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| Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | Award_Holder_Name | ORCiD | Involvement_Type | HRCS _Health_Category | HRCS_RAC_Category | UKCRC_Value_RAC | NIHR_Curated_Portfolio | Downstream_Partner_Country |
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| Project_ID | Project_Title | Funding_and_Awards_Link | Funder | Programme_Type | Project_Status | Programme | Programme_Stream | Funding_Stream | Award_Amount | Start_date | End_Date | Plain_English_Abstract | Scientific_Abstract | Organisation_Type | Contracted_Organisation | Postcode | Latitude | Longitude | Award_Holder_Name | ORCiD | Involvement_Type | HRCS _Health_Category | HRCS_RAC_Category | UKCRC_Value_RAC | NIHR_Curated_Portfolio | Downstream_Partner_Country | |
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1 | 16/136/68 | NIHR Global Health Research Unit on Diabetes and Cardiovascular Disease in South Asians, Imperial College London | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Unit | £6,768,449 | 1 June 2017 | 30 September 2021 | Heart disease and diabetes are the world’s leading health problems. Approximately 18 million people die from heart disease every year and another 420 million people live with diabetes. The burden of heart disease and diabetes are especially high in South Asia.
The ambition of the GHRU on Diabetes and Cardiovascular Disease in South Asians is to create an inter-disciplinary environment that fosters development and implementation of acceptable, equitable, scalable and sustainable approaches to reduce the burden of diabetes and heart disease in Bangladesh, India, Pakistan and Sri Lanka.
Working in partnership with leading Universities and Healthcare organisations in the partner countries, we are pursuing 5 inter-related projects
•Strengthening disease surveillance. We will work in partnership with the Governmental and Non-Governmental sectors to establish a sustainable network of Health Observatories in the 4 countries and distributed in both rural and urban settings. The infor | Strategic objectives and positioning
Imperial College London identifies improving global health and wellbeing as one of four key strategic objectives.(1) Transformational global health research for T2D and CVD is delivered through the School of Public Health, the Wellcome Centre for Global Health Research, the WHO Collaborating Centre for NCD Surveillance and Epidemiology, the WHO Collaborating Centre for Public Health Education and Training, the Institute of Global Health Innovation, the Clinical Trials Unit and Imperial College Business School. Our inter-disciplinary team (9 Chairs, >30 researchers) harnesses expertise in translational research for prevention and control of T2D and CVD in national and global settings, including South Asia. Imperial further commits 2 tenured Lecturer positions, educational funding for LMIC researchers (stipends for MPH courses, an exchange program, and an international workshop), and space within the School of Public Health.
Institutional part | Academic | Imperial College London | SW7 2AZ | 51.499 | -0.179 | Professor John Chambers | 0000-0003-0209-4541 | Chief Investigator | Cardiovascular/Metabolic and Endocrine | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/7. Management of Diseases and Conditions | 3.5 Resources and infrastructure (prevention)/7.4 Resources and infrastructure (disease management) | Diabetes | India/Pakistan/Sri Lanka/Bangladesh/UK institution/India/Sri Lanka | |
2 | 16/137/34 | NIHR Global Health Research Group on Diet and Activity, MRC Epidemiology Unit, University of Cambridge | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Group | £2,499,602 | 1 June 2017 | 30 November 2021 | The goal of the Global Diet and Activity Research (GDAR) Group and Network is to help prevent non-communicable diseases (NCDs), including type 2 diabetes, heart disease, and cancers, in low and middle income countries (LMICs). These diseases are a growing cause of death and disability, driven in large part by unhealthy diets and physical inactivity, both of which are associated with rapid economic development. The GDAR Group and Network will generate evidence on the factors that lead to poor diet and inactivity in LMICs, design and evaluate interventions to change these factors, and use mathematical modelling to investigate the long-term health and economic effects of such interventions.
Although NCDs are often thought of as diseases of affluence, they are more common in LMICs than in high income countries. They affect primarily those of working age, and cause financial destitution among those in poorer sections of society. NCDs are, therefore, limiting the ability of LMICs to devel | Alignment with the Strategic Objectives of the Cambridge University.
Cambridge University is committed to pursuing excellence in research to address the health needs of populations in low and middle income countries (LMICs), and doing so through equitable partnerships. Examples include the Cambridge-Africa programme [1], Training Health Researchers in Vocational Excellence [2], and the Wellcome Trust-Cambridge Centre for Global Health Research [3]. This proposal builds on this commitment, and would substantially enhance Cambridge’s ability to contribute to research and capacity building for the prevention of NCDs in LMICs.
Institutional Strengths and Partnerships
The proposed Global Diet and Activity Research (GDAR) Group and Network will build on the Centre for Diet and Activity Research (CEDAR) which is internationally recognised for its research in the UK on: population-level determinants of diet and physical activity; evaluation of natural experiments and planned interv | Academic | University of Cambridge | CB2 1TN | 52.205 | 0.116 | Professor Nigel Unwin/Professor Nicholas Wareham | 0000-0002-1368-1648/0000-0003-1422-2993 | Joint Lead Applicant/Chief Investigator | Cancer and neoplasms/Cardiovascular/Oral and Gastrointestinal/Metabolic and Endocrine/Stroke | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/7. Management of Diseases and Conditions | 3.5 Resources and infrastructure (prevention)/7.4 Resources and infrastructure (disease management) | Obesity | Kenya/UK institution/Jamaica/South Africa/South Africa/Cameroon | |
3 | 17/63/121 | NIHR Global Health Research Group on Atrial Fibrillation management at the University of Birmingham | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Group | £1,926,893 | 1 April 2018 | 30 September 2022 | Atrial fibrillation(AF), the most common heart rhythm disorder globally, is associated with a high risk of
death, disability, ill health and poor life quality. Over 25%of strokes are due to AF and adults have a 1
in 4 lifetime risk of developing AF. The main causes of AF (eg high blood pressure, diabetes) are
common in low- & middle-income countries (LMICs). AF under-treatment is common, leading to
missed opportunities in preventing fatal and disabling strokes.
