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NIHR Open Data - Funded Portfolio

Project_ID
Project_Title
Funding_and_Awards_Link
Funder
Programme_Type
Project_Status
Programme
Programme_Stream
Funding_Stream
Award_Amount
Start_date
End_Date
Plain_English_Abstract
Scientific_Abstract
Organisation_Type
Contracted_Organisation
Postcode
Latitude
Longitude
X
Y
Devolved Administrations
English Regions
Parliamentary Constituencies
Local Authorities
Integrated Care Boards
1
001/0010
Injury Trends and Social Gradients
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£88,155
1 أغسطس 2004
30 سبتمبر 2007
Not Available
BackgroundAims To contribute to evidence based accident prevention policy through:1. describing cause specific injury mortality gradients for children and young adults 2. determining whether gradients have widened or narrowed over last 10 years 3. determining how far gradients are explained by exposure to risk 4. identify geographic areas where injury rates are highest5. utilise the findings from aims 1-4 with those from other projects funded under this programme to develop bids for interventions designed to address inequalities in injury rates for children and young peopleResearch design and methods This project will be a secondary analysis of existing data sets including ONS mortality data, Hospital Episode Statistics and the Health Survey for England morbidity data and DoT travel survey data. These will be analysed using census denominators to identify social class, regional, and (where possible) ethnic group injury rate trends.Involvement of stakeholders A steering group will inclu
Academic
London School of Hygiene and Tropical Medicine
WC1E 7HT
51.521
-0.131
529790
181879
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
2
001/0013
Preventing Falls amongst Older People: Socio-Economic and Ethnic Factors
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£179,782
1 سبتمبر 2004
31 مارس 2008
Not Available
BackgroundFalls and fractures amoungst older people are a major public health challenge. Suprisingly little is known about the association of falls and use of falls-related services with socio economic status and ethnicity. The present proposal is for a series of three studies to investigate the question: 'what are the socio-economic and ethnic differences in fall-related morality, morbidity, health care seeking behaviour and provision of services?' The first study will perform novel secondary analysis on three different existing data sources (ONS morality statistics, Hospital Episode Statistics (HES), and Health Survey for England (HSE). This will provide statistics variation in falls and health care seeking behaviour, but will not permit us to identify the reasons for observed variations, and may not provide sufficient data on ethnic minorities. To supplement the data on ethnic variations and to identify the reasons for variations we will undertake new primary research by carryi
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
3
001/0014
Facilitators and Barriers to Older People Accepting and Complying With Interventions to Reduce Falling and Fractures
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£130,035
1 سبتمبر 2004
31 أكتوبر 2008
Not Available
BackgroundThe overall aims of the project are to:identify the barriers and facilitators to the implementation of falls injury prevention strategies and programmes for older people and to investigate why older people may either refuse to participate in an intervention or, not adhere to specific social or clinical recommendationsMethodsThis will involve a two-phase process using both qualitative and quantitative methods. The first phase consists of a systematic literature review. Through inclusion of all available studies, including grey literature, the views, preferences and experiences of older people in relation to falls prevention strategies will be assessed alongside the effectiveness of interventions to promote falls injury prevention. The second phase, informed by the review, will involve focus groups and interviews to provide an in-depth investigation of older people's perceptions of fall injury prevention strategies. This will cover a broad range of interventions and will includ
Academic
University of Hertfordshire
AL10 9AB
51.753
-0.242
521517
207512
England
East of England
Welwyn Hatfield
Welwyn Hatfield
NHS Hertfordshire and West Essex Integrated Care Board
4
002/0010
Cardiac Rhythm and Personal Exposure to Air Pollution in Patients with Heart Failure
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£249,178
1 أكتوبر 2002
30 سبتمبر 2007
Not Available
BackgroundThe majority of excess deaths associated with rises in air pollution appear to be from cardiac causes. Particles and nitrogen dioxide are the pollutants most closely associated with this effect but which of these, and the mechanisms, remain speculative. The hypothesis is that the effects are mediated by secondary changes in blood coagulability. Another is that pollution causes changes in the irritability of the heart, with changes in rate, rhythm and variability. These hypotheses are not in conflict and this project will investigate both.The study will look at the associations between exposure to particles and NO2, alterations in cardiac rhythm, and coagulation factors in 100 patients recrutied from 200 with stable heart failure. In each it will measure personal exposure to NO2 and estimate personal exposure to particle mass and number for 3 consecutive days on six separate occasions over a year. On the 3rd day it will record a 24-hour cardiograph and take blood for ind
Academic
University of Aberdeen
AB24 3FX
57.165
-2.100
394104
808245
Scotland
Not Applicable
Aberdeen North
Aberdeen City
Not Applicable
5
002/0015
Health Effects of Long-Term Exposure to Air Pollutants in Scotland
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£188,761
1 أبريل 2003
30 يونيو 2007
Not Available
BackgroundThe purpose of the proposed research is to simultaneously quantify the health effects of long-term exposure to air pollutants and shortening of life from short-term exposures. Primary outcome measures are cause-specific mortality and morbidity , with particular attention to cardiovascular outcomes. We will compare the results of cohort studies to corresponding estimates from time-series studies of the population from which the cohorts are drawn. Outcomes in 26,360 subjects in 3 cohorts will be investigated in the period between 1970 and 2002. Detailed baseline risk data and the unique advantages of the Scottish Health Record Linkage system (including algorithmic linking of individual hospital admission & mortality records) will enable novel ways of quantifying effect magnitudes in susceptible population sub-groups, and coherence in medical outcomes. We shall examine the potential for confounding and effect modification by both individual and aggregate level factors (including
Academic
University of Strathclyde
G1 1XQ
55.861
-4.245
259609
665397
Scotland
Not Applicable
Glasgow Central
Glasgow City
Not Applicable
6
002/0025
Pilot Study of Risks and Long Term Effects of Carbon Monoxide Poisoning
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£65,415
1 يوليو 2008
30 سبتمبر 2010
Carbon monoxide poisonings arise mostly from faulty domestic appliances - gas heaters, boilers, stoves, cookers. Among those who survive poisoning incidents, the oxygen starvation may cause long-term damage, and there is a need to understand the risks and causes of various symptoms and conditions. A full study might recruit up to 800 cases from Scottish hospital A&E admissions in the last two decades, using postal questionnaires and details from hospital patient notes. The questionnaires will include questions on general health before and after the accident, lifestyle (smoking, alcohol), and questions relating to mental state, because we suspect some long-term symptom patterns may be due to psychological stress rather than physical damage. In some patients we may see symptoms of poisoning some time before the actual poisoning incident and this will indicate whether carbon monoxide poisoning goe unrecognised in the community both by doctors and the victims. In this pilot study we
Background In non-fatal CO poisoning, there may be acute hypoxic damage to the brain, and/or long-term sequelae in the central nervous system, including chronic cognitive impairment. The reporting of chronic symptoms following lower levels of exposure may be coloured by multiple factors, and in some cases the putative effects of CO poisoning may be better understood as a somatoform disorder. Using NHS Scotland electronic databases, it should be possible to identify up to 800 past CO poisoning victims and to obtain data about their symptoms and health status since the incident. This could both address long-term sequelae and investigate possibilities of somatoform disorders. We propose a pilot study to investigate the feasibility of the approach and to develop and validate appropriate methods. Aims Given the hypotheses to be tested by a full study (Section 9), we propose a pilot study with the aims: • to obtain permission to contact study patients and controls through S
Non-Profit/Charity
Institute of Occupational Medicine
EH14 4AP
55.916
-3.316
317743
669728
Scotland
Not Applicable
Edinburgh South West
City of Edinburgh
Not Applicable
7
002/0027
Health Implications of Polycyclic Aromatic Hydrocarbons in Indoor Environments
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£74,730
1 يناير 2009
31 مارس 2010
Polycyclic aromatic hydrocarbons are a group of chemical substances emitted into the air from combustion processes. They get into indoor air from indoor sources such as smoking as well as infiltrating from outdoors. The concern over polycyclic aromatic hydrocarbons is that some of them are known to be carcinogenic (cancer causing) agents and breathing air polluted with them increases the risk of contracting lung cancer, even in non-smokers. Whilst the government funds widespread measurements of polycyclic aromatic hydrocarbons in outdoor air, there are very few measurements, particularly from the UK, of polycyclic aromatic hydrocarbons in indoor air. This project is concerned with using data and samples collected in an earlier study to compare the concentrations of polycyclic aromatic hydrocarbons in indoor air with those out-of-doors and to see whether the profile of individual compounds making up the mixture is similar indoors and outdoors. Using potency factors for the cancer-c
BackgroundPolycyclic aromatic hydrocarbons are known pollutants of indoor air. They arise from indoor sources such as tobacco smoke and cooking as well as from infiltration of outdoor air. PAH comprise a range of compounds and there is currently little information on whether the profile of compounds in indoor air matches that outdoors. Most probably it does not, since the sources will be significantly different. This has implications for the toxicity of the mixture and the suitability of the outdoor air quality standard as a guideline for indoor concentrations.AimsThese are as follows:• to investigate the concentrations and profile of PAH compounds in air sampled in UK indoor environments and to compare it with outdoor samples collected in the same localities;• by use of relative potency factors to estimate the carcinogenic risk associated with indoor air;• to evaluate whether the use of benzo(a)pyrene as a marker for the mixture is applicable to PAH in indoor air in the same wa
Academic
University of Birmingham
B15 2TT
52.453
-1.928
404851
283719
England
West Midlands
Birmingham, Edgbaston
Birmingham
NHS Birmingham and Solihull Integrated Care Board
8
002/0038
2012 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£23,777
26 مارس 2012
31 ديسمبر 2012
Organisation and conduct of a 2 day air pollution and health research review meeting on 3 & 4 May 2012. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2012 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site.
2012 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
Academic
Cranfield University
MK43 0AL
52.070
-0.631
494079
242615
England
East of England
Mid Bedfordshire
Central Bedfordshire
NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board
9
002/0039
2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£24,052
1 يناير 2013
31 ديسمبر 2013
Organisation and conduct of a 2 day air pollution and health research review meeting on 23 & 24 April 2013. The purpose is for researchers to present and discuss their work with policymakers from DH, the HPA and Defra and with other researchers in the field. The meeting will include contributions from invited speakers and a selection of those submitted in response to a call for abstracts for presentation at the meeting. A report of the meeting will be written by the organisers. This will include abstracts of the oral and poster papers presented and a summary of the discussions. The aim will be to highlight developments in the field and inform prioritisation of future research on air pollution and health. A draft report will be submitted to DH before 31 December 2013 and a final report will be published as an electronic (pdf) file freely available for download from the organiser’s web site.
