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Project_ID
Project_Title
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Programme_Type
Project_Status
Programme
Programme_Stream
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Award_Amount
Start_date
End_Date
Plain_English_Abstract
Scientific_Abstract
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Contracted_Organisation
Postcode
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Longitude
Award_Holder_Name
ORCiD
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HRCS _Health_Category
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1
001/0013
Preventing Falls amongst Older People: Socio-Economic and Ethnic Factors
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£179,782
1 September 2004
31 March 2008
BackgroundFalls and fractures amoungst older people are a major public health challenge. Suprisingly little is known about the association of falls and use of falls-related services with socio economic status and ethnicity. The present proposal is for a series of three studies to investigate the question: 'what are the socio-economic and ethnic differences in fall-related morality, morbidity, health care seeking behaviour and provision of services?' The first study will perform novel secondary analysis on three different existing data sources (ONS morality statistics, Hospital Episode Statistics (HES), and Health Survey for England (HSE). This will provide statistics variation in falls and health care seeking behaviour, but will not permit us to identify the reasons for observed variations, and may not provide sufficient data on ethnic minorities. To supplement the data on ethnic variations and to identify the reasons for variations we will undertake new primary research by carryi
Academic
The University of Manchester
M13 9PL
53.467
-2.234
Professor Chris Todd
0000-0001-6645-4505
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
2
001/0016
Estimating Costs and Quality of Life Loss Due to Fractures
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£36,227
1 August 2004
31 March 2008
BackgroundEstimating the costs and quality of life loss due to fractures and falls.Fractures and falls are a serious cause of morbidity and cost society. The cost burden of fractures t society has been estimated in the region of 1.8 billion. Equally important is the health related quality lii loss (HRQoL) due to hip and other fall related fractures. In this proposal we seek to take advantage of number of data-sets we have to ascertain the cost and quality of life consequences of both fractures an falls in a primary care sample of women and a secondary care sample of men. These data will also allot a more detailed description of the costs and consequences of fractures. treatment received, length of stay at hospital, length of stay at residential care/ sheltered or nursing accommodation, and social services support. Resource use data will be combined with 2004 unit prices to obtain an updated estimate of the cost of treating hip, wrist, vertebral and other fractures. The data produced fr
Academic
University of York
YO10 5DD
53.948
-1.054
Professor Cynthia Iglesias
0000-0002-3426-0930
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
3
001/0017
The Long Term Health and Health Care Outcomes of Accidental Injury
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£330,750
1 October 2004
31 January 2008
BackgroundBackground: Some previous research has examined long-term disability resulting from accidental injury using a wide variety of different measures, but little is known about quality of life and costs. The long-term health and health care burden in different types of accidents, patients, and injuries is also uncertain, and hence priorities for prevention and public health research are not evidencebased.Aims: This research project aims to quantify the long-term mortality, morbidity, and costs arising in different groups of accidentally injured patients. Morbidity will be assessed in terms of quality of life and post-traumatic stress as well as disability, and the overall burden of injury will be measured using Quality Adjusted Life Years lost.Design: Six existing injury datasets will be re-examined. Five of these datasets were collected by the Medical Care Research Unit in Sheffield between 1988 and 1997, and include a total of 8,588 injured patients admitted to over 50 different
Academic
University of Sheffield
S10 2TN
53.381
-1.489
Professor Jon Nicholl
0000-0001-5436-1264
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
4
001/0018
Neighbourhood and Household Influences on Injuries to Preschool Children
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£159,022
1 October 2004
31 January 2009
BackgroundInjuries caused by accidents are a particular problem in young children and children's injury rates vary considerably from place replace Low-income neighbourhoods have higher child injury rates than high-income neighbourhoods, and recent research suggests that only part of the difference is due to variations in the social, economic and demographic composition of local populations. This research aims to find out the relative contributions of family characteristics and neighbourhood features to the risk of injury to children aged 0-4 years in Bristol and its surrounding region, to discover some of the mechanisms that create patterns of inequality. The objectives are:" to determine the risk factors acting at the level of the child, the household and the neighbourhood, and whether these risks act independently," to determine whether residents' perceptions ofneighbourhood and local social networks are related to geographical variations in the risk of injury," to determine the size
Academic
University of East Anglia
NR4 7TJ
52.622
1.241
Dr Robin Haynes
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
5
002/0010
Cardiac Rhythm and Personal Exposure to Air Pollution in Patients with Heart Failure
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£249,178
1 October 2002
30 September 2007
BackgroundThe majority of excess deaths associated with rises in air pollution appear to be from cardiac causes. Particles and nitrogen dioxide are the pollutants most closely associated with this effect but which of these, and the mechanisms, remain speculative. The hypothesis is that the effects are mediated by secondary changes in blood coagulability. Another is that pollution causes changes in the irritability of the heart, with changes in rate, rhythm and variability. These hypotheses are not in conflict and this project will investigate both.The study will look at the associations between exposure to particles and NO2, alterations in cardiac rhythm, and coagulation factors in 100 patients recrutied from 200 with stable heart failure. In each it will measure personal exposure to NO2 and estimate personal exposure to particle mass and number for 3 consecutive days on six separate occasions over a year. On the 3rd day it will record a 24-hour cardiograph and take blood for ind
Academic
University of Aberdeen
AB24 3FX
57.165
-2.100
Professor Anthony Seaton
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
6
002/0015
Health Effects of Long-Term Exposure to Air Pollutants in Scotland
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£188,761
1 April 2003
30 June 2007
BackgroundThe purpose of the proposed research is to simultaneously quantify the health effects of long-term exposure to air pollutants and shortening of life from short-term exposures. Primary outcome measures are cause-specific mortality and morbidity , with particular attention to cardiovascular outcomes. We will compare the results of cohort studies to corresponding estimates from time-series studies of the population from which the cohorts are drawn. Outcomes in 26,360 subjects in 3 cohorts will be investigated in the period between 1970 and 2002. Detailed baseline risk data and the unique advantages of the Scottish Health Record Linkage system (including algorithmic linking of individual hospital admission & mortality records) will enable novel ways of quantifying effect magnitudes in susceptible population sub-groups, and coherence in medical outcomes. We shall examine the potential for confounding and effect modification by both individual and aggregate level factors (including
Academic
University of Strathclyde
G1 1XQ
55.861
-4.245
Dr Iain Beverland
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
7
002/0017
Quantitative Systematic Review of Short Term Associations between Ambient Air Pollution (Particles, Ozone, Nitrogen Dioxide, Sulphur Dioxide and Carbon Monoxide), and Mortality and Morbidity
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£48,834
1 February 2004
30 November 2007
BackgroundThe published literature on the short term associations between air pollution and health is now very large. The traditional narrative review is no longer appropriate and there is now a trend towards adopting the methods of systematic review and meta-analysis (statistical combination of results from a number of studies) in the evaluation of observational epidemiological evidence. At the same time, there is a demand for more information about the size and consistency of estimates, and about factors affecting heterogeneity across different environments. Very few existing reviews have carried out quantification or have been reported to be systematic. We have identified all published literature and created a database of the relevant data. Up to August 2001, there were 242 time series studies of daily mortality or morbidity (eg hospital admissions) and 95 studies of daily lung function and symptoms in panels of subjects. These studies describe thousands of pollution-outcome e
Government/NHS
St George's University Hospitals NHS Foundation Trust
SW17 0QT
51.427
-0.176
Professor Ross Anderson
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
8
002/0039
2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£24,052
1 January 2013
31 December 2013
Organisation and conduct of a 2 day air pollution and health research review meeting on 23 & 24 April 2013. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2013 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site.