A third of people with AF, more in LMIC settings, do not know they have the condition and are not
receiving life-saving treatment. Anticoagulation to stop blood clotting can be highly effective in
reducing stroke. Warfarin, the most common anticoagulant, needs careful monitoring, but services are
patchy. Newer direct oral anticoagulants are too expensive and care is rarely joined-up (‘integrated
care’) (incl. detection, anticoagulation and management of other conditions).
Our established group has successfully led chan | University of Birmingham (UoB) has global ambitions around its reach and research impact, based on
effective engagement, collaboration and partnerships to inform, utilise and contextualise its research.
UoB has world-leading experts in AF management, and strengths in the improvement of ambulatory
and local health care. Various global research studies into AF epidemiology and management are
ongoing (Lip, Lane, Kirchhof). This, in partnership with LMIC counterparts’ regional expertise, can be
co-developed to synergistically achieve a global impact on the management of AF and its direct
health benefits to patients with this condition. Alongside this broad strategy UoB also supports
focused engagement in several key strategic regions including China and Brazil (2 of our bid partners,
although our focus will be on impoverished populations in these settings), to develop research to
improve care and reduce inequalities. Moreover, UoB is investing in a new Institute for Global
Innova | Academic | University of Birmingham | B15 2TT | 52.453 | -1.928 | Professor Gregory Lip/Professor G Neil Thomas | 0000-0002-7566-1626/0000-0002-2777-1847 | Chief Investigator/Joint Lead Applicant | Cardiovascular | 7. Management of Diseases and Conditions/8. Health and Social Care Services Research | 7.4 Resources and infrastructure (disease management)/8.5 Resources and infrastructure (health services) | Award not coded to a curated portfolio | China/China/UK institution/Sri Lanka/Sri Lanka/Brazil/UK institution | |
4 | NIHR132995 | NIHR Global Health Research Group on collaborative care for cardiometabolic disease in Africa | NIHR (ODA) | Research | Active | Global Health Research Units and Groups | Researcher Led | Global Health Research Groups | £2,224,638 | 1 September 2021 | 31 May 2025 | The problem
African healthcare was developed to focus on infectious diseases like HIV. This means that African healthcare is not set up well to cope with non-infectious diseases becoming more common.
The most common non-infectious diseases are ‘cardiometabolic diseases’. This includes heart disease, diabetes, and high blood pressure. All of these can lead to early death. It makes sense to tackle cardiometabolic diseases together because they can be treated in similar ways. For example, losing weight and increasing exercise can help with all of them.
Our aim
Improve care and outcomes for heart disease, diabetes, and high blood pressure in three low income African countries: Ghana, Kenya, and Mozambique.
How we will do it
We will complete four work packages (WPs) in all three countries.
WP1: Find out from patients, doctors and other key people what the most important healthcare needs are in this area. We will also find out what resources already exist so that we can make sure our | Research question
Can a model of care based on the chronic care model (CCM) and collaborative care model (CoCM) sustainably improve cardiometabolic health in low-to-middle income countries?
Background
Non-communicable diseases are rising in sub-Saharan Africa, mainly driven by cardiometabolic disease (CMD; cardiovascular disease, diabetes, hypertension). From a patient and healthcare systems perspective, it is more effective and efficient to have a cohesive approach to caring for CMDs given their shared aetiology and management. Based on unmet needs, local context, and evidence gaps, this Group will focus on CMD management in 3 ODA-eligible sub-Saharan African countries.
Aim
Develop a CCM and CoCM model of care to improve care, outcomes and risk factor control for adults with CMD in Ghana, Kenya, and Mozambique in the COVID-19-era and beyond to contribute to the UN Sustainable Development Goals of promoting good health/well-being and reducing poverty/inequalities.
Objectives
WP1: Id | Academic | University of Leicester | LE1 7RH | 52.621 | -1.126 | Professor Kamlesh Khunti/Dr Roberta Lamptey | 0000-0003-2343-7099/0000-0002-4260-9442 | Chief Investigator/Joint Lead Applicant | Cardiovascular/Metabolic and Endocrine | 8. Health and Social Care Services Research/7. Management of Diseases and Conditions | 8.1 Organisation and delivery of services/7.3 Management and decision making | Award not coded to a curated portfolio | Mozambique/UK institution/UK institution/Ghana/Ghana/Kenya/Kenya/Kenya/UK institution/Ghana/UK institution | |
5 | NIHR134544 | NIHR Global Research Group on Improving Hypertension Control in Rural Sub-Saharan Africa (IHCoR-Africa) | NIHR (ODA) | Research | Active | Global Health Research Units and Groups | Researcher Led | Global Health Research Groups | £2,752,708 | 1 August 2022 | 31 January 2026 | Background
Many people live with high blood pressure in Sub-Saharan Africa (SSA, the areas of Africa south of the Sahara Desert), where the rate is amongst the highest in the world. In SSA, high blood pressure occurs at young ages, few people are treated, and high blood pressure causes severe complications and premature deaths. This is a serious health concern particularly in SSA where there is little knowledge of, or treatment for this condition.