2013 Annual UK Review Meeting on Outdoor and Indoor Air Pollution Research
Academic
Cranfield University
MK43 0AL
52.070
-0.631
494079
242615
England
East of England
Mid Bedfordshire
Central Bedfordshire
NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board
10
005/0163
Developing Options for Evidence Based Formula for the Need for Children's Social Services
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£114,961
1 أبريل 2005
31 يوليو 2007
Not Available
Background1. A small area analysis based on the national data set of activities and costs compiled for CIN 2003, attributing socio-economic characteristics from postcode districts and on subsets that are more homogenous with respect to ethnicity;2. Collection of ward identifiers on children in CIN 2003 from a representative sample of Local Authorities to replicate the small area analysis carried out in 19963. Analysing the individual data in CIN 2003 for all children and for subsets defined as in 1, to identify the factors that affect the level of expenditure on current clients.4. Combined analysis of one or more years of the national GHS in conjunction with CIN 2003 to assess the factors that influence the likelihood of a child being a current client.5. Special investigation of the factors affecting the costs of fostering with a view to developing a more robust adjustmentThroughout, the study will be designed and conducted in close collaboration with DfES and representatives of the Lo
Academic
University of York
YO10 5DD
53.948
-1.054
462215
450672
England
Yorkshire and The Humber
York Outer
York
NHS Humber and North Yorkshire Integrated Care Board
11
006/0037
The Mersey Cerebral Palsy Register
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£235,598
1 أبريل 2003
31 يناير 2010
Not Available
BackgroundAims of the project:To maintain and develop the Mersey Cerebral Palsy Register (MCPR). The register's aims are, within Merseyside and Cheshire, to monitor population trends in prevalence of cerebral palsy (CP); assess cohort effect on life expectancy of affected individuals; and determine trends in severity of functional disability.Research subject group:Cerebral Palsy, a group of disorders of movement and posture due to a defect/lesion of the immature brain, and the commonest cause of severe physical disability affecting children in England.Sample Size:Anticipated annual recruitment of 40-60 cases, (area has 25,000 births annually, and birth prevalence of CP of 2 to 2.5 per 1,000 live births)Type of Location:Population-based disease register, located within the University of Liverpool, established 1980, covers Merseyside and Cheshire. Case definition: a clinical diagnosis of CP, and mother resident in the area at time of birth.Methods of working:Identification by active su
Academic
University of Liverpool
L69 7ZX
53.406
-2.967
335836
390320
England
North West
Liverpool, Riverside
Liverpool
NHS Cheshire and Merseyside Integrated Care Board
12
006/0055
NPEU Birth at Home in England
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£838,794
1 أبريل 2007
31 يناير 2012
Not Available
BackgroundThe Birth at Home study will collect outcomes of planned birth at home to allow comparison with outcomes measurede by the ongoing Evaluation of Maternity Units (www.npeu.ox.ac.uk/EMU) research programme amongst women at low risk of complications who have planned birth in midwifery units and obesteris units. Data items and methods for collection will be the same as in EMU. Cost-effectiveness of the different planned places will be compared. Phase 1 (April 2007 - march 2088, months 1-12), will act as a pilot study. During this phase the feasibility of collecting data from all women planning a home birth will be explored in three local authority areas. By the 9th month, feasibility of conducting the national study will be assessed and the decision made about whether or not to proceed to national-scale data collection. I ffeasibiliyt is not demonstrated the study will stop, be reported, and funding will be terminated on March 31st 2008.Transition period (January - March 200
Academic
University of Oxford
OX1 2JD
51.758
-1.262
451034
206852
England
South East
Oxford East
Oxford
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
13
006/0060
Evaluating the Family Nurse Partnership Programme in England: a Randomised Controlled Trial
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£5,167,489
1 أكتوبر 2008
31 مارس 2016
The Family Nurse Partnership (FNP) is a programme of home visits by specially trained nurses to support young first time mothers during their pregnancy and up to two years after birth. It has been developed in the US, and is currently undergoing an initial evaluation in England. Our proposed study will evaluate the impact of the FNP upon the health and well-being of both mother and child during pregnancy and childbirth and, in the first two years after birth, the child’s development and the mothers’ well-being. Measurements will include the baby’s weight, accidents and injuries to the young child and whether the mother has further pregnancies within the next two years. In the 20 geographical sites taking part in the study, 2400 women under 20 years old will be allocated at random to either enter the FNP programme or to continue receiving only existing local services for pregnant women. A research nurse will interview all participating women face-to-face at the start and end of the stud
BackgroundThe Family Nurse Partnership (FNP) is a structured programme of home visits delivered by specially trained nurses for at-risk first time mothers. Part of the Child Health Promotion Programme, this intensive intervention has been introduced to address the elevated risk of social exclusion and health disadvantage that such women and their off-spring face. The programme aims to modify behavioural risk factors and enhance protective factors through regular home visits that start in early pregnancy and continue until the child’s second birthday. Based on the original US programme which has been widely evaluated, the FNP is currently undergoing formative evaluation at 10 English sites. Ten more sites will join to form a sample for a trial of the effectiveness and cost-effectiveness of the FNP.AimsOur study aims firstly to evaluate the effectiveness of the FNP within three outcome domains: pregnancy and birth, child health and development, and parental life course and self-sufficien
Academic
Cardiff University
CF24 0DE
51.484
-3.166
319119
176776
Wales
Not Applicable
Cardiff Central
Cardiff
Not Applicable
14
007/0063
The National CJD Surveillance Unit (CJDSU) Tissue Resource: Support for Continued Banking Activities
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£247,623
1 مارس 2003
30 أبريل 2008
Not Available
BackgroundThe National CJD Surveillance Unit (NCJDSU) was established in 1990 and in 1991 additional funding was obtained from the Department of Health (DH) to establish a neuropathology laboratory for pathological diagnosis, surveillance and research. Since then, NCJDSU has systematically collected a range of tissue samples from the central nervous system (CNS) and other tissues from a wide range of cases of human prion diseases and from other cases of progressive neurodegenerative diseases that were initially suspected as being human prion diseases, but in whom an alternative neuropathological diagnosis was made. All material in the NCJDSU bank has consent for research and local ethical committee approval has been obtained for the collection, storage and use of the material.In subsequent years it became clear that the tissue collected in NCJDSU formed an invaluable unique resource for research and increasing requests for access for the material (particularly variant CJD) were obtai
Academic
University of Edinburgh
EH8 9YL
55.948
-3.187
325946
673376
Scotland
Not Applicable
Edinburgh East
City of Edinburgh
Not Applicable
15
007/0073
Development of Rapid Visual and Epimicroscopy Techniques
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£755,147
1 يناير 2002
31 مارس 2009
Not Available
BackgroundAdvanced light microscopy techniques will be used to assess contamination of various grades of surgical steel coupons and medical instruments, initially using mucins, heparin sulphate and chondroitin sulphate, as models of saliva or brain glycosaminoglycan contamination, and blood. A mouse animal model will be used to supply infected brain homogenate for these contamination studies. Contaminated steel surfaces will be treated with proteinase K to remove normal prion and other brain material, leaving PrPsc which will be scraped/washed off, concentrated by ultrafiltration (assayed by two site ELISA) and serial dilutions injected into the brains of mice to show that the material is still infective. Sensitive pathological and behavioural measures will be used to assay for evidence of low levels of infectivity that might not lead to overt clinical disease.The industrial collaborators (Microgen Bioproducts) have developed a diagnostic kit capable of detecting specific protein ac
Academic
University of Southampton
SO17 1BJ
50.934
-1.396
442560
115135
England
South East
Southampton, Test
Southampton
NHS Hampshire and Isle of Wight Integrated Care Board
16
007/0077
Removal of Infective Protein Residues from Medical Instruments
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£1,295,022
1 يونيو 2002
31 يوليو 2011
Not Available
BackgroundThis project has the objective of developing new methods to remove and verify the removal of prions from surgical instruments. The project consists of three interactive themes: 1) the development of plasma cleaning methods for the removal of biologically derived materials; 2) the development of 'on-line' fluorescence techniques for detection of protein residues; 3) biological verification of these methodologies. The outcome of the project will be an integrated and verified strategy for the decontamination and screening of surgical instruments.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Potential ImpactHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field
Academic
University of Edinburgh
EH8 9YL
55.948
-3.187
325946
673376
Scotland
Not Applicable
Edinburgh East
City of Edinburgh
Not Applicable
17
007/0099
Examination of the Potential for Transmission of vCJD through Dentistry
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£1,510,737
1 مايو 2004
31 مارس 2010
Not Available
BackgroundThe evidence base for a risk -assessment of the potential for transmission of human spongiform encephalopathy through dental procedures is extremely limited. This is particularly so in respect to variant Creutzfeldt-Jakob disease with its recent origin, wider tissue distribution and unknown level of incidence. To help address the paucity of data available, five key areas of uncertainty have been identified for detailed investigation: 1. Prion distribution and infectivity in oral tissues. 2. Determination of the residual soiling of instruments used in dentistry. 3. Dental instrument decontamination procedures and the inactivation of vCm infectivity. 4. Determination of human tissue contamination of Dental Unit Water Systems (DUWS). 5. Investigation of the extent of aerosolisation of human tissue during dental procedures. These investigations will be of two separate types and take place in two distinct locations. Laboratory-based studies specifically utilising vCm/BSE infectiou
Undefined
Centre for Emergency Preparedness & Response
SP4 0JG
51.135
-1.700
421069
137358
England
South West
Salisbury
Wiltshire
NHS Bath and North East Somerset, Swindon and Wiltshire Integrated Care Board
18
007/0101
Surveillance for Asymptomatic Prion Infection in Primary Immunodeficiency Patients Exposed to UK Sourced Immunoglobulin
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£339,983
1 سبتمبر 2006
31 مارس 2015
Variant Creutzfeldt-Jakob disease (vCJD) is a type of dementia, caused by an abnormal prion which originally came from cattle with ‘mad cow disease’ or bovine spongiform encephalopathy (BSE). In addition, we know that human to human transmission can occur. Blood donors who at the time were unaware that they were infected with vCJD, donated blood which infected recipients with vCJD. There are 3 known cases in the UK. This has only happened in the UK. Immunoglobulin is a product derived from blood used primarily to treat patients with antibody deficiencies. Each injection is made from several thousand blood donations. This means that any immunoglobulin infected with vCJD could possibly spread abnormal prions from person to person. Our research is to find out if this has happened to patients exposed to British-sourced immunoglobulin and we have recruited volunteers to participate in the study. VCJD and other prion diseases can only be diagnosed from tissue samples. We are collecting tissu
BackgroundThe possibility that the abnormal prions responsible for variant Creutzfeldt-Jakob disease (vCJD) may be transmitted through plasma products has considerable ramifications for patients with Primary Immunodeficiency (PID) receiving immunoglobulin.Although abnormal prions are transmissible by whole blood between animals, there are no data showing this can happen between humans. Abnormal prions can now be detected in lymphoid tissue from asymptomatically infected individuals with reasonable specificity and sensitivity. The technology to detect abnormal prions in blood samples is also improving.The proposed project will be carried out on approximately 130 PID patients exposed to UK sourced immunoglobulin between 1996 and 1998, attending PID centres across the UK. The proposal is to produce:- a confidential data base containing exposure details and prospective clinical evaluations- a retrospective and prospective collections of lymphoid and spleen material for histological prio
Government/NHS
Manchester University NHS Foundation Trust
M13 9WL
53.462
-2.228
384979
396212
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
19
007/0104
Conditional Expression of PRP in the Gut of Transgenic Mice to Investigate the Uptake of Infectivity in the Gut in the TSEs
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£341,422
1 أغسطس 2005
31 مارس 2007
Not Available