2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
Academic
Cranfield University
MK43 0AL
52.070
-0.631
Dr Derrick Crump
Not Provided
Chief Investigator
Respiratory
2. Aetiology
2.2 Factors relating to physical environment
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
9
004/0080
The Childhood Cancer Research Group
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,201,890
1 January 2008
30 April 2011
BackgroundGeneral BackgroundThe Childhood Cancer Research Group (CCRG) is based in the University of Oxford. Currently housed at 57 Woodstock Road, Oxford OX2 6HJ, it is administratively part of the University Department of Paediatrics (itself located across several sites, several miles away). For the foreseeable future, the core funding of the CCRG is envisaged to come from the Department of Health for England (& Wales) through the Policy Research Programme, with a further contribution made on behalf of the Scottish Ministers. Additional funding from other sources is therefore to be sought in a complementary rather than substitutive fashion.The CCRG houses the National Registry of Childhood Tumours (NRCT) - a population based register of malignancies and benign brain tumours diagnosed in children (less than 15 years of age), and domiciled in England, Wales or Scotland at the time of diagnosis - which covers the 1950s incompletely and the period 1962 to the present day as completely
Academic
University of Oxford
OX1 2JD
51.758
-1.262
Dr Michael Francis Grant Murphy
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
10
004/0086
Modelling of Impact of Increasing GP Access to Diagnostic Tests for Cancer
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£39,890
1 November 2010
16 June 2011
Bowel cancer (or colorectal cancer) is the second most common cancer in England, with 30,727 new cases diagnosed in 2007 (ONS). However pathways for the diagnosis, treatment, and follow-up of bowel cancer vary considerably across England. In 2005 the Department of Health commissioned a study to assess the costs and benefits of the current bowel cancer service and the expected costeffectiveness of options for change to ensure that investment in bowel cancer services is directed to those areas that will give maximum benefit to patients. This study involved the development of a mathematical model of the pathways of care experienced by people who are suspected of having colorectal cancer and traces them through to either a negative „all clear? diagnosis or through subsequent treatment. This work informed the Cancer Reform Strategy of 2007. The work proposed here will develop the previous modelling of the colorectal cancer system specifically to examine ways of supporting primary care in
Background (400-800 characters): ScHARR has an internationally recognised work programme in colorectal cancer modelling. The models that ScHARR develops and maintains encapsulate the best current hypotheses regarding disease epidemiology and natural history, diagnostic test characteristics, treatment options and the organisation and delivery of cancer services within the UK. These models are used to provide support for policy decision making and the design of intervention evaluation studies, to develop and test hypotheses regarding disease natural history and to support the optimal design of interventions in the light of the full evidence base. This work programme has impacted directly on the Cancer Reform Strategy of 2007, the establishment of screening programmes in England and Ireland and on many NICE guidelines. Aims (400-800 characters): The research aims to understand the impact on lives saved and healthcare resources required of (i) introducing direct access to col
Academic
University of Sheffield
S10 2TN
53.381
-1.489
Mr Jim Chilcott
Not Provided
Chief Investigator
Cancer and neoplasms
8. Health and Social Care Services Research/8. Health and Social Care Services Research
8.1 Organisation and delivery of services/8.2 Health and welfare economics
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
11
006/0034
National Perinatal Epidemiology Unit (Jan 2006 - Dec 2010)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£5,818,310
1 January 2006
31 October 2011
BackgroundAs the future Programme of Work covers the period 2006-2010, we are aware that much of the work the NPEU will undertake in this period cannot be precisely specified at this stage as policy imperatives may change and new opportunities and priorities are difficult to predict. Therefore, the specific projects referred to in this document are mostly those that will be started early in the next Programme of Work and for which there is already a clear idea that the project is necessary and feasible. The current document assumes that all of the resources requested from the Department of Health for the proposed future Programme of Work 2006-2010 are granted. In addition, further prioritisation will take place following on-going discussions between the NPEU and the Department of Health RDD and Policy teams.Cross-cutting Theme 1: Service organisation and delivery Service provision, organisation and staffing are key inter-linked aspects of maternity care . The NSF places emphasis on
Academic
University of Oxford
OX1 2JD
51.758
-1.262
Professor Peter Brocklehurst
0000-0002-9950-6751
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Social Care
Award does not have an ODA Downstream Partner
12
006/0035
4CHILD - The Four Counties Database of Cerebral Palsy, Vision Loss and Hearing Loss in Children
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£368,804
1 April 2003
31 January 2009
BackgroundAims: . To continue to monitor the rates and characteristics of children with major motor and sensory impairment born since 1984. . To provide support for local, regional and national research initiatives involving the ORECI data. (see Appendix 2) . To participate in research within the network of UKCP registers (Appendix 3). . To collaborate with 14 centres in Europe (SCPE) to develop a central database of children with cerebral palsy and for research (Appendix 4). Subject group: ORECI is a population-based register of childhood impairment. It includes all children with cerebral palsy, severe vision loss and/or sensorineural deafness born since 1984 to mothers resident in the four counties of Berkshire, Buckinghamshire, Northamptonshire and Oxfordshire. The register covers a population of 2.6 million and a birth population of 35,000 babies per year, which represents 5% of all births in England. Approximately 1700 children with impairments have been included on the regist
Academic
University of Oxford
OX1 2JD
51.758
-1.262
Professor Jennifer Kurinczuk
0000-0001-9554-6337
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
13
006/0036
The Northern Congenital Abnormality Survey: A Collaborative Survey of Congenital Anomalies in the Northern Region
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£427,079
1 April 2003
31 January 2009