The causes of the high impact of high blood pressure in rural SSA are multiple including lack of clear symptoms; restricted access to healthcare; and competing demands on time which may prevent people from going to clinics and seeking care.
One suggested approach to improve the management of people with high blood pressure in rural SSA is to use a community-centred approach, where care is more actively promoted and brought into the community to remove obstacles in accessing it.
Aims
Our proposed NIHR Group will develop and assess a comm | Sub-Saharan Africa (SSA) has one of the highest prevalences of hypertension worldwide. The impact is particularly damaging in rural SSA where the prevalence of hypertension is as high as urban settings, but awareness, treatment and control is lower.
The failure to control hypertension in rural SSA has multiple and complex causes across the hypertension control cascade, including limited access to healthcare services.
Community-centred approaches using community health workers can play a key role in managing hypertension in areas remote from health facilities. However, no study has been conducted in rural SSA that demonstrates this.
We will co-develop (with strong community and stakeholder engagement) a feasible and sustainable community-centred approach to target hypertension management more effectively and efficiently.
Our activities will take place across two rural sites in: Kilifi, Kenya, and Kiang West, The Gambia; settings with a high burden of both hypertension an | Academic | London School of Hygiene & Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | Dr Anthony Etyang/Professor Pablo Perel | 0000-0003-1267-6422/0000-0002-2342-301X | Joint Lead Applicant/Chief Investigator | Cardiovascular | 8. Health and Social Care Services Research/7. Management of Diseases and Conditions | 8.1 Organisation and delivery of services/7.3 Management and decision making | Award not coded to a curated portfolio | UK institution/Gambia/Kenya | |
6 | NIHR158821 | Harmful alcohol use in Southern Africa: Studying drivers of drinking to inform effective intervention | NIHR (ODA) | Research | Active | Global Health Policy and Systems Research | Undefined | Global Health Policy and Systems Research - Consortia Awards | £4,040,655 | 1 January 2025 | 31 December 2029 | Harmful alcohol use is substantial problem globally with negative impacts on health/wellbeing. The alcohol industry is a key driver of consumption/harms. It has responded to reduced consumption in many high-income countries (from increased regulation) by developing new sources of growth/profit in low/middle-income countries where harms are greater and policies weaker. Expansion into Africa, with South Africa (SA) as a gateway, is an explicit part of this strategy.
Many factors influence how much people drink, which vary from country-to-country: how easy/affordable is it to purchase alcohol, prevailing attitudes/ideas about drinking, where/what type of alcohol people usually drink? It is usually the country’s alcohol policy (i.e. regulations about when/where alcohol can be sold) and enforcement that determine these factors.
Although health impacts of alcohol are well known, alcohol production and sales are part of the economy and arguments about potential economic benefits, e.g. by pro | SUMMARY
Harmful alcohol use is a major public health concern in South Africa (SA) and other African countries including Botswana. The drivers and influences of harmful alcohol use are complex and to reduce alcohol-related harm we need to understand the total alcohol environment.
AIMS AND OBJECTIVES
Our proposal aims to examine political, commercial, environmental and cultural influences on harmful alcohol use, assess impacts of harmful use on health and co-create with stakeholders politically feasible policy and programme interventions. We address 4 research questions via 4 work packages (WPs):
WP1: Political economy of the alcohol environment. What characterises the political, economic and regulatory context of harmful alcohol use in SA and Botswana, incl. strategies by industry to further their interests?
WP2: Alcohol acquisition and consumption environments in SA and Botswana. What community-level and cultural factors influence alcohol acquisition/consumption?
WP3 Impacts of politic | Academic | University of Cape Town | 7701 | Cancer and neoplasms/Stroke/Cardiovascular/Oral and Gastrointestinal | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/8. Health and Social Care Services Research | 3.1 Primary prevention interventions to modify behaviours or promote well-being/8.3 Policy, ethics and research governance | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||||||
7 | NIHR201708 | Multimorbidity-associated emergency hospital admissions: a “screen and link” strategy to improve outcomes for high-risk patients in sub-Saharan Africa | NIHR (ODA) | Research | Active | Research and Innovation for Global Health Transformation | Researcher Led | Research and Innovation for Global Health Transformation | £4,999,665 | 1 September 2021 | 31 August 2025 | AIM To design and test a system which identifies patients suffering from multiple diseases (multimorbidity) when they seek emergency care in sub-Saharan African hospitals. This could improve early disease treatment (reducing death), and ensure better follow-up (preventing complications, disability, and hospital readmission). BACKGROUND In sub-Saharan Africa, multimorbidity is increasing due to high burdens of infectious diseases (such as HIV) and rising rates of non-communicable diseases (such as high blood pressure and diabetes). Multimorbidity increases as people live longer, and can be worsened by HIV and the drugs required to treat it. Patients delay seeking help until they are severely ill, affecting the poorest people most, and meaning that emergency departments are often key to healthcare delivery. In hospitals, doctors often focus on a single disease. Treating the immediate problem is important, but failure to identify and treat multimorbidity leads to frequent hospital rea | RESEARCH QUESTION What is the optimal structure for healthcare systems to effectively recognise and treat adults admitted to hospital with multimorbidity in sub-Saharan Africa? BACKGROUND Sub-Saharan Africa suffers from an interplay of high rates of infectious disease and rising prevalence of non-communicable diseases, resulting in multimorbidity. Importantly, HIV (and anti-retroviral treatment) can accelerate non-communicable disease. Patients frequently delay seeking treatment until they are severely ill and require emergency management. Hospital care then predominantly focusses on the primary presenting problem, overlooking multimorbidity. This oversight precipitates frequent hospital admissions, increases health system and out-of-pocket expenses, and leads to disability and death. AIM To design and test a system which identifies patients suffering from multimorbidity during emergency assessment in sub-Saharan African hospitals, optimises immediate treatment, and ensures post-d | Academic | Liverpool School of Tropical Medicine | L3 5QA | 53.409 | -2.969 | Dr Eve Worrall/Dr Felix Limbani | 0000-0001-9147-3388/0000-0003-0176-7011 | Chief Investigator/Joint Lead Applicant | Infection/Cardiovascular/Metabolic and Endocrine | 8. Health and Social Care Services Research | 8.1 Organisation and delivery of services | MLTC/Diabetes | United Kingdom/Malawi/Malawi/United Kingdom/Tanzania/United States/Tanzania | |
8 | 16/136/77 | NIHR Global Health Research Unit Action on Salt China (ASC), Queen Mary University of London | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Unit | £6,707,474 | 1 June 2017 | 30 June 2022 | Salt reduction lowers blood pressure and reduces cardiovascular disease including strokes, heart attacks and heart failure. China is the largest developing country in the world. Salt intake in China is very high with an average daily intake of 12-14 g/d. Over 244 million Chinese adults had hypertension in 2012 and raised blood pressure attributed to 2.33 million cardiovascular deaths.