BackgroundWe aim to establish whether PrP expression in the gut is required for the uptake of TSE infectivity and whether in the absence of intestinal PrP expression, uptake and transport of infectivity to peripheral sites of agent replication is blocked. We will address this using two lines of gene-targeted transgenic mice which allow us to control the expression of the PrP gene in a temporal and/or spatial fashion. These mice allow us to switch PrP expression on (NS line) or off (ORFR line) when crossed with Cre recombinase transgenic mice. We will cross the ORFR and NS lines with an inducible P450-Cre line which expresses Cre recombinase in the stem cells of the intestine following administration of the p450-inducer, beta-napthoflavone. Used in conjunction with an inducible neurone-specific Cre line we will be able to control PrP expression in the intestine and neurones prior to orally infecting with a murine TSE agent. These studies will determine the potential for early inter
Undefined
Institute for Animal Health
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
20
007/0107
The Development of a Novel Human Cell Culture Model of Prion Disease
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£215,853
1 أبريل 2004
31 مارس 2007
Not Available
BackgroundThere are no human cell culture models of prion disease available, these are urgently needed for several reasons. This project aims to develop and characterise an in vitro cell culture system of human prion disease. Human and transgenic murine neural and non-neural cell lines are in development. These lines will be infected with various human, and BSE, prion strains; and cell populations screened for infected cells. All the techniques, infrastructure and collaborations necessary for the success of this project are already in place. This human cell line will be used as a diagnostic tool to develop a bioassay system to replace traditional mouse innoculation assays which are expensive and time-consuming, often taking up to one year for a result; a cell culture based bioassay would only take 3-4 weeks to achieve similair results. The human line will also be used for the development and screening of therapeutics aimed at the removal and clearance of human PrPSc. A clinical scienti
Academic
University College London
WC1E 6BT
51.524
-0.132
529662
182170
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
21
007/0113
Predicting Future Numbers of Cases of vCJD 2
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£268,353
1 مايو 2005
30 نوفمبر 2008
Not Available
BackgroundThe aims of the project are:To develop vCJD prediction models which:i) take into account differences in the evolution of the vCJD epidemic in different birth cohorts, regional differences in the incidence of vCJD, the possibility of secondary transmission among humansii) incorporate data available on asymptomatic infections (appendix, tonsil, blood)iii) distinguish between different short-term trends in the pattern of disease occurrenceTo investigate the efficiency and cost-effectiveness of different strategies for testing for asymptomatic infection.Current data on vCJD cases in the UK are available through the NCJDSU. Population estimates will be obtained from the Census Dissemination Unit. Data on risk of secondary transmission of vCJD through transfusions of blood and blood products from the Transfusion Medicine Epidemiological Review will be available through the NCJDSU. Data from surveys deploying tests for asymptomatic infection will be obtained by negotiation with the
Academic
London School of Hygiene and Tropical Medicine
WC1E 7HT
51.521
-0.131
529790
181879
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
22
007/0119
The Development of an Effective Treatment for Prion Infection of Humans
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£7,238,766
1 فبراير 2006
30 يونيو 2013
Prion diseases are fatal untreatable brain disorders caused by prions, germs that grow in the brain. The best known is Creutzfeldt-Jakob disease (CJD). Unlike other germs, like bacteria and viruses, prions do not carry genes and are made just of protein. This protein (called PrP) is one of the body’s own proteins. Prions consist of clumps of misshapen PrP (rogue form) and grow and multiply as more and more normal PrP ends up in this form. Prions affect many types of animal, causing scrapie in sheep and BSE in cattle. Sometimes prions can jump from one species to another, and we know that BSE prions can infect humans and cause variant CJD. There is always a long delay (years or decades) between someone being infected with prions and developing the disease. Healthy carriers of infection can pose a risk to others if they donate blood or organs, and surgical instruments can also become contaminated by prions and pose a risk to other patients. Although only around 200 people have developed
BackgroundThe majority of the UK population have potentially been exposed to BSE prions, the causative agent of variant CJD. The number infected, eventual epidemic size and secondary transmission dynamics are unknown. The central molecular event in prion replication is the conversion of a neuronal glycoprotein (PrPc) into a conformational isomer that accumulates as aggregated material (PrPs) in a self-propagating process. The availability of PrPc substrate is an absolute requirement for prion propagation and pathogenesis. We propose to identify and characterise novel small molecules that stabilise the native conformation of PrPc and inhibit its ability to be recruited into PrP$0. Inhibition of prion replicationkinetics to below those of natural clearance mechanisms should cure prion infection. The MRC Unit has developed an effective collaboration with GlaxoSmithKline R&D Ltd, performed successful pilot stage studies and produced further experimental underpinning of our therapeutic stra
Academic
University College London
WC1E 6BT
51.524
-0.132
529662
182170
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
23
007/0120
The Effect of Leucodepletion on Transmission of BSE by Transfusion of Sheep Blood Components
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£795,296
1 نوفمبر 2005
31 مارس 2007
Not Available
BackgroundThis project will use sheep experimentally infected with BSE as a model to study the risks of transmission of variant CJD by blood components in humans. The aim of the project is to determine the distribution of BSE infectivity in sheep blood components, and the effectiveness of human leucodepletion filters in removing infectivity. The methods used for collection of blood and separation and filtration of components will follow as closely as possible those routinely employed for human blood by transfusion services, and will initially be developed and validated for normal sheep blood in the laboratories of SNBTS. A secondary aim of the project is to develop a bioassay for measurement of titres of infectivity in blood components, using transgenic mouse lines that over-express ovine PrP. The sheep experiments will be carried out using BSE-infected donors and will assess the effect of leucodepleting blood components (plasma, platelets and erythrocytes) on transmission at a single
Undefined
Institute for Animal Health
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
Not Available
24
007/0136
National Tonsil Archive phase III
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£7,024,560
1 أبريل 2006
31 مارس 2013
Not Available
BackgroundThe overall aim of the prion prevalence tissue archive is to estimate the prevalence of infection with the BSE agent in residents of England who are likely to have been exposed to the BSE agent through their diet. This will be achieved by measuring the prevalence of detectable abnormal prion protein (PrPsc) in the tonsil tissue of at least 50,000 residents of England born before 1st January 1996.The project will be implemented in three phases: Phase one: Establishing a project management team Phase two: Developing a preliminary collection network Phase three: National roll-out and main collection.This application is for funding to establish a project management team at PHLS to develop the scientific, logistic, ethical, financial and accountability framework for establishing national collection of tonsil tissue.AimsHISTORIC PROJECT - Entire abstract transferred from the previous database into the [Scientific summary background] field of this database.Plan of InvestigationHIS
Academic
Health Protection Agency
NW9 5EQ
51.595
-0.255
520992
189896
England
London
Hendon
Barnet
NHS North Central London Integrated Care Board
25
007/0163
Investigation into Transmissibility of TSEs via Blood
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£9,377
1 أبريل 2007
31 أغسطس 2008
Not Available
BackgroundThe research protocol will include collection of blood and preparation of buff y coat from animals involved in one MAFF-funded pathogenesis studies. Blood samples will be taken on the basis of 10ml per Kg body weight at various time points and used either as whole blood or blood processed to give buffy coat. Buffy coat samples will only be taken from animals which are being killed either at terminal stages of disease or as part of one of the pre-clinical kill points of the pathogenesis experiments. The blood and buffy coat will be transfused or introduced intravenously into recipient animals which will subsequently be maintained for their natural lifespan. Each animal will be examined regularly for clinical signs of TSE. Those animals which develop clinical signs of infection will be killed and subjected to a full post-mortem examination. Selected tissues will be taken for histopathological studies and immunochemical testing for the disease-related form of the PrP protein. Ot
Undefined
The Roslin Institute
EH25 9RG
55.866
-3.201
325005
664178
Scotland
Not Applicable
Midlothian
Midlothian
Not Applicable
26
007/0169
Investigating Dental Treatment as a Possible Risk Factor for Variant CJD
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£256,621
1 أبريل 2008
30 سبتمبر 2009
Not Available
BackgroundLittle work has been performed examining accurate past dental history of CJD cases and controls by direct review of dental records. The NCJDSU has MREC approval to collate information from the medical records of CJD cases and matched controls. Following on from a DH funded pilot study, this study will attempt to access the dental case records of UK variant CJD cases (n=166 as of 9/8/07) and 166 general population controls. In addition, payment schedule records will be accessed where possible in collaboration with NHSBSA Dental Practice Division (England and Wales) and NHSNSS Information and Statistics Division (Scotland). The case record and payment schedule data will be reviewed by a dental healthcare professional and will, where possible, include the presence or absence of oral disease, dates and types of treatment performed and additional risk factor information, e.g., human dura mater grafting. Data will be coded and entered into a database for subsequent analysis. Geogra
Academic
University of Edinburgh
EH8 9YL
55.948
-3.187
325946
673376
Scotland
Not Applicable
Edinburgh East
City of Edinburgh
Not Applicable
27
007/1031
National Prion Monitoring Cohort
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£3,036,383
1 أبريل 2008
31 مارس 2012
Not Available
BackgroundThe National Prion Monitoring Cohort comprises three strata: 1) symptomatic patients with confirmed prion disease (Appendix 1), 2) asymptomatic individuals with confirmed pre-clinical prion infection or disease (confirmed genetic mutation or positive PrP immunocytochemistry or Western blot on tissue biopsy but no symptoms at present) and 3) asymptomatic individuals without a confirmed diagnosis but at high risk due to known exposure (either through iatrogenic exposures , or close kinship with a person with confirmed inherited prion disease (IPD)). The first stratum includes those patients already enrolled in any of the threeparts of the PRION-1 trial (randomised controlled trial of immediate versus deferredquinacrine, open-label study of quinacrine, or study of no quinacrine treatment), patients receiving pentosan polysulphate, terminally ill patients not eligible for PRION-1 and patients not wishing to join PRION-1. The second stratum would include those individuals without
Academic
University College London
WC1E 6BT
51.524
-0.132
529662
182170
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
28
009/0036
A Randomised Controlled Trial of a Nurse-Led Self-Management Intervention for Patients Admitted to Hospital with Heart Failure
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£223,102
1 يناير 2004
29 فبراير 2008
Not Available
BackgroundHeart Failure is associated with high costs and poor outcome. Patients with this diagnosis are expected to adhere to a complex behavioural regimen including taking medication, monitoring for signs of fluid re-accumulation and a range of life-style changes. Without intervention adherence is about 50%. Standard education alone does not modify this figure. We aim to explore the hypothesis that a brief nurse-Ied self-management intervention will empower patients to positively modify their behaviour and so outcome. The efficacy of this intervention, based on a problem solving approach using cognitive behavioural principles, will be assessed by a randomised controlled trial of 250 patients admitted to hospital with a definite diagnosis of heart failure, randomised to either the nurse-Ied intervention or standard hospital care. The primary outcome measure will be the number and duration of re-admissions at three months. Secondary analyses include costs, mortality at 12 months and pr
Government/NHS
Whittington Health NHS Trust
N19 5NF
51.566
-0.139
529110
186912
England
London
Islington North
Islington
NHS North Central London Integrated Care Board
29
009/0052
Evaluation of the NHS Health Checks programme
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£550,080
1 يناير 2012
30 سبتمبر 2020