BackgroundCongenital anomalies are a significant cause of stillbirth and infant mortality accounting for around 1,000 stillbirths and 1,250 infant deaths in England and Wales annually. They also contribute to morbidity in the first years of life and beyond. The Northern Congenital Abnormality Survey (NorCAS), established in 1984, is an ongoing population based register of all congenital abnormalities arising within the population of the former Northern Region whether occurring in miscarriages, terminations of pregnancy or registered births, and whether diagnosed antenatally or later. Notification of cases is made from multiple sources, and all obstetric units in the Region contribute to the survey enabling high case ascertainment. It is managed by the Northern & Yorkshire Public Health Observatory in partnership with academic departments at Newcastle University. NorCAS is more complete than the National Congenital Anomaly System due to the strong local clinical network and the inclusio
Academic
University of Newcastle upon Tyne
NE1 7RU
54.980
-1.616
Professor Judith Rankin
0000-0001-5355-454X
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
14
006/0060
Evaluating the Family Nurse Partnership Programme in England: a Randomised Controlled Trial
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£5,167,489
1 October 2008
31 March 2016
The Family Nurse Partnership (FNP) is a programme of home visits by specially trained nurses to support young first time mothers during their pregnancy and up to two years after birth. It has been developed in the US, and is currently undergoing an initial evaluation in England. Our proposed study will evaluate the impact of the FNP upon the health and well-being of both mother and child during pregnancy and childbirth and, in the first two years after birth, the child’s development and the mothers’ well-being. Measurements will include the baby’s weight, accidents and injuries to the young child and whether the mother has further pregnancies within the next two years. In the 20 geographical sites taking part in the study, 2400 women under 20 years old will be allocated at random to either enter the FNP programme or to continue receiving only existing local services for pregnant women. A research nurse will interview all participating women face-to-face at the start and end of the stud
BackgroundThe Family Nurse Partnership (FNP) is a structured programme of home visits delivered by specially trained nurses for at-risk first time mothers. Part of the Child Health Promotion Programme, this intensive intervention has been introduced to address the elevated risk of social exclusion and health disadvantage that such women and their off-spring face. The programme aims to modify behavioural risk factors and enhance protective factors through regular home visits that start in early pregnancy and continue until the child’s second birthday. Based on the original US programme which has been widely evaluated, the FNP is currently undergoing formative evaluation at 10 English sites. Ten more sites will join to form a sample for a trial of the effectiveness and cost-effectiveness of the FNP.AimsOur study aims firstly to evaluate the effectiveness of the FNP within three outcome domains: pregnancy and birth, child health and development, and parental life course and self-sufficien
Academic
Cardiff University
CF24 0DE
51.484
-3.166
Professor Michael Robling
0000-0002-1004-036X
Chief Investigator
Blood/Neurological
3. Prevention of Disease and Conditions, and Promotion of Well-Being
3.1 Primary prevention interventions to modify behaviours or promote well-being
Social Care
Award does not have an ODA Downstream Partner
15
006/0068
Pre-Pregnancy Health and Care in England: Exploring Implementation and Public Health Impact
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£414,832
1 January 2011
30 April 2014
Research shows that the health and care of women and their partners before pregnancy and in the first weeks when a women may not realise she is pregnant is very important. Good health and pre pregnancy care at this time can improve the wellbeing of the baby and lead to the prevention of future disease in adulthood. Pre pregnancy care involves women and men taking care of themselves before pregnancy by eating healthily, not smoking and following guidelines for lifestyle and dietary advice. Women should take folic acid tablets to prevent spina bifida twelve weeks before pregnancy and for the first twelve weeks. Medication should be reviewed and environmental hazards avoided to prevent damage to the baby. Research has shown that many women and men are not aware and do not comply with guidelines for pre pregnancy care with only half to two-thirds of women planning their pregnancies. A study is proposed to examine pre-pregnancy health and care in England to find out which issues are imp
BackgroundGood maternal & paternal health before and at conception can shape a child's future life course. This raises the importance of pre pregnancy care for screening, prevention & management of risk factors that affect pregnancy outcomes & the future health of families. There is little information about the provision of pre pregnancy care in England. Better understanding of the bio-psychosocial, cultural and economic factors affecting access to pre pregnancy care is needed if services are to be improved and more pregnancies planned. Only about 50% of pregnancies are planned. Holistic study of the complexity of health care before and between pregnancies is needed to identify interventions that are effective & acceptable to women & men, and the key contextual factors that enable health gain.AimsThe overall aim of the study is to provide high quality evidence regarding the implementation & public health impact of pre pregnancy health & care for women & men in England in order to infor
Academic
University College London
WC1E 6BT
51.524
-0.132
Professor Judith Stephenson
0000-0002-8852-0881
Chief Investigator
Reproductive Health and Childbirth
8. Health and Social Care Services Research
8.1 Organisation and delivery of services
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
16
007/0015
Adsorption of Prion Isoforms to Stainless Steel Surfaces: Implications for Surgical Decontamination Procedures
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£176,042
1 December 2006
31 January 2009
BackgroundVariations of grant management and staff. (i) the PI of this proposal has been moved from IAH to NIMR in 2005; (ii) it is now proposed to continue this project at the NIMR and to employ a new Research Assistant to carry out planned experiments on various cellular models including human and mouse neurospheres derived from EC and ES cells.Variations of animal and cellular studies. Some of the original experiments that were planned to be performed with animals will be carried out with human and mouse cellular models. We suggest restricting all experiments to human and mouse neurospheres derived from human embryonic carcinomas and mouse embryonal stem cells, focusing on the toxicity and physiological activity of endogenous PrP material obtained from cellular homogenates with elevated level of PrP expression, and also from blood serum. In addition various oligomeric and fibrillar forms of recombinant PrP protein will be tested using the same cellular models. Cell lines expressing
Undefined
MRC National Institute for Medical Research