To support China to reduce its population salt intake, the UK–China Collaboration Unit – Action on Salt China (ASC) has been set up, built upon an established collaboration between QMUL (Queen Mary University of London) and TGI (The George Institute for Global Health) China. The aim of ASC is to develop and implement a comprehensive, effective and sustainable salt reduction program in China. The goal is to achieve a 15% reduction in salt intake by 2021, and contribute to China’s commitment of achieving WHO’s target of 30% reduction of population salt intake by 2025.
ASC has developed a strategic | Global Health is a key area of focus at QMUL, supported by our internationally recognised medical research (we are ranked among the top 5 Medical Schools in the UK for Clinical Medicine and Population Health, 2014 REF); strong clinical expertise through our partnership with Barts Health NHS Trust; strong interdisciplinary teams across QMUL in Life Sciences (QMUL is ranked 9th among UK multi-disciplinary universities and a track record of productive international collaborations). Global Health is a key strand of QMUL’s Life Sciences Initiative (LSI), a multidisciplinary endeavour involving all three of our Faculties. QMUL is a leading health research school with extensive global health experience.
Excessive salt intake is linked to over 1.6 million deaths globally each year, about 80% of which occur in developing countries[1]. WHO requires member states to reduce salt by 30% by 2025[2]. Average salt intake in China is high at 12-14 g/d[3]. Salt reduction will have enormous health be | Academic | Queen Mary University of London | E1 4NS | 51.525 | -0.041 | Professor Graham MacGregor | 0000-0001-9206-4500 | Chief Investigator | Stroke/Cardiovascular/Generic Health Relevance | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/7. Management of Diseases and Conditions | 3.5 Resources and infrastructure (prevention)/7.4 Resources and infrastructure (disease management) | Award not coded to a curated portfolio | UK institution/China | |
9 | 16/137/101 | NIHR Global Health Research Group on warfarin anticoagulation in patients with cardiovascular disease in Sub-Saharan Africa, University of Liverpool | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Group | £2,473,260 | 1 June 2017 | 31 August 2022 | The NIHR Global Health Research Group on warfarin anticoagulation in patients with cardiovascular disease in Sub-Saharan Africa is a 4-year project between University of Liverpool, Infectious Diseases Institute, Makerere University, Uganda, and University of Cape Town, South Africa.
The project focuses on a clinically important non-communicable disease area which requires the use of anticoagulation. Anticoagulants, in particular warfarin, are used in these countries for the treatment of venous thromboembolism, rheumatic heart disease and prevention of strokes in patients with irregular heart rhythms (atrial fibrillation). Anticoagulation represents an unmet clinical need in Sub-Saharan Africa as patients either do not receive anticoagulation (due to difficulties in monitoring) or are poorly anticoagulated because of poor dosing guidelines. This results in potentially preventable morbidity and mortality which affects poorer sectors of the population in particular. We have extensive e | Personalised Health is a University-wide research theme at Liverpool. Using our knowledge of clinical pharmacology, genomics and our understanding of diseases, our aim is for every patient to receive the right drugs at optimal doses, maximising efficacy and tolerability, and pre-empting adverse drug reactions. We have shown that personalising medicines to individual patients, based on their genetics, clinical and environmental factors, can reduce both risk and time it takes for the medicine to become effective. Our work has largely focused on developed countries; it is important that the drive towards personalised health does not ignore LMICs, which would exacerbate health inequalities. The WHO has stated that “genomic health divide must be kept in check and ultimately bridged through equitable economic investment, clinical research, and provision and use of genomic services and technologies globally”. Personalisation does not only depend on genomic testing, but can also be based on cl | Academic | University of Liverpool | L69 7ZX | 53.406 | -2.967 | Professor Sir Munir Pirmohamed | 0000-0002-7534-7266 | Chief Investigator | Stroke/Blood/Cardiovascular | 5. Development of Treatments and Therapeutic Interventions/None | 5.1 Pharmaceuticals/5.9 Resources and infrastructure (treatment development) | Award not coded to a curated portfolio | UK institution/Uganda/UK institution/South Africa | |
10 | 16/137/87 | NIHR Global Health Research Group on prevention and management of non-communicable diseases and HIV-infection in Africa, Liverpool School of Tropical Medicine | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Group | £2,497,505 | 1 June 2017 | 30 November 2021 | HIV, diabetes and hypertension are major determinants of the massive disease burden in Africa and provision of accessible effective care for these conditions is probably Africa’s biggest health challenge.