This study will be one of the first major evaluations of the NHS Health Checks programme designed to reduce heart attacks and stroke. In a local study in three east London Boroughs (pop 800,000) and in a national study based on 4 million people in the national QResearch database we will access GP records to determine the following. Uptake of the NHS health Checks programme and variation by age, gender, ethnic group and deprivation to see if the Checks are accessible and equitably provided. Views of providers on implementing the Checks (east London study). The extent to which the Checks identify people who are at low, medium and high risk of heart attack or stroke using a high quality ‘risk score’ to predict these risks. The extent to which people at high risk (a greater than 1 in 5 chance of a heart attack or stroke in 10 years) are treated with statins or for high blood pressure. New diagnoses of diabetes, hypertension and chronic kidney disease as a result of the Checks – and the ext
Evaluation of the NHS Health Checks programme
Academic
Queen Mary University of London
E1 4NS
51.525
-0.041
536021
182455
England
London
Bethnal Green and Bow
Tower Hamlets
NHS North East London Integrated Care Board
30
010/0003
The Yorkshire Register of Diabetes in Children and Young People
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£302,999
1 أبريل 2003
31 يناير 2009
Not Available
BackgroundRising numbers of children and young people with diabetes are of great public health concern and present an increasing burden to the NHS. Population-based registers of diabetes in this vulnerable age group are essential for monitoring trends, evaluating standards of care and researching disease aetiology. The Yorkshire Register of Diabetes in Children and Young Adults is a well-established high quality population-based register of over 4,000 0-29 year olds diagnosed since 1978. Data are held at the Paediatric Epidemiology Group, Leeds University, alongside other chronic disease registers and where researchers have skills in analysing population-based data applying various methodologies. The aim of the register is to describe the epidemiology of diabetes, investigate the molecular and environmental aetiology and facilitate health services research. Individuals are ascertained from two sources (hospitals and GPs), with completeness estimated at 99%, and basic clinical and demog
Academic
University of Leeds
LS2 9JT
53.808
-1.553
429512
434722
England
Yorkshire and The Humber
Leeds Central
Leeds
NHS West Yorkshire Integrated Care Board
31
011/0036
Estimating and Explaining Early Exit from Drug Treatment
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£114,743
1 يونيو 2005
31 مارس 2008
Not Available
BackgroundThis project focuses on dependent drug users who do not engage, or drop out early from tier 3 and 4 services, despite having offered a place in treatment.This research wil provide policy-relevant information by achieving the following aims:- To provide an estimate of the rates of early exit from tier 3 and 4 services in two regions of England - one provincial and metroplitan- To identify the characteristics of those dependent drug users who are most likely not to engage or exit early- To provide information on why drug users do not engage in treatment or leave early-To make recommendations on how rates of early exit can be reduced.All these aims will be achieved with a specific emphasis on groups who are particularly vulnerable to early exit, includiong women, members of ethnic minority groups, young people (aged 18-25) and offenders.The research will involve quantitative (logistic regression) analysis of monitoring and primart data on treatment attendance of over 3,000 peopl
Academic
University of Kent
CT2 7NZ
51.299
1.071
614184
159965
England
South East
Canterbury
Canterbury
NHS Kent and Medway Integrated Care Board
32
011/0041
Exploring Young People's Views and Experiences of Drug Treatment Services - A Qualitative Study
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£101,054
1 سبتمبر 2005
31 مارس 2008
Not Available
BackgroundAbstract of Research: No more than 200 words covering the following topics: aims of project; research subject group; sample size, type and location; methods of working. Exploring young people's views and experiences of drug treatment services- a qualitative study. This study will inform policy and practice in the area of drug treatment services for young people. It will provide insights into:- Young people's decision to seek and processes leading to treatment- including barriers young- people faced in accessing treatment;Young people's views and experiences of treatment services;- The perceived impact of treatment on young people's lives- including any impact on their drug- use, associated risk behaviours, offending behaviour, mental and physical well-being and overall quality of life;The perceived impact of factors other than treatment on the level and nature of drug use in- which young people engage (identifying factors that may contribute to a young person's resilience to
Academic
National Centre for Social Research
EC1V 0AX
51.527
-0.103
531689
182599
England
London
Islington South and Finsbury
Islington
NHS North Central London Integrated Care Board
33
011/0056
Drug Recovery Wing (DRW) Pilots Evaluation
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£799,134
1 أكتوبر 2012
28 فبراير 2016
Following the UK drug strategy (2010) there has been a major commitment to ensuring that drug treatment services are maximising the opportunities for the recovery of dependent drug users and that drug users in prison and in the community have access to high quality recovery focussed treatment. Delivering abstinence focussed drug treatment services within prisons presents different challenges to those developed within the community not the least of which is the need to combine both treatment and custodial responsibilities. The research outlined in this application will answer questions in three main areas. First, based upon a detailed qualitative assessment of the drug recovery wings, it will provide a detailed description of the therapeutic programme within the wings and the experience of both staff and prisoners involved within them. This element of the research will provide rigorous information on how the wings are operating, what interventions are used with prisoners and how links
Background Following the UK Drug Strategy and the Patel report, there is a commitment to ensure that prisoners have access to high quality recovery-focussed drug and alcohol treatment services and that the link between prison and community is better managed. Research has shown that 50% of male prisoners and 65% of female prisoners have a drug problem (Singleton et al., 1997). According to Stewart (2009) who surveyed 1457 recently received prisoners across 49 prions in England 28% had used heroin in the last four weeks and 25% had used crack cocaine. It is known that in some cases prisoners are initiating injecting within prison (Boys, 2002) and that on release prisoners are at a heightened risk of death (Farrell and Marsden, 2007). Whilst prison offers an important opportunity for drug and alcohol treatment it is recognised that there are multiple challenges associated with the development of drug and alcohol services within prisons (McIntosh and Saville, 2006). Aims This research
Academic
University of York
YO10 5DD
53.948
-1.054
462215
450672
England
Yorkshire and The Humber
York Outer
York
NHS Humber and North Yorkshire Integrated Care Board
34
012/0016
Social Medicine and Health Services Research Unit (2006 - 2010)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,894,154
1 يناير 2006
31 ديسمبر 2011
Not Available
BackgroundThe work programmeThe Unit's focus will remain in two main areas. The first is in the nutritional epidemiology of asthma, the second on the role of airborne allergen in asthma exacerbations. A third area, which relates to each of these, is development of the molecular epidemiology of asthma, building on the experience of the STARS studies.Nutritional Epidemiology of AsthmaThe fellow replacing Dr Shaheen will take on a portfolio of work on asthma and nutrition. This includes ongoing work with the ECRHS data, new studies on asthma and dietary sodium, potentially work undertaken through the GA2LEN network of excellence, and a new application following up Dr Calvert's studies of nutrition and asthma in Africa.The trial of selenium supplementation in adults with asthma has now finished and is being analysed (Dr Shaheen). Dr Okoko though he will not any longer be formally on the DH unit strength will continue his studies of asthma and apple intake. A cross-sectional survey in schoo
Academic
Imperial College of Science, Technology and Medicine
SW7 2AZ
51.498
-0.177
526645
179284
England
London
Cities of London and Westminster
Westminster
NHS North West London Integrated Care Board
35
012/0305
LWEC EEHI: Traffic Pollution and Health in London
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£650,000
1 مارس 2011
31 ديسمبر 2014
Need to insert Abstract
Introduction Urbanisation and dependence on motorised transport has increased population exposure to traffic hazards. Traumatic injuries aside, these include toxic air pollutants and noise (which we refer to as traffic pollution) for which there is increasing evidence for adverse health effects. Near-road pollution is a complex mixture of particle and gas phase components that are influenced by both exhaust and non-exhaust vehicle emissions, resuspension of road dust, atmospheric processes and photochemical reactions. To achieve more effective traffic management policies and reduce the public health burden, it will be necessary to develop more realistic, flexible and sophisticated approaches to exposure assessment. Important gaps and uncertainties exist in our understanding of health effects of traffic pollution (Health Effects Institute [HEI], 2010). First, there is an inadequate understanding of patterns of human exposure to traffic and a lack of adequate models with which to evaluat
Academic
King's College London
SE1 8WA
51.505
-0.113
531085
180144
England
London
Vauxhall
Lambeth
NHS South East London Integrated Care Board
36
013/0007
Health Promotion and Public Health Reviews Facility
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£4,057,348
1 أغسطس 2004
31 مايو 2014
Not Available
BackgroundThis programme of work builds on 9 years of DH funding to the EPPI-Centre to develop a research capacity in policy-relevant systematic research synthesis for health promotion and public health (HP & PH). The new programme has distinctive features, specifically an enhanced focus on the provision of policy-relevant research reviews, the provision of training in systematic review methods, more intensive networking with other key players in the field, and the further development of accessible user-friendly databases of HP & PH research filling an important gap in the evidence base for HP & PH. The aims of the new programme are: 1/ to undertake a series of innovative, policy-relevant and broadly based systematic reviews of the evidence in key topic areas underpinning HP & PH decision-making; 2/ to provide a reviews facility encompassing training, materials and tools for those wishing to undertake systematic reviews; 3/ to co-ordinate review and bibliographic work in HP & PH, thr
Academic
Institute of Education, University of London
WC1H 0AL
51.523
-0.128
529973
182112
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
37
014/0005
Data Archiving
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£6,913
1 مارس 2012
30 يونيو 2012
Not Available
Data Archiving
Academic
University of York
YO10 5DD
53.948
-1.054
462215
450672
England
Yorkshire and The Humber
York Outer
York
NHS Humber and North Yorkshire Integrated Care Board
38
015/0306
Effectiveness of testing for treatment of hard-to-reach groups for latent tuberculosis, hepatitis B virus and hepatitis C virus in England: The HALT Study
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£875,672
1 يناير 2013
30 يونيو 2017
The aim of this programme of work is to inform the control of hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection and latent tuberculosis infection (LTBI) by assessing the cost effectiveness of active case finding, case holding and treatment. In particular, as outlined in the invitation to tender, our specific objectives include: 1. To determine whether case finding of LTBI, HBV and HCV in hard-to-reach groups is costeffective (Work package 1 and 3), 2. To determine whether case holding during treatment for HBV and HCV in hard-to-reach groups is cost-effective (Work package 1 and 3), 3. To determine the factors that could influence uptake of vaccination for HBV in hard-toreach groups via a community outreach programme (Work package 1), 4. To assess the likelihood of adverse effects when individuals over the age of 35 years are treated for LTBI (Work package 2).
Hard-to-reach groups, such as homeless persons, substance misusers and exprisoners, have difficulty accessing, and remaining engaged with, healthcare services as a result of a variety of lifestyle factors. The same factors render them susceptible to a range of infectious diseases, such as TB and hepatitis. To examine the effectiveness and cost-effectiveness of two key methods to prevent the transmission of infection in the hard-to-reach: a) testing for LTBI, chronic HBV and HCV, b) supported HBV/HCV treatment among those with diagnosed infection. This will be in addition to assessing barriers to the success of HBV community vaccination programmes. Finally, determine whether side effects really should prohibit treatment of LTBI in individuals over 35 years of age. Research plan and methods of investigation: Hard-to-reach individuals will be screened in the community for LTBI, HBV and HCV infection. Individuals identified with chronic HCV and HBV will be randomly assigned to eit
Academic
University College London
WC1E 6BT
51.524
-0.132
529662
182170
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
39
015/0313
Identifying interventional approaches to improve health care access for Hepatitis B in high prevalence groups.- A study of knowledge, beliefs, and attitudes about Hepatitis B among Chinese and Far East Asian residents of South Yorkshire and factors restricting appropriate risk evaluation, testing, preventative activities and referral for treatment to inform review of current policy.