NW7 1AA
51.618
-0.220
Professor Guy Dodson
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
17
007/0073
Development of Rapid Visual and Epimicroscopy Techniques
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£755,147
1 January 2002
31 March 2009
BackgroundAdvanced light microscopy techniques will be used to assess contamination of various grades of surgical steel coupons and medical instruments, initially using mucins, heparin sulphate and chondroitin sulphate, as models of saliva or brain glycosaminoglycan contamination, and blood. A mouse animal model will be used to supply infected brain homogenate for these contamination studies. Contaminated steel surfaces will be treated with proteinase K to remove normal prion and other brain material, leaving PrPsc which will be scraped/washed off, concentrated by ultrafiltration (assayed by two site ELISA) and serial dilutions injected into the brains of mice to show that the material is still infective. Sensitive pathological and behavioural measures will be used to assay for evidence of low levels of infectivity that might not lead to overt clinical disease.The industrial collaborators (Microgen Bioproducts) have developed a diagnostic kit capable of detecting specific protein ac
Academic
University of Southampton
SO17 1BJ
50.934
-1.396
Professor Bill Keevil
0000-0003-1917-7706
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
18
007/0074
Heart Rate Variability as an Aid to Diagnosis of vCJD
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£102,349
1 January 2002
30 June 2004
BackgroundThis is a pilot study to evaluate whether there is any clinical utility in the use of heart rate variability (HRV) measurement as a non-invasive, ante-mortem differential diagnosis for vCJD in human subjects. It has been suggested that the vagus nerve is the primary route of neuroinvasion of TSE agent after oral challenge. In that event, the vagal nuclei of the medulla oblongata are the first sites where abnormal prions will have the opportunity to damage the central nervous system. HRV is a widely used tool for assessing medullary brainstem function, and the objective of this study is to determine whether vCJD does affect HRV in an objectively quantifiable manner. HRV has already been described as a putative test for BSE in cattle in two patents filed by independent University research groups. AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJEC
Academic
The University of Manchester
M13 9PL
53.467
-2.234
Dr Chris Pomfrett
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
19
007/0077
Removal of Infective Protein Residues from Medical Instruments
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£1,295,022
1 June 2002
31 July 2011
BackgroundThis project has the objective of developing new methods to remove and verify the removal of prions from surgical instruments. The project consists of three interactive themes: 1) the development of plasma cleaning methods for the removal of biologically derived materials; 2) the development of 'on-line' fluorescence techniques for detection of protein residues; 3) biological verification of these methodologies. The outcome of the project will be an integrated and verified strategy for the decontamination and screening of surgical instruments.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field
Academic
University of Edinburgh
EH8 9YL
55.948
-3.187
Professor Robert Baxter
Not Provided
Chief Investigator
Neurological
5. Development of Treatments and Therapeutic Interventions
5.3 Medical devices
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
20
007/0085
Gene Targeted Transgenic Mice Expressing Human PRP as Models for Studying CJD
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£763,947
1 April 2003
31 May 2007
BackgroundWe have produced transgenic mice in which the endogenous murine PrP gene has been altered by gene targeting to replace the murine PrP coding region with that of human PrP. One line encodes 129MM and the other 129VV. This proposal aims to assess potential of these mice as models to study CJD, strains of TSE in humans and the influence of the 129 polymorphism in disease susceptibility. Mice will be innoculated with brain material which has been prepared in a WHO collaborative study as an International Reference Material for Diagnosis and Study of TSEs. Five different brains have been prepared and aliquoted at NIBSC, two sporadic CJD, one variant CJD and one non-CJD control all from 129MM individuals and one sCJD from a 129M129V individual. Material from a sCJD individual carrying a PrP gene encoding V129V129 (available from the CJD Surveillance Unit) will also be used in the study. For each successful transmission, strain typing, PrP deposition and PrPSc analysis will be carrie
Undefined
Institute for Animal Health
Professor Jean Manson
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
21
007/0094
CJD Surgical Instrument Storage Facility
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£423,971
1 March 2003
31 December 2013
BackgroundA facility is required by the Department of Health for the long-term secure storage of surgical instruments used in connection with the treatment of patients subsequently found to be incubating variant Creutzfeld-Jakob disease (vCJD). The instruments used on each patient need to be fully identified and securely packaged on site prior to collection from surgical units in a safe and uniform manner. Following receipt, the instrument containers require rack-mounted storage in an environmentally controlled room for extended periods. The containers must be held in such a form that they can subsequently be sent out identified but unopened to researchers with appropriate facilities for further investigations.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] fi
Government/NHS
Public Health England
SE1 8UG
51.502
-0.109
Dr J. Mark Sutton
0000-0002-2288-0446
Chief Investigator
Neurological
2. Aetiology
2.6 Resources and infrastructure (aetiology)
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
22
007/0101
Surveillance for Asymptomatic Prion Infection in Primary Immunodeficiency Patients Exposed to UK Sourced Immunoglobulin
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£339,983
1 September 2006
31 March 2015
Variant Creutzfeldt-Jakob disease (vCJD) is a type of dementia, caused by an abnormal prion which originally came from cattle with ‘mad cow disease’ or bovine spongiform encephalopathy (BSE). In addition, we know that human to human transmission can occur. Blood donors who at the time were unaware that they were infected with vCJD, donated blood which infected recipients with vCJD. There are 3 known cases in the UK. This has only happened in the UK. Immunoglobulin is a product derived from blood used primarily to treat patients with antibody deficiencies. Each injection is made from several thousand blood donations. This means that any immunoglobulin infected with vCJD could possibly spread abnormal prions from person to person. Our research is to find out if this has happened to patients exposed to British-sourced immunoglobulin and we have recruited volunteers to participate in the study. VCJD and other prion diseases can only be diagnosed from tissue samples. We are collecting tissu