Our aim is to build a programme of research to inform integrated approaches for the prevention and management of HIV, diabetes and hypertension.
The objectives are:
1). To develop a partnership between the Liverpool School of Tropical Medicine (LSTM), African researchers in Uganda and Tanzania, health policy makers and programme managers, patient groups and community representatives for the purposes of conducting research that has maximum immediate benefit on patient outcomes in Africa.
2). To develop and strengthen capacity in NCDs and in research methods
3). To conduct early phase (pilot) studies and assess how diagnostic and treatment services for HIV- infection, diabetes and hypertension should be integrated at health facilities, how these integrated services sh | a) Hosts’ strategy
LSTM conducts research that reduces disease burden in low-resource settings. To date its research has been in infection, but the institution recently committed to expand to the interface between infection and non-communicable diseases (NCDs). It has recently made senior appointments to facilitate this expansion and will use its environment in communicable diseases to nurture the new group.
b). Why LSTM now?
LSTM has made two new appointments to facilitate its move to the interface between communicable diseases and NCDs: Prof Shabbar Jaffar (Epidemiologist) and Prof Louis Niessen (Health Economist). In addition, LSTM is to fund a further senior epidemiologist (currently advertised with a preference for applicants in the HIV- NCDs interface). Support will also be provided by the Head of Clinical Sciences, Prof Luis Cuevas, who desires to move to the interface between tuberculosis and diabetes research. At LSTM, the group will employ and train an epidemiologist | Academic | Liverpool School of Tropical Medicine | L3 5QA | 53.409 | -2.969 | Professor Shabbar Jaffar | 0000-0002-9615-1588 | Chief Investigator | Cardiovascular/Generic Health Relevance/Infection/Metabolic and Endocrine | 8. Health and Social Care Services Research | 8.5 Resources and infrastructure (health services) | Diabetes | UK institution/Uganda/Uganda/Tanzania/India | |
11 | NIHR134530 | NIHR CLEAN-Air(Africa) Unit “Clean modern energy for all”. Benefitting health, society, environment and climate in sub-Saharan Africa to achieve the 2030 Sustainable Development Goals. | NIHR (ODA) | Research | Active | Global Health Research Units and Groups | Researcher Led | Global Health Research Units | £6,999,294 | 1 June 2022 | 31 May 2027 | Nearly half of the world relies on polluting fuels such as wood and kerosene for cooking. Years of research has uncovered that household air pollution (HAP) from burning these fuels is one of the biggest risk factors for global disease (responsible for >2 million deaths in 2019 – more than all deaths from COVID-19 in 2020). To reduce the dangers of cooking with polluting fuels, the UN created Sustainable Development Goal 7 (SDG 7) that sets a deadline of 2030 for “universal access to clean, modern energy”. Unfortunately, data show that the world is not on track to meet SDG 7, particularly in sub-Saharan Africa (SSA), due to population growth outpacing the rate of households acquiring clean cooking fuels. Increasing use of liquefied petroleum gas (LPG), a clean burning fuel with much lower air pollution emissions than traditional fuels, is the short-term solution promoted by most countries for its rapid scale up potential (see India and Indonesia).
The NIHR CLEAN-Air(Africa) Global He | Globally 3.8 billion people rely on polluting fuels (e.g. wood, charcoal, kerosene) for cooking. Household air pollution (HAP) from burning these fuels caused 2.3 million premature deaths in 2019 (more than HIV/AIDS, malaria and tuberculosis). With 695,000 premature deaths and 38 million Disability-Adjusted-Life-Years (DALYs) in 2019, Sub-Saharan Africa (SSA) bears a disproportionate fraction (30%) of the global HAP-related disease burden. The NIHR CLEAN-Air(Africa) Unit will accelerate the understanding of HAP-related disease burden through a unique set of studies that will (i) strengthen national health systems for community health prevention of HAP-related disease and (ii) provide evidence-based recommendations for population transition to clean household and institutional energy.