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£266,671
1 أكتوبر 2013
31 مارس 2017
Hepatitis B – a serious infectious disease caused by a virus transmitted in blood and body fluids – is common among migrant Chinese communities , being found in around 1 in 10 people. However, research in the UK and elsewhere shows that access to healthcare is low among this population, and that late diagnosis and delayed treatment is widespread. US research has found poor understanding about hepatitis B in migrant Chinese communities, with lack of awareness about risks and mistaken beliefs regarding transmission. These studies also suggest healthcare professionals may not offer testing appropriately. To-date, UK research is limited and we know little about the barriers to testing and treatment in this context. The present study addresses this knowledge gap. In South Yorkshire, Chinese residents constitute 0.2 - 1.3% of the population and pilot work by members of the research team has confirmed high levels of infection and low levels of testing and treatment in this
Background: The high prevalence of hepatitis B inChinaand other Far East Asian countries has been well documented in international epidemiological studies. Transmission occurs most frequently vertically, but also sexually, among household contacts and through healthcare. Chronic carriage is frequent, with considerable disease burden including morbidity and mortality from cirrhosis and hepatocellular carcinoma. Early treatment can prevent complications; however, access to specialist healthcare is known to be impaired in this group. Aims: This study objective is to identify the factors associated with poor levels of diagnosis and treatment operating at three levels in theUK: the Chinese community, the health care providers and the health system. This in turn should provide a base to help formulate policy to improve prevention and care. Three aims are: 1 - To identify within the target communities health seeking behaviours as well as knowledge, attitudes and misconceptions in rela
Government/NHS
Sheffield Teaching Hospitals NHS Foundation Trust
S10 2SB
53.378
-1.496
433595
386960
England
Yorkshire and The Humber
Sheffield Central
Sheffield
NHS South Yorkshire Integrated Care Board
40
016/0030
Nursing Research Unit (See Notes before Sending and Correspondence)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£2,107,097
1 أكتوبر 2002
31 مارس 2008
Not Available
BackgroundThe Nursing Research Unit (NRU) is a unique and established national centre for nursing research that contributes to professional, academic and policy development. It has expertise in research on the evaluation of change in complex health care organisations and on the health care workforce. Funded by the Department of Health Policy Research Programme, its main aims are:1 To carry out primary R&D2 To develop research methods and techniques designed to facilitate and enhance the quality of research into nursing and contribute to debate in the wider health care and research community3 To act as a centre for information and advice on nursing research4 To contribute to research capacity building in nursing 5 To disseminate research findings to the professional and academic communitiesCurrently our work focuses on research that answers questions like these:Do nurses make a difference?What helps and hinders successful change in health care practice?What career pathways do health se
Academic
King's College London
SE1 8WA
51.505
-0.113
531085
180144
England
London
Vauxhall
Lambeth
NHS South East London Integrated Care Board
41
016/0049
Developing Skills in the NHS
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£232,172
1 ديسمبر 2003
30 يونيو 2008
Not Available
BackgroundThis proposal outlines plans for the identification, analysis and evaluation of the use; of the skills escalator concept and associated support for learning in the NHS. The skills escalator aims to attract a wider range of people to work in the NHS whilst also supporting career potential and development across its workforce. Through investing in a lifelong learning approach, the NHS seeks to encourage staff towards new ways of working which extend their current skills and contribute to wider service/process redesign and improvements in health services. The proposed evaluation is -intended to be both academically rigorous and practically relevant. It has three main aims: to identify and map the use of the skills escalator and associated support for learning; to analyse and evaluate the outcome of these practices; and to develop methodologies for the local evaluation of such practices. The approach we propose is intended to make maximum use of existing sources of data including
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
42
016/0056
Evaluation of the National Expansion of Medical Schools
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£238,736
1 نوفمبر 2003
31 مارس 2008
Not Available
BackgroundAim of ResearchOur proposal is based on two key principles: (a) to evaluate those objectives which can be assessed in the short-term (3-years); and (b) to lay the groundwork for further collaborative bids which will form for the longer-term evaluations.Structure of research:The proposal comprises five inter-related projects based around the following areas (I) School infrastructure and intended curriculum; (ii) Admission to medical school; (iii) The student experience; (iv) The impacts of the expansion of medical schools on the NHS and wider community; (v) The primary policy objective: training more doctors:Methods:We will use a range of qualitative and quantitative research methods, including (I) Scrutiny of documents made available by the various medical schools; (ii) Analysis of applications and admission data; (iii) Analysis of information relating to student performance; (iv) Interviews / focus groups with medical school and NHS staff; (v) Interviews / focus groups with
Academic
University of Birmingham
B15 2TT
52.453
-1.928
404851
283719
England
West Midlands
Birmingham, Edgbaston
Birmingham
NHS Birmingham and Solihull Integrated Care Board
43
016/0065
Improving Health through Resource Management
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£252,495
1 نوفمبر 2004
29 فبراير 2008
Not Available
BackgroundThis study explores how HRM interventions can contribute to positive employee attitudes and behaviours and to improved performance. The study brings together a team that have been at the forefront of both HRM and health policy research, and who have experience of working together on a variety of projects. Whilst we have considerable knowledge of HRM in the NHS, the research team also has an extensive understanding of leading-edge practices in other sectors, a factor that allows for additional insights into HRM in the NHS. The main purpose of the study is to examine the HR-performance link and to get inside the `black box' of behaviours that flow from effective HRM, thus extending previous work in this area. Three aims of the study are: to provide detailed synthesis of existing knowledge linking HR to organisational performance; to assess the impact of HR interventions on performance for different types of services within specific NHS organisations and; to develop guidance for
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
44
016/0070
General Primary Care Nursing in Prisons: The Essentials of Care
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£244,050
1 يوليو 2004
31 مارس 2007
Not Available
BackgroundThis is a twenty month collaborative research project that will map how mainstream NHS standards in nursing translate to the prison setting, to ensure the equivalence of primary health care provision within prisons to that available outside. The setting up for a prisoner refernece group and a prison nurses' stakeholder conference at the start of the research will support user and stakeholder involvement at all stages. Qualitative interview data from prisoners and nurses working in prisons in a geographical cluster sample of 16 prisons in England (15% of all prisons in England) will be together with published evidence and all prisoner groups (including category A,young offenders, women, open, and private prisons) will be included.The research will also: provide an economic cost consequences type of analysis of specified nurse/GP activities in primary care that that will help inform decisions about the best use of resources in prison health care; build capacity and capability
Academic
University of the West of England, Bristol
BS16 1QY
51.501
-2.547
362096
178158
England
South West
Filton and Bradley Stoke
South Gloucestershire
NHS Bristol, North Somerset and South Gloucestershire Integrated Care Board
45
016/0074
How Do Nurses Use New Technologies to Inform Decision-Making?
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£254,378
1 نوفمبر 2004
31 مارس 2008
Not Available
Background1. Identify areas of practice in the NHS where new decision support technologies have beenintroduced or where their introduction is imminent.2. Explore how new technologies are used to inform nurse decision making in practice and thepotential effect these may have on the care delivery process and patient outcomes.3. Examine the role of education and training in the introduction and use of new technologies inpractice.The above aims will be addressed using a mixed methods approach:i)Telephone survey of more than 25% (140) of Health Care Trusts in England.ii)Systematic review of the effectiveness of computerised clinical decision support systems in nursing.iii)Secondary analysis of existing data sets of nurses engaging with decision technologies. Data includes 380 hours of observation, 296 interviews and 14,000 out of hours recorded consultation calls.iv)A series of four case studies with data analysed at the level of clinician, department and organisation. Sites will be purposi
Academic
University of York
YO10 5DD
53.948
-1.054
462215
450672
England
Yorkshire and The Humber
York Outer
York
NHS Humber and North Yorkshire Integrated Care Board
46
016/0084
International Recruitment for Health Professionals: A Development Evaluation
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£47,278
1 يوليو 2005
30 نوفمبر 2007
Not Available
BackgroundIn accordance with the tender brief, the proposed evaluation sets out to:-Document/map the international recruitment initiatives/methods currently being, or that could potentially be, used by and on behalf of the NHS to attract doctors, nurses and AHPs;-Distinguish the features associated with good/best/effective (including ethical) practice in terms of direct outcomes;-Capture the broadest possible set of stakeholder perspectives on impacts, costs and benefits of different schemes;-Help inform UK policy and NHS organisations' activities by establishing an analytical framework against which the success of different international recruitment actions can be judged.To achieve these aims the evaluation methodology will consist of:-A rapid literature/secondary evidence review, and initial consultations with relevant UK and EU-level stakeholders;-A national scoping survey of recruiters/schemes and NHS employers operating at national, regional/sub regional and local level to ascerta
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
47
016/0085
Front Line Managers and Delivery of Effective People Management
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£59,457
1 فبراير 2005
31 مايو 2008
Not Available
BackgroundThe effective delivery of people management by front line managers, including clinical professionals with managerial responsibilities is central to agenda for Change especially KSF. recent research has indicated a relative neglect of this population in HR management yet they are of findamental importance in 'bringing policies to life' Qualitative and quantitive research in four acute trusts and two ambulance trusts chosen to allow comparisons in performance will explore FLM roles in implementing HR policies,, examine the barriers to undertaking the roles on employee attitudes and behaviour, and in knowledge sharing. Two final areas focus on how FLMs are themselves managed, and the links to patient care and operational performance. The research will be undertaken in two departments or direcorates in the four acute trusts )one better and one less good) and accross the two ambulance trusts. Interviews with the senior management team at at trust and directorate level will be
Academic
University of Bath (The)
BA2 7AY
51.379
-2.327
377083
164651
England
South West
Bath
Bath and North East Somerset
NHS Bath and North East Somerset, Swindon and Wiltshire Integrated Care Board
48
016/0113
Scientific Advisor: Nursing and Workforce Related Research
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£15,392
14 يونيو 2008
13 يناير 2009
Not Available
BackgroundNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.AimsNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Plan of InvestigationNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.Potential ImpactNEW PROJECT - this project was not commissioned through the online commissioning process. All available project details have been transferred from project proposal to respective fields in this database.
For-Profit Company
Abi Masterson Consulting Ltd
SE1 2DE
51.501
-0.073
533878
179720
England
London
Bermondsey and Old Southwark
Southwark
NHS South East London Integrated Care Board
49
016/0114
Evaluation of Modernising Medical Careers Pilots
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£695,819
15 أغسطس 2008
14 مارس 2011
Selecting the right doctors for training to become specialists is important for the doctors applying, those with whom they will work and for patients treated by them in the NHS. This means selection methods must be valid (testing what they aim to test) and reliable (a test gives the same result each time).This study will test the validity and reliability of 20 pilot projects that will use new methods to select junior doctors for training to become specialists. It will also examine whether the methods are feasible in practice and cost-effective in their use of resources. Statistical procedures will be used to decide upon the validity, reliability and cost-effectiveness of the different methods. The study will also examine how medical selection is undertaken in other countries and what can be learned from experience in other professions. It will collect evidence on existing ways of selecting doctors for training in the UK. All this evidence will be drawn together to provide an overall as
BackgroundSelecting doctors for training in a specialty best matched to their skills and abilities is important for applicants, selectors and NHS users. It requires selection that is: based on good evidence; suitably organised; and supported by the profession and other relevant stakeholders. Evidence must draw on existing practice nationally and internationally and assess the validity and reliability of the pilots. Assessment is also needed of the significance of size of recruitment to specialties, transferability of skills and the history of selection in disciplines. Organisational issues need to be considered and the cost-effectiveness of alternatives assessed. Securing the involvement of the profession is the third key area if the outcomes are to influence policy and practice.AimsThe aims of the research can be summarised into four principal statements.1. Describe and analyse the effectiveness and suitability of the selection processes to postgraduate specialist medical training u
Academic
University of Birmingham
B15 2TT
52.453
-1.928
404851
283719
England
West Midlands
Birmingham, Edgbaston
Birmingham
NHS Birmingham and Solihull Integrated Care Board
50
016/0116
Cohort Studies of Doctors Careers 2011-2013
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£936,660
1 أبريل 2011
31 مارس 2013
For any health care system, its qualified professionals are its most important asset. This means having the right number of doctors, with the right training, in the right specialties in the right places. The project comprises questionnaire-based surveys in which all doctors who qualified from all medical schools in the UK, in one year in every three, are surveyed. The doctors are sent questionnaires in their first year after qualification, at three, five and seven years, and at longer time intervals after that. The doctors are asked about their future career intentions and they are then followed up to study their career progression, any changes of intentions, and their eventual destinations. The questionnaires include closed questions on a range of specific themes. They also include free text comments from the respondents, who are invited to write to us, if they wish, about any aspect of their training, career choice, career plans and progression, and working in medicine. The free te