BackgroundThe possibility that the abnormal prions responsible for variant Creutzfeldt-Jakob disease (vCJD) may be transmitted through plasma products has considerable ramifications for patients with Primary Immunodeficiency (PID) receiving immunoglobulin.Although abnormal prions are transmissible by whole blood between animals, there are no data showing this can happen between humans. Abnormal prions can now be detected in lymphoid tissue from asymptomatically infected individuals with reasonable specificity and sensitivity. The technology to detect abnormal prions in blood samples is also improving.The proposed project will be carried out on approximately 130 PID patients exposed to UK sourced immunoglobulin between 1996 and 1998, attending PID centres across the UK. The proposal is to produce:- a confidential data base containing exposure details and prospective clinical evaluations- a retrospective and prospective collections of lymphoid and spleen material for histological prio
Government/NHS
Manchester University NHS Foundation Trust
M13 9WL
53.462
-2.228
Dr Matthew Helbert
Not Provided
Chief Investigator
Neurological
2. Aetiology
2.4 Surveillance and distribution
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
23
007/0108
Prion 1 Clinical Trial
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,749,330
1 June 2004
31 August 2008
BackgroundBackground: The propagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, involves post-translational conversion of normal cellular prion protein (PrPC) to disease-associated forms (PrPSc). Quinacrine, an anti-malarial agent that potently blocks PrPSc production in vitro, was administered to patients with a variety of prion diseases to assess its safety and efficacy in altering the course of these invariably fatal and untreatable diseases.Methods: Patients with prion disease were recruited from neurologists in the UK and were offered a choice between: (1) randomisation to immediate, versus deferred (by six months), quinacrine; (2) immediate quinacrine; (3) no quinacrine. The primary endpoints were death and serious adverse events possibly/probably related to quinacrine.Findings: 107 patients were enrolled (45 sporadic, 2 iatrogenic, 18 variant and 42 inherited), 23 in a pilot and 84 in the main study. Only 2 patients chose random
Non-Profit/Charity
Medical Research Council
SN2 1FL
51.567
-1.785
Professor John Collinge
0000-0003-2220-7566
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
24
007/0110
Evaluation of Ozone Sterilisation as Methods for Inactivation of TSE Agents
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£383,659
1 April 2005
31 January 2009
BackgroundThis project aims to evaluate a novel sterilisation protocol based on ozone as a method for the inactivation of TSE agents, specifically BSE/vCJD on surgical instruments. The proposal will be carried out as part of a larger package of work in collaboration with the manufacturer of the ozone steriliser (TSO3 inc, Quebec, Canada), University of Montreal and Health Canada. Current studies by TS03 have demonstrated the potential of ozone to destroy prions as assessed by Western blot and are currently looking at bioassays of scrapie strain 263K in hamsters.This section of work will evaluate the ability of an ozone steriliser to inactivate the BSE agent in direct comparison with a standard steam sterilisation protocol. The work will use BSE 301V dried onto surgical steel wires and implanted directly into the brain of VM mice, to generate a worse case for the possible entry of CJD into the human brain following neurosurgery. The inactivation process will be assessed principally agai
Academic
Health Protection Agency
NW9 5EQ
51.595
-0.255
Dr J. Mark Sutton
0000-0002-2288-0446
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
25
007/0120
The Effect of Leucodepletion on Transmission of BSE by Transfusion of Sheep Blood Components
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£795,296
1 November 2005
31 March 2007
BackgroundThis project will use sheep experimentally infected with BSE as a model to study the risks of transmission of variant CJD by blood components in humans. The aim of the project is to determine the distribution of BSE infectivity in sheep blood components, and the effectiveness of human leucodepletion filters in removing infectivity. The methods used for collection of blood and separation and filtration of components will follow as closely as possible those routinely employed for human blood by transfusion services, and will initially be developed and validated for normal sheep blood in the laboratories of SNBTS. A secondary aim of the project is to develop a bioassay for measurement of titres of infectivity in blood components, using transgenic mouse lines that over-express ovine PrP. The sheep experiments will be carried out using BSE-infected donors and will assess the effect of leucodepleting blood components (plasma, platelets and erythrocytes) on transmission at a single
Undefined
Institute for Animal Health
Dr Fiona Houston
0000-0002-4082-2274
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
26
007/0160
Gene Targeted Transgenic Mice Expressing Human PRP as Models for Studying CJD
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£203,761
1 April 2007
31 August 2008
BackgroundWe have produced transgenic mice in which the endogenous murine PrP gene has been altered by gene targeting to replace the murine PrP coding region with that of human PrP. One line encodes 129MM and the other 129VV. This proposal aims to assess potential of these mice as models to study CJD, strains of TSE in humans and the influence of the 129 polymorphism in disease susceptibility. mice will be innoculated with brain material which has been prepared in a WHO collaborative study as an International Reference Material for Diagnosis and Study of TSEs. Five different brains have been prepared and aliquoted at NIBSC, two sporadic CJD, one variant CJD and one non-CJD control all from 129MM individuals and one sCJD from a 129M129V individual. Material from a sCJD individual carrying a PrP gene encoding V129V129 (available from the CJD Surveillance Unit) will also be used in the study. For each successful transmission, strain typing, PrP deposition and PrPSc analysis will be carrie
Undefined
The Roslin Institute
EH25 9RG
55.866
-3.201
Professor Jean Manson
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
27
007/0161
Conditional Expression of PRP in the Gut of Transgenic Mice to Investigate the Uptake of Infectivity in the Gut in the TSEs
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£831,419
1 April 2007
31 January 2011
BackgroundWe aim to establish whether PrP expression in the gut is required for the uptake of TSE infectivity and whether in the absence of intestinal PrP expression, uptake and transport of infectivity to peripheral sites of agent replication is blocked. We will address this using two lines of gene-targeted transgenic mice which allow us to control the expression of the PrP gene in a temporal and/or spatial fashion. These mice allow us to switch PrP expression on (NS line) or off (ORFR line) when crossed with Cre recombinase transgenic mice. We will cross the ORFR and NS lines with an inducible P450-Cre line which expresses Cre recombinase in the stem cells of the intestine following administration of the p450-inducer, beta-napthoflavone. Used in conjunction with an inducible neurone-specific Cre line we will be able to control PrP expression in the intestine and neurones prior to orally infecting with a murine TSE agent. These studies will determine the potential for early inter