The Unit will leverage the expertise of community health workers (CHWs), an overlooked frontline health promotion workforce, via implementation of a national Ministry of Health (MoH) led training of CHWs | Academic | University of Liverpool | L69 7ZX | 53.406 | -2.967 | Dr James Mwitari/Professor Daniel Pope | 0000-0001-7464-1677/0000-0003-2694-5478 | Joint Lead Applicant/Chief Investigator | Cardiovascular/Injuries and Accidents/Respiratory | 2. Aetiology/8. Health and Social Care Services Research/3. Prevention of Disease and Conditions, and Promotion of Well-Being | 2.4 Surveillance and distribution/8.1 Organisation and delivery of services/3.2 Interventions to alter physical and biological environmental risks | Award not coded to a curated portfolio | Cameroon/Uganda/Kenya/Kenya/Rwanda/Tanzania/UK institution | |
12 | NIHR201816 | Development and evaluation of a targeted, integrated, coherent and people-centred approach to the management of Multiple Long-Term Conditions (MLTC-M) in South African primary healthcare | NIHR (ODA) | Research | Active | Research and Innovation for Global Health Transformation | Researcher Led | Research and Innovation for Global Health Transformation | £4,486,021 | 1 September 2021 | 31 August 2025 | Multimorbidity is the experience of living with more than one long-term condition – like HIV, diabetes, depression. In South Africa, we have large epidemics of all three, and others, like TB and hypertension, but are unsure how commonly they occur together and in what combinations. Coping with multimorbidity is difficult for people with several conditions and their health workers because healthcare is usually provided separately for each condition and treatment is complex. In South Africa health workers use PACK (Practical Approach to Care Kit) – a compilation of clinical policies and guidelines – to help them decide how to manage their patients. PACK standardises an approach to long-term care, but when there is more than one condition, the number of different components to check is overwhelming, making decisions difficult about what to prioritise and leaving little space for patients to share their health concerns. This research aims to develop and test a solution | Against the background of 1) rising multiple long-term conditions – multimorbidity (MLTC-M) in low- and middle-income countries (LMICs) as a result of unplanned urbanization and the globalization of unhealthy lifestyles; as well as 2) historically fragile, vertically organized organised health systems that are ill-equipped to deal with MLTC-M, this body of research addresses a critical overarching research aim: To produce evidence-based scalable solutions for care, treatment and support systems for people living with MLTC-M in LMICs so as to enhance their health and well-being. The research will be conducted across two diverse provinces in South Africa. This country provides an opportune setting for this research given: 1) A high burden of all three MLTC-M disease clusters (mental disorders as well as communicable and non-communicable diseases); 2) Widely used functional public primary care system; and 3) Policy reforms that provide an enabling policy environment. These include | Academic | King's College London | SE1 8WA | 51.505 | -0.113 | Professor Lara Fairall/Professor Naomi Levitt | 0000-0002-7460-4670/0000-0001-6480-8066 | Chief Investigator/Joint Lead Applicant | Infection/Cardiovascular/Mental Health/Metabolic and Endocrine | 7. Management of Diseases and Conditions/8. Health and Social Care Services Research | 7.1 Individual care needs/8.1 Organisation and delivery of services | MLTC | South Africa/United Kingdom/South Africa/Netherlands/South Africa/United Kingdom/United Kingdom/South Africa/South Africa | |
13 | NIHR302421 | Advancing Research to Reduce Alcohol Related Harms -Lessons for Policy, Practice and Sustainable Development in India | NIHR (ODA) | Training | Active | NIHR Professorships | Trainee Development | NIHR Global Health Research Professorship | £1,799,555 | 1 April 2023 | 31 March 2028 | Problem drinking affects large numbers of individuals and their families across the world. It also leads to social harm through violence, loss of work, and increased direct law enforcement and healthcare costs. As India and other similar countries become more affluent, drinking is becoming more common. Furthermore, the harms related to drinking are disproportionately affecting the poorest in society. Despite this burden of problem drinking, only one out of ten such drinkers has any access to appropriate care in India. This is due to the inability of our health systems to successfully integrate and scale-up effective treatments in a sustainable manner. Through my programme I aim to bridge this gap between 'what works' and 'how to make it work at the population level' by developing contextually-relevant strategies to guide the translation of such research evidence in low resource settings. I will do this by using the lessons learnt in a series of research studies conducted in India. In o | Background Hazardous/harmful drinking are major contributors to morbidity, mortality and disability across the world. India, and other low- and middle-income countries (LMICs), are experiencing a steady increase in alcohol consumption and hazardous/harmful drinking. 86% of such individuals in India do not have access to any kind of care for their drinking problems, the highest treatment gap amongst all mental and substance use disorders. There is robust evidence of the effectiveness of psychosocial treatments for drinking problems, there remains a gap in the understanding of (a) integrated interventions that can be used to respond to the whole spectrum of drinking problems, (b) providing care for difficult to engage hazardous/harmful drinking individuals, and (c) effective implementation models to scale up such treatments. Hence, we have been unable to translate to implementation at scale, most commonly due to the lack of contextually relevant interventions and capacity of the health s | Academic | London School of Hygiene and Tropical Medicine | WC1E 7HT | 51.521 | -0.131 | Dr Abhijit Nadkarni | 0000-0001-5832-5236 | Award Holder | Cancer and neoplasms/Mental Health/Cardiovascular/Respiratory/Stroke | 6. Evaluation of Treatments and Therapeutic Interventions/7. Management of Diseases and Conditions/8. Health and Social Care Services Research | 6.6 Psychological and behavioural/7.1 Individual care needs/8.1 Organisation and delivery of services | Award not coded to a curated portfolio | India | |
14 | 17/63/76 | NIHR Global Health Research Group on Addressing Smokeless Tobacco and building Research capacity in south Asia (ASTRA) at the University of York | NIHR (ODA) | Research | Complete | Global Health Research Units and Groups | Researcher Led | NIHR Global Health Research Group | £1,999,998 | 1 April 2018 | 31 March 2022 | Smokeless tobacco (ST) refers to tobacco products that are consumed without being burnt. Smokeless tobacco has historically been assumed to be less harmful than cigarettes; however, most ST products are highly addictive and are known to cause cancers of the mouth, pharynx and oesophagus, as well as leading to cardiovascular deaths and pregnancy problems.