Background: The planning and provision of health services is fundamentally underpinned by the distribution of doctors: this includes the distribution of doctors by specialty, geographical location and grade. Policy interests include the maintenance of a sufficient supply, without over-production, of doctors to enable the NHS to meet its service commitments; assessment of doctors’ views on their education and training; junior doctors’ hours and patterns of working; changes to GP and consultant contracts; equality of opportunity by gender and ethnicity; societal change in the domestic roles of men and women; and changing expectations in society generally in respect of the balance between work and family/leisure time. For these reasons, among others, research into doctors' careers is important. Aims: To determine the career choices of UK doctors, at regular intervals after qualification, and to study the factors which influence them; to study career progression,
Academic
University of Oxford
OX1 2JD
51.758
-1.262
451034
206852
England
South East
Oxford East
Oxford
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
51
018/0042
Public Health Research Consortium
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£4,081,815
1 أكتوبر 2005
30 سبتمبر 2011
Not Available
BackgroundThe Public Health Research Consortium (PHRC) brings together senior researchers from 10 UK institutions in a new integrated programme of research. Its aim is to strengthen the evidence base for interventions to improve health, with a strong emphasis on tackling socioeconomic inequalities in health. The consortium is funded by England's Department of Health Policy Research Programme for a 5-year period from October 2005. The PHRC is built around a series of research studies, together with associated projects and dissemination activities to facilitate the translation of evidence into policy and practice. A major focus in on understanding and addressing inequalities in risk factors and wider determinants, including obesity and cigarette smoking. The PHRC is directed by Professor Hilary Graham (Department of Health Sciences, University of York) with a team of collaborators with expertise in public health, social epidemiology, sociology, health sciences, social marketing and h
Academic
University of York
YO10 5DD
53.948
-1.054
462215
450672
England
Yorkshire and The Humber
York Outer
York
NHS Humber and North Yorkshire Integrated Care Board
52
018/0070
Meeting the Health Needs of Families Referred to Family Intervention Projects (FIPs)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£243,514
7 ديسمبر 2009
6 أكتوبر 2011
Not Available
BackgroundThe current research is proposed at a time when the role of Family Intervention Projects is growing and becoming further diversified. In particular, the Department of Health is investing significant funding in the development of FIPs in order to improve their contribution to health (and to reduce health-related risk factors). In this context, it is important to consider how well FIPs meet the complex health needs of the families that are referred to their provision.AimsThe proposed study will complement the ongoing large-scale NatCen evaluation of FIPs by focusing in depth on work in relation to health. The research will determine: the extent to which FIPs take a multi-disciplinary approach to determining child and family needs; FIPs workers’ perceptions of family mental and physical health needs, and the extent to which these are emphasised in intervention and support planning; the extent to which FIPs account for and respond to families’ own priorities and perceived need
Academic
Institute of Education, University of London
WC1H 0AL
51.523
-0.128
529973
182112
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
53
019/0014
A Study of the Efficacy and Cost-Effectiveness of MRSA Screening and Monitoring On Surgical Wards Using a New, Rapid Molecular Test (EMMS)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£1,071,177
1 يوليو 2005
30 سبتمبر 2011
Not Available
BackgroundRecently a sensitive and specific PCR based test has become available (IDI Infectio MRSA) which can be used to screen patients for the carriage of MRSA. This test has been licensed by the FDA and Health Canada but has not yet been evaluated for cost-effectiveness in a U.K. NHS setting. We propose to carry out a prospective comparative study in which the rapid provision of screening results within the working day will be compared with the provision of results using conventional culture based techniques and standard NHS reporting systems. In order to assess outcomes in a rigorous fashion, once patients have been identified as being colonised or infected with MRSA, standard hand contact and isolation or if this proves impossible, cohorting precautions will be instituted in both arms of the study. The target population will be all surgical admissions to 7 surgical wards within the Birmingham Heartlands Hospital. Wards will be divided into molecular who will receive results rapi
Academic
University of Birmingham
B15 2TT
52.453
-1.928
404851
283719
England
West Midlands
Birmingham, Edgbaston
Birmingham
NHS Birmingham and Solihull Integrated Care Board
54
019/0030
Pre-Clinical Evaluation of Candidate Pre-Pandemic Influenza Vaccines: Proposal from the Pandemic Influenza Vaccine Evaluation Consortium (PIVEC - A)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£500,065
1 يونيو 2008
31 أكتوبر 2010
Not Available
BackgroundA comprehensive programme of pre-clinical and clinical research is proposed using stock-piled pre-pandemic influenza vaccines with the aim of evaluating their relative protective efficacy and interchangeability in children, adults and the elderly. We propose “head to head “studies in the ferret animal model and clinical trials in humans using the same vaccines and vaccination schedules that will reflect realistic options for use of the stock-piled vaccines and thus provide a more secure evidence base to support their use. Parallels between indicative experimental animal models and immunogenicity data obtained from human trials will provide the most comprehensive evidence. Optimal interpretation of data requires common evaluation methods likely to reflect relevant correlates of protection in both human and animal systems. These include measurement of functional antibody and assessment of cell-mediated immunity in response to vaccination in the human and evaluation of protecti
Academic
Health Protection Agency
NW9 5EQ
51.595
-0.255
520992
189896
England
London
Hendon
Barnet
NHS North Central London Integrated Care Board
55
019/0041
The SWIne Flu Triage (SWIFT) study: Development and Ongoing Refinement of a Triage Tool to Provide Regular Information to Guide Immediate Policy and Practice for the Use of Critical Care Services During the H1N1 Swine Influenza Pandemic
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£173,518
1 أغسطس 2009
31 يناير 2011
Not Available
BackgroundStudy managed by NETSCC. Please refer to managing agent.AimsStudy managed by NETSCC. Please refer to managing agent.Plan of InvestigationStudy managed by NETSCC. Please refer to managing agent.Potential ImpactStudy managed by NETSCC. Please refer to managing agent.
Government/NHS
INTENSIVE CARE NATIONAL AUDIT AND RESEARCH CENTRE
WC1V 6AZ
51.519
-0.113
531020
181647
England
London
Holborn and St Pancras
Camden
NHS North Central London Integrated Care Board
56
019/0042
A Randomised, Partially Observer-Blind, Multi-Centre, Head-to-Head Comparison of a Two Dose Regimen of Baxter and GSK H1N1 Pandemic Vaccines, Administered 21 Days Apart
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£404,835
1 أكتوبر 2009
30 يونيو 2011
Not Available
BackgroundStudy managed by NETSCC. Please refer to managing agent.AimsStudy managed by NETSCC. Please refer to managing agent.Plan of InvestigationStudy managed by NETSCC. Please refer to managing agent.Potential ImpactStudy managed by NETSCC. Please refer to managing agent.
Government/NHS
University Hospitals Of Leicester NHS Trust
LE1 5WW
52.627
-1.136
458627
303554
England
East Midlands
Leicester South
Leicester
NHS Leicester, Leicestershire and Rutland Integrated Care Board
57
019/0046
Virus Shedding and Environmental Deposition of Novel A(H1N1) Pandemic Influenza Virus
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£372,223
24 أغسطس 2009
23 مايو 2010
Not Available
BackgroundStudy managed by NETSCC. Please refer to managing agent.AimsStudy managed by NETSCC. Please refer to managing agent.Plan of InvestigationStudy managed by NETSCC. Please refer to managing agent.Potential ImpactStudy managed by NETSCC. Please refer to managing agent.
Academic
University of Nottingham
NG7 2RD
52.941
-1.191
454452
338429
England
East Midlands
Nottingham South
Nottingham
NHS Nottingham and Nottinghamshire Integrated Care Board
58
019/0048
Market Research Evaluation of the Secretary of State HCAI Public Campaign to Improve Public Confidence in Clean, Safe Care in the NHS
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£44,542
16 فبراير 2010
15 أكتوبر 2010
Not Available
BackgroundIn September 2008, Secretary of State for Health announced a public/patient campaignto inform the public and patients of action being taken to reduce healthcare associatedinfections (HCAI). The aim of this campaign is to combat public perceptions that theNHS is not ‘getting infections under control’. These perceptions exist despite the factthat data indicates that the number of healthcare associated infections are, in fact,down compared to the same period in previous years. Thus the aim of the publiccampaign is to reduce unnecessary anxiety, challenge misconceptions, outlineresponsibilities and generally build public and patient confidence in the ability of theNHS to control and prevent healthcare associated infections.The NHS Institute for Improvement and Innovation (NHSI) has been commissioned todeliver this HCAI campaign as a social movement (that is getting people to changeperceptions) to increase the proportion of the public and patients who believe thatHCAI are in contr
For-Profit Company
Ipsos MORI UK Limited
E1W 1YW
51.507
-0.067
534232
180499
England
London
Poplar and Limehouse
Tower Hamlets
NHS North East London Integrated Care Board
59
019/0051
Head-to-Head Comparison of two H1N1 Swine Influenza Vaccines in Children Aged 6 Months to 12 Years – Part 2
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£350,626
1 نوفمبر 2010
31 مارس 2011
Not Available
Head-to-Head Comparison of two H1N1 Swine Influenza Vaccines in Children Aged 6 Months to 12 Years – Part 2
Academic
University of Oxford
OX1 2JD
51.758
-1.262
451034
206852
England
South East
Oxford East
Oxford
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
60
019/0053
The Patient Experience of the MRSA Screening Process and the Impact of an MRSA-Positive Result
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£64,516
5 يناير 2012
31 ديسمبر 2012
MRSA is a bacteria carried by many people on the skin and in the nose. Among healthy people it does not usually cause problems. However, in hospitals where people are unwell, MRSA can cause life threatening infections that are difficult to treat. Screening patients, by wiping a cotton bud swab over parts of the body, can determine if they carry MRSA. In England most patients going into hospital are screened. If a patient is found to be carrying MRSA (known as being MRSA positive ) it can be removed. Removal of MRSA is called decolonisation , and involves using a special body wash, shampoo and nasal cream. Patient representatives have suggested that people going into hospital: can be anxious about developing a MRSA infection; may not receive full information about screening; and if they are carrying MRSA, may find using the decolonisation treatment difficult. This study will explore patient s experiences of MRSA screening and in particular, of being MRSA positive. It will also inv
Reducing healthcare associated infection (HCAI) is a priority for the NHS and screening all patients for MRSA on admission to hospital is mandatory, affecting over 14 million patients per year. Research suggests that patients have a poor understanding of MRSA and may be afraid of contracting it if admitted to hospital. However, we do not understand patients experiences of MRSA screening and decolonisation and there is little information to inform screening protocols from a patient perspective and no patient reported experience measures (PREMs). This study aims to explore the MRSA screening process from the perspective of the patient and provide an assessment of the role that screening plays in reassuring patients and maintaining confidence in efforts to minimise the risk of acquiring HCAI. The objectives of the study are to: RO1. Examine the patient s experience of MRSA screening and decolonisation with a particular focus on those who are colonised with MRSA prior to or on admissio
Academic
University of West London
W5 5RF
51.507
-0.303
517870
180068
England
London
Ealing Central and Acton
Ealing
NHS North West London Integrated Care Board
61
019/0054
An investigation of the Patient Experience of MRSA screening
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£37,778
1 يناير 2012
31 مارس 2013
Screening patients for MRSA on or prior to admission to an acute NHS hospital has been standard practice since 2009 and is one means of reducing healthcare associated infections. Although evidence suggests that patients accept the need for screening, little is known about the overall experience and in particular the quality of the information about the significance of a positive result and the decolonisation treatment. As there is no agreed decolonisation treatment protocol patients receive different advice depending on which hospital they visit, which may well be confusing and affect adherence, particularly if their health needs require contact with more than one healthcare organisation. This study will be carried out at four major London hospitals (Guys and St Thomas , King s College and Lewisham Hospitals) to understand the patient experience of being screened and the treatment process. These hospitals provide a wide range of care facilities and serve diverse ethnic and cultural po
MRSA screening on or prior to admission to hospital has been standard practice since 2009 and now affects all but a few admissions who are exempted in accordance with DH guidelines (DH 2010). Patients scheduled for elective surgery are screened at pre admission clinics and, if necessary decolonised prior to admission. Emergency and other admissions are screened within 24 hours of admission. The results of screening tests are usually known within 24 - 48 hours of laboratory submission. Screening test results can be returned to the patient either same day (with PCR based testing), within 24-48 hours (with chromogenic agar based techniques) or anything up to 5 days (with routine culture +/- enrichment). Patients found to be MRSA positive are then likely to undergo decolonisation using a variety of different agents and policies either in the acute setting or in the community. This variation has the potential to significantly influence patients perception of the inconvenience, the import
Academic
King's College London
SE1 8WA
51.505
-0.113
531085
180144
England
London
Vauxhall
Lambeth
NHS South East London Integrated Care Board
62
02/02/01
Computed tomographic colonography versus colonoscopy or barium enema for diagnosis of colorectal cancer in older symptomatic patients: two multicentre randomised trials with economic evaluation (the SIGGAR trials)
NIHR (non-ODA)
Research
Complete
Health Technology Assessment
Commissioned
HTA Commissioned
£1,739,905
1 فبراير 2004
30 يونيو 2011
CT colonography (CTC) is a new health technology for examination of the large bowel that is disseminating at a rapid rate, based on results from small trials that suggest that it is as sensitive as colonoscopy for detecting bowel cancer and large polyps but safer and more acceptable to patients. Many advocate using CTC to screening for bowel cancer (notably in the USA where the technique has received considerable media attention) but in the UK it is more likely that it will find a role for detecting bowel cancer in patients who have symptoms. The symptoms of bowel cancer are very non-specific (e.g. abdominal pain, rectal bleeding, change in bowel habit, etc) and most people who have these symptoms won't have bowel cancer. However, they may still need to see a doctor and undergo a bowel examination in order to exclude the disease. The standard tests for looking at the large bowel are colonoscopy and barium enema. Colonoscopy involves the passage of a thin endoscope around the large b
CT colonography (CTC) is a new health technology for whole-colon examination that is disseminating at a rapid rate, based on results suggesting that it is as sensitive as colonoscopy for colonic cancer and large polyps but safer and more acceptable to patients. In the UK the use of CTC as a screening tool is controversial but a systematic review of the literature suggests that it is very sensitive for cancer and may thus have an important role in the NHS for rapid, accurate, acceptable, safe, and cost-effective investigation of symptomatic patients, most of whom are older and less tolerant of colonoscopy. CTC will be compared to the accepted standards of total colonoscopy and barium enema in two parallel, prospective multicentre randomised trials (randomised 2 to 1 in favour of the standard test), with choice of the standard test depending on local factors such as availability and expertise. The detection or exclusion of significant colorectal neoplasia (cancer and/or polyps >1cm) will