Undefined
The Roslin Institute
EH25 9RG
55.866
-3.201
Professor Jean Manson
Not Provided
Chief Investigator
Neurological
2. Aetiology
2.1 Biological and endogenous factors
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
28
007/0169
Investigating Dental Treatment as a Possible Risk Factor for Variant CJD
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£256,621
1 April 2008
30 September 2009
BackgroundLittle work has been performed examining accurate past dental history of CJD cases and controls by direct review of dental records. The NCJDSU has MREC approval to collate information from the medical records of CJD cases and matched controls. Following on from a DH funded pilot study, this study will attempt to access the dental case records of UK variant CJD cases (n=166 as of 9/8/07) and 166 general population controls. In addition, payment schedule records will be accessed where possible in collaboration with NHSBSA Dental Practice Division (England and Wales) and NHSNSS Information and Statistics Division (Scotland). The case record and payment schedule data will be reviewed by a dental healthcare professional and will, where possible, include the presence or absence of oral disease, dates and types of treatment performed and additional risk factor information, e.g., human dura mater grafting. Data will be coded and entered into a database for subsequent analysis. Geogra
Academic
University of Edinburgh
EH8 9YL
55.948
-3.187
Dr Hester Ward
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
29
009/0036
A Randomised Controlled Trial of a Nurse-Led Self-Management Intervention for Patients Admitted to Hospital with Heart Failure
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£223,102
1 January 2004
29 February 2008
BackgroundHeart Failure is associated with high costs and poor outcome. Patients with this diagnosis are expected to adhere to a complex behavioural regimen including taking medication, monitoring for signs of fluid re-accumulation and a range of life-style changes. Without intervention adherence is about 50%. Standard education alone does not modify this figure. We aim to explore the hypothesis that a brief nurse-Ied self-management intervention will empower patients to positively modify their behaviour and so outcome. The efficacy of this intervention, based on a problem solving approach using cognitive behavioural principles, will be assessed by a randomised controlled trial of 250 patients admitted to hospital with a definite diagnosis of heart failure, randomised to either the nurse-Ied intervention or standard hospital care. The primary outcome measure will be the number and duration of re-admissions at three months. Secondary analyses include costs, mortality at 12 months and pr
Government/NHS
Whittington Health NHS Trust
N19 5NF
51.566
-0.139
Dr Suzanna Hardman
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
30
009/0037
A Randomised Controlled Trial of Exercise Rehabilitation in Addition to Specialist Heart Failure Nurse Intervention
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£312,248
1 February 2004
30 September 2007
BackgroundAims To investigate: (i) whether there are benefits from including exercise rehabilitation with specialist heart failure nurse management for patients with heart failure; (ii) the cost-effectiveness and patient acceptability of a predominantly home-based programme of rehabilitation; (iii) the patient experience of heart failure and exercise rehabilitation. Research Subject Group 11 (iv) Does multidisciplinary care improve outcomes? 11 (v): Patient and carer centred studies. Sample 270 patients admitted with decompensated heart failure or classified as NYHA III in previous 12 months, seen at a specialist heart failure clinic at a trust serving an inner city, multi-ethnic population. Methods RCT of exercise rehabilitation. The intervention group will be offered a predominantly home-based exercise programme to avoid the problems of low uptake and adherence to hospital rehabilitation programmes, in addition to specalist heart fail
Academic
University of Birmingham
B15 2TT
52.453
-1.928
Professor Kate Jolly
0000-0002-6224-2115
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
31
011/0035
Barriers to the Effective Treatment of Injecting Drug Users
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£84,036
1 October 2005
30 June 2007
BackgroundThe proposed study will build on existing research to provide essential information on how IDU engagement with services can be improved and the cost/ benefit implications of successfully increasing take-up. Specifically, it will combine qualitative and economic data to investigate the nature and extent of barriers to the effective treatment of IDUs; the particular circumstances in which barriers do/ do not prevent ]DUs accessing treatment; how barriers may vary between key IDU sub-groups and between service types; ways of removing barriers to treating IDUs; the costs of IDUs not entering treatment; and the costs of removing barriers to IDU treatment. Following an initial review of the literature, in-depth interviews - incorporating structured economic components - will be conducted with 75 injectors recruited from needle exchanges in Leeds, and urban and rural West Yorkshire. Data will be collected on socio-demographic characteristics; life circumstances; drug use; treatment
Academic
Oxford Brookes University
OX3 0BP
51.754
-1.223
Professor Joanne Neale
0000-0003-1502-5983
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
32
011/0038
User Involvement in Efforts to Improve the Quality of Drug Misuse Services: Factors That Promote and Hinder Successful Working
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£119,949
1 September 2005
30 September 2007
BackgroundUser involvement has been recommended as a means of improving service quality. While research in other fields has identified factors which enhance effective involvement, very little independent research into user involvement in drug services has taken place.We therefore propose to combine a cross-sectional survey of service providers and user groups with a series of in-depth case studies with the aim of evaluating methods for user involvement. We will survey Trusts, voluntary sector service providers and user groups in 50 Drug Action Team areas and collect qualitative data from service providers and users in six areas through in-depth interviews, focus groups and non-participant observation. By combining the collection and analysis of qualitative and quantitative data we will estimate the level of user involvement in efforts to develop more accessible, acceptable and effective drug misuse services, examine different methods used for involving service users, and investigate fa