The types of ST used worldwide vary greatly and products used in South Asia usually contain higher levels of cancer-producing chemicals than those used in Europe and the US. There are 300 million ST users in the world, with the vast majority (85%) living in South Asia. Despite almost 350,000 people dying every year due to ST-related cancers and other diseases, ST remains largely neglected by policy makers and researchers. Policies to reduce tobacco use are mainly based on research carried out on cigarettes and/or in high-income countries. Furthermore, most South Asian institutions do not have enough researchers or funds to carry out | The University of York (henceforth York) has an excellent research reputation and a vision to become a global leader in research - its key strategic objective. In its strategic plan (2014-2020), York is committed to expand its research activity and continue to build its international alliances and collaborations. The strategy states Research excellence defines York and further strengthening and improving our research, to be dynamic, inspirational and life-changing in its impact, is an absolute priority. Ranked 28th for International Outlook in the latest THE World University Rankings, York is ideally placed to respond to the global challenges of our time. York's seven research themes (https://www.york.ac.uk/research/themes/), including health and well-being, align its academic strengths with both the United Nation's sustainability goals and the four strategic objectives of the UK Aid Strategy (gov.uk). York's response to the Global Challenges Research Fund (GCRF) is ambitious. Supporte | Academic | University of York | YO10 5DD | 53.948 | -1.054 | Professor Kamran Siddiqi | 0000-0003-1529-7778 | Chief Investigator | Cancer and neoplasms/Cardiovascular/Mental Health/Generic Health Relevance/Stroke | 3. Prevention of Disease and Conditions, and Promotion of Well-Being/None/None | 3.1 Primary prevention interventions to modify behaviours or promote well-being/5.9 Resources and infrastructure (treatment development)/6.9 Resources and infrastructure (treatment evaluation) | Award not coded to a curated portfolio | India/Pakistan/UK institution/UK institution/UK institution/UK institution/UK institution/UK institution/India/India/Pakistan/Bangladesh/UK institution/Pakistan | |
15 | NIHR131273 | Controlling chronic diseases in Africa: development and evaluation of an integrated community-based management for HIV-infection, diabetes and hypertension in Tanzania and Uganda. The INTE-COMM study | NIHR (ODA) | Research | Active | Global Health Policy and Systems Research | Commissioned | Global Health Policy and Systems Research Commissioned | £4,303,161 | 1 October 2020 | 31 December 2025 | We are an NIHR-funded team researching the management and prevention of HIV-infection, diabetes and hypertension. In our earlier NIHR Group award (16/137/87) we had an ambitious objective to bring together vertically delivered HIV services (generally well-resourced and protected) and diabetes and hypertension care (currently less structured and poorly resourced), under one roof in Tanzania and Uganda. This approach was innovative, unique and risky. With support and in partnership with policy makers and disease control programme managers, we have successfully established and are currently evaluating this “integrated care clinic” model in this NIHR Global Health Policy and Systems Research project. However, the prevalence of chronic conditions is so high that clinic-based care alone cannot meet demand. Our team is being urged by health services to evaluate decentralising integrated care to the community-level.
Our primary research question for the proposed research is:
How can we desi | We are an NIHR-funded team researching the management and prevention of HIV-infection, diabetes and hypertension. In our earlier NIHR Group award (16/137/87) we had an ambitious objective to bring together vertically delivered HIV services (generally well-resourced and protected) and diabetes and hypertension care (currently less structured and poorly resourced), under one roof in Tanzania and Uganda. This approach was innovative, unique and risky. With support and in partnership with policy makers and disease control programme managers, we have successfully established and are currently evaluating this “integrated care clinic” model in this NIHR Global Health Policy and Systems Research project. However, the prevalence of chronic conditions is so high that clinic-based care alone cannot meet demand. Our team is being urged by health services to evaluate decentralising integrated care to the community-level.
Our primary research question for the proposed research is: How can we desig | Academic | University College London | WC1E 6BT | 51.524 | -0.132 | Professor Moffat Nyirenda/Professor Shabbar Jaffar | 0000-0003-2120-4806/0000-0002-9615-1588 | Joint Lead Applicant/Chief Investigator | Infection/Metabolic and Endocrine/Cardiovascular | 8. Health and Social Care Services Research/8. Health and Social Care Services Research/8. Health and Social Care Services Research | 8.5 Resources and infrastructure (health services)/8.3 Policy, ethics and research governance/8.1 Organisation and delivery of services | Diabetes | UK institution/UK institution/Uganda/Tanzania | |
16 | NIHR132960 | NIHR Global Health Research Unit and Network for Diabetes and Cardiovascular disease in South Asia | NIHR (ODA) | Research | Active | Global Health Research Units and Groups | Researcher Led | Global Health Research Units | £7,000,000 | 1 September 2021 | 31 August 2026 | Diabetes and heart disease are leading causes of death and disability worldwide, and are especially common amongst people living in South Asia (Bangladesh, India, Pakistan and Sri Lanka). The impact of diabetes and heart disease on South Asian people is magnified by the limited access to high quality health care. Diabetes and heart disease are thus recognised as high priority public health challenges requiring urgent action across South Asia.
Our Global Health research work aims to improve understanding of the mechanisms underlying diabetes and heart disease in South Asian populations, and to improve prevention and control of these diseases through personalised and health systems based interventions. Our research will be pursued in four complementary, interconnected themes that build on the work carried out to date:
Theme 1. We will determine the health outcomes for 150,000 South Asian men and women, who were initially comprehensively assessed in 2018-21, and who have agreed to be f | Our Global Health Research Network is a partnership between research intensive organisations in Bangladesh, India, Pakistan, Sri Lanka and the UK, and key collaborators in Australia and Singapore. Our primary ambitions are to: i. improve understanding of the mechanisms underlying the high burden of Type-2 diabetes (T2D) and cardiovascular disease (CVD) in South Asians, and ii. improve prevention and control of these major diseases through personalised, health systems and policy-based interventions, that are scalable, sustainable, effective and equitable.
