access to specialist advice and treatment drug and non-drug treatment. Little is known about how decisions concerning presentation, help-seeking and referral in dementia. There is a particular lack of information about how these may be influenced by patient ethnicity. We propose to address this knowledge gap by completing a qualitative study in three ethnic groups to investigate the knowledge, attitudes and behaviour of GPs and older adults concerning dementia with a particular focus on identifying barriers and facilitators to accessing care | Academic | King's College London | SE1 8WA | 51,505 | -0,113 | Professor Sube Banerjee | 0000-0002-8083-7649 | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Dementia | Award does not have an ODA Downstream Partner | ||
77 | 025/0047 | National Evaluation of the Partnership for Older People Projects | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £693.877 | 1 april 2006 | 31 maart 2011 | BackgroundThe aim of the National Evaluation is to compare and critically analyse the innovative partnership and financial approaches of the POPPs pilots. Six objectives have been set and, to respond to these a three phase case study approach has been designed. Within the first phase (36 sites), a literature review will develop a synergy of previously published work by members of the proposed team allowing further work to concentrate on partnership/ financial models and appropriate theoretical paradigms to assist in the identification of 'what works, where and for whom'. The documentary analysis will focus on the models and interventions within the POPP sites. These two pieces of work will feed into the 'Framework Development', a mechanism to ensure theoretical development, comparative data collection and transferable learning. The development of the Core dataset will be guided by these stages as will the construction and administration of the self-completion questionnaires. Phase | Academic | University of Kent | CT2 7NZ | 51,299 | 1,071 | Professor Karen Windle | 0000-0002-2136-735X | Chief Investigator | Neurological | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
78 | 025/0048 | Wired For the Third Age - An Evaluation of an Electronic Service Delivery Project For Older People in Durham | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £32.516 | 6 januari 2006 | 5 oktober 2006 | BackgroundRecent policy directives signify the importance to the UK government of new information and communication technologies (ICTs) for the modernisation of social care services through Electronic Service Delivery (ESD) (Department of health, 1998; c-Envoy Office, 2002; Blair, 2000; Cabinet Office, 2000; Department of Health, 2000). As a contribution to its c-government initiative ESD offers the prospect of transforming the structure, culture and administrative operations of statutory and voluntary social services institutions by facilitating integrated and seamless services for welfare users (Silcock, 2001). Whilst this does not include the physical delivery of services online, such a modernisation policy does have significant implications for the production, use, consumption and governance of welfare services, One vital area, and the focus of this research proposal, is the potential impact such ICT driven initiatives may have upon the quality and experience of social care provisi | Academic | University of York | YO10 5DD | 53,948 | -1,054 | Mr Brian Loader | Not Provided | Chief Investigator | Awaiting Health Category Coding | 9. Awaiting RAC Coding | 9.1 Awaiting RAC Coding | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||
79 | 025/0055 | Dignity and Respect in Residential Care: Issues for Black and Minority Ethnic Groups | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £148.202 | 16 februari 2009 | 15 maart 2011 | Very little is known of the experiences of black and minority ethnic older people who are living in residential care, though as the BME population ages even more rapidly than the general population, increasing numbers of people are likely to seek residential care. Our previous research and some other sources have indicated potential for significant problems for BME older people of abuse, neglect and loss of dignity in residential care. This may be linked with cultural misunderstandings and/or (probably unintentional) racism. In large scale surveys, it is difficult to include BME older people because they are a minority, often missed by sampling, and they face some different issues from the general population, which survey questions may not address.This project, which builds on and learns from our previous research on these issues in communities, aims to get a qualitative understanding of the understandings and experiences of BME older people living in residential care about issues of a | BackgroundThe study, complementary to and linked with the main study, will develop further understanding of the engagement of black and minorty ethnic (BME) groups with institutional care for older people and explore issues of abuse, neglect and loss of dignity in such settings. Our previous work on mistreatment of BME older people (Bowes, Avan and Macintosh 2008) confirmed limited use of residential care, but also some examples of mistreatment resulting in some cases from cultural misunderstanding and in others from (probably unintentional) racism. Further cases reflected a more general experience seen in other studies of the general population. Little is known of the experiences of BME older people in residential care and research on mistreatment is limited.Aims1. to develop understanding of the experiences of older people from BME communities living in care homes;2. to explore issues of mistreatment in care homes, with a particular focus on issues of dignity;3. to discuss understand | Academic | University of Stirling | FK9 4LA | 56,145 | -3,920 | Professor Alison Bowes | Not Provided | Chief Investigator | Generic Health Relevance | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | |
80 | 025/0056 | Promoting Excellence in All Care Homes (PEACH) Exploring Knowledge, Practices & Training Needs of the Care Home Workforce | NIHR (non-ODA) | Research | Complete | Policy Research Programme | Researcher Led | Policy Research Programme | £449.266 | 1 april 2009 | 31 maart 2012 | What we know:Many people believe that abuse, neglect & lack of dignity are widespread in institutional care for older people, but we have little evidence that this is so. There is limited evidence that some care home staff commit psychological abuse to older residents. We also know what care workers claim affects their ability to provide appropriate care including values & motivation of individuals, such as their attitude to older people and job satisfaction, organisational factors such as the numbers of staff and residents, inadequate resources such as poor environments with lack of facilities & lack of education.What we don't know:We need to know more about the actual experiences of care home staff, the care practices in care homes and what impact education has on attitudes, practices, and behaviour.What we will do:- observe care practices & interactions between residents & paid carers in 8 different care homes.- ask staff to complete questionnaires about their attitudes to older p | BackgroundDespite belief that abuse, neglect & lack of dignity is common in institutional care for older people, hard evidence is lacking. A systematic review identified only 5 care home studies with 16% of staff admitting significant psychological abuse. Identified obstacles to appropriate care include values & motivation of practitioners, organisational factors, inadequate resources & lack of education. For many paid carers these factors result in frustration & loss of personal dignity. There is little guidance or training in relation to dignified care & lack of knowledge about recognising & dealing with abuse & neglect. The proposed study will build on work being undertaken by Tadd with the NHS workforce & will inform the prevalence study of abuse & neglect of older people in care homes. Aims1.Explore views & experiences of care home sector & workforce in relation to provision of dignified care & avoidance of abuse & neglect2.Explore effect of an evidence based training interven | Academic | Cardiff University | CF24 0DE | 51,484 | -3,166 | Dr Winifred Tadd | Not Provided | Chief Investigator | Infection | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | Social Care | Award does not have an ODA Downstream Partner | |
Geen resultaten