Academic
Imperial College of Science, Technology and Medicine
SW7 2AZ
51.498
-0.177
Professor Mike Crawford
0000-0003-3137-5772
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
33
011/0041
Exploring Young People's Views and Experiences of Drug Treatment Services - A Qualitative Study
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£101,054
1 September 2005
31 March 2008
BackgroundAbstract of Research: No more than 200 words covering the following topics: aims of project; research subject group; sample size, type and location; methods of working. Exploring young people's views and experiences of drug treatment services- a qualitative study. This study will inform policy and practice in the area of drug treatment services for young people. It will provide insights into:- Young people's decision to seek and processes leading to treatment- including barriers young- people faced in accessing treatment;Young people's views and experiences of treatment services;- The perceived impact of treatment on young people's lives- including any impact on their drug- use, associated risk behaviours, offending behaviour, mental and physical well-being and overall quality of life;The perceived impact of factors other than treatment on the level and nature of drug use in- which young people engage (identifying factors that may contribute to a young person's resilience to
Academic
National Centre for Social Research
EC1V 0AX
51.527
-0.103
Ms Jane Lewis
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
34
011/0043
Interventions for Children and Families Where There is Problematic Drug Use: The Development and Evaluation of an Inter-Agency Model of Good Practice in Devon
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£102,500
1 September 2005
30 June 2008
BackgroundThis study aims to promote the welfare and `visibility' of children with drug-misusing parents by improving multi-agency assessment and intervention. . This will be done through the development, piloting and evaluation of a model of inter-agency assessment and intervention which builds on both the Framework for the Assessment of Children in Need and their Families (Department of Health2000) and effective, evidence-based models drawn form both adult and child-focused practice. In partnership with Devon Social Services Department, Drug Action Teams, Devon Partnership Trust and a sample of families, we aim to develop shared protocols, procedures and effective models of work with children and parents, reducing unnecessary or prolonged periods in the `looked after'system which result in poor outcomes. The emphasis will be on child- centred practice within an holistic, family focused context which addresses the impact of particular environmental factors in both urban and rural area
Academic
University of Plymouth
PL4 8AA
50.375
-4.138
Dr Brynna Kroll
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
35
011/0056
Drug Recovery Wing (DRW) Pilots Evaluation
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£799,134
1 October 2012
28 February 2016
Following the UK drug strategy (2010) there has been a major commitment to ensuring that drug treatment services are maximising the opportunities for the recovery of dependent drug users and that drug users in prison and in the community have access to high quality recovery focussed treatment. Delivering abstinence focussed drug treatment services within prisons presents different challenges to those developed within the community not the least of which is the need to combine both treatment and custodial responsibilities. The research outlined in this application will answer questions in three main areas. First, based upon a detailed qualitative assessment of the drug recovery wings, it will provide a detailed description of the therapeutic programme within the wings and the experience of both staff and prisoners involved within them. This element of the research will provide rigorous information on how the wings are operating, what interventions are used with prisoners and how links
Background Following the UK Drug Strategy and the Patel report, there is a commitment to ensure that prisoners have access to high quality recovery-focussed drug and alcohol treatment services and that the link between prison and community is better managed. Research has shown that 50% of male prisoners and 65% of female prisoners have a drug problem (Singleton et al., 1997). According to Stewart (2009) who surveyed 1457 recently received prisoners across 49 prions in England 28% had used heroin in the last four weeks and 25% had used crack cocaine. It is known that in some cases prisoners are initiating injecting within prison (Boys, 2002) and that on release prisoners are at a heightened risk of death (Farrell and Marsden, 2007). Whilst prison offers an important opportunity for drug and alcohol treatment it is recognised that there are multiple challenges associated with the development of drug and alcohol services within prisons (McIntosh and Saville, 2006). Aims This research
Academic
University of York
YO10 5DD
53.948
-1.054
Professor Charlie Lloyd
0000-0003-3524-0947
Chief Investigator
Mental Health
8. Health and Social Care Services Research
8.1 Organisation and delivery of services
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
36
012/0016
Social Medicine and Health Services Research Unit (2006 - 2010)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,894,154
1 January 2006
31 December 2011
BackgroundThe work programmeThe Unit's focus will remain in two main areas. The first is in the nutritional epidemiology of asthma, the second on the role of airborne allergen in asthma exacerbations. A third area, which relates to each of these, is development of the molecular epidemiology of asthma, building on the experience of the STARS studies.Nutritional Epidemiology of AsthmaThe fellow replacing Dr Shaheen will take on a portfolio of work on asthma and nutrition. This includes ongoing work with the ECRHS data, new studies on asthma and dietary sodium, potentially work undertaken through the GA2LEN network of excellence, and a new application following up Dr Calvert's studies of nutrition and asthma in Africa.The trial of selenium supplementation in adults with asthma has now finished and is being analysed (Dr Shaheen). Dr Okoko though he will not any longer be formally on the DH unit strength will continue his studies of asthma and apple intake. A cross-sectional survey in schoo
Academic
Imperial College of Science, Technology and Medicine
SW7 2AZ
51.498
-0.177
Professor Peter Burney
Not Provided
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
37
015/0307
Revised Title: Evaluation of TB Control Interventions in the Community and Emergency Medicine Departments: The ACE Study (A & E Screening, Cohort review, Comprehensive local service review, Contact Tracing, Latent TB screening in Primary Care, Pre entry screening, Improving Service Coordination)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£414,455
1 September 2013
30 September 2016