Academic
Imperial College London
SW7 2AZ
51.498
-0.177
526645
179284
England
London
Cities of London and Westminster
Westminster
NHS North West London Integrated Care Board
63
02/06/02
Long-term randomised controlled trial in primary care of the effectiveness and cost-effectiveness of levonorgestrel containing coil (Mirena) against standard treatment for menorrhagia: LAST trial
NIHR (non-ODA)
Research
Complete
Health Technology Assessment
Commissioned
HTA Commissioned
£1,434,393
1 نوفمبر 2004
31 ديسمبر 2014
Heavy periods (menorrhagia) is a very common problem affecting women's lives. The impact of this condition has considerable demand on time and resources in primary and secondary care. However, it is unclear which treatment options are the most effective and the most acceptable to women, particularly in the long term, and experience of care varies widely. Currently 1 in 5 women in the UK have a hysterectomy, half of whom present with heavy periods. This trial will assess the effectiveness, cost-effectiveness and acceptability of using the levonorgestrel IUS (Mirena coil) compared to standard medical treatment for women with menorrhagia presenting in primary care. We want to involve around 120 general practices each recruiting 4 to 5 women with menorrhagia per year to the trial. We wish to recruit around 1200 patients over a two to three year period, commencing November 2004. We will then follow up women, by questionnaire over several years, to look at outcomes such as menorrha
1. Previous trials show that Mirena is more effective than standard medical treatment in reducing the amount of menstrual blood loss in the short term but have not addressed quality of life or longer-term outcomes. We, therefore, propose a RCT, by intention to treat, to evaluate the effects of Mirena versus standard medical treatment (based on RCOG guidelines) over the longer term and in the primary care setting. 2. The project will measure patient centred and surgical outcomes over the "patient journey" along with resource use, in primary and secondary care, over time. 3. The project will model the utilisation and costs of the different intended treatments on the basis of these data. We will thereby be able to confirm, or refute, the hypothesis that treatment of menorrhagia with Mirena in primary care results in gain for patient and health services in the short and long-term compared to standard medical treatment. 4. Extensive sensitivity analysis will be conducted to explore th
Academic
University of Birmingham
B15 2TT
52.453
-1.928
404851
283719
England
West Midlands
Birmingham, Edgbaston
Birmingham
NHS Birmingham and Solihull Integrated Care Board
64
020/0052
Integrating Telecare Systems for Chronic Disease Management in the Community; What Needs to Be Done?
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£561,189
1 نوفمبر 2006
30 يونيو 2010
Not Available
BackgroundThe purpose of the study is to: (i) To identify, describe and understand those factors that promote or inhibit the implementation and integration of telecare systems for chronic disease management in the community with reference to key stakeholders; (ii) To make practical recommendations for the effective resolution of implementation and integration problems in the UK. The objectives of the study are to underpin the development of workable telecare systems for people with chronic disease in the community, and develop principles for this grounded in the experiences of key stakeholders across a range of lay, professional, and private sector communities. We will undertake six interlinked work-packages which span the objectives set out in the commissioning brief, and which aim to step beyond current research, (which provides considerable data on problems of implementation, integration and normalisation within specific NHS contexts), to better understand developments across policy
Academic
University of Newcastle upon Tyne
NE1 7RU
54.980
-1.616
424693
565147
England
North East
Newcastle upon Tyne Central
Newcastle upon Tyne
NHS North East and North Cumbria Integrated Care Board
65
023/0071
Oxford Monitoring System for Attempted Suicide
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£443,468
1 أبريل 2003
31 يناير 2009
Not Available
BackgroundThis application is to support the Oxford Monitoring System for Attempted Suicide, which is a long-term register of all deliberate self-harm (DSH) i.e. self-poisoning and self-injury) presentations to the general hospital in Oxford. Aims of research (i) Comprehensive monitoring of long-term trends in DSH (ii) Identification of information (causes, risk factors and outcome) relevant to service provision for DSH patients (iii) Evaluation of suicide prevention Strategies(iv) Specific research projects on DSH. The Oxford Centre provides extensive advice to other investigators who wish to monitor DSH. We are also in a position to act as a co-ordinating centre for multicentre monitoring of DSH in the UK. Research subject group Individuals presenting to general hospital because ofDSH. Sample size, type and location 1000 persons and 1600 episodes per year (approximate ). The database currently includes information on nearly 28,000 episodes by 17000 individuals. The data are collected
Academic
University of Oxford
OX1 2JD
51.758
-1.262
451034
206852
England
South East
Oxford East
Oxford
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
66
023/0072
Outcomes of Involuntary Hospital Admission in England
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£636,551
1 سبتمبر 2003
31 يناير 2009
Not Available
BackgroundThe study will provide empirical evidence about the practice of involuntary hospital admissions and their outcomes in England. It will benchmark outcomes of involuntary hospital admissions for different patient groups and in different contexts, and identify what patient charactoristics and processes are associated with more or less positive outcome.The study will be conducted at four sites that represent different regions across England and different types of catchment areas, including those charactorised as inner-city, suburban and rural areas, in addition to ethnic mix. A total of 616 sectioned patients will be assessed within one week of admission, and followed up four weeks later. Clinical staff will also be interviewed about practice and events of coercive treatment. Most interviews will be conducted by user researchers. The main outcome is patients' retrospective assessment of involuntary treatment, secondary outcomes, include satisfaction with treatment, clinical c
Academic
Queen Mary University of London
E1 4NS
51.525
-0.041
536021
182455
England
London
Bethnal Green and Bow
Tower Hamlets
NHS North East London Integrated Care Board
67
023/0131
An Evaluation of the Impact of the Chief Nursing Officer's Review of Mental Health Nursing
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£248,208
1 سبتمبر 2007
28 فبراير 2010
Nurses are the biggest professional group in mental health in the UK. They are recognised as central to delivering helpful services. Their work is valued highly by users. Several health, social care and legal changes in recent years mean that nurses are now thinking of the best way of continuing to provide the nursing care users and carers need. To help nurses in this task, the Government’s Chief Nursing Officer for England carried out a review of mental health nursing by asking users, carers, nurses, and other interested groups, about their views of mental health nursing. After doing this, the Government issued a report recommending 16 ways for services to improve mental health nursing for the benefit of users and carers. Recently, the Government asked for proposals to consider how Trusts are doing in meeting these recommendations; this is the aim of our study. Working in partnership users and carers, we will first carry out a survey of mental health services, including Universities,
BackgroundThe Chief Nursing Officer's review of mental health nursing was set up in 2005 and reported in 2006. The final report made 16 recommendations designed to enable mental health services and Universities educating mental health nurses with the ultimate aim to improve the care and experiences of users and their carers. Central to the review was the need to evaluate formally, the impact of the review in addressing this aim, hence the proposed research.AimsAim: To evaluate progress towards and impact of implementation of CNO review recommendations in MHTs and HEIsObejctives1)To establish progress and strategies for implementation of recommendations and accompanying guidance2)To identify facilitators and barriers to implementation3)To examine impact of implementation on user/carer experiences, outcomes of mental health, organisational structures, roles, relationships, staff recruitment and satisfaction 4)To explore the relationship between organisational ownership, implementation p
Government/NHS
Nottinghamshire Healthcare NHS Foundation Trust
NG3 6AA
52.979
-1.126
458752
342793
England
East Midlands
Nottingham East
Nottingham
NHS Nottingham and Nottinghamshire Integrated Care Board
68
023/0135
Self-harm in England: a multicentre investigation of self-harm presentations to general hospital Emergency Departments with implications for suicide prevention, public health policy and clinical services
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£470,361
1 أبريل 2011
30 يونيو 2012
Not Available
Self-harm in England: a multicentre investigation of self-harm presentations to general hospital Emergency Departments with implications for suicide prevention, public health policy and clinical services
Academic
University of Oxford
OX1 2JD
51.758
-1.262
451034
206852
England
South East
Oxford East
Oxford
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
69
023/0163
Exploring the use of the Internet in relation to suicidal behaviour: identifying priorities for prevention
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£233,769
1 أكتوبر 2013
31 مارس 2016
This research will explore how people with suicidal feelings use the Internet and the impact of this on suicidal behaviour (research area 4). It will provide scientific evidence about: how, why, and when people who are feeling suicidal use suicide-related Internet content; how common this is; the characteristics of people more likely to use the Internet; the range of suicide-related content online (including support materials); and how this is interpreted and used. This research is essential because of mounting concern that the Internet can promote suicide. A key challenge for suicide prevention is to deal with harmful content, while capitalising upon the Internet s possibilities for support and preventing suicide. There is currently insufficient evidence available to meet this challenge. The research will gather the experiences of a wide range of people through several samples. At its centre are in-depth interviews with people with lived experience to understand issues from the po
Background: The Internet is transforming the environment for communication about suicide. There are examples of suicides influenced by the Internet, but also suggestions that the Internet can provide support and prevent harm. The Internet thus presents both risks and opportunities for suicide prevention but progress is hampered because systematic empirical evidence is sparse. Aims: The research aims to provide the necessary evidence to derive policy and best practice for the Internet Industry, to guide the development of future online support and suicide prevention approaches, and to inform clinical practice regarding patients Internet use. This will cover: how, when, for what purpose and to what effect the Internet is used by individuals with suicidal feelings; the prevalence of and factors associated with suicide-related Internet use; and description of the types of material accessed and how this is interpreted by users. Research plan and methods of investigation: The research wil
Academic
University of Bristol
BS8 1QU
51.457
-2.607
357890
173309
England
South West
Bristol West
Bristol, City of
NHS Bristol, North Somerset and South Gloucestershire Integrated Care Board
70
023/0164
The ‘Listen-Up!’ Project: Understanding and Helping Looked-After Young People Who Self-Harm
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£480,069
1 نوفمبر 2013
31 أكتوبر 2016
Self-harm (intentionally taking an overdose or causing injury with or without the intent to die) is a sign of serious distress and is poorly understood. Research asking why young people self-harm is lacking especially in those who are looked-after by foster parents or who are in residential care. Self-harm is strongly linked to suicide so it is very important that we understand the behaviour better and gather accurate information to design suitable supports and services. We aim to find out why young people self-harm, whether there are any common pathways into and out of self-harm and what helps with recovery. In one study young people aged 11-18 years and their carers (recruited via the NHS and in the community) will be interviewed to ask what they think got them started with self-harm and what keeps them self-harming. In another study young people will take part in a computer-based self-interview asking about which services are useful and promote recovery from self-harm, and whi
Background. Self-harm is a sign of serious emotional distress and is still poorly understood by academics and clinicians. Significant NHS resources are required to deal with the assessment and management of self-harm. Each year approximately 200,000 episodes of self-harm are seen in general hospitals and many more hidden episodes occur in the community. Self-harm in young people appears to be increasing. This is very worrying because self-harm is the strongest predictor of eventual suicide and each suicide significantly affects many other individuals. Looked-after young people are at particularly high risk of self-harmful behaviour yet there is sparse research targeting this group. Aims in relation to the issue to be addressed. Our aim is to increase understanding of the experience of self-harm in looked-after children and adolescents (aged 11-18 years). We will investigate: 1. What factors most influence the initiation and maintenance of self-harm? (Pathways into self-harm) (Stud
Academic
University of Nottingham
NG7 2RD
52.941
-1.191
454452
338429
England
East Midlands
Nottingham South
Nottingham
NHS Nottingham and Nottinghamshire Integrated Care Board
71
023/0166
Self-harm in primary care patients: a nationally representative cohort study examining patterns of attendance, treatment and referral, and risk of self-harm repetition, suicide and other causes of premature death
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£203,513
1 فبراير 2014
31 يوليو 2015
This application directly addresses Research Areas 1 and 3 in the specification for this funding call. We aim to generate new evidence concerning the treatment received by people who have self-harmed and who are seen in primary care, thereby indicating how risk of self-harm repetition and completed suicide might be lowered in this setting (Area 1). Area 3 is also highly relevant because we will consider how the observed associations and patterns of risk vary by age. The proposed research is particularly important for two reasons: (i) due to a lack of available data, very little research evidence exists for self-harming patients in primary care; (ii) as indicated in the National Institute for Health and Clinical Excellence (NICE) guidelines for self-harm (2004, 2011), primary care should play an important role in assessing and treating this high risk patient group. Unfortunately, we do not currently know whether or not this is so, because the necessary evidence does not exist. The plann
Background: Around 220,000 people annually in England attend hospital immediately after harming themselves. However, very little is known about their subsequent healthcare trajectories and the evidence-base concerning self-harming primary care patients is thin. We need to know more about the self-harm rates among these individuals, their patterns of attendance, treatment and referral, and their subsequent risks of self-harm repetition, completed suicide and premature death from other causes. We need to quantify how frequently patients attend their general practice following self-harm, and the extent to which those who do attend receive effective treatment and / or referral. Aims: We will estimate the self-harm rate in these patients. For those who have self-harmed we will examine patterns of attendance to delineate three distinct groups: (i) regular attendees; (ii) irregular attendees; (iii) those who disengage completely. We will profile these groups by their clinical and socio-de
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
72
023/0167
Risk and resilience: Self-harm and suicide ideation, attempts and completion among high risk groups and the population as a whole.
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£155,829
1 أكتوبر 2013
31 مايو 2017
This research directly addresses the first three research specification questions. Existing general population survey data allow for examination of prevalence, trends, patterning, and risk and protective factors for: self-harm, and suicide ideation, attempts and completion, for the population as a whole and for a wide range of different groups. We will apply consistent and innovative population segmentation analysis techniques to a variety of survey datasets. Central to the study is the review of statistical findings with people with lived experience of self-harm and suicidal crisis through facilitated participatory consultation. General population samples include people without contact with health and social services, and enable people with and without experience of suicidal crisis to be compared. Questions administered sensitively by self-completion mean some people report experiences they have never told anyone - service provider or friend - before, people invisible to other forms
Background With the launch of the new national suicide prevention strategy, high quality research is needed to support its implementation and evaluation of progress. Government and Research Councils have highlighted that ultilising existing data sources can be an efficient and effective use of resources. Epidemiological survey datasets are inclusive of people not in contact with services, enable subgroups to be identified and include controls for comparison. Excellent data resources exist, which have only been partially examined. Aims 1. To prioritise factors to address to reduce suicide behavior among people with a history of self-harm. Including identifying the different factors that predict people who self-harm and have a history of suicide attempts and those who self-harm and have not attempted suicide. 2. To identify the patterns, associations and characteristics of self-harm and suicide behaviour, including risk and protective factors relevant at a time of economic recession,
Academic
National Centre for Social Research
EC1V 0AX
51.527
-0.103
531689
182599
England
London
Islington South and Finsbury
Islington
NHS North Central London Integrated Care Board
73
024/0035
The Dose Response of Fruit and Vegetables on Insulin Resistance in Healthy Participants who are Overweight and at High - Risk of Cardiovascular Disease (CVD): A Randomised Control Trial
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£213,829
1 أبريل 2011
31 أغسطس 2011
Not Available
The Dose Response of Fruit and Vegetables on Insulin Resistance in Healthy Participants who are Overweight and at High - Risk of Cardiovascular Disease (CVD): A Randomised Control Trial
Academic
Queen's University of Belfast
BT7 1NN
54.585
-5.934
145838
528078
Northern Ireland
Not Applicable
Belfast South
Belfast
Not Applicable
74
024/0037
The Impact of Common Gene Variants on the Response of Cardiovascular Risk Factors to Fish Oil Fatty Acids (FINGEN2)
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£73,913
1 أبريل 2011
31 أغسطس 2011
Not Available
The Impact of Common Gene Variants on the Response of Cardiovascular Risk Factors to Fish Oil Fatty Acids (FINGEN2)
Academic
University of Reading
RG6 6AH
51.458
-0.946
473352
173710
England
South East
Reading East
Wokingham
NHS Buckinghamshire, Oxfordshire and Berkshire West Integrated Care Board
75
024/0042
Effect of 1 Year Vitamin D Intervention on Risk of Cardiovascular Disease: A Randomized Controlled Trial at 57ºN
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£195,161
1 أبريل 2011
31 يوليو 2011
Not Available
Effect of 1 Year Vitamin D Intervention on Risk of Cardiovascular Disease: A Randomized Controlled Trial at 57ºN
Academic
University of Aberdeen
AB24 3FX
57.165
-2.100
394104
808245
Scotland
Not Applicable
Aberdeen North
Aberdeen City
Not Applicable
76
024/0043
Biomarker Discovery for the Assessment of Zinc Status
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£474,178
1 أبريل 2011
31 مارس 2014
Not Available
Biomarker Discovery for the Assessment of Zinc Status
Academic
University of Aberdeen
AB24 3FX
57.165
-2.100
394104
808245
Scotland
Not Applicable
Aberdeen North
Aberdeen City
Not Applicable
77
024/0044
Development of a Dose-Responsive Biological Marker for Sucrose Intake Based on Metabolomics and Machine Learning
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£96,721
1 أبريل 2011
31 يوليو 2011
Not Available
Development of a Dose-Responsive Biological Marker for Sucrose Intake Based on Metabolomics and Machine Learning
Academic
Cranfield University
MK43 0AL
52.070
-0.631
494079
242615
England
East of England
Mid Bedfordshire
Central Bedfordshire
NHS Bedfordshire, Luton and Milton Keynes Integrated Care Board
78
024/0050
Modelling approach to determine the duration and intensity of sunlight exposure required to maintain and achieve adequate vitamin D status in winter in ‘at risk’ population groups.
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£282,029
1 ديسمبر 2012
31 أغسطس 2014
This proposal will model the duration and intensity of sunlight required to maintain adequate vitamin D status in winter, and determine whether this is safely achievable in diverse sectors of the UK population. Vitamin D is made in skin when exposed to ultraviolet-B (UVB) in sunlight, but when the sun is low in the sky, as during winter months in UK, there is insufficient UVB to make appreciable vitamin D. Thus a well-documented seasonal cycle of vitamin D status exists. Avoiding vitamin D deficiency entails acquiring a high level of vitamin D during summer, to last through winter: dietary guidance assumes this is mainly achieved by exposure of skin to low levels of sunlight. It is this assumption that we will challenge. We will use a well-validated model to calculate the UVB reaching different parts of the UK year round. The maximum UVB is when the sky is cloudless: we will consider this best case and then modify it using UVB measurements from around the UK. Then we need to know th
Background – the UK s current nutritional guidelines assume that from school age to retirement, vitamin D requirements are met by skin exposure to UVB in sunlight. It is well documented that at latitudes such as the UK there is insufficient sunlight in winter to synthesise appreciable vitamin D, and vitamin D levels fall from autumn to early spring. To maintain year-round adequate supply of vitamin D through sun exposure alone therefore requires a sufficiently high vitamin D status to be reached in summer to last throughout the winter months. The main determinants of quantity of vitamin D synthesis in skin are: available UVB, exposure time and pattern, skin area exposed, skin pigment and age. Given the diversity of the UK population, the latitudinal gradient, and modern lifestyles, is it valid to assume vitamin D requirements can be met by sun exposure? Moreover, with suggestions that vitamin D requirements are higher than previously supposed, can enough vitamin D be synthesised
Academic
The University of Manchester
M13 9PL
53.467
-2.234
384691
397756
England
North West
Manchester Central
Manchester
NHS Greater Manchester Integrated Care Board
79
024/0051
25(OH)D half-life as a marker of vitamin D expenditure and function
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£274,651
2 يوليو 2012
9 يونيو 2014
Vitamin D is essential for bone health and development. Recent evidence also suggests a broader role for vitamin D in other conditions. The prevalence of a low vitamin D status is higher amongst older than younger people and the functionality of vitamin D is reduced, which may be related to ageing processes. Vitamin D status is usually assessed by measuring the amount of 25-hydroxyvitamin D (25(OH)D) in the blood but this depends on both the amount of vitamin D coming into the body from the diet and skin and the amount being used up (vitamin D expenditure). We have developed a method to determine vitamin D expenditure –25(OH)D half-life. There is a lack of clarity what the vitamin D expenditure and thus requirements of different groups of the population is and how this is affected by their vitamin D status, age, body composition kidney function and other factors. This study will capitalise on a vitamin D supplementation trial in the elderly in Newcastle (VDOP) and a 25(OH)D
Background Vitamin D is important for calcium homeostasis and skeletal metabolism and in other areas of health and disease prevention. Recently the IOM updated their recommendations, but recognised that there are uncertainties about how and what amount of vitamin D is needed to achieve the plasma concentrations of 25-hydroxyvitamin D (25(OH)D) associated with optimal health outcomes in different population groups. The plasma concentration of 25(OH)D is used to assess vitamin D status. However, the relationships between intake, plasma 25(OH)D and vitamin D function are not well understood and are influenced by physiological factors including baseline 25(OHD, life-stage and body composition. New biomarkers to assess vitamin D expenditure and function are needed. Aims in relation to the issue to be addressed This study aims to assess the 25(OH)D half-life, reflecting the expenditure of 25(OH)D, and its relationship with determinants such as vitamin D supply, age, kidney function an
Undefined
MRC Human Nutrition Research Unit
CB1 9NL
52.183
0.181
549193
256059
England
East of England
Cambridge
Cambridge
NHS Cambridgeshire and Peterborough Integrated Care Board
80
025/0014
Coordinating Initiative on Older People
NIHR (non-ODA)
Research
Complete
Policy Research Programme
Researcher Led
Policy Research Programme
£208,456
1 أبريل 2002
31 يناير 2009
Not Available
BackgroundThis post is to support the academic quality of the Department of Health's Research Programme which accompanies implementation of the National Service Framework for Older People. The Academic Co-ordinator will offer external scientific and expert advice, support and assistance. This will include: (i) advising on the commissioning process; (ii) advising on and assisting with the management of the programme of studies, communicating with the project researchers, monitoring progress, fostering communication between the projects, disseminating information and establishing links with other programmes, networks, etc.; (iii) advising on completion of projects, enhancing dissemination of findings and identifying their implications for policy and practice. The role of the Academic Co-ordinatior (which will occupy on average one day per week of the Co-ordinator's time over the next three years) is advisory to the Director of Research and Development.AimsHISTORIC PROJECT - Entire abs
Academic
King's College London
SE1 8WA
51.505
-0.113
531085
180144
England
London
Vauxhall
Lambeth
NHS South East London Integrated Care Board
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