Our research comprises four interconnected themes. Theme 1 (Population health) will determine cardiovascular and metabolic outcomes at 4 years, for the ~150,000 South Asian men and women in our Surveillance study (baseline evaluation 2018-21). Using face-face and electronic methods, we will identify ~6,800 cases of incident T2D, and ~3,100 of incident CVD. We will complete molecular phenotyping of baseline samples, and use the data t | Academic | Imperial College London | SW7 2AZ | 51.499 | -0.179 | Professor John Chambers/Dr Anjana Ranjit Mohan | 0000-0003-0209-4541/0000-0002-4843-1374 | Chief Investigator/Joint Lead Applicant | Metabolic and Endocrine/Cardiovascular | 8. Health and Social Care Services Research/2. Aetiology/6. Evaluation of Treatments and Therapeutic Interventions | 8.1 Organisation and delivery of services/2.6 Resources and infrastructure (aetiology)/6.6 Psychological and behavioural | Diabetes/Obesity | India/UK institution/Bangladesh/Singapore/India/Pakistan/Sri Lanka/Sri Lanka | |
17 | NIHR156161 | Developing a learning health system to address the growing burden of non-communicable diseases in Thailand | NIHR (ODA) | Research | Active | Global Health Research Units and Groups | Researcher Led | Global Health Research Groups | £2,223,177 | 1 July 2024 | 30 June 2028 | Aim: To formally test whether a new approach for delivering healthcare, called a Learning Health System, results in better and fairer care for people with high blood pressure, diabetes, and kidney disease compared to routine care in Thai primary care settings. This project will deliver many long-term benefits for the Thai population by reducing the number of people who develop these conditions, preventing early death and disability, and reducing costs to society.
Background: Long term conditions such as heart disease, diabetes and kidney disease are the leading causes of death in Thailand. It is estimated that reducing the number of people living with high blood pressure in Thailand can prevent 14,000 deaths, 27,000 strokes, and 18,000 heart attacks over the next five years. In Thailand, computerised medical records are used by the Ministry of Public Health to understand how whole regions deliver care. However, this information is not available to healthcare providers in a format that | Research question: Can a Learning Health System (LHS) approach improve delivery of care and reduce inequalities in outcomes for people with hypertension and related non-communicable diseases (NCDs) compared to routine care in primary care settings in Thailand?
Background: NCDs account for 74% of all deaths in Thailand. Electronic health record data is used in Thailand to monitor how well whole regions deliver care, but is not directly available to healthcare teams in an actionable format which allows them to identify individuals in need of earlier, or more active management. LHS’ are an effective framework for empowering healthcare teams to drive quality improvement (QI), reduce inequalities, and translate electronic health record data into actionable clinical insight.
Aims and objectives: We will conduct a stratified cluster randomized controlled trial to compare the LHS approach to routine care in two Thai provinces. We will randomize 16 primary care units to the intervention over t | Academic | Queen Mary University of London | E1 4NS | 51.525 | -0.041 | Professor Rohini Mathur/Dr Chaisiri Angkurawaranon | 0000-0002-3817-8790/0000-0003-4206-9164 | Chief Investigator/Joint Lead Applicant | Renal and Urogenital/Cardiovascular/Metabolic and Endocrine | 8. Health and Social Care Services Research/8. Health and Social Care Services Research | 8.2 Health and welfare economics/8.1 Organisation and delivery of services | Award not coded to a curated portfolio | UK institution/Thailand/UK institution | |
18 | NIHR158745 | Embedding system change for people with long-term conditions: Learning from Primary Health Care reform in Georgia (ChangePHC Georgia) | NIHR (ODA) | Research | Active | Global Health Policy and Systems Research | Undefined | Global Health Policy and Systems Research - Consortia Awards | £2,055,657 | 1 November 2024 | 31 October 2028 | Primary health care (PHC) is a community’s first and main point of contact with the health system. Many countries are trying to improve PHC, especially as people are getting older and have more health problems which are often complex. This is particularly important for countries where long-term health problems such as heart disease or diabetes are common and where PHC is under-developed.
Georgia plans to fundamentally change its PHC system to make it easier to access, especially for people in rural areas. Currently some community members find it difficult to get to see a health worker because there are too few or they are overworked, while others are referred to specialists for care that could be provide at the primary level. Also, patients often have to pay directly for services, including for medicines. To address these challenges Georgia is introducing a package of reforms to improve PHC financing, organisation and quality. We know from other countries how challenging such comprehe | Primary health care (PHC) is fundamental to sustainable and equitable health systems, but remains weak in many low- and middle-income countries (LMIC), with challenges exacerbated by an increasing burden of non-communicable diseases (NCDs). While there is increasing evidence on “what works” for enhancing PHC, few LMIC have successfully implemented these strategies. Effective implementation of such complex reform requires in-depth understanding of the consequences for stakeholders at multiple system levels, and the wider social, economic and cultural context within which PHC systems operate.
ChangePHC takes advantage of ongoing PHC reform in Georgia to examine these issues in depth and in real time. Our aim is to (i) understand the performance and consequences of Georgia’s planned PHC reform across different regions and health system levels, and the likelihood of any changes being sustained; and, (ii) significantly strengthen Health Policy and Systems Research (HPSR) capacity in Georg | Undefined | Curatio International Foundation | 179 | Respiratory/Metabolic and Endocrine/Cardiovascular | 8. Health and Social Care Services Research/8. Health and Social Care Services Research/8. Health and Social Care Services Research | 8.2 Health and welfare economics/8.1 Organisation and delivery of services/8.3 Policy, ethics and research governance | Award not coded to a curated portfolio | Award does not have an ODA Downstream Partner | ||||||
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