This proposal is focused upon early diagnosis, referral and treatment of latent and active tuberculosis, which has two key components: 1) ensuring optimal outcome for individuals; 2) contributing to disease control in public health terms by preventing further spread. A&E Departments are an important point of testing and referral for the client group that constitute those at greatest risk, as for many this will be their only interaction with the health service [Althaus et al 2011]. Currently, A&E Departments contribute about 20% of those diagnosed with TB (See table on p.7). The majority of these individuals are most likely to have presented with symptoms indicative of disease, compared to those attending for other reasons who would have been unlikely to have been tested or referred. This study will seek to evaluate specific measures currently being undertaken by the Health Protection Agency and the NHS to control TB as well as investigate whether case finding in for latent and a
Background: Control of infectious diseases requires prompt, effective identification and treatment to safeguard health and prevent transmission. Identifying those in high risk groups, evaluating signs and symptoms and referring individuals for testing and management are key to control efforts. Tuberculosis (TB) causes significant morbidity in the UK. Early treatment may have the greatest impact by interrupting transmission. Between 2000-9, TB cases in England rose from 12.4 to 16 per 100,000 with over 8000 cases diagnosed annually, mostly among individuals from identified risk groups. In London A&E accounts for 20% Mtb cases diagnosed and 49% from primary care overall. Aim: Research plan and methods Work Package 1: Determining the prevalence of latent TB infection and active TB disease and cost effectiveness of testing high risk groups attending A&E departments. An observational study, which prospectively recruits participants for latent TB testing, combined with health eco
Academic
University College London
WC1E 6BT
51.524
-0.132
Professor Ibrahim Abubakar
0000-0002-0370-1430
Chief Investigator
Infection
8. Health and Social Care Services Research/4. Detection, Screening and Diagnosis
8.2 Health and welfare economics/4.4 Population screening
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
38
015/0313
Identifying interventional approaches to improve health care access for Hepatitis B in high prevalence groups.- A study of knowledge, beliefs, and attitudes about Hepatitis B among Chinese and Far East Asian residents of South Yorkshire and factors restricting appropriate risk evaluation, testing, preventative activities and referral for treatment to inform review of current policy.
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£266,671
1 October 2013
31 March 2017
Hepatitis B – a serious infectious disease caused by a virus transmitted in blood and body fluids – is common among migrant Chinese communities , being found in around 1 in 10 people. However, research in the UK and elsewhere shows that access to healthcare is low among this population, and that late diagnosis and delayed treatment is widespread. US research has found poor understanding about hepatitis B in migrant Chinese communities, with lack of awareness about risks and mistaken beliefs regarding transmission. These studies also suggest healthcare professionals may not offer testing appropriately. To-date, UK research is limited and we know little about the barriers to testing and treatment in this context. The present study addresses this knowledge gap. In South Yorkshire, Chinese residents constitute 0.2 - 1.3% of the population and pilot work by members of the research team has confirmed high levels of infection and low levels of testing and treatment in this
Background: The high prevalence of hepatitis B inChinaand other Far East Asian countries has been well documented in international epidemiological studies. Transmission occurs most frequently vertically, but also sexually, among household contacts and through healthcare. Chronic carriage is frequent, with considerable disease burden including morbidity and mortality from cirrhosis and hepatocellular carcinoma. Early treatment can prevent complications; however, access to specialist healthcare is known to be impaired in this group. Aims: This study objective is to identify the factors associated with poor levels of diagnosis and treatment operating at three levels in theUK: the Chinese community, the health care providers and the health system. This in turn should provide a base to help formulate policy to improve prevention and care. Three aims are: 1 - To identify within the target communities health seeking behaviours as well as knowledge, attitudes and misconceptions in rela
Government/NHS
Sheffield Teaching Hospitals NHS Foundation Trust
S10 2SB
53.378
-1.496
Professor Andrew Lee/Dr Alicia Beatriz Vedio
0000-0002-9795-3793/Not Provided
Joint Lead Applicant/Chief Investigator
Infection
7. Management of Diseases and Conditions/4. Detection, Screening and Diagnosis
7.1 Individual care needs/4.3 Influences and impact
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
39
016/0049
Developing Skills in the NHS
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£232,172
1 December 2003
30 June 2008
BackgroundThis proposal outlines plans for the identification, analysis and evaluation of the use; of the skills escalator concept and associated support for learning in the NHS. The skills escalator aims to attract a wider range of people to work in the NHS whilst also supporting career potential and development across its workforce. Through investing in a lifelong learning approach, the NHS seeks to encourage staff towards new ways of working which extend their current skills and contribute to wider service/process redesign and improvements in health services. The proposed evaluation is -intended to be both academically rigorous and practically relevant. It has three main aims: to identify and map the use of the skills escalator and associated support for learning; to analyse and evaluate the outcome of these practices; and to develop methodologies for the local evaluation of such practices. The approach we propose is intended to make maximum use of existing sources of data including
Academic
The University of Manchester
M13 9PL
53.467
-2.234
Dr Anne McBride
0000-0003-1047-1319
Chief Investigator
Awaiting Health Category Coding
9. Awaiting RAC Coding
9.1 Awaiting RAC Coding
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
40
016/0058
Nursing Research Unit (2007-2012)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,512,956
1 October 2007
31 December 2012
BackgroundHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.AimsHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Potential ImpactHISTORIC PROJECT - all available project details have been transferred from project proposal to respective fields in this database.Policy RelevanceUnknown
Academic
King's College London
SE1 8WA
51.505
-0.113
Professor Jill Maben
0000-0002-6168-0455
Chief Investigator
Generic Health Relevance
8. Health and Social Care Services Research
8.1 Organisation and delivery of services
Award not coded to a curated portfolio
Award does not have an ODA Downstream Partner
No